JO3339B1 - شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه - Google Patents

شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه

Info

Publication number
JO3339B1
JO3339B1 JOP/2013/0247A JOP20130247A JO3339B1 JO 3339 B1 JO3339 B1 JO 3339B1 JO P20130247 A JOP20130247 A JO P20130247A JO 3339 B1 JO3339 B1 JO 3339B1
Authority
JO
Jordan
Prior art keywords
agomelatine
preparation
amorphous form
pharmaceutical compositions
compositions containing
Prior art date
Application number
JOP/2013/0247A
Other languages
English (en)
Inventor
Pean Jean-Manuel
Lafargue David
Poirier Cecile
Letellier Philippe
Lynch Michael
Shan Hanbin
Luo Ying
Shen Yuhui
Original Assignee
Shanghai Inst Pharmaceutical Ind
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2012/081250 external-priority patent/WO2014040228A1/en
Priority claimed from FR1259064A external-priority patent/FR2995896B1/fr
Application filed by Shanghai Inst Pharmaceutical Ind, Servier Lab filed Critical Shanghai Inst Pharmaceutical Ind
Application granted granted Critical
Publication of JO3339B1 publication Critical patent/JO3339B1/ar

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • B29K2079/00—Use of polymers having nitrogen, with or without oxygen or carbon only, in the main chain, not provided for in groups B29K2061/00 - B29K2077/00, as moulding material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)

Abstract

الشكل المستقر غير المتبلور لمركب الصيغة (1): الأدوية
JOP/2013/0247A 2012-09-11 2013-08-20 شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه JO3339B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2012/081250 WO2014040228A1 (en) 2012-09-11 2012-09-11 Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
FR1259064A FR2995896B1 (fr) 2012-09-26 2012-09-26 Forme amorphe stabilisee de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent.

Publications (1)

Publication Number Publication Date
JO3339B1 true JO3339B1 (ar) 2019-03-13

Family

ID=49165740

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0247A JO3339B1 (ar) 2012-09-11 2013-08-20 شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه

Country Status (34)

Country Link
US (1) US20150238614A1 (ar)
EP (1) EP2895195B1 (ar)
JP (1) JP6559065B2 (ar)
KR (1) KR102081071B1 (ar)
AR (1) AR092485A1 (ar)
AU (1) AU2013314396B2 (ar)
BR (1) BR112015005303A2 (ar)
CA (1) CA2882927C (ar)
CY (1) CY1119984T1 (ar)
DK (1) DK2895195T3 (ar)
EA (1) EA030645B1 (ar)
ES (1) ES2659196T3 (ar)
GE (2) GEP20186881B (ar)
HK (1) HK1206994A1 (ar)
HR (1) HRP20180019T1 (ar)
HU (1) HUE036043T2 (ar)
JO (1) JO3339B1 (ar)
LT (1) LT2895195T (ar)
ME (1) ME02988B (ar)
MX (1) MX358995B (ar)
MY (1) MY181682A (ar)
NO (1) NO2895195T3 (ar)
NZ (1) NZ705802A (ar)
PL (1) PL2895195T3 (ar)
PT (1) PT2895195T (ar)
RS (1) RS56699B1 (ar)
RU (1) RU2676476C9 (ar)
SG (1) SG11201501333TA (ar)
SI (1) SI2895195T1 (ar)
TW (1) TWI581811B (ar)
UA (1) UA116994C2 (ar)
UY (1) UY35004A (ar)
WO (1) WO2014041015A1 (ar)
ZA (1) ZA201501493B (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2705023A4 (en) * 2011-01-04 2014-11-19 Symed Labs Ltd PROCESSES FOR THE PREPARATION OF N- [2- (7-METHOXY-1-NAPHTHYLLELYHYL) ACETAMIDE
WO2015153971A1 (en) * 2014-04-03 2015-10-08 Ovid Therapeutics Inc. Methods of treating sleep disorders associated with neurodegenerative diseases
JP7244536B2 (ja) 2018-04-06 2023-03-22 キャプシュゲル・ベルジウム・エヌ・ヴィ メタクリル酸メチル－メタクリル酸コポリマーからなる低アスペクト比の粒子のための噴霧乾燥方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU763309B2 (en) * 1998-07-20 2003-07-17 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
ATE404178T1 (de) * 1999-02-10 2008-08-15 Pfizer Prod Inc Vorrichtung mit matrixgesteuerter wirkstofffreisetzung
FR2795326B1 (fr) * 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
US20050112198A1 (en) * 2003-10-27 2005-05-26 Challapalli Prasad V. Bupropion formulation for sustained delivery
AU2007253704A1 (en) * 2006-05-22 2007-11-29 Vanda Pharmaceuticals, Inc. Treatment for depressive disorders
US20080107725A1 (en) * 2006-10-13 2008-05-08 Albano Antonio A Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
WO2008137461A1 (en) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphthyl(ethyl) acetamides
US20110207660A1 (en) * 2008-08-07 2011-08-25 Schering Corporation Pharmaceutical formulations of an hcv protease inhibitor in a solid molecular dispersion
CN101836966A (zh) * 2010-05-27 2010-09-22 北京万全阳光医药科技有限公司 一种含有阿戈美拉汀的口腔崩解片
HUP1000327A2 (en) * 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Composition containing nanostructured ezetibime and process for it's preparation
US20120087986A1 (en) * 2010-10-11 2012-04-12 Nagaraju Nagesh Pharmaceutical formulations comprising desvenlafaxine
EP2705023A4 (en) * 2011-01-04 2014-11-19 Symed Labs Ltd PROCESSES FOR THE PREPARATION OF N- [2- (7-METHOXY-1-NAPHTHYLLELYHYL) ACETAMIDE
WO2012130837A1 (en) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Solid agomelatine in non-crystalline form
CN102716493B (zh) * 2011-03-31 2014-05-28 天津药物研究院 含无定型态阿戈美拉汀的共聚物、其制备方法、其药物组合物及用途
CZ2012108A3 (en) * 2012-02-15 2013-02-27 Zentiva Ks A method for the manufacture of a polymorphously stable pharmaceutical composition containing agomelatine
CN102670514B (zh) * 2012-04-29 2017-05-10 浙江华海药业股份有限公司 阿戈美拉汀固体制剂

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AR092485A1 (es) 2015-04-22
JP6559065B2 (ja) 2019-08-14
GEP20186881B (en) 2018-07-25
UY35004A (es) 2014-03-31
CA2882927C (en) 2016-11-29
BR112015005303A2 (pt) 2019-11-26
PL2895195T3 (pl) 2018-04-30
CA2882927A1 (en) 2014-03-20
NZ705802A (en) 2018-06-29
SI2895195T1 (en) 2018-01-31
EP2895195B1 (en) 2017-11-08
ME02988B (me) 2018-10-20
KR102081071B1 (ko) 2020-02-25
MX2015003015A (es) 2015-06-10
AU2013314396B2 (en) 2017-12-21
DK2895195T3 (en) 2018-02-05
SG11201501333TA (en) 2015-03-30
PT2895195T (pt) 2017-12-11
MX358995B (es) 2018-09-12
UA116994C2 (uk) 2018-06-11
RU2676476C2 (ru) 2018-12-29
HK1211854A1 (en) 2016-06-03
TWI581811B (zh) 2017-05-11
RU2015113306A (ru) 2016-11-10
LT2895195T (lt) 2017-12-11
NO2895195T3 (ar) 2018-04-07
AU2013314396A1 (en) 2015-03-12
GEAP201813784A (en) 2018-03-26
ES2659196T3 (es) 2018-03-14
HUE036043T2 (hu) 2018-06-28
HK1206994A1 (en) 2016-01-22
RU2676476C9 (ru) 2019-02-19
EA030645B1 (ru) 2018-09-28
HRP20180019T1 (hr) 2018-02-09
EP2895195A1 (en) 2015-07-22
US20150238614A1 (en) 2015-08-27
ZA201501493B (en) 2016-01-27
EA201500313A1 (ru) 2015-09-30
JP2015529215A (ja) 2015-10-05
TW201412348A (zh) 2014-04-01
KR20150056599A (ko) 2015-05-26
RS56699B1 (sr) 2018-03-30
WO2014041015A1 (en) 2014-03-20
MY181682A (en) 2020-12-31
CY1119984T1 (el) 2018-12-12

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