HK1218878A1 - 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 - Google Patents

3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Download PDF

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Publication number
HK1218878A1
HK1218878A1 HK16106954.3A HK16106954A HK1218878A1 HK 1218878 A1 HK1218878 A1 HK 1218878A1 HK 16106954 A HK16106954 A HK 16106954A HK 1218878 A1 HK1218878 A1 HK 1218878A1
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HK
Hong Kong
Prior art keywords
methyl
crystalline form
mixture
total weight
imidazo
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HK16106954.3A
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English (en)
Chinese (zh)
Inventor
Christopher K. Murray
Leonard W. Rozamus
John J. CHABER
Pradeep Sharma
Original Assignee
阿里亚德医药股份有限公司
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Application filed by 阿里亚德医药股份有限公司 filed Critical 阿里亚德医药股份有限公司
Publication of HK1218878A1 publication Critical patent/HK1218878A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK16106954.3A 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 HK1218878A1 (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US61/736,543 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US61/737,007 2012-12-13
US201361788208P 2013-03-15 2013-03-15
US61/788,208 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK42023069906.8A Division HK40080449A (en) 2012-12-12 2016-06-16 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK42023069906.8A Addition HK40080449A (en) 2012-12-12 2016-06-16 Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt

Publications (1)

Publication Number Publication Date
HK1218878A1 true HK1218878A1 (zh) 2017-03-17

Family

ID=50929140

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16106954.3A HK1218878A1 (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Country Status (9)

Country Link
US (9) US9493470B2 (enExample)
JP (4) JP6447508B2 (enExample)
CN (2) CN115043843A (enExample)
CA (3) CA3167093A1 (enExample)
CL (1) CL2015001643A1 (enExample)
HK (1) HK1218878A1 (enExample)
MX (11) MX359147B (enExample)
NZ (1) NZ709648A (enExample)
WO (2) WO2014093579A2 (enExample)

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US20210024527A1 (en) 2021-01-28
MX2021002254A (es) 2021-05-27
MX2015007578A (es) 2016-03-21
MX2021002264A (es) 2021-05-27
CN115043843A (zh) 2022-09-13
CA3022250A1 (en) 2014-06-12
MX359147B (es) 2018-09-17
US11384086B2 (en) 2022-07-12
US20210277010A1 (en) 2021-09-09
MX391445B (es) 2025-03-21
MX2021002258A (es) 2021-05-27
MX2021002253A (es) 2021-05-27
US11279705B2 (en) 2022-03-22
JP2022037122A (ja) 2022-03-08
MX2021002255A (es) 2021-05-27
JP2023179498A (ja) 2023-12-19
WO2014093579A2 (en) 2014-06-19
US20190169196A1 (en) 2019-06-06
US20170190707A1 (en) 2017-07-06
CA3167093A1 (en) 2014-06-12
US10125136B2 (en) 2018-11-13
MX2021002256A (es) 2021-05-27
MX2021002259A (es) 2021-05-27
CN105188701A (zh) 2015-12-23
CA2815506C (en) 2018-12-11
US11192895B2 (en) 2021-12-07
CA2815506A1 (en) 2014-06-12
US20210340149A1 (en) 2021-11-04
CL2015001643A1 (es) 2015-10-02
MX2021002261A (es) 2021-05-27
US20210277012A1 (en) 2021-09-09
WO2014093583A3 (en) 2014-08-07
WO2014093583A2 (en) 2014-06-19
JP6447508B2 (ja) 2019-01-09
MX2021002257A (es) 2021-05-27
US11192896B2 (en) 2021-12-07
US20210277011A1 (en) 2021-09-09
US20240083902A1 (en) 2024-03-14
JP2018168191A (ja) 2018-11-01
JP7352841B2 (ja) 2023-09-29
US20150315194A1 (en) 2015-11-05
WO2014093579A3 (en) 2014-07-10
JP2016503010A (ja) 2016-02-01
NZ709648A (en) 2020-05-29
US9493470B2 (en) 2016-11-15
US11192897B2 (en) 2021-12-07
JP7042175B2 (ja) 2022-03-25
US10662197B2 (en) 2020-05-26

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