PE20110028A1 - Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato - Google Patents
Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamatoInfo
- Publication number
- PE20110028A1 PE20110028A1 PE2010001111A PE2010001111A PE20110028A1 PE 20110028 A1 PE20110028 A1 PE 20110028A1 PE 2010001111 A PE2010001111 A PE 2010001111A PE 2010001111 A PE2010001111 A PE 2010001111A PE 20110028 A1 PE20110028 A1 PE 20110028A1
- Authority
- PE
- Peru
- Prior art keywords
- isoxazole
- dihydro
- chloro
- alkyl
- metabotropic glutamate
- Prior art date
Links
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title abstract 3
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title abstract 3
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical class C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003623 enhancer Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 PYRROLIDINE-1-CARBONYL Chemical class 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/083—Clips, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/10—Surgical instruments, devices or methods for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/10—Surgical instruments, devices or methods for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
- A61B17/105—Wound clamp magazines
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5948508P | 2008-06-06 | 2008-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110028A1 true PE20110028A1 (es) | 2011-02-11 |
Family
ID=41398335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001111A PE20110028A1 (es) | 2008-06-06 | 2009-06-08 | Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato |
Country Status (40)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| MX2010002536A (es) | 2007-09-14 | 2010-08-10 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetrahidro-2h, 1'h-[1,4]bipiridinil-2'-onas 1',3'-disubstituidas. |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| SA109300358B1 (ar) * | 2008-06-06 | 2012-11-03 | Ų§Ų³ŲŖŲ±Ų§Ų²ŁŁŁŁŲ§ Ų§ŁŁ ŲØŁ | Ł ŁŁŁŲ§ŲŖ Ł Ų³ŲŖŁŲØŁ Ų¬ŁŁŲŖŲ§Ł Ų§ŲŖ Ų°Ł Ų§ŁŲŖŲŲ§Ų” Ų£ŁŲ¶Ł Ł Ł Ų£ŁŲ²Ł Ų„ŁŲÆŁŁŁŁ |
| BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrĆ³picos de glutamato. |
| JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ćøć£ć³ć»ć³ ćć”ć¼ćć·ć„ć¼ćć£ć«ć«ćŗļ¼ ć¤ć³ć³ć¼ćć¬ć¤ćććļ¼ | 代č¬åć°ć«ćæćć³é øå容ä½ć¢ćøć„ć¬ć¼ćæć¼ćØćć¦ć®ć¤ć³ćć¼ć«ććć³ćć³ć¾ć¢ć«ććŖć³ć®čŖå°ä½ |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostƩricos positivos de los receptores mGluR2 |
| SG176021A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorĆ³w receptorĆ³w mGluR2 |
| WO2012062759A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | Ł Ų±ŁŲØŲ§ŲŖ 6Ų 7- Ų«Ų§ŁŁ ŁŁŲÆŲ±Ł ŲØŁŲ±Ų§Ų²ŁŁŁ [5Ų1-a] ŲØŁŲ±Ų§Ų²ŁŁ- 4 (5 ŁŲÆ)- Ų§ŁŁ ŁŲ§Ų³ŲŖŲ®ŲÆŲ§Ł ŁŲ§ ŲØŲµŁŲ© Ł ŁŲøŁ Ų§ŲŖ ŲŖŁŲ§Ų±ŲŗŁŲ© Ų³ŁŲØŁŲ© ŁŁ Ų³ŲŖŁŲØŁŲ§ŲŖ Ł ŁŲ¬ŁŁŲ± 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | Ł Ų±ŁŲØŲ§ŲŖ 2Ų1Ų 4- Ų«ŁŲ§Ų«Ł Ų²ŁŁŁ [3Ų4-a] ŲØŁŲ±ŁŲÆŁŁ ŁŲ§Ų³ŲŖŲ®ŲÆŲ§Ł ŁŲ§ ŲØŲµŁŲ© Ł ŁŲøŁ Ų§ŲŖ ŲŖŁŲ§Ų±ŲŗŁŲ© Ł ŁŲ¬ŲØŲ© ŁŁ Ų³ŲŖŁŲØŁŲ§ŲŖ Ł ŁŲ¬ŁŁŲ± 2 |
| PT3096790T (pt) | 2014-01-21 | 2019-10-15 | Janssen Pharmaceutica Nv | CombinaƧƵes compreendendo moduladores alostĆ©ricos positivos ou agonistas ortostĆ©ricos do recetor glutamatĆ©rgico metabotrĆ³pico do subtipo 2 e seu uso |
| EA202192105A3 (ru) | 2014-02-04 | 2022-02-28 | ŠÆŠ½ŃŃŠµŠ½ Š¤Š°ŃŠ¼Š°ŃŠµŠ²ŃŠøŠŗŠ° ŠŠ² | ŠŠ¾Š¼Š±ŠøŠ½Š°ŃŠøŠø, ŃŠ¾Š“ŠµŃŠ¶Š°ŃŠøŠµ ŠæŠ¾Š»Š¾Š¶ŠøŃŠµŠ»ŃŠ½ŃŠµ Š°Š»Š»Š¾ŃŃŠµŃŠøŃŠµŃŠŗŠøŠµ Š¼Š¾Š“ŃŠ»ŃŃŠ¾ŃŃ ŠøŠ»Šø Š¾ŃŃŠ¾ŃŃŠµŃŠøŃŠµŃŠŗŠøŠµ Š°Š³Š¾Š½ŠøŃŃŃ Š¼ŠµŃŠ°Š±Š¾ŃŃŠ¾ŠæŠ½Š¾Š³Š¾ Š³Š»ŃŃŠ°Š¼Š°ŃŠµŃŠ³ŠøŃŠµŃŠŗŠ¾Š³Š¾ ŃŠµŃŠµŠæŃŠ¾ŃŠ° 2 ŠæŠ¾Š“ŃŠøŠæŠ°, Šø ŠøŃ ŠæŃŠøŠ¼ŠµŠ½ŠµŠ½ŠøŠµ |
| US10099993B2 (en) | 2014-04-06 | 2018-10-16 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof |
| KR101663662B1 (ko) * | 2015-06-17 | 2016-10-14 | ķźµź³¼ķźø°ģ ģ°źµ¬ģ | ėģ¬ģ± źøė£Øķė©ģ“ķø ģģ©ģ²“ 1ģ ķģ±ģ ģ§ė ģ ź· ģė¦“ ģģ“ģģ„ģ¬ģ”ø ģ ėģ²“ |
| US20170145002A1 (en) * | 2015-11-25 | 2017-05-25 | Astrazeneca Ab | Deuterated isoxazole derivatives and their use as metabotropic glutamate receptor potentiators |
| US11161838B2 (en) | 2018-11-13 | 2021-11-02 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
| US11396502B2 (en) | 2018-11-13 | 2022-07-26 | Incyte Corporation | Substituted heterocyclic derivatives as PI3K inhibitors |
| US11078204B2 (en) | 2018-11-13 | 2021-08-03 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE620654C (de) | 1933-04-29 | 1935-10-24 | Smith & Sons Ltd S | Geschwindigkeitsanzeiger |
| US3993617A (en) | 1975-10-30 | 1976-11-23 | Morton-Norwich Products, Inc. | Antifungal 2-substituted phthalimidines |
| US5175157A (en) | 1985-11-27 | 1992-12-29 | Boehringer Ingelheim Gmbh | Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them |
| WO1992017448A1 (fr) | 1991-04-01 | 1992-10-15 | Kyowa Hakko Kogyo Co., Ltd. | Derive de 3-methylenisoindolin-1-one |
| TW219935B (enExample) | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
| EP0602814A1 (en) | 1992-12-18 | 1994-06-22 | Takeda Chemical Industries, Ltd. | Crystal forms of optically active isoindolines and their use |
| US5681954A (en) | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| WO1997029079A1 (en) | 1996-02-06 | 1997-08-14 | Japan Tobacco Inc. | Novel compounds and pharmaceutical use thereof |
| EP0999208A4 (en) | 1997-05-30 | 2001-08-08 | Meiji Seika Kaisha | NITROGEN-BASED HETEROCYCLIC COMPOUNDS AND MEDICINES FOR TREATING HYPERLIPEMIA THAT CONTAIN THEM |
| CA2311131A1 (en) | 1997-11-21 | 1999-06-03 | Nps Pharmaceuticals, Inc. | Metabotropic glutamate receptor antagonists for treating central nervous system diseases |
| ATE366249T1 (de) | 2000-02-29 | 2007-07-15 | Mitsubishi Pharma Corp | Zyklische amid-derivate |
| CN1444573A (zh) | 2000-07-31 | 2003-09-24 | å²åÆäøå č±ę©ęÆå½»å§ęéå ¬åø | ē²é °čŗååē©åå ¶ä½äøŗäŗŗ11cbyåä½ę®ęåēēØé |
| PL368129A1 (en) | 2001-08-09 | 2005-03-21 | Ono Pharmaceutical Co, Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| WO2003087044A2 (en) | 2002-04-09 | 2003-10-23 | 7Tm Pharma A/S | Novel carboxamide compounds for use in mch receptor related disorders |
| FR2840302B1 (fr) | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue CarbonsƤureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB0223232D0 (en) | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| JP2006521358A (ja) | 2003-03-26 | 2006-09-21 | ć”ć«ćÆććØć³ććć«ć ććć¼ćć¤ć³ć³ć¼ćć¬ć¼ććć | 代č¬čŖæēÆåć°ć«ćæćć³é øå容ä½ć®ćć³ćŗć¢ććć¢ćøć„ć¬ć¼ćæ |
| GB0308025D0 (en) | 2003-04-07 | 2003-05-14 | Glaxo Group Ltd | Compounds |
| US7129260B2 (en) | 2003-06-02 | 2006-10-31 | Abbott Laboratories | Isoindolinone kinase inhibitors |
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| MY152888A (en) | 2004-02-18 | 2014-11-28 | Astrazeneca Ab | Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists. |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | ę„äŗ§åå¦å·„äøę Ŗå¼ä¼ē¤¾ | å¼åååå代čÆē²é °čŗååē©ēå¶å¤äøé“ä½ |
| CN1934094A (zh) | 2004-03-05 | 2007-03-21 | äøęå¶čÆę Ŗå¼ä¼ē¤¾ | äŗč³åŗå代ęēÆ5å ēÆč”ēē© |
| SE0400970D0 (sv) | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| CN101048157A (zh) | 2004-10-25 | 2007-10-03 | é»å å ¬åø | ä»£č°¢åč°·ę°Øé øåä½ēęēÆäŗę°¢čé ®å¢å¼ŗå |
| WO2006091496A2 (en) | 2005-02-24 | 2006-08-31 | Merck & Co., Inc. | Benzazole potentiators of metabotropic glutamate receptors |
| JP2008540635A (ja) | 2005-05-18 | 2008-11-20 | ć¢ćććÆć¹ ćć”ć¼ć ć½ć·ćØć ć¢ććć | 代č¬åć°ć«ćæćć³é øå容ä½ć®ę£ć®ć¢ćć¹ććŖććÆčŖæēÆå åćØćć¦ć®ē½®ęććććŖćć·ćøć¢ć¾ć¼ć«čŖå°ä½ |
| GB0510142D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| TW200728277A (en) | 2005-06-29 | 2007-08-01 | Palau Pharma Sa | Bicyclic derivatives as P38 inhibitors |
| JP5031745B2 (ja) * | 2005-08-12 | 2012-09-26 | ć¢ć¹ćć©ć¼ćć« ć¢ćÆććć©ć° | 代č¬åć°ć«ćæćć³é øå容ä½å¢å¼·ę§ć¤ć½ć¤ć³ććć³ |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| US7868008B2 (en) | 2005-08-12 | 2011-01-11 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
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| TW200804281A (en) | 2006-02-16 | 2008-01-16 | Astrazeneca Ab | New metabotropic glutamate receptor-potentiating isoindolones |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | ļäŗåč”ēē©åå ¶ä½ēŗ代č¬åéŗ©čŗé øåé«å¢ęå-ļ¼ļ¼ļ¼ä¹ēØé |
| TW200911255A (en) | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
| SA109300358B1 (ar) * | 2008-06-06 | 2012-11-03 | Ų§Ų³ŲŖŲ±Ų§Ų²ŁŁŁŁŲ§ Ų§ŁŁ ŲØŁ | Ł ŁŁŁŲ§ŲŖ Ł Ų³ŲŖŁŲØŁ Ų¬ŁŁŲŖŲ§Ł Ų§ŲŖ Ų°Ł Ų§ŁŲŖŲŲ§Ų” Ų£ŁŲ¶Ł Ł Ł Ų£ŁŲ²Ł Ų„ŁŲÆŁŁŁŁ |
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