CL2015002488A1 - Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienen - Google Patents
Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienenInfo
- Publication number
- CL2015002488A1 CL2015002488A1 CL2015002488A CL2015002488A CL2015002488A1 CL 2015002488 A1 CL2015002488 A1 CL 2015002488A1 CL 2015002488 A CL2015002488 A CL 2015002488A CL 2015002488 A CL2015002488 A CL 2015002488A CL 2015002488 A1 CL2015002488 A1 CL 2015002488A1
- Authority
- CL
- Chile
- Prior art keywords
- salt
- preparation
- pharmaceutical compositions
- abexinostat
- novel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Abstract
SAL DE ABEXINOSTATO; FORMA CRISTALINA RELACIONADA; MÉTODO DE PREPARACIÓN DE ESTA Y LAS COMPOSICIONES FARMACÉUTICAS QUE LA CONTIENEN.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361772191P | 2013-03-04 | 2013-03-04 | |
FR1351898A FR3002733B1 (fr) | 2013-03-04 | 2013-03-04 | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015002488A1 true CL2015002488A1 (es) | 2016-03-11 |
Family
ID=48521256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002488A CL2015002488A1 (es) | 2013-03-04 | 2015-09-04 | Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienen |
Country Status (39)
Country | Link |
---|---|
US (3) | US9115108B2 (es) |
EP (2) | EP3252044A1 (es) |
JP (2) | JP6449177B2 (es) |
CN (2) | CN105263917B (es) |
AR (1) | AR094935A1 (es) |
AU (2) | AU2014224456B2 (es) |
BR (1) | BR112015021443A2 (es) |
CA (1) | CA2903369C (es) |
CL (1) | CL2015002488A1 (es) |
CR (1) | CR20150456A (es) |
CY (1) | CY1119147T1 (es) |
DK (1) | DK2964622T3 (es) |
DO (1) | DOP2015000215A (es) |
EA (2) | EA039113B1 (es) |
ES (1) | ES2632471T3 (es) |
FR (1) | FR3002733B1 (es) |
GE (1) | GEP201706760B (es) |
HK (1) | HK1220965A1 (es) |
HR (1) | HRP20171041T1 (es) |
HU (1) | HUE035299T2 (es) |
IL (1) | IL241038B (es) |
JO (1) | JO3402B1 (es) |
LT (1) | LT2964622T (es) |
MA (1) | MA38423B1 (es) |
ME (1) | ME02814B (es) |
MX (1) | MX355436B (es) |
MY (1) | MY192027A (es) |
NI (1) | NI201500122A (es) |
PE (1) | PE20151591A1 (es) |
PL (1) | PL2964622T3 (es) |
PT (1) | PT2964622T (es) |
RS (1) | RS56224B1 (es) |
SG (1) | SG11201506952YA (es) |
SI (1) | SI2964622T1 (es) |
TN (1) | TN2015000367A1 (es) |
TW (1) | TWI506023B (es) |
UA (1) | UA118550C2 (es) |
UY (1) | UY35356A (es) |
WO (1) | WO2014135776A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
AU2013293087B2 (en) | 2012-07-24 | 2017-08-31 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK) |
CA2888960C (en) | 2012-11-02 | 2017-08-15 | Pfizer Inc. | Bruton's tyrosine kinase inhibitors |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
KR20170043648A (ko) | 2014-09-03 | 2017-04-21 | 파마싸이클릭스 엘엘씨 | 3-[(디메틸아미노)메틸]-n-{2-[4-(히드록시카르바모일)페녹시]에틸}-1-벤조푸란-2-카르복사미드의 신규 염, 관련 결정형, 이의 제조 방법 및 이를 함유하는 약학 조성물 |
FR3025197B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveau sel de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3025196B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveaux sels de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2017011314A1 (en) * | 2015-07-10 | 2017-01-19 | Paharmacyclics Llc | Btk and hdac combinations |
WO2022261401A1 (en) | 2021-06-10 | 2022-12-15 | Teva Pharmaceuticals International Gmbh | Solid state forms of abexinostat and process for preparation thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3038004A (en) * | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Quaternary ammonium compounds |
GB0020721D0 (en) * | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
AU2004230889B2 (en) * | 2003-04-07 | 2008-03-13 | Pharmacyclics Llc | Hydroxamates as therapeutic agents |
US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
US8603521B2 (en) * | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
CA2775229C (en) * | 2009-09-24 | 2014-07-29 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
WO2013039956A2 (en) * | 2011-09-14 | 2013-03-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating mood disorders |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2013
- 2013-03-04 FR FR1351898A patent/FR3002733B1/fr active Active
-
2014
- 2014-02-18 JO JOP/2014/0040A patent/JO3402B1/ar active
- 2014-02-27 UY UY0001035356A patent/UY35356A/es not_active Application Discontinuation
- 2014-02-28 AR ARP140100648A patent/AR094935A1/es unknown
- 2014-03-03 RS RS20170687A patent/RS56224B1/sr unknown
- 2014-03-03 EP EP17166690.2A patent/EP3252044A1/fr not_active Withdrawn
- 2014-03-03 BR BR112015021443A patent/BR112015021443A2/pt not_active IP Right Cessation
- 2014-03-03 EA EA201891023A patent/EA039113B1/ru unknown
- 2014-03-03 MY MYPI2015002172A patent/MY192027A/en unknown
- 2014-03-03 LT LTEP14711833.5T patent/LT2964622T/lt unknown
- 2014-03-03 SI SI201430278T patent/SI2964622T1/sl unknown
- 2014-03-03 PT PT147118335T patent/PT2964622T/pt unknown
- 2014-03-03 MA MA38423A patent/MA38423B1/fr unknown
- 2014-03-03 GE GEAP201413950A patent/GEP201706760B/en unknown
- 2014-03-03 WO PCT/FR2014/050455 patent/WO2014135776A1/fr active Application Filing
- 2014-03-03 TW TW103107081A patent/TWI506023B/zh active
- 2014-03-03 ES ES14711833.5T patent/ES2632471T3/es active Active
- 2014-03-03 JP JP2015560740A patent/JP6449177B2/ja active Active
- 2014-03-03 SG SG11201506952YA patent/SG11201506952YA/en unknown
- 2014-03-03 PE PE2015001875A patent/PE20151591A1/es unknown
- 2014-03-03 EP EP14711833.5A patent/EP2964622B1/fr active Active
- 2014-03-03 PL PL14711833T patent/PL2964622T3/pl unknown
- 2014-03-03 CA CA2903369A patent/CA2903369C/en active Active
- 2014-03-03 HU HUE14711833A patent/HUE035299T2/en unknown
- 2014-03-03 CN CN201480012148.5A patent/CN105263917B/zh active Active
- 2014-03-03 AU AU2014224456A patent/AU2014224456B2/en active Active
- 2014-03-03 DK DK14711833.5T patent/DK2964622T3/en active
- 2014-03-03 ME MEP-2017-139A patent/ME02814B/me unknown
- 2014-03-03 EA EA201591530A patent/EA030689B1/ru unknown
- 2014-03-03 US US14/195,186 patent/US9115108B2/en active Active
- 2014-03-03 UA UAA201508558A patent/UA118550C2/uk unknown
- 2014-03-03 MX MX2015011566A patent/MX355436B/es active IP Right Grant
- 2014-03-03 CN CN201811248983.5A patent/CN109734690B/zh active Active
-
2015
- 2015-07-13 US US14/798,412 patent/US20150315167A1/en not_active Abandoned
- 2015-08-26 TN TN2015000367A patent/TN2015000367A1/fr unknown
- 2015-09-02 CR CR20150456A patent/CR20150456A/es unknown
- 2015-09-02 IL IL241038A patent/IL241038B/en active IP Right Grant
- 2015-09-04 NI NI201500122A patent/NI201500122A/es unknown
- 2015-09-04 CL CL2015002488A patent/CL2015002488A1/es unknown
- 2015-09-04 DO DO2015000215A patent/DOP2015000215A/es unknown
-
2016
- 2016-06-28 HK HK16107535.9A patent/HK1220965A1/zh unknown
-
2017
- 2017-01-12 US US15/405,021 patent/US10150748B2/en active Active
- 2017-07-06 CY CY20171100723T patent/CY1119147T1/el unknown
- 2017-07-07 HR HRP20171041TT patent/HRP20171041T1/hr unknown
-
2018
- 2018-04-26 AU AU2018202881A patent/AU2018202881B2/en active Active
- 2018-12-05 JP JP2018228486A patent/JP6720280B2/ja active Active
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