SG11201501333TA - Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it. - Google Patents

Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it.

Info

Publication number
SG11201501333TA
SG11201501333TA SG11201501333TA SG11201501333TA SG11201501333TA SG 11201501333T A SG11201501333T A SG 11201501333TA SG 11201501333T A SG11201501333T A SG 11201501333TA SG 11201501333T A SG11201501333T A SG 11201501333TA SG 11201501333T A SG11201501333T A SG 11201501333TA
Authority
SG
Singapore
Prior art keywords
agomelatine
preparation
pharmaceutical compositions
compositions containing
amorphous form
Prior art date
Application number
SG11201501333TA
Inventor
David Lafargue
Michael Lynch
Cécile Poirier
Philippe Letellier
Jean-Manuel Pean
Ying Luo
Hanbin Shan
Yuhui Shen
Original Assignee
Servier Lab
Shanghai Inst Pharm Industry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2012/081250 external-priority patent/WO2014040228A1/en
Priority claimed from FR1259064A external-priority patent/FR2995896B1/en
Application filed by Servier Lab, Shanghai Inst Pharm Industry filed Critical Servier Lab
Publication of SG11201501333TA publication Critical patent/SG11201501333TA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/10—Dispersions; Emulsions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/02—Nutrients, e.g. vitamins, minerals
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/001—Combinations of extrusion moulding with other shaping operations
    • B29C48/0022—Combinations of extrusion moulding with other shaping operations combined with cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2079/00—Use of polymers having nitrogen, with or without oxygen or carbon only, in the main chain, not provided for in groups B29K2061/00 - B29K2077/00, as moulding material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
SG11201501333TA 2012-09-11 2013-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it. SG11201501333TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2012/081250 WO2014040228A1 (en) 2012-09-11 2012-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
FR1259064A FR2995896B1 (en) 2012-09-26 2012-09-26 STABILIZED AMORPHOUS FORM OF AGOMELATIN, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
PCT/EP2013/068792 WO2014041015A1 (en) 2012-09-11 2013-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it.

Publications (1)

Publication Number Publication Date
SG11201501333TA true SG11201501333TA (en) 2015-03-30

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SG11201501333TA SG11201501333TA (en) 2012-09-11 2013-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it.

Country Status (34)

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US (1) US20150238614A1 (en)
EP (1) EP2895195B1 (en)
JP (1) JP6559065B2 (en)
KR (1) KR102081071B1 (en)
AR (1) AR092485A1 (en)
AU (1) AU2013314396B2 (en)
BR (1) BR112015005303A2 (en)
CA (1) CA2882927C (en)
CY (1) CY1119984T1 (en)
DK (1) DK2895195T3 (en)
EA (1) EA030645B1 (en)
ES (1) ES2659196T3 (en)
GE (1) GEP20186881B (en)
HK (2) HK1206994A1 (en)
HR (1) HRP20180019T1 (en)
HU (1) HUE036043T2 (en)
JO (1) JO3339B1 (en)
LT (1) LT2895195T (en)
ME (1) ME02988B (en)
MX (1) MX358995B (en)
MY (1) MY181682A (en)
NO (1) NO2895195T3 (en)
NZ (1) NZ705802A (en)
PL (1) PL2895195T3 (en)
PT (1) PT2895195T (en)
RS (1) RS56699B1 (en)
RU (1) RU2676476C9 (en)
SG (1) SG11201501333TA (en)
SI (1) SI2895195T1 (en)
TW (1) TWI581811B (en)
UA (1) UA116994C2 (en)
UY (1) UY35004A (en)
WO (1) WO2014041015A1 (en)
ZA (1) ZA201501493B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2705023A4 (en) * 2011-01-04 2014-11-19 Symed Labs Ltd Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
WO2015153971A1 (en) * 2014-04-03 2015-10-08 Ovid Therapeutics Inc. Methods of treating sleep disorders associated with neurodegenerative diseases
ES2967689T3 (en) 2018-04-06 2024-05-03 Capsugel Belgium Nv Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)]

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004862A2 (en) * 1998-07-20 2000-02-03 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
EP1027887B1 (en) * 1999-02-10 2008-08-13 Pfizer Products Inc. Matrix controlled release device
FR2795326B1 (en) * 1999-06-28 2001-08-31 Adir SOLID THERMOFORMABLE PHARMACEUTICAL COMPOSITION WITH CONTROLLED RELEASE
US20050112198A1 (en) * 2003-10-27 2005-05-26 Challapalli Prasad V. Bupropion formulation for sustained delivery
BRPI0712014A2 (en) * 2006-05-22 2011-12-27 Vanda Pharmaceuticals Inc treatment of depressive disorders
US20080107725A1 (en) * 2006-10-13 2008-05-08 Albano Antonio A Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
US7608737B2 (en) * 2007-05-01 2009-10-27 Concert Pharmaceuticasl Inc. Naphthyl(ethyl)acetamides
AR072991A1 (en) * 2008-08-07 2010-10-06 Schering Corp PHARMACEUTICAL FORMULATIONS OF AN INHIBITOR OF THE ENZYME PROTEASE OF HCV IN A SOLID MOLECULAR DISPERSION
CN101836966A (en) * 2010-05-27 2010-09-22 北京万全阳光医药科技有限公司 Agomelatine-containing orally disintegrating tablet
HUP1000327A2 (en) * 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Composition containing nanostructured ezetibime and process for it's preparation
US20120087986A1 (en) * 2010-10-11 2012-04-12 Nagaraju Nagesh Pharmaceutical formulations comprising desvenlafaxine
EP2705023A4 (en) * 2011-01-04 2014-11-19 Symed Labs Ltd Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
WO2012130837A1 (en) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Solid agomelatine in non-crystalline form
CN102716493B (en) * 2011-03-31 2014-05-28 天津药物研究院 Copolymer containing amorphous agomelatine, and preparation method, pharmaceutical composition and application thereof
CZ2012108A3 (en) * 2012-02-15 2013-02-27 Zentiva Ks A method for the manufacture of a polymorphously stable pharmaceutical composition containing agomelatine
CN102670514B (en) * 2012-04-29 2017-05-10 浙江华海药业股份有限公司 Agomelatine solid preparation

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HK1206994A1 (en) 2016-01-22
EA030645B1 (en) 2018-09-28
UY35004A (en) 2014-03-31
MX358995B (en) 2018-09-12
EP2895195B1 (en) 2017-11-08
GEP20186881B (en) 2018-07-25
AR092485A1 (en) 2015-04-22
CA2882927A1 (en) 2014-03-20
LT2895195T (en) 2017-12-11
EA201500313A1 (en) 2015-09-30
ES2659196T3 (en) 2018-03-14
US20150238614A1 (en) 2015-08-27
DK2895195T3 (en) 2018-02-05
JP2015529215A (en) 2015-10-05
JP6559065B2 (en) 2019-08-14
ZA201501493B (en) 2016-01-27
KR102081071B1 (en) 2020-02-25
UA116994C2 (en) 2018-06-11
HUE036043T2 (en) 2018-06-28
EP2895195A1 (en) 2015-07-22
JO3339B1 (en) 2019-03-13
MY181682A (en) 2020-12-31
KR20150056599A (en) 2015-05-26
PL2895195T3 (en) 2018-04-30
NO2895195T3 (en) 2018-04-07
WO2014041015A1 (en) 2014-03-20
SI2895195T1 (en) 2018-01-31
RU2015113306A (en) 2016-11-10
MX2015003015A (en) 2015-06-10
RU2676476C9 (en) 2019-02-19
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CA2882927C (en) 2016-11-29
RU2676476C2 (en) 2018-12-29
AU2013314396B2 (en) 2017-12-21
TWI581811B (en) 2017-05-11
HRP20180019T1 (en) 2018-02-09
TW201412348A (en) 2014-04-01
HK1211854A1 (en) 2016-06-03
NZ705802A (en) 2018-06-29
ME02988B (en) 2018-10-20
PT2895195T (en) 2017-12-11
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BR112015005303A2 (en) 2019-11-26

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