BR112015021443A2 - novo sal de abexinostato, forma cristalina associada, um processo para preparação dos mesmos e composições farmacêuticas contendo-os - Google Patents
novo sal de abexinostato, forma cristalina associada, um processo para preparação dos mesmos e composições farmacêuticas contendo-osInfo
- Publication number
- BR112015021443A2 BR112015021443A2 BR112015021443A BR112015021443A BR112015021443A2 BR 112015021443 A2 BR112015021443 A2 BR 112015021443A2 BR 112015021443 A BR112015021443 A BR 112015021443A BR 112015021443 A BR112015021443 A BR 112015021443A BR 112015021443 A2 BR112015021443 A2 BR 112015021443A2
- Authority
- BR
- Brazil
- Prior art keywords
- abexinostate
- crystalline form
- salt
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
resumo patente de invenção "novo sal de abexinostato, forma cristalina associada, um processo para preparação dos mesmos e composições farmacêuticas contendo-os" a presente invenção refere-se ao tosilato de abexinostato de fórmula (ii): e a sua forma cristalina i, caracterizada pelo seu diagrama de difração de raios x por pó, seu espectro de raman e seu espectro 13c cp/mas nmr de estado sólido.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361772191P | 2013-03-04 | 2013-03-04 | |
FR1351898A FR3002733B1 (fr) | 2013-03-04 | 2013-03-04 | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
PCT/FR2014/050455 WO2014135776A1 (fr) | 2013-03-04 | 2014-03-03 | Nouveau sel de l'abexinostat, forme cristalline associee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015021443A2 true BR112015021443A2 (pt) | 2017-07-18 |
Family
ID=48521256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015021443A BR112015021443A2 (pt) | 2013-03-04 | 2014-03-03 | novo sal de abexinostato, forma cristalina associada, um processo para preparação dos mesmos e composições farmacêuticas contendo-os |
Country Status (39)
Country | Link |
---|---|
US (3) | US9115108B2 (pt) |
EP (2) | EP3252044A1 (pt) |
JP (2) | JP6449177B2 (pt) |
CN (2) | CN105263917B (pt) |
AR (1) | AR094935A1 (pt) |
AU (2) | AU2014224456B2 (pt) |
BR (1) | BR112015021443A2 (pt) |
CA (1) | CA2903369C (pt) |
CL (1) | CL2015002488A1 (pt) |
CR (1) | CR20150456A (pt) |
CY (1) | CY1119147T1 (pt) |
DK (1) | DK2964622T3 (pt) |
DO (1) | DOP2015000215A (pt) |
EA (2) | EA030689B1 (pt) |
ES (1) | ES2632471T3 (pt) |
FR (1) | FR3002733B1 (pt) |
GE (1) | GEP201706760B (pt) |
HK (1) | HK1220965A1 (pt) |
HR (1) | HRP20171041T1 (pt) |
HU (1) | HUE035299T2 (pt) |
IL (1) | IL241038B (pt) |
JO (1) | JO3402B1 (pt) |
LT (1) | LT2964622T (pt) |
MA (1) | MA38423B1 (pt) |
ME (1) | ME02814B (pt) |
MX (1) | MX355436B (pt) |
MY (1) | MY192027A (pt) |
NI (1) | NI201500122A (pt) |
PE (1) | PE20151591A1 (pt) |
PL (1) | PL2964622T3 (pt) |
PT (1) | PT2964622T (pt) |
RS (1) | RS56224B1 (pt) |
SG (1) | SG11201506952YA (pt) |
SI (1) | SI2964622T1 (pt) |
TN (1) | TN2015000367A1 (pt) |
TW (1) | TWI506023B (pt) |
UA (1) | UA118550C2 (pt) |
UY (1) | UY35356A (pt) |
WO (1) | WO2014135776A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3113343A1 (en) | 2010-06-03 | 2011-12-08 | Pharmacyclics Llc | Use of inhibitors of bruton's tyrosine kinase (btk) in the treatment of follicular lymphoma |
EP3550031A1 (en) | 2012-07-24 | 2019-10-09 | Pharmacyclics, LLC | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
AP2015008381A0 (en) | 2012-11-02 | 2015-04-30 | Pfizer | Bruton's tyrosine kinase inhibitors |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
AU2015311905B2 (en) * | 2014-09-03 | 2020-03-05 | Pharmacyclics Llc | Novel salts of 3-[(dimethylamino)methyl)-N-{2-(4-(hydroxycarbamoyl) phenoxy)ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same |
FR3025196B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveaux sels de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3025197B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveau sel de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2017011314A1 (en) * | 2015-07-10 | 2017-01-19 | Paharmacyclics Llc | Btk and hdac combinations |
WO2022261401A1 (en) | 2021-06-10 | 2022-12-15 | Teva Pharmaceuticals International Gmbh | Solid state forms of abexinostat and process for preparation thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3038004A (en) * | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Quaternary ammonium compounds |
GB0020721D0 (en) * | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
AU2004230889B2 (en) * | 2003-04-07 | 2008-03-13 | Pharmacyclics Llc | Hydroxamates as therapeutic agents |
US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
US8603521B2 (en) * | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
US8609854B2 (en) * | 2009-09-24 | 2013-12-17 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
WO2013039956A2 (en) * | 2011-09-14 | 2013-03-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating mood disorders |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2013
- 2013-03-04 FR FR1351898A patent/FR3002733B1/fr active Active
-
2014
- 2014-02-18 JO JOP/2014/0040A patent/JO3402B1/ar active
- 2014-02-27 UY UY0001035356A patent/UY35356A/es not_active Application Discontinuation
- 2014-02-28 AR ARP140100648A patent/AR094935A1/es unknown
- 2014-03-03 MA MA38423A patent/MA38423B1/fr unknown
- 2014-03-03 EP EP17166690.2A patent/EP3252044A1/fr not_active Withdrawn
- 2014-03-03 BR BR112015021443A patent/BR112015021443A2/pt not_active IP Right Cessation
- 2014-03-03 MX MX2015011566A patent/MX355436B/es active IP Right Grant
- 2014-03-03 UA UAA201508558A patent/UA118550C2/uk unknown
- 2014-03-03 PE PE2015001875A patent/PE20151591A1/es unknown
- 2014-03-03 CN CN201480012148.5A patent/CN105263917B/zh active Active
- 2014-03-03 TW TW103107081A patent/TWI506023B/zh active
- 2014-03-03 EP EP14711833.5A patent/EP2964622B1/fr active Active
- 2014-03-03 US US14/195,186 patent/US9115108B2/en active Active
- 2014-03-03 ES ES14711833.5T patent/ES2632471T3/es active Active
- 2014-03-03 DK DK14711833.5T patent/DK2964622T3/en active
- 2014-03-03 GE GEAP201413950A patent/GEP201706760B/en unknown
- 2014-03-03 HU HUE14711833A patent/HUE035299T2/en unknown
- 2014-03-03 RS RS20170687A patent/RS56224B1/sr unknown
- 2014-03-03 EA EA201591530A patent/EA030689B1/ru unknown
- 2014-03-03 PT PT147118335T patent/PT2964622T/pt unknown
- 2014-03-03 PL PL14711833T patent/PL2964622T3/pl unknown
- 2014-03-03 JP JP2015560740A patent/JP6449177B2/ja active Active
- 2014-03-03 CA CA2903369A patent/CA2903369C/en active Active
- 2014-03-03 SI SI201430278T patent/SI2964622T1/sl unknown
- 2014-03-03 AU AU2014224456A patent/AU2014224456B2/en active Active
- 2014-03-03 LT LTEP14711833.5T patent/LT2964622T/lt unknown
- 2014-03-03 CN CN201811248983.5A patent/CN109734690B/zh active Active
- 2014-03-03 WO PCT/FR2014/050455 patent/WO2014135776A1/fr active Application Filing
- 2014-03-03 ME MEP-2017-139A patent/ME02814B/me unknown
- 2014-03-03 EA EA201891023A patent/EA039113B1/ru unknown
- 2014-03-03 SG SG11201506952YA patent/SG11201506952YA/en unknown
- 2014-03-03 MY MYPI2015002172A patent/MY192027A/en unknown
-
2015
- 2015-07-13 US US14/798,412 patent/US20150315167A1/en not_active Abandoned
- 2015-08-26 TN TN2015000367A patent/TN2015000367A1/fr unknown
- 2015-09-02 IL IL241038A patent/IL241038B/en active IP Right Grant
- 2015-09-02 CR CR20150456A patent/CR20150456A/es unknown
- 2015-09-04 DO DO2015000215A patent/DOP2015000215A/es unknown
- 2015-09-04 CL CL2015002488A patent/CL2015002488A1/es unknown
- 2015-09-04 NI NI201500122A patent/NI201500122A/es unknown
-
2016
- 2016-06-28 HK HK16107535.9A patent/HK1220965A1/zh unknown
-
2017
- 2017-01-12 US US15/405,021 patent/US10150748B2/en active Active
- 2017-07-06 CY CY20171100723T patent/CY1119147T1/el unknown
- 2017-07-07 HR HRP20171041TT patent/HRP20171041T1/hr unknown
-
2018
- 2018-04-26 AU AU2018202881A patent/AU2018202881B2/en active Active
- 2018-12-05 JP JP2018228486A patent/JP6720280B2/ja active Active
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2660 DE 28-12-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |