AU2016397047B2 - Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease - Google Patents

Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease Download PDF

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Publication number
AU2016397047B2
AU2016397047B2 AU2016397047A AU2016397047A AU2016397047B2 AU 2016397047 B2 AU2016397047 B2 AU 2016397047B2 AU 2016397047 A AU2016397047 A AU 2016397047A AU 2016397047 A AU2016397047 A AU 2016397047A AU 2016397047 B2 AU2016397047 B2 AU 2016397047B2
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AU
Australia
Prior art keywords
methylbenzamide
cyclopropyl
pyrazol
amino
cyanobenzoyl
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Application number
AU2016397047A
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English (en)
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AU2016397047A1 (en
Inventor
Cyril Clarke
Stefan De Buck
Colm Farrell
Colin ORFORD
Jacqueline PARKIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mereo Biopharma 1 Ltd
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Mereo Biopharma 1 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of AU2016397047A1 publication Critical patent/AU2016397047A1/en
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Publication of AU2016397047B2 publication Critical patent/AU2016397047B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016397047A 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease Active AU2016397047B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2016/050636 WO2017153702A1 (en) 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease

Publications (2)

Publication Number Publication Date
AU2016397047A1 AU2016397047A1 (en) 2018-09-06
AU2016397047B2 true AU2016397047B2 (en) 2022-04-07

Family

ID=55586330

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016397047A Active AU2016397047B2 (en) 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease

Country Status (9)

Country Link
US (2) US10603306B2 (enExample)
JP (1) JP6741774B2 (enExample)
KR (2) KR20180118667A (enExample)
AU (1) AU2016397047B2 (enExample)
BR (1) BR112018067454A2 (enExample)
CA (1) CA3016488C (enExample)
MX (1) MX385717B (enExample)
RU (1) RU2713203C1 (enExample)
WO (1) WO2017153702A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX385717B (es) * 2016-03-08 2025-03-18 Mereo Biopharma 1 Ltd Regimen de dosificacion para el tratamiento de exacerbaciones agudas de enfermedad pulmonar obstructiva cronica.
GB201612240D0 (en) 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide
GB201612238D0 (en) 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide
EP3845228A1 (en) 2017-12-11 2021-07-07 Mereo BioPharma 1 Limited Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease
JP7280627B2 (ja) * 2017-12-11 2023-05-24 メレオ バイオファーマ １ リミテッド 慢性閉塞性肺疾患の急性増悪の処置における３－［５－アミノ－４－（３－シアノベンゾイル）－ピラゾール－１－イル］－ｎ－シクロプロピル－４－メチルベンズアミドの使用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009973A1 (en) * 2003-06-26 2005-02-03 Novartis Ag 5-membered heterocycle-based p38 kinase inhibitors
WO2013139809A1 (en) * 2012-03-20 2013-09-26 Novartis Ag Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
TWI439284B (zh) 2004-04-09 2014-06-01 Abbvie Biotechnology Ltd 用於治療ＴＮＦα相關失調症之多重可變劑量療法
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
US20050277602A1 (en) 2004-05-21 2005-12-15 Grunstein Michael M Methods employing agonists of P38 map kinase for the treatment of asthma
US20090270350A1 (en) 2006-02-10 2009-10-29 Pfizer Inc. Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives
GB0603684D0 (en) * 2006-02-23 2006-04-05 Novartis Ag Organic compounds
MX385717B (es) * 2016-03-08 2025-03-18 Mereo Biopharma 1 Ltd Regimen de dosificacion para el tratamiento de exacerbaciones agudas de enfermedad pulmonar obstructiva cronica.
KR20180119597A (ko) * 2016-03-08 2018-11-02 메레오 바이오파마 1 리미티드 염증 상태의 급성 악화의 치료를 위한 투약법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009973A1 (en) * 2003-06-26 2005-02-03 Novartis Ag 5-membered heterocycle-based p38 kinase inhibitors
WO2013139809A1 (en) * 2012-03-20 2013-09-26 Novartis Ag Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DE BUCK S. ET AL., "Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197", CPT PHARMACOMETRICS SYST. PHARMACOL., (2015), vol. 4, pages 691 - 700 *

Also Published As

Publication number Publication date
BR112018067454A2 (pt) 2019-01-15
US20190060279A1 (en) 2019-02-28
CA3016488C (en) 2023-04-11
JP2019507786A (ja) 2019-03-22
US20200281896A1 (en) 2020-09-10
WO2017153702A1 (en) 2017-09-14
KR20240101698A (ko) 2024-07-02
MX2018010782A (es) 2019-01-10
US11129810B2 (en) 2021-09-28
AU2016397047A1 (en) 2018-09-06
CA3016488A1 (en) 2017-09-14
US10603306B2 (en) 2020-03-31
MX385717B (es) 2025-03-18
KR20180118667A (ko) 2018-10-31
KR102762199B1 (ko) 2025-02-07
JP6741774B2 (ja) 2020-08-19
RU2713203C1 (ru) 2020-02-04

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