PE20110028A1 - Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato - Google Patents
Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamatoInfo
- Publication number
- PE20110028A1 PE20110028A1 PE2010001111A PE2010001111A PE20110028A1 PE 20110028 A1 PE20110028 A1 PE 20110028A1 PE 2010001111 A PE2010001111 A PE 2010001111A PE 2010001111 A PE2010001111 A PE 2010001111A PE 20110028 A1 PE20110028 A1 PE 20110028A1
- Authority
- PE
- Peru
- Prior art keywords
- isoxazole
- dihydro
- chloro
- alkyl
- metabotropic glutamate
- Prior art date
Links
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title abstract 3
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title abstract 3
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical class C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003623 enhancer Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 PYRROLIDINE-1-CARBONYL Chemical class 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/083—Clips, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B17/085—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound with adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/10—Surgical instruments, devices or methods for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/10—Surgical instruments, devices or methods for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
- A61B17/105—Wound clamp magazines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5948508P | 2008-06-06 | 2008-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110028A1 true PE20110028A1 (es) | 2011-02-11 |
Family
ID=41398335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001111A PE20110028A1 (es) | 2008-06-06 | 2009-06-08 | Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato |
Country Status (40)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| ES2409215T3 (es) | 2007-09-14 | 2013-06-25 | Janssen Pharmaceuticals, Inc. | 4-fenil-1H-piridin-2-onas 1-3-disustituidas |
| PL2203439T3 (pl) | 2007-09-14 | 2011-06-30 | Addex Pharmaceuticals Sa | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony |
| US7790760B2 (en) * | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ćøć£ć³ć»ć³ ćć”ć¼ćć·ć„ć¼ćć£ć«ć«ćŗļ¼ ć¤ć³ć³ć¼ćć¬ć¤ćććļ¼ | 代č¬åć°ć«ćæćć³é øå容ä½ć®čŖæēÆå åćØćć¦ć®ļ¼āć¢ć¶ćć·ćÆćļ¼»ļ¼ļ¼ļ¼ļ¼ļ¼ļ¼½ććć·ć«čŖå°ä½ |
| BRPI0920354A2 (pt) | 2008-10-16 | 2017-06-27 | Addex Pharmaceuticals Sa | derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrĆ³picos |
| KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | ģģ¼ ķė§ģķ°ģ¹¼ģ¦, ģøģ½ķ¬ė ģ“ķ°ė | 1,ļ¼,ļ¼āķøė¦¬ģģ”øė”ļ¼»ļ¼,ļ¼āļ½ļ¼½ķ¼ė¦¬ė ģ ėģ²“ ė° ģ ź²½ģ ģ ģ§ķģ ģ¹ė£ ėė ģė°©ģ ģķ ģ“ė¤ģ ģ©ė |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| AU2010246607B2 (en) | 2009-05-12 | 2012-09-27 | Addex Pharma S.A. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | ęØę£®å¶čÆå ¬åø | 1,2,4-äøå并[4,3-a]å”å¶č”ēē©åå ¶ä½äøŗMGLUR2åä½ēę£åęč°čåēēØé |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| AU2011328194B2 (en) | 2010-11-08 | 2015-04-16 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | Ł Ų±ŁŲØŲ§ŲŖ 6Ų 7- Ų«Ų§ŁŁ ŁŁŲÆŲ±Ł ŲØŁŲ±Ų§Ų²ŁŁŁ [5Ų1-a] ŲØŁŲ±Ų§Ų²ŁŁ- 4 (5 ŁŲÆ)- Ų§ŁŁ ŁŲ§Ų³ŲŖŲ®ŲÆŲ§Ł ŁŲ§ ŲØŲµŁŲ© Ł ŁŲøŁ Ų§ŲŖ ŲŖŁŲ§Ų±ŲŗŁŲ© Ų³ŁŲØŁŲ© ŁŁ Ų³ŲŖŁŲØŁŲ§ŲŖ Ł ŁŲ¬ŁŁŲ± 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | Ł Ų±ŁŲØŲ§ŲŖ 2Ų1Ų 4- Ų«ŁŲ§Ų«Ł Ų²ŁŁŁ [3Ų4-a] ŲØŁŲ±ŁŲÆŁŁ ŁŲ§Ų³ŲŖŲ®ŲÆŲ§Ł ŁŲ§ ŲØŲµŁŲ© Ł ŁŲøŁ Ų§ŲŖ ŲŖŁŲ§Ų±ŲŗŁŲ© Ł ŁŲ¬ŲØŲ© ŁŁ Ų³ŲŖŁŲØŁŲ§ŲŖ Ł ŁŲ¬ŁŁŲ± 2 |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| SI3431106T1 (sl) | 2014-01-21 | 2021-03-31 | Janssen Pharmaceutica Nv | Kombinacije, ki vsebujejo pozitivne alosteriÄne modulatorje metabotropnega glutamatergiÄnega receptorja podtipa 2 in njihova uporaba |
| EP3129345B1 (en) | 2014-04-06 | 2023-03-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor positive allosteric modulators (pams) and uses thereof |
| KR101663662B1 (ko) * | 2015-06-17 | 2016-10-14 | ķźµź³¼ķźø°ģ ģ°źµ¬ģ | ėģ¬ģ± źøė£Øķė©ģ“ķø ģģ©ģ²“ 1ģ ķģ±ģ ģ§ė ģ ź· ģė¦“ ģģ“ģģ„ģ¬ģ”ø ģ ėģ²“ |
| WO2017089892A1 (en) * | 2015-11-25 | 2017-06-01 | Astrazeneca Ab | Deuterated isoxazole derivatives and their use as metabotropic glutamate receptor potentiators |
| US11161838B2 (en) | 2018-11-13 | 2021-11-02 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
| US11078204B2 (en) | 2018-11-13 | 2021-08-03 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
| US11396502B2 (en) | 2018-11-13 | 2022-07-26 | Incyte Corporation | Substituted heterocyclic derivatives as PI3K inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE620654C (de) | 1933-04-29 | 1935-10-24 | Smith & Sons Ltd S | Geschwindigkeitsanzeiger |
| US3993617A (en) | 1975-10-30 | 1976-11-23 | Morton-Norwich Products, Inc. | Antifungal 2-substituted phthalimidines |
| US5175157A (en) | 1985-11-27 | 1992-12-29 | Boehringer Ingelheim Gmbh | Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them |
| WO1992017448A1 (fr) | 1991-04-01 | 1992-10-15 | Kyowa Hakko Kogyo Co., Ltd. | Derive de 3-methylenisoindolin-1-one |
| TW219935B (enExample) | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
| EP0602814A1 (en) | 1992-12-18 | 1994-06-22 | Takeda Chemical Industries, Ltd. | Crystal forms of optically active isoindolines and their use |
| US5681954A (en) | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| WO1997029079A1 (en) | 1996-02-06 | 1997-08-14 | Japan Tobacco Inc. | Novel compounds and pharmaceutical use thereof |
| WO1998054135A1 (en) | 1997-05-30 | 1998-12-03 | Meiji Seika Kaisha, Ltd. | Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same |
| CN1554649A (zh) | 1997-11-21 | 2004-12-15 | NPSŅ©ļæ½ļæ½ļæ½ļæ½ļ潎¹ļæ½Ė¾ | ēØäŗę²»ēäøę¢ē„ē»ē³»ē»ē¾ē ēä»£č°¢ę§č°·ę°Øé øåä½ę®ęå |
| DK1260512T3 (da) | 2000-02-29 | 2007-11-05 | Mitsubishi Pharma Corp | Hidtil ukendte, cykliske amidderivater |
| OA12346A (en) | 2000-07-31 | 2004-04-13 | Smithkline Beecham Plc | Carboxamide compounds and their use as antagonistsof a human 11 CBY receptor. |
| IL160253A0 (en) | 2001-08-09 | 2004-07-25 | Ono Pharmaceutical Co | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| WO2003087044A2 (en) | 2002-04-09 | 2003-10-23 | 7Tm Pharma A/S | Novel carboxamide compounds for use in mch receptor related disorders |
| FR2840302B1 (fr) | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue CarbonsƤureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB0223232D0 (en) | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| JP2006521358A (ja) | 2003-03-26 | 2006-09-21 | ć”ć«ćÆććØć³ććć«ć ććć¼ćć¤ć³ć³ć¼ćć¬ć¼ććć | 代č¬čŖæēÆåć°ć«ćæćć³é øå容ä½ć®ćć³ćŗć¢ććć¢ćøć„ć¬ć¼ćæ |
| GB0308025D0 (en) | 2003-04-07 | 2003-05-14 | Glaxo Group Ltd | Compounds |
| US7129260B2 (en) | 2003-06-02 | 2006-10-31 | Abbott Laboratories | Isoindolinone kinase inhibitors |
| US20070135485A1 (en) | 2003-10-22 | 2007-06-14 | Gillig James R | Novel mch receptor antagonists |
| US20080275062A1 (en) | 2004-01-30 | 2008-11-06 | David Harold Drewry | Chemical Compounds |
| CA2556320A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists for the treatment of gastrointestinal disorders |
| WO2005085216A1 (ja) | 2004-03-05 | 2005-09-15 | Nissan Chemical Industries, Ltd. | ć¤ć½ććµć¾ćŖć³ē½®ęćć³ćŗć¢ććååē©åć³ę害ēē©é²é¤å¤ |
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| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
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| TW200911255A (en) | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
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