MX355436B - Sal novedosa de abexinostato, forma cristalina asociada, método de preparacion de la misma y las composiciones farmaceuticas que contienen la misma. - Google Patents
Sal novedosa de abexinostato, forma cristalina asociada, método de preparacion de la misma y las composiciones farmaceuticas que contienen la misma.Info
- Publication number
- MX355436B MX355436B MX2015011566A MX2015011566A MX355436B MX 355436 B MX355436 B MX 355436B MX 2015011566 A MX2015011566 A MX 2015011566A MX 2015011566 A MX2015011566 A MX 2015011566A MX 355436 B MX355436 B MX 355436B
- Authority
- MX
- Mexico
- Prior art keywords
- crystalline form
- abexinostate
- salt
- novel
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Abexinostato tosilato de fórmula (II): (ver Fórmula) y la forma cristalina I del mismo caracterizada por el patrón de difracción de polvo X del mismo, el espectro Raman del mismo, y el espectro en estado sólido 13C CP/MAS RMN del mismo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361772191P | 2013-03-04 | 2013-03-04 | |
| FR1351898A FR3002733B1 (fr) | 2013-03-04 | 2013-03-04 | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2014/050455 WO2014135776A1 (fr) | 2013-03-04 | 2014-03-03 | Nouveau sel de l'abexinostat, forme cristalline associee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015011566A MX2015011566A (es) | 2016-06-24 |
| MX355436B true MX355436B (es) | 2018-04-18 |
Family
ID=48521256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015011566A MX355436B (es) | 2013-03-04 | 2014-03-03 | Sal novedosa de abexinostato, forma cristalina asociada, método de preparacion de la misma y las composiciones farmaceuticas que contienen la misma. |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US9115108B2 (es) |
| EP (2) | EP3252044A1 (es) |
| JP (2) | JP6449177B2 (es) |
| CN (2) | CN105263917B (es) |
| AR (1) | AR094935A1 (es) |
| AU (2) | AU2014224456B2 (es) |
| BR (1) | BR112015021443A2 (es) |
| CA (1) | CA2903369C (es) |
| CL (1) | CL2015002488A1 (es) |
| CR (1) | CR20150456A (es) |
| CY (1) | CY1119147T1 (es) |
| DK (1) | DK2964622T3 (es) |
| DO (1) | DOP2015000215A (es) |
| EA (2) | EA030689B1 (es) |
| ES (1) | ES2632471T3 (es) |
| FR (1) | FR3002733B1 (es) |
| GE (1) | GEP201706760B (es) |
| HK (1) | HK1220965A1 (es) |
| HR (1) | HRP20171041T1 (es) |
| HU (1) | HUE035299T2 (es) |
| IL (1) | IL241038B (es) |
| JO (1) | JO3402B1 (es) |
| LT (1) | LT2964622T (es) |
| MA (1) | MA38423B1 (es) |
| ME (1) | ME02814B (es) |
| MX (1) | MX355436B (es) |
| MY (1) | MY192027A (es) |
| NI (1) | NI201500122A (es) |
| PE (1) | PE20151591A1 (es) |
| PL (1) | PL2964622T3 (es) |
| PT (1) | PT2964622T (es) |
| RS (1) | RS56224B1 (es) |
| SG (1) | SG11201506952YA (es) |
| SI (1) | SI2964622T1 (es) |
| TN (1) | TN2015000367A1 (es) |
| TW (1) | TWI506023B (es) |
| UA (1) | UA118550C2 (es) |
| UY (1) | UY35356A (es) |
| WO (1) | WO2014135776A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| US20150291554A1 (en) | 2012-11-02 | 2015-10-15 | Pfizer Inc. | Bruton's Tyrosine Kinase Inhibitors |
| FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2942528A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| MX2017002858A (es) * | 2014-09-03 | 2017-10-24 | Pharmacyclics Llc | Sales novedosas de 3-[(dimetilamino)metil]-n-{2-[4-(hidroxicarbamo il)fenoxi]etil}-1-benzofuran-2-carboxamida, formas cristalinas relacionadas, metodo para preparar las mismas y las composiciones farmaceuticas que contiene las mismas. |
| FR3025197B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveau sel de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3025196B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveaux sels de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2017011314A1 (en) * | 2015-07-10 | 2017-01-19 | Paharmacyclics Llc | Btk and hdac combinations |
| WO2022261401A1 (en) | 2021-06-10 | 2022-12-15 | Teva Pharmaceuticals International Gmbh | Solid state forms of abexinostat and process for preparation thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3038004A (en) * | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Quaternary ammonium compounds |
| GB0020721D0 (en) * | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
| BRPI0409227C1 (pt) * | 2003-04-07 | 2021-05-25 | Axys Pharm Inc | composto, composição farmacêutica, uso de um composto e processo para a preparação de um composto de fórmula (i) |
| US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
| US8603521B2 (en) * | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
| EP2480534A1 (en) * | 2009-09-24 | 2012-08-01 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
| WO2013039956A2 (en) * | 2011-09-14 | 2013-03-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating mood disorders |
| FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2013
- 2013-03-04 FR FR1351898A patent/FR3002733B1/fr active Active
-
2014
- 2014-02-18 JO JOP/2014/0040A patent/JO3402B1/ar active
- 2014-02-27 UY UY0001035356A patent/UY35356A/es not_active Application Discontinuation
- 2014-02-28 AR ARP140100648A patent/AR094935A1/es unknown
- 2014-03-03 PT PT147118335T patent/PT2964622T/pt unknown
- 2014-03-03 LT LTEP14711833.5T patent/LT2964622T/lt unknown
- 2014-03-03 CN CN201480012148.5A patent/CN105263917B/zh active Active
- 2014-03-03 ES ES14711833.5T patent/ES2632471T3/es active Active
- 2014-03-03 DK DK14711833.5T patent/DK2964622T3/en active
- 2014-03-03 ME MEP-2017-139A patent/ME02814B/me unknown
- 2014-03-03 CN CN201811248983.5A patent/CN109734690B/zh active Active
- 2014-03-03 JP JP2015560740A patent/JP6449177B2/ja active Active
- 2014-03-03 PL PL14711833T patent/PL2964622T3/pl unknown
- 2014-03-03 SI SI201430278T patent/SI2964622T1/sl unknown
- 2014-03-03 AU AU2014224456A patent/AU2014224456B2/en active Active
- 2014-03-03 GE GEAP201413950A patent/GEP201706760B/en unknown
- 2014-03-03 MY MYPI2015002172A patent/MY192027A/en unknown
- 2014-03-03 PE PE2015001875A patent/PE20151591A1/es unknown
- 2014-03-03 EP EP17166690.2A patent/EP3252044A1/fr not_active Withdrawn
- 2014-03-03 UA UAA201508558A patent/UA118550C2/uk unknown
- 2014-03-03 WO PCT/FR2014/050455 patent/WO2014135776A1/fr active Application Filing
- 2014-03-03 EA EA201591530A patent/EA030689B1/ru unknown
- 2014-03-03 HU HUE14711833A patent/HUE035299T2/en unknown
- 2014-03-03 BR BR112015021443A patent/BR112015021443A2/pt not_active IP Right Cessation
- 2014-03-03 SG SG11201506952YA patent/SG11201506952YA/en unknown
- 2014-03-03 US US14/195,186 patent/US9115108B2/en active Active
- 2014-03-03 MX MX2015011566A patent/MX355436B/es active IP Right Grant
- 2014-03-03 MA MA38423A patent/MA38423B1/fr unknown
- 2014-03-03 EP EP14711833.5A patent/EP2964622B1/fr active Active
- 2014-03-03 RS RS20170687A patent/RS56224B1/sr unknown
- 2014-03-03 CA CA2903369A patent/CA2903369C/en active Active
- 2014-03-03 TW TW103107081A patent/TWI506023B/zh active
- 2014-03-03 EA EA201891023A patent/EA039113B1/ru unknown
-
2015
- 2015-07-13 US US14/798,412 patent/US20150315167A1/en not_active Abandoned
- 2015-08-26 TN TN2015000367A patent/TN2015000367A1/fr unknown
- 2015-09-02 IL IL241038A patent/IL241038B/en active IP Right Grant
- 2015-09-02 CR CR20150456A patent/CR20150456A/es unknown
- 2015-09-04 NI NI201500122A patent/NI201500122A/es unknown
- 2015-09-04 DO DO2015000215A patent/DOP2015000215A/es unknown
- 2015-09-04 CL CL2015002488A patent/CL2015002488A1/es unknown
-
2016
- 2016-06-28 HK HK16107535.9A patent/HK1220965A1/zh unknown
-
2017
- 2017-01-12 US US15/405,021 patent/US10150748B2/en active Active
- 2017-07-06 CY CY20171100723T patent/CY1119147T1/el unknown
- 2017-07-07 HR HRP20171041TT patent/HRP20171041T1/hr unknown
-
2018
- 2018-04-26 AU AU2018202881A patent/AU2018202881B2/en active Active
- 2018-12-05 JP JP2018228486A patent/JP6720280B2/ja active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |