JP2013544887A5 - - Google Patents
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- Publication number
- JP2013544887A5 JP2013544887A5 JP2013543255A JP2013543255A JP2013544887A5 JP 2013544887 A5 JP2013544887 A5 JP 2013544887A5 JP 2013543255 A JP2013543255 A JP 2013543255A JP 2013543255 A JP2013543255 A JP 2013543255A JP 2013544887 A5 JP2013544887 A5 JP 2013544887A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- laquinimod
- medicament
- patient
- score
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 claims description 70
- 229960004577 laquinimod Drugs 0.000 claims description 70
- 201000006417 multiple sclerosis Diseases 0.000 claims description 12
- 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims description 9
- 230000006866 deterioration Effects 0.000 claims description 9
- 210000003169 central nervous system Anatomy 0.000 claims description 8
- 230000036541 health Effects 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 230000000977 initiatory effect Effects 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000004770 neurodegeneration Effects 0.000 claims description 4
- 230000009223 neuronal apoptosis Effects 0.000 claims description 4
- 230000006764 neuronal dysfunction Effects 0.000 claims description 4
- 230000004112 neuroprotection Effects 0.000 claims description 4
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 230000001537 neural effect Effects 0.000 claims description 3
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 230000003340 mental effect Effects 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 25
- 238000004519 manufacturing process Methods 0.000 claims 4
- 206010016256 fatigue Diseases 0.000 claims 3
- 230000003190 augmentative effect Effects 0.000 claims 1
- 230000005182 global health Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 45
- 230000002411 adverse Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 108010005716 Interferon beta-1a Proteins 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010053395 Progressive multiple sclerosis Diseases 0.000 description 1
- 229940003504 avonex Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229960004461 interferon beta-1a Drugs 0.000 description 1
- 230000003961 neuronal insult Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42074210P | 2010-12-07 | 2010-12-07 | |
| US61/420,742 | 2010-12-07 | ||
| US201161542996P | 2011-10-04 | 2011-10-04 | |
| US61/542,996 | 2011-10-04 | ||
| PCT/US2011/063460 WO2012078591A1 (en) | 2010-12-07 | 2011-12-06 | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016251360A Division JP2017095476A (ja) | 2010-12-07 | 2016-12-26 | 多発性硬化症患者において疲労を軽減し、機能状態を改善し、生活の質を改善するための、ラキニモド（ｌａｑｕｉｎｉｍｏｄ）の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013544887A JP2013544887A (ja) | 2013-12-19 |
| JP2013544887A5 true JP2013544887A5 (enExample) | 2015-05-07 |
Family
ID=46162796
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543255A Pending JP2013544887A (ja) | 2010-12-07 | 2011-12-06 | 多発性硬化症患者において疲労を軽減し、機能状態を改善し、生活の質を改善するための、ラキニモド（ｌａｑｕｉｎｉｍｏｄ）の使用 |
| JP2016251360A Pending JP2017095476A (ja) | 2010-12-07 | 2016-12-26 | 多発性硬化症患者において疲労を軽減し、機能状態を改善し、生活の質を改善するための、ラキニモド（ｌａｑｕｉｎｉｍｏｄ）の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016251360A Pending JP2017095476A (ja) | 2010-12-07 | 2016-12-26 | 多発性硬化症患者において疲労を軽減し、機能状態を改善し、生活の質を改善するための、ラキニモド（ｌａｑｕｉｎｉｍｏｄ）の使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20120142730A1 (enExample) |
| EP (1) | EP2648732A4 (enExample) |
| JP (2) | JP2013544887A (enExample) |
| KR (1) | KR20130124518A (enExample) |
| CN (1) | CN103260624B (enExample) |
| AU (2) | AU2011338647A1 (enExample) |
| BR (1) | BR112013014061A2 (enExample) |
| CA (1) | CA2820586A1 (enExample) |
| CL (1) | CL2013001602A1 (enExample) |
| EA (1) | EA201390827A1 (enExample) |
| IL (1) | IL250726A0 (enExample) |
| MX (1) | MX2013006464A (enExample) |
| NZ (1) | NZ611628A (enExample) |
| PE (1) | PE20140872A1 (enExample) |
| PH (1) | PH12013501193A1 (enExample) |
| SG (2) | SG190449A1 (enExample) |
| UA (1) | UA111959C2 (enExample) |
| WO (1) | WO2012078591A1 (enExample) |
| ZA (1) | ZA201304237B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1937642T3 (en) * | 2005-10-19 | 2014-12-15 | Teva Pharma | Crystals of sodium laquinimod and the process for its preparation |
| PT2682120T (pt) | 2007-12-20 | 2016-11-07 | Teva Pharma | Preparações de laquinimod estáveis |
| JP5882208B2 (ja) * | 2009-07-30 | 2016-03-09 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドによるクローン病の治療 |
| AU2010282948C1 (en) | 2009-08-10 | 2017-03-02 | Active Biotech, Ab | Treatment of BDNF-related disorders using laquinimod |
| SI2542079T1 (sl) * | 2010-03-03 | 2014-08-29 | Teva Pharmaceutical Industries Ltd. | Zdravljenje revmatoidnega artritisa s kombinacijo lakvinimoda in metotreksata |
| EA201290837A1 (ru) * | 2010-03-03 | 2013-05-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение волчаночного нефрита с применением лаквинимода |
| KR20130092558A (ko) | 2010-07-09 | 2013-08-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 중수소화된 n-에틸-n-페닐-1,2-다이하이드로-4-하이드록시-5-클로로-1-메틸-2-옥소퀴놀린-3-카복스아마이드, 그의 염 및 용도 |
| JP2014530821A (ja) | 2011-10-12 | 2014-11-20 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療 |
| WO2013116657A1 (en) | 2012-02-03 | 2013-08-08 | Teva Pharmaceutical Industries Ltd. | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
| JP6215238B2 (ja) | 2012-02-16 | 2017-10-18 | テバ ファーマシューティカル インダストリーズ リミティド | Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用 |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| IN2015DN03219A (enExample) * | 2012-09-27 | 2015-10-02 | Teva Pharma | |
| PE20151435A1 (es) * | 2012-10-12 | 2015-10-15 | Teva Pharma | Laquinimod para reducir el dano talamico en la esclerosis multiple |
| MX2015005632A (es) | 2012-11-07 | 2016-02-05 | Teva Pharma | Sales de amina de laquinimod. |
| HK1218254A1 (zh) * | 2013-02-15 | 2017-02-10 | Teva Pharmaceutical Industries Ltd. | 用拉喹莫德治疗多发性硬化症 |
| WO2014153145A2 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| JP2016513665A (ja) | 2013-03-14 | 2016-05-16 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドの経皮製剤 |
| EP3082814A4 (en) * | 2013-12-20 | 2017-06-21 | Teva Pharmaceutical Industries Ltd. | Use of laquinimod to delay huntington's disease progression |
| EP3094330A4 (en) * | 2014-01-17 | 2017-09-27 | Teva Pharmaceutical Industries Ltd | Treatment of crohn's disease using low doses of laquinimod |
| SG11201608674UA (en) * | 2014-04-29 | 2016-11-29 | Teva Pharma | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
| JP6731915B2 (ja) | 2014-10-16 | 2020-07-29 | ノバルティス アーゲー | 多発性硬化症治療用のシポニモドとラキニモドを含む組み合わせ |
| CA2970799A1 (en) | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
| US10946071B2 (en) * | 2018-10-09 | 2021-03-16 | Medicinova, Inc. | Combination of ibudilast and interferon-beta and methods of using same |
| CN114144175A (zh) * | 2019-07-22 | 2022-03-04 | 埃科特莱茵药品有限公司 | 治疗多发性硬化症的方法 |
| CN110688373A (zh) * | 2019-09-17 | 2020-01-14 | 杭州绿度信息技术有限公司 | 一种基于逻辑回归的offset方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2572811T3 (es) * | 2004-09-09 | 2016-06-02 | Yeda Research And Development Co., Ltd. | Mezclas de polipéptidos, composiciones que las contienen y procedimientos para obtener los mismos, y usos de los mismos |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| EA018031B1 (ru) * | 2006-06-12 | 2013-05-30 | Тева Фармасьютикал Индастриз, Лтд. | Стабильные препараты лаквинимода |
| EP2680006A1 (en) * | 2007-02-08 | 2014-01-01 | Biogen Idec MA Inc. | Treatment for Amyotrophic Lateral Sclerosis |
| BR112012000568A2 (pt) * | 2009-06-19 | 2015-10-06 | Teva Pharma | tratamento da esclerose múltipla com laquinimod |
-
2011
- 2011-12-06 MX MX2013006464A patent/MX2013006464A/es unknown
- 2011-12-06 CA CA2820586A patent/CA2820586A1/en not_active Abandoned
- 2011-12-06 NZ NZ611628A patent/NZ611628A/en not_active IP Right Cessation
- 2011-12-06 EP EP11846599.6A patent/EP2648732A4/en not_active Withdrawn
- 2011-12-06 WO PCT/US2011/063460 patent/WO2012078591A1/en not_active Ceased
- 2011-12-06 JP JP2013543255A patent/JP2013544887A/ja active Pending
- 2011-12-06 PE PE2013001357A patent/PE20140872A1/es not_active Application Discontinuation
- 2011-12-06 KR KR1020137017362A patent/KR20130124518A/ko not_active Ceased
- 2011-12-06 SG SG2013042403A patent/SG190449A1/en unknown
- 2011-12-06 AU AU2011338647A patent/AU2011338647A1/en not_active Abandoned
- 2011-12-06 UA UAA201308448A patent/UA111959C2/uk unknown
- 2011-12-06 EA EA201390827A patent/EA201390827A1/ru unknown
- 2011-12-06 BR BR112013014061A patent/BR112013014061A2/pt not_active Application Discontinuation
- 2011-12-06 CN CN201180060414.8A patent/CN103260624B/zh not_active Expired - Fee Related
- 2011-12-06 SG SG10201509831XA patent/SG10201509831XA/en unknown
- 2011-12-06 US US13/312,284 patent/US20120142730A1/en not_active Abandoned
- 2011-12-06 PH PH1/2013/501193A patent/PH12013501193A1/en unknown
-
2013
- 2013-06-05 CL CL2013001602A patent/CL2013001602A1/es unknown
- 2013-06-10 ZA ZA2013/04237A patent/ZA201304237B/en unknown
-
2016
- 2016-12-26 JP JP2016251360A patent/JP2017095476A/ja active Pending
-
2017
- 2017-02-22 IL IL250726A patent/IL250726A0/en unknown
- 2017-03-28 AU AU2017202055A patent/AU2017202055A1/en not_active Abandoned