DOP2015000215A - Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienen - Google Patents
Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienenInfo
- Publication number
- DOP2015000215A DOP2015000215A DO2015000215A DO2015000215A DOP2015000215A DO P2015000215 A DOP2015000215 A DO P2015000215A DO 2015000215 A DO2015000215 A DO 2015000215A DO 2015000215 A DO2015000215 A DO 2015000215A DO P2015000215 A DOP2015000215 A DO P2015000215A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- crystalline form
- novedosa
- abexinostato
- salt
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
TOSILATO ABEXINOSTATO DE LA FÓRMULA (II): Y LA FORMA I CRISTALINA DE ESTE CARACTERIZADO POR EL PATRÓN DE DIFRACCIÓN X EN POLVO DEL MISMO, EL ESPECTRO DE RAMAN DE ESTE, Y EL ESPECTRO DE NMR CP/MAS 13C EN ESTADO SÓLIDO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361772191P | 2013-03-04 | 2013-03-04 | |
FR1351898A FR3002733B1 (fr) | 2013-03-04 | 2013-03-04 | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2015000215A true DOP2015000215A (es) | 2015-09-30 |
Family
ID=48521256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2015000215A DOP2015000215A (es) | 2013-03-04 | 2015-09-04 | Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienen |
Country Status (39)
Country | Link |
---|---|
US (3) | US9115108B2 (es) |
EP (2) | EP3252044A1 (es) |
JP (2) | JP6449177B2 (es) |
CN (2) | CN109734690B (es) |
AR (1) | AR094935A1 (es) |
AU (2) | AU2014224456B2 (es) |
BR (1) | BR112015021443A2 (es) |
CA (1) | CA2903369C (es) |
CL (1) | CL2015002488A1 (es) |
CR (1) | CR20150456A (es) |
CY (1) | CY1119147T1 (es) |
DK (1) | DK2964622T3 (es) |
DO (1) | DOP2015000215A (es) |
EA (2) | EA039113B1 (es) |
ES (1) | ES2632471T3 (es) |
FR (1) | FR3002733B1 (es) |
GE (1) | GEP201706760B (es) |
HK (1) | HK1220965A1 (es) |
HR (1) | HRP20171041T1 (es) |
HU (1) | HUE035299T2 (es) |
IL (1) | IL241038B (es) |
JO (1) | JO3402B1 (es) |
LT (1) | LT2964622T (es) |
MA (1) | MA38423B1 (es) |
ME (1) | ME02814B (es) |
MX (1) | MX355436B (es) |
MY (1) | MY192027A (es) |
NI (1) | NI201500122A (es) |
PE (1) | PE20151591A1 (es) |
PL (1) | PL2964622T3 (es) |
PT (1) | PT2964622T (es) |
RS (1) | RS56224B1 (es) |
SG (1) | SG11201506952YA (es) |
SI (1) | SI2964622T1 (es) |
TN (1) | TN2015000367A1 (es) |
TW (1) | TWI506023B (es) |
UA (1) | UA118550C2 (es) |
UY (1) | UY35356A (es) |
WO (1) | WO2014135776A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020004501A (es) | 2010-06-03 | 2021-11-09 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
KR20180088926A (ko) | 2012-07-24 | 2018-08-07 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
US20150291554A1 (en) | 2012-11-02 | 2015-10-15 | Pfizer Inc. | Bruton's Tyrosine Kinase Inhibitors |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
FR3025196B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveaux sels de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU2015311905B2 (en) * | 2014-09-03 | 2020-03-05 | Pharmacyclics Llc | Novel salts of 3-[(dimethylamino)methyl)-N-{2-(4-(hydroxycarbamoyl) phenoxy)ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same |
FR3025197B1 (fr) * | 2014-09-03 | 2019-09-06 | Pharmacyclics, Inc. | Nouveau sel de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2017011314A1 (en) * | 2015-07-10 | 2017-01-19 | Paharmacyclics Llc | Btk and hdac combinations |
WO2022261401A1 (en) | 2021-06-10 | 2022-12-15 | Teva Pharmaceuticals International Gmbh | Solid state forms of abexinostat and process for preparation thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3038004A (en) * | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Quaternary ammonium compounds |
GB0020721D0 (en) * | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
MXPA05010782A (es) * | 2003-04-07 | 2005-12-12 | Axys Pharm Inc | Nuevos hidroxamatos como agentees terapeuticos. |
US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
US8603521B2 (en) * | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
WO2011036647A1 (en) * | 2009-09-24 | 2011-03-31 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
WO2013039956A2 (en) * | 2011-09-14 | 2013-03-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating mood disorders |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2013
- 2013-03-04 FR FR1351898A patent/FR3002733B1/fr active Active
-
2014
- 2014-02-18 JO JOP/2014/0040A patent/JO3402B1/ar active
- 2014-02-27 UY UY0001035356A patent/UY35356A/es not_active Application Discontinuation
- 2014-02-28 AR ARP140100648A patent/AR094935A1/es unknown
- 2014-03-03 MY MYPI2015002172A patent/MY192027A/en unknown
- 2014-03-03 EP EP17166690.2A patent/EP3252044A1/fr not_active Withdrawn
- 2014-03-03 EA EA201891023A patent/EA039113B1/ru unknown
- 2014-03-03 CN CN201811248983.5A patent/CN109734690B/zh active Active
- 2014-03-03 WO PCT/FR2014/050455 patent/WO2014135776A1/fr active Application Filing
- 2014-03-03 LT LTEP14711833.5T patent/LT2964622T/lt unknown
- 2014-03-03 MX MX2015011566A patent/MX355436B/es active IP Right Grant
- 2014-03-03 SI SI201430278T patent/SI2964622T1/sl unknown
- 2014-03-03 HU HUE14711833A patent/HUE035299T2/en unknown
- 2014-03-03 EP EP14711833.5A patent/EP2964622B1/fr active Active
- 2014-03-03 CN CN201480012148.5A patent/CN105263917B/zh active Active
- 2014-03-03 ES ES14711833.5T patent/ES2632471T3/es active Active
- 2014-03-03 UA UAA201508558A patent/UA118550C2/uk unknown
- 2014-03-03 JP JP2015560740A patent/JP6449177B2/ja active Active
- 2014-03-03 GE GEAP201413950A patent/GEP201706760B/en unknown
- 2014-03-03 DK DK14711833.5T patent/DK2964622T3/en active
- 2014-03-03 PL PL14711833T patent/PL2964622T3/pl unknown
- 2014-03-03 PT PT147118335T patent/PT2964622T/pt unknown
- 2014-03-03 MA MA38423A patent/MA38423B1/fr unknown
- 2014-03-03 PE PE2015001875A patent/PE20151591A1/es unknown
- 2014-03-03 TW TW103107081A patent/TWI506023B/zh active
- 2014-03-03 EA EA201591530A patent/EA030689B1/ru unknown
- 2014-03-03 ME MEP-2017-139A patent/ME02814B/me unknown
- 2014-03-03 US US14/195,186 patent/US9115108B2/en active Active
- 2014-03-03 CA CA2903369A patent/CA2903369C/en active Active
- 2014-03-03 SG SG11201506952YA patent/SG11201506952YA/en unknown
- 2014-03-03 RS RS20170687A patent/RS56224B1/sr unknown
- 2014-03-03 AU AU2014224456A patent/AU2014224456B2/en active Active
- 2014-03-03 BR BR112015021443A patent/BR112015021443A2/pt not_active IP Right Cessation
-
2015
- 2015-07-13 US US14/798,412 patent/US20150315167A1/en not_active Abandoned
- 2015-08-26 TN TN2015000367A patent/TN2015000367A1/fr unknown
- 2015-09-02 CR CR20150456A patent/CR20150456A/es unknown
- 2015-09-02 IL IL241038A patent/IL241038B/en active IP Right Grant
- 2015-09-04 DO DO2015000215A patent/DOP2015000215A/es unknown
- 2015-09-04 NI NI201500122A patent/NI201500122A/es unknown
- 2015-09-04 CL CL2015002488A patent/CL2015002488A1/es unknown
-
2016
- 2016-06-28 HK HK16107535.9A patent/HK1220965A1/zh unknown
-
2017
- 2017-01-12 US US15/405,021 patent/US10150748B2/en active Active
- 2017-07-06 CY CY20171100723T patent/CY1119147T1/el unknown
- 2017-07-07 HR HRP20171041TT patent/HRP20171041T1/hr unknown
-
2018
- 2018-04-26 AU AU2018202881A patent/AU2018202881B2/en active Active
- 2018-12-05 JP JP2018228486A patent/JP6720280B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DOP2015000215A (es) | Sal de abexinostato novedosa, forma cristalina relacionada, método de preparación de esta y las composiciones farmacéuticas que la contienen | |
CY1124068T1 (el) | Στερεες μορφες ενος εκλεκτικου αναστολεα cdk4/6 | |
CR20150633A (es) | Derivados del bipirazol como inhibidores jak | |
UA116648C2 (uk) | Фумарати як проліки та їх застосування при лікуванні різних захворювань | |
DOP2015000157A (es) | Lactamas fusionadas de arilo y heteroarilo | |
CU20170162A7 (es) | Derivados de fenil-tieno(2,3-d)pirimidina-hidroxiácido útiles en el tratamiento del cáncer y enfermedades autoinmunes, método de preparación de los mismos y composiciones farmacéuticas que los contienen | |
CU20140048A7 (es) | Novedosos derivados de purina útiles en el tratamiento del cáncer y trastornos neurodegenerativos | |
UY34657A (es) | ?derivados macrocíclicos para el tratamiento de enfermedades?. | |
MX2015014298A (es) | Compuestos de dihidropirido pirimidina como inhibidores de autotaxina. | |
UY36070A (es) | Triterpenoides con actividad inhibidora de la maduración de hiv | |
SV2016005310A (es) | Derivados de diheterociclo enlazado a cicloalquilo | |
NI201500176A (es) | Derivados de prodroga de triazolpiridinas sustituidas | |
CR20120655A (es) | Forma cristalina delta de la sal de arginina de perindoprilo, su procedimiento de preparación, y las composiciones farmacéuticas que la contienen | |
EA201791396A1 (ru) | ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ | |
CY1119540T1 (el) | Υποκατασταθεντα απο γλυκοπυρανοσυλιο παραγωγα ινδολο-ουριας και η χρηση τους ως αναστολεις sglt | |
UY35004A (es) | Forma amorfa estabilizada de la agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que la contienen | |
BR112018008319A2 (pt) | formulação de fviii | |
NI201500172A (es) | Composiciones farmacéuticas | |
CO2017007074A2 (es) | Sintesis total de trioxacarcina dc-45-a2 y preparación de analogos de trioxacarcina | |
EA201700037A1 (ru) | Производные 2н-хромена в качестве анальгезирующих средств |