JP2010528011A5 - - Google Patents
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- Publication number
- JP2010528011A5 JP2010528011A5 JP2010509380A JP2010509380A JP2010528011A5 JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5 JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound according
- fluoropyridin
- methylphenyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- NPFDWHQSDBWQLH-QZTJIDSGSA-N filorexant Chemical compound C([C@@H]1CC[C@H](N(C1)C(=O)C=1C(=CC=C(C)C=1)C=1N=CC=CN=1)C)OC1=CC=C(F)C=N1 NPFDWHQSDBWQLH-QZTJIDSGSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 5-fluoropyridin-2-yl Chemical group 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93145807P | 2007-05-23 | 2007-05-23 | |
| US60/931,458 | 2007-05-23 | ||
| PCT/US2008/006563 WO2008147518A1 (en) | 2007-05-23 | 2008-05-22 | Pyridyl piperidine orexin receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Division JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528011A JP2010528011A (ja) | 2010-08-19 |
| JP2010528011A5 true JP2010528011A5 (enExample) | 2011-12-08 |
| JP4881476B2 JP4881476B2 (ja) | 2012-02-22 |
Family
ID=39708485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509380A Expired - Fee Related JP4881476B2 (ja) | 2007-05-23 | 2008-05-22 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Country Status (33)
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007002809A1 (es) * | 2006-09-29 | 2008-04-18 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 3-aza biciclo [3.1.0]hexano; y su uso en el tratamiento de enfermedades tales como desordenes psicoticos y de ansiedad, desordenes del sueno, uso y abuso de sustancias psicoactivas, demencia y deterioro de funciones cognitivas |
| ES2357992T3 (es) | 2006-12-01 | 2011-05-04 | Actelion Pharmaceuticals Ltd. | Derivados de 3-heteroaril(amino o amido)-1-(bifenil o feniltiazolil)carbonilpiperidina como inhibidores del receptor de orexina. |
| AR064561A1 (es) | 2006-12-28 | 2009-04-08 | Actelion Pharmaceuticals Ltd | Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. |
| CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| EP2152690B1 (en) | 2007-05-23 | 2012-01-11 | Merck Sharp & Dohme Corp. | Pyridyl piperidine orexin receptor antagonists |
| RU2478099C2 (ru) * | 2007-07-27 | 2013-03-27 | Актелион Фармасьютиклз Лтд | Производные 2-аза-бицикло[3.3.0]октана |
| WO2009040730A2 (en) * | 2007-09-24 | 2009-04-02 | Actelion Pharmaceuticals Ltd | Pyrrolidines and piperidines as orexin receptor antagonists |
| US8236801B2 (en) * | 2008-02-21 | 2012-08-07 | Actelion Pharmaceuticals Ltd. | 2-aza-bicyclo[2.2.1]heptane derivatives |
| GB0806536D0 (en) * | 2008-04-10 | 2008-05-14 | Glaxo Group Ltd | Novel compounds |
| EP2318367B1 (en) * | 2008-04-30 | 2013-03-20 | Actelion Pharmaceuticals Ltd. | Piperidine and pyrrolidine compounds |
| CA2724648A1 (en) * | 2008-05-22 | 2009-11-26 | Merck Sharp & Dohme Corp. | Process for the preparation of an orexin receptor antagonist |
| US8546576B2 (en) * | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| CA2739927A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
| AU2009307920A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,3-disubstituted piperidine orexin receptor antagonists |
| US8357709B2 (en) * | 2008-10-21 | 2013-01-22 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| AU2009307915A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| US8669272B2 (en) * | 2008-10-21 | 2014-03-11 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| EP2349270B1 (en) | 2008-10-21 | 2015-09-09 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
| EP2275421A1 (en) | 2009-07-15 | 2011-01-19 | Rottapharm S.p.A. | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction |
| WO2011023578A1 (en) * | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | 5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder |
| WO2012058129A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | Process for the preparation of an orexin receptor antagonist |
| EP2484674A1 (en) | 2011-02-02 | 2012-08-08 | Rottapharm S.P.A. | Spiro aminic compounds with NK1 antagonist activity |
| WO2012114252A1 (en) * | 2011-02-21 | 2012-08-30 | Actelion Pharmaceuticals Ltd | Novel indole and pyrrolopyridine amides |
| EP2730573A4 (en) * | 2011-07-05 | 2014-12-03 | Taisho Pharmaceutical Co Ltd | METHYLPIPERIDINDERIVAT |
| KR20180069934A (ko) * | 2011-07-28 | 2018-06-25 | 켐팜 인코포레이티드 | 메틸페니데이트 프로드러그, 이의 제조 방법 및 사용 방법 |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| US9029364B2 (en) * | 2011-10-21 | 2015-05-12 | Merck Sharp & Dohme Corp. | 2,5-disubstituted thiomorpholine orexin receptor antagonists |
| ITMI20112329A1 (it) | 2011-12-21 | 2013-06-22 | Rottapharm Spa | Nuovi derivati spiro amminici |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| CN104220065A (zh) | 2012-02-07 | 2014-12-17 | Eolas治疗公司 | 取代的脯氨酸/哌啶用作食欲素受体拮抗剂 |
| EP2814798B1 (en) * | 2012-02-17 | 2019-04-03 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
| ITMI20120322A1 (it) | 2012-03-01 | 2013-09-02 | Rottapharm Spa | Composti di 4,4-difluoro piperidina |
| ITMI20120424A1 (it) | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
| SI2862860T1 (sl) * | 2012-06-15 | 2017-01-31 | Taisho Pharmaceutical Co., Ltd. | Spojine 1,3-oksazolidina ali 1,3-oksazinana kot antagonisti receptorja oreksina |
| US9273033B2 (en) | 2012-11-20 | 2016-03-01 | Merck Sharp & Dohme Corp. | Substituted pyridone derivatives as PDE10 inhibitors |
| JP2016028017A (ja) * | 2012-12-13 | 2016-02-25 | 大正製薬株式会社 | フッ素置換ピペリジン化合物 |
| US9765057B2 (en) | 2012-12-20 | 2017-09-19 | Merck Sharp & Dohme Corp. | 3-ester-4 substituted orexin receptor antagonists |
| US9556145B2 (en) | 2012-12-20 | 2017-01-31 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ester orexin receptor antagonists |
| EP2934517A4 (en) * | 2012-12-20 | 2016-05-25 | Merck Sharp & Dohme | 2-PYRIDYLOXY-3-NITRIL-4-SUBSTITUTED OREXINE RECEPTOR ANTAGONISTS |
| WO2014113303A1 (en) | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | 4-fluoropiperidine orexin receptor antagonists |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| US9745284B2 (en) | 2013-03-08 | 2017-08-29 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ether orexin receptor antagonists |
| US9725434B2 (en) * | 2013-04-23 | 2017-08-08 | Merck Sharp & Dohme Corp. | Hydroxy-substituted orexin receptor antagonists |
| US20160068514A1 (en) * | 2013-04-23 | 2016-03-10 | Merck Sharp & Dohme Corp. | Halo and trifluoromethyl substituted orexin receptor antagonists |
| WO2015018029A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2015018027A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
| WO2015095441A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-amino-3-ester-pyridyl orexin receptor antagonists |
| WO2015131773A1 (zh) * | 2014-03-06 | 2015-09-11 | 上海海雁医药科技有限公司 | 作为食欲素受体拮抗剂的哌啶衍生物 |
| KR102553870B1 (ko) | 2014-03-27 | 2023-07-10 | 버드 락 바이오, 인크. | 인간 카나비노이드 1(cb1) 수용체 결합 항체 |
| US10221170B2 (en) | 2014-08-13 | 2019-03-05 | Eolas Therapeutics, Inc. | Difluoropyrrolidines as orexin receptor modulators |
| WO2016065587A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole orexin receptor antagonists |
| WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2016065586A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole, triazole and tetrazole orexin receptor antagonists |
| WO2016065584A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| WO2016065585A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine isoxazole and isothiazole orexin receptor antagonists |
| US9994570B2 (en) | 2014-11-26 | 2018-06-12 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
| WO2016085784A1 (en) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
| WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
| WO2016086358A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Hydroxymethyl piperidine orexin receptor antagonists |
| WO2016100162A2 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | 5,5-bicyclic oxazole orexin receptor antagonists |
| WO2016095205A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Heteroaryl orexin receptor antagonists |
| US9938276B2 (en) | 2014-12-19 | 2018-04-10 | Merck Sharp & Dohme Corp. | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists |
| WO2016100161A1 (en) * | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
| WO2016095204A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor antagonists |
| WO2016101119A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Fused heteroaryl derivatives as orexin receptor antagonists |
| WO2016101118A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
| WO2017012502A1 (en) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| JP6772251B2 (ja) * | 2015-08-14 | 2020-10-21 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | オレキシン受容体拮抗薬の化合物の結晶形およびその製造方法と使用 |
| CN108025040A (zh) * | 2015-08-25 | 2018-05-11 | 阿尔莫生物科技股份有限公司 | 使用白介素-10治疗疾病和病症的方法 |
| MA43049A (fr) | 2015-09-30 | 2018-08-08 | Bird Rock Bio Inc | Anticorps de liaison à un récepteur cannabinoïde 1 humain (cb1) |
| HUE057696T2 (hu) * | 2016-02-04 | 2022-05-28 | Takeda Pharmaceuticals Co | Helyettesített piperidin vegyület és alkalmazása |
| SMT202200323T1 (it) | 2016-02-12 | 2022-09-14 | Astrazeneca Ab | Piperidine alo-sostituite come modulatori del recettore di oressina |
| US20190151304A1 (en) | 2016-05-10 | 2019-05-23 | Inserm (Institut National De La Santé Et De La Rechercjae Médicale | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory |
| SI3551619T1 (sl) | 2016-12-11 | 2024-08-30 | Zevra Therapeutics, Inc. | Sestavki, ki vsebujejo metilfenidat-predzdravila, postopki izdelave in uporabe le-teh |
| EP3816153B1 (en) | 2018-06-29 | 2023-10-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
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| CA3140170A1 (en) | 2019-06-04 | 2020-12-10 | Belew Mekonnen | Imidazolo derivatives, compositions and methods as orexin antagonists |
| KR20250036472A (ko) | 2023-09-07 | 2025-03-14 | 경희대학교 산학협력단 | Cid16020046의 체중감소 효능과 비만치료제로 적용 |
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