CY1119984T1 - Σταθεροποιημενη αμορφη μορφη αγομελατινης, μια μεθοδος για την παρασκευη της και φαρμακευτικες συνθεσεις που την περιεχουν - Google Patents

Σταθεροποιημενη αμορφη μορφη αγομελατινης, μια μεθοδος για την παρασκευη της και φαρμακευτικες συνθεσεις που την περιεχουν

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Publication number
CY1119984T1
CY1119984T1 CY20181100099T CY181100099T CY1119984T1 CY 1119984 T1 CY1119984 T1 CY 1119984T1 CY 20181100099 T CY20181100099 T CY 20181100099T CY 181100099 T CY181100099 T CY 181100099T CY 1119984 T1 CY1119984 T1 CY 1119984T1
Authority
CY
Cyprus
Prior art keywords
stabilized
amporated
agomelatinin
preparing
pharmaceutical compositions
Prior art date
Application number
CY20181100099T
Other languages
English (en)
Inventor
David LAFARGUE
Michael Lynch
Cécile Poirier
Philippe Letellier
Jean-Manuel Pean
Ying Luo
Hanbin Shan
Yuhui SHEN
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2012/081250 external-priority patent/WO2014040228A1/en
Priority claimed from FR1259064A external-priority patent/FR2995896B1/fr
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1119984T1 publication Critical patent/CY1119984T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/10—Dispersions; Emulsions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • B29K2079/00—Use of polymers having nitrogen, with or without oxygen or carbon only, in the main chain, not provided for in groups B29K2061/00 - B29K2077/00, as moulding material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)

Abstract

Σταθεροποιημένη μορφή της ένωσης του τύπου (I): Φάρμακα
CY20181100099T 2012-09-11 2018-01-24 Σταθεροποιημενη αμορφη μορφη αγομελατινης, μια μεθοδος για την παρασκευη της και φαρμακευτικες συνθεσεις που την περιεχουν CY1119984T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2012/081250 WO2014040228A1 (en) 2012-09-11 2012-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
FR1259064A FR2995896B1 (fr) 2012-09-26 2012-09-26 Forme amorphe stabilisee de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent.
PCT/EP2013/068792 WO2014041015A1 (en) 2012-09-11 2013-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it.

Publications (1)

Publication Number Publication Date
CY1119984T1 true CY1119984T1 (el) 2018-12-12

Family

ID=49165740

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100099T CY1119984T1 (el) 2012-09-11 2018-01-24 Σταθεροποιημενη αμορφη μορφη αγομελατινης, μια μεθοδος για την παρασκευη της και φαρμακευτικες συνθεσεις που την περιεχουν

Country Status (34)

Country Link
US (1) US20150238614A1 (el)
EP (1) EP2895195B1 (el)
JP (1) JP6559065B2 (el)
KR (1) KR102081071B1 (el)
AR (1) AR092485A1 (el)
AU (1) AU2013314396B2 (el)
BR (1) BR112015005303A2 (el)
CA (1) CA2882927C (el)
CY (1) CY1119984T1 (el)
DK (1) DK2895195T3 (el)
EA (1) EA030645B1 (el)
ES (1) ES2659196T3 (el)
GE (1) GEP20186881B (el)
HK (2) HK1206994A1 (el)
HR (1) HRP20180019T1 (el)
HU (1) HUE036043T2 (el)
JO (1) JO3339B1 (el)
LT (1) LT2895195T (el)
ME (1) ME02988B (el)
MX (1) MX358995B (el)
MY (1) MY181682A (el)
NO (1) NO2895195T3 (el)
NZ (1) NZ705802A (el)
PL (1) PL2895195T3 (el)
PT (1) PT2895195T (el)
RS (1) RS56699B1 (el)
RU (1) RU2676476C9 (el)
SG (1) SG11201501333TA (el)
SI (1) SI2895195T1 (el)
TW (1) TWI581811B (el)
UA (1) UA116994C2 (el)
UY (1) UY35004A (el)
WO (1) WO2014041015A1 (el)
ZA (1) ZA201501493B (el)

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Publication number Priority date Publication date Assignee Title
WO2012093402A1 (en) * 2011-01-04 2012-07-12 Symed Labs Limited Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
WO2015153971A1 (en) * 2014-04-03 2015-10-08 Ovid Therapeutics Inc. Methods of treating sleep disorders associated with neurodegenerative diseases
WO2019193488A1 (en) 2018-04-06 2019-10-10 Capsugel Belgium Nv Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)]

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US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
ATE404178T1 (de) * 1999-02-10 2008-08-15 Pfizer Prod Inc Vorrichtung mit matrixgesteuerter wirkstofffreisetzung
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Publication number Publication date
HK1211854A1 (en) 2016-06-03
EP2895195A1 (en) 2015-07-22
RU2015113306A (ru) 2016-11-10
UY35004A (es) 2014-03-31
ME02988B (me) 2018-10-20
EA201500313A1 (ru) 2015-09-30
DK2895195T3 (en) 2018-02-05
PT2895195T (pt) 2017-12-11
TWI581811B (zh) 2017-05-11
TW201412348A (zh) 2014-04-01
CA2882927C (en) 2016-11-29
AR092485A1 (es) 2015-04-22
JP2015529215A (ja) 2015-10-05
RU2676476C2 (ru) 2018-12-29
ES2659196T3 (es) 2018-03-14
LT2895195T (lt) 2017-12-11
MX2015003015A (es) 2015-06-10
RU2676476C9 (ru) 2019-02-19
WO2014041015A1 (en) 2014-03-20
AU2013314396B2 (en) 2017-12-21
SI2895195T1 (en) 2018-01-31
HUE036043T2 (hu) 2018-06-28
JO3339B1 (ar) 2019-03-13
CA2882927A1 (en) 2014-03-20
AU2013314396A1 (en) 2015-03-12
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MX358995B (es) 2018-09-12
RS56699B1 (sr) 2018-03-30
EA030645B1 (ru) 2018-09-28
BR112015005303A2 (pt) 2019-11-26
NZ705802A (en) 2018-06-29
KR102081071B1 (ko) 2020-02-25
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EP2895195B1 (en) 2017-11-08
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MY181682A (en) 2020-12-31
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UA116994C2 (uk) 2018-06-11
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