JP2010528011A5 - - Google Patents
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- Publication number
- JP2010528011A5 JP2010528011A5 JP2010509380A JP2010509380A JP2010528011A5 JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5 JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound according
- fluoropyridin
- methylphenyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- NPFDWHQSDBWQLH-QZTJIDSGSA-N filorexant Chemical compound C([C@@H]1CC[C@H](N(C1)C(=O)C=1C(=CC=C(C)C=1)C=1N=CC=CN=1)C)OC1=CC=C(F)C=N1 NPFDWHQSDBWQLH-QZTJIDSGSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 5-fluoropyridin-2-yl Chemical group 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93145807P | 2007-05-23 | 2007-05-23 | |
| US60/931,458 | 2007-05-23 | ||
| PCT/US2008/006563 WO2008147518A1 (en) | 2007-05-23 | 2008-05-22 | Pyridyl piperidine orexin receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Division JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528011A JP2010528011A (ja) | 2010-08-19 |
| JP2010528011A5 true JP2010528011A5 (enExample) | 2011-12-08 |
| JP4881476B2 JP4881476B2 (ja) | 2012-02-22 |
Family
ID=39708485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509380A Expired - Fee Related JP4881476B2 (ja) | 2007-05-23 | 2008-05-22 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Country Status (33)
Families Citing this family (80)
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| EP2484674A1 (en) | 2011-02-02 | 2012-08-08 | Rottapharm S.P.A. | Spiro aminic compounds with NK1 antagonist activity |
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| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
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| WO2015018027A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
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| JP6262885B2 (ja) * | 2014-03-06 | 2018-01-17 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | オレキシン受容体拮抗剤としてのピペリジン誘導体 |
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2008
- 2008-05-22 WO PCT/US2008/006563 patent/WO2008147518A1/en not_active Ceased
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- 2008-05-22 AU AU2008257411A patent/AU2008257411B2/en not_active Ceased
- 2008-05-22 US US12/600,388 patent/US8242121B2/en active Active
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- 2008-05-22 PT PT08754659T patent/PT2152690E/pt unknown
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