JP2011522816A5 - - Google Patents
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- Publication number
- JP2011522816A5 JP2011522816A5 JP2011512416A JP2011512416A JP2011522816A5 JP 2011522816 A5 JP2011522816 A5 JP 2011522816A5 JP 2011512416 A JP2011512416 A JP 2011512416A JP 2011512416 A JP2011512416 A JP 2011512416A JP 2011522816 A5 JP2011522816 A5 JP 2011522816A5
- Authority
- JP
- Japan
- Prior art keywords
- symptoms
- compound
- schizophrenia
- anxiety
- delaying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 morpholin-4-carbonyl Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5948508P | 2008-06-06 | 2008-06-06 | |
| US61/059,485 | 2008-06-06 | ||
| PCT/SE2009/050682 WO2009148403A1 (en) | 2008-06-06 | 2009-06-08 | Isoxazole derivatives and their use as metabotropic glutamate receptor potentiators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014020956A Division JP5815765B2 (ja) | 2008-06-06 | 2014-02-06 | イソオキサゾール誘導体及び代謝型グルタミン酸受容体ポテンシエーターとしてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011522816A JP2011522816A (ja) | 2011-08-04 |
| JP2011522816A5 true JP2011522816A5 (enExample) | 2012-07-19 |
| JP5476371B2 JP5476371B2 (ja) | 2014-04-23 |
Family
ID=41398335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512416A Expired - Fee Related JP5476371B2 (ja) | 2008-06-06 | 2009-06-08 | イソオキサゾール誘導体及び代謝型グルタミン酸受容体ポテンシエーターとしてのその使用 |
| JP2014020956A Expired - Fee Related JP5815765B2 (ja) | 2008-06-06 | 2014-02-06 | イソオキサゾール誘導体及び代謝型グルタミン酸受容体ポテンシエーターとしてのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014020956A Expired - Fee Related JP5815765B2 (ja) | 2008-06-06 | 2014-02-06 | イソオキサゾール誘導体及び代謝型グルタミン酸受容体ポテンシエーターとしてのその使用 |
Country Status (40)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| ES2409215T3 (es) | 2007-09-14 | 2013-06-25 | Janssen Pharmaceuticals, Inc. | 4-fenil-1H-piridin-2-onas 1-3-disustituidas |
| US7790760B2 (en) * | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
| ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
| CA2738849C (en) | 2008-10-16 | 2016-06-28 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| SG176018A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2440001T3 (es) | 2009-05-12 | 2014-01-27 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CN103298809B (zh) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| US10537573B2 (en) | 2014-01-21 | 2020-01-21 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| IL279202B2 (en) | 2014-01-21 | 2023-09-01 | Janssen Pharmaceutica Nv | Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use |
| WO2015157187A1 (en) | 2014-04-06 | 2015-10-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor positive allosteric modulators (pams) and uses thereof |
| KR101663662B1 (ko) * | 2015-06-17 | 2016-10-14 | 한국과학기술연구원 | 대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 아이소옥사졸 유도체 |
| US20170145002A1 (en) * | 2015-11-25 | 2017-05-25 | Astrazeneca Ab | Deuterated isoxazole derivatives and their use as metabotropic glutamate receptor potentiators |
| WO2020102150A1 (en) | 2018-11-13 | 2020-05-22 | Incyte Corporation | Heterocyclic derivatives as pi3k inhibitors |
| WO2020102216A1 (en) | 2018-11-13 | 2020-05-22 | Incyte Corporation | Substituted heterocyclic derivatives as pi3k inhibitors |
| WO2020102198A1 (en) | 2018-11-13 | 2020-05-22 | Incyte Corporation | Heterocyclic derivatives as pi3k inhibitors |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE620654C (de) | 1933-04-29 | 1935-10-24 | Smith & Sons Ltd S | Geschwindigkeitsanzeiger |
| US3993617A (en) * | 1975-10-30 | 1976-11-23 | Morton-Norwich Products, Inc. | Antifungal 2-substituted phthalimidines |
| US5175157A (en) * | 1985-11-27 | 1992-12-29 | Boehringer Ingelheim Gmbh | Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them |
| WO1992017448A1 (fr) | 1991-04-01 | 1992-10-15 | Kyowa Hakko Kogyo Co., Ltd. | Derive de 3-methylenisoindolin-1-one |
| TW219935B (enExample) | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
| EP0602814A1 (en) | 1992-12-18 | 1994-06-22 | Takeda Chemical Industries, Ltd. | Crystal forms of optically active isoindolines and their use |
| US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| AU1618697A (en) * | 1996-02-06 | 1997-08-28 | Japan Tobacco Inc. | Novel compounds and pharmaceutical use thereof |
| AU7548298A (en) | 1997-05-30 | 1998-12-30 | Meiji Seika Kaisha Ltd. | Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same |
| IL136250A0 (en) | 1997-11-21 | 2001-05-20 | Nps Pharma Inc | Metabotropic glutamate receptor antagonist compounds |
| NZ521576A (en) * | 2000-02-29 | 2005-06-24 | Mitsubishi Pharma Corp | Novel cyclic amide derivatives |
| HUP0302966A2 (hu) | 2000-07-31 | 2003-12-29 | Smithkline Beecham P.L.C. | Karboxamid-vegyületek és alkalmazásuk humán 11CBY receptor antagonistákként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| BR0211810A (pt) | 2001-08-09 | 2004-08-24 | Ono Pharmaceutical Co | Derivados ácido carboxìlico e agente farmacêutico compreendendo os mesmos como ingrediente ativo |
| WO2003087044A2 (en) | 2002-04-09 | 2003-10-23 | 7Tm Pharma A/S | Novel carboxamide compounds for use in mch receptor related disorders |
| FR2840302B1 (fr) | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB0223232D0 (en) | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| US7507836B2 (en) | 2003-03-26 | 2009-03-24 | Merck & Co. Inc. | Benzamide modulators of metabotropic glutamate receptors |
| GB0308025D0 (en) | 2003-04-07 | 2003-05-14 | Glaxo Group Ltd | Compounds |
| US7129260B2 (en) * | 2003-06-02 | 2006-10-31 | Abbott Laboratories | Isoindolinone kinase inhibitors |
| WO2005040157A2 (en) | 2003-10-22 | 2005-05-06 | Eli Lilly And Company | Novel mch receptor antagonists |
| WO2005074643A2 (en) | 2004-01-30 | 2005-08-18 | Smithkline Beecham Corporation | Benzamide compounds useful as rock inhibitors |
| EP1716152B1 (en) | 2004-02-18 | 2008-07-30 | AstraZeneca AB | Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders |
| EP1726585A4 (en) | 2004-03-05 | 2009-07-15 | Banyu Pharma Co Ltd | DIARYLSUBSTITUTED FIVE-GLOSS HETEROCYCLUS DERIVAT |
| CN1930136B (zh) | 2004-03-05 | 2012-02-08 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物及有害生物防除剂 |
| SE0400970D0 (sv) | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| AU2005299797A1 (en) | 2004-10-25 | 2006-05-04 | Merck & Co., Inc. | Heterocyclic indanone potentiators of metabotropic glutamate receptors |
| WO2006091496A2 (en) | 2005-02-24 | 2006-08-31 | Merck & Co., Inc. | Benzazole potentiators of metabotropic glutamate receptors |
| KR20080027463A (ko) | 2005-05-18 | 2008-03-27 | 아덱스 파마 에스에이 | 대사성 글루타메이트 수용체의 양성 알로스테릭조절자로서의 치환된 옥사디아졸 유도체 |
| GB0510142D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| TW200728277A (en) | 2005-06-29 | 2007-08-01 | Palau Pharma Sa | Bicyclic derivatives as P38 inhibitors |
| US7868008B2 (en) | 2005-08-12 | 2011-01-11 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
| US7807706B2 (en) * | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| JP5031745B2 (ja) * | 2005-08-12 | 2012-09-26 | アストラゼネカ アクチボラグ | 代謝型グルタミン酸受容体増強性イソインドロン |
| ES2340321T3 (es) | 2005-09-27 | 2010-06-01 | F.Hoffmann-La Roche Ag | Oxadiazolilpirazolo-pirimidinas, como antagonistas de mglur2. |
| TW200804281A (en) | 2006-02-16 | 2008-01-16 | Astrazeneca Ab | New metabotropic glutamate receptor-potentiating isoindolones |
| TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
| TW200911255A (en) * | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
| US7790760B2 (en) * | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
-
2009
- 2009-06-03 US US12/477,347 patent/US7790760B2/en not_active Expired - Fee Related
- 2009-06-03 SA SA109300358A patent/SA109300358B1/ar unknown
- 2009-06-04 TW TW098118593A patent/TWI382027B/zh not_active IP Right Cessation
- 2009-06-04 TW TW101129417A patent/TWI477499B/zh not_active IP Right Cessation
- 2009-06-04 TW TW103145569A patent/TW201514173A/zh unknown
- 2009-06-05 AR ARP090102031A patent/AR072016A1/es unknown
- 2009-06-05 UY UY0001031870A patent/UY31870A/es not_active Application Discontinuation
- 2009-06-08 JP JP2011512416A patent/JP5476371B2/ja not_active Expired - Fee Related
- 2009-06-08 CA CA2726925A patent/CA2726925A1/en not_active Abandoned
- 2009-06-08 UA UAA201014034A patent/UA107649C2/uk unknown
- 2009-06-08 PL PL09758630T patent/PL2303872T3/pl unknown
- 2009-06-08 DK DK09758630.9T patent/DK2303872T3/da active
- 2009-06-08 EP EP14164664.6A patent/EP2772492B1/en active Active
- 2009-06-08 MY MYPI2010005780A patent/MY156552A/en unknown
- 2009-06-08 HR HRP20140451AT patent/HRP20140451T1/hr unknown
- 2009-06-08 SI SI200930928T patent/SI2303872T1/sl unknown
- 2009-06-08 EA EA201001724A patent/EA018412B1/ru not_active IP Right Cessation
- 2009-06-08 AU AU2009255784A patent/AU2009255784B2/en not_active Ceased
- 2009-06-08 NZ NZ590344A patent/NZ590344A/en not_active IP Right Cessation
- 2009-06-08 EA EA201300342A patent/EA201300342A1/ru unknown
- 2009-06-08 CN CN200980129149.7A patent/CN102105466B/zh not_active Expired - Fee Related
- 2009-06-08 WO PCT/SE2009/050682 patent/WO2009148403A1/en not_active Ceased
- 2009-06-08 RS RS20140295A patent/RS53392B/sr unknown
- 2009-06-08 EP EP09758630.9A patent/EP2303872B1/en active Active
- 2009-06-08 ES ES09758630.9T patent/ES2469837T3/es active Active
- 2009-06-08 PT PT97586309T patent/PT2303872E/pt unknown
- 2009-06-08 BR BRPI0913585A patent/BRPI0913585A2/pt not_active IP Right Cessation
- 2009-06-08 KR KR1020107027224A patent/KR20110020797A/ko not_active Abandoned
- 2009-06-08 PE PE2010001111A patent/PE20110028A1/es not_active Application Discontinuation
- 2009-06-08 MX MX2010012949A patent/MX2010012949A/es active IP Right Grant
- 2009-10-08 US US12/575,891 patent/US7781434B2/en not_active Expired - Fee Related
-
2010
- 2010-08-13 NI NI201000209A patent/NI201000209A/es unknown
- 2010-08-20 US US12/860,330 patent/US8148372B2/en not_active Expired - Fee Related
- 2010-08-26 US US12/869,263 patent/US7888353B2/en not_active Expired - Fee Related
- 2010-11-26 CO CO10149429A patent/CO6321239A2/es active IP Right Grant
- 2010-11-29 IL IL209622A patent/IL209622A0/en unknown
- 2010-11-30 ZA ZA2010/08611A patent/ZA201008611B/en unknown
- 2010-12-03 CL CL2010001348A patent/CL2010001348A1/es unknown
- 2010-12-06 SV SV2010003751A patent/SV2010003751A/es not_active Application Discontinuation
- 2010-12-06 NI NI2010002091A patent/NI201002091A/es unknown
- 2010-12-06 GT GT201000342A patent/GT201000342A/es unknown
- 2010-12-06 NI NI2010002092A patent/NI201002092A/es unknown
- 2010-12-06 CR CR11826A patent/CR11826A/es unknown
- 2010-12-06 DO DO2010000375A patent/DOP2010000375A/es unknown
- 2010-12-06 HN HN2010002582A patent/HN2010002582A/es unknown
- 2010-12-06 CU CU20100238A patent/CU23883B1/es not_active IP Right Cessation
- 2010-12-07 EC EC2010010662A patent/ECSP10010662A/es unknown
-
2014
- 2014-02-06 JP JP2014020956A patent/JP5815765B2/ja not_active Expired - Fee Related
- 2014-06-11 CY CY20141100416T patent/CY1115301T1/el unknown
-
2015
- 2015-02-13 HK HK15101607.6A patent/HK1201255A1/en unknown
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