JP2013535437A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013535437A5 JP2013535437A5 JP2013519724A JP2013519724A JP2013535437A5 JP 2013535437 A5 JP2013535437 A5 JP 2013535437A5 JP 2013519724 A JP2013519724 A JP 2013519724A JP 2013519724 A JP2013519724 A JP 2013519724A JP 2013535437 A5 JP2013535437 A5 JP 2013535437A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- rich
- pharmaceutically acceptable
- acceptable salt
- dihydroquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 54
- 229910052805 deuterium Inorganic materials 0.000 claims description 54
- 150000001875 compounds Chemical class 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 38
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 claims description 32
- 229960004577 laquinimod Drugs 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 22
- BZKCTVZVKAXVFH-UHFFFAOYSA-N 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenylquinoline-3-carboxamide Chemical class O=C1N(C)C2=CC=CC(Cl)=C2C(O)=C1C(=O)NC1=CC=CC=C1 BZKCTVZVKAXVFH-UHFFFAOYSA-N 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 12
- 208000023275 Autoimmune disease Diseases 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- OQZQXOFJGSSYNX-UHFFFAOYSA-N 1,2-dihydroquinoline-3-carboxamide Chemical compound C1=CC=C2NCC(C(=O)N)=CC2=C1 OQZQXOFJGSSYNX-UHFFFAOYSA-N 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 description 2
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 description 2
- 229940125782 compound 2 Drugs 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- RMOFHUSKOLURAA-UHFFFAOYSA-N 1-phenyl-2H-quinoline-3-carboxamide Chemical compound C1C(C(=O)N)=CC2=CC=CC=C2N1C1=CC=CC=C1 RMOFHUSKOLURAA-UHFFFAOYSA-N 0.000 description 1
- DZOOMZBMCVCDDF-UHFFFAOYSA-N 2-oxo-n-phenyl-1h-quinoline-3-carboxamide Chemical compound C=1C2=CC=CC=C2NC(=O)C=1C(=O)NC1=CC=CC=C1 DZOOMZBMCVCDDF-UHFFFAOYSA-N 0.000 description 1
- 0 C*c1c(*)c(*)c(*=*)c(N(C(*)(*)C(*)(*)*)C(C(C(N(C)c2cccc(Cl)c22)=O)=C2O)=O)c1* Chemical compound C*c1c(*)c(*)c(*=*)c(N(C(*)(*)C(*)(*)*)C(C(C(N(C)c2cccc(Cl)c22)=O)=C2O)=O)c1* 0.000 description 1
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 description 1
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39929710P | 2010-07-09 | 2010-07-09 | |
| US61/399,297 | 2010-07-09 | ||
| PCT/US2011/043383 WO2012006538A1 (en) | 2010-07-09 | 2011-07-08 | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148514A Division JP2017014238A (ja) | 2010-07-09 | 2016-07-28 | 重水素化されたｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４−ヒドロキシ−５−クロロ−１−メチル−２−オキソキノリン−３−カルボキサミド、その塩および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013535437A JP2013535437A (ja) | 2013-09-12 |
| JP2013535437A5 true JP2013535437A5 (enExample) | 2014-08-28 |
Family
ID=45439026
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013519724A Withdrawn JP2013535437A (ja) | 2010-07-09 | 2011-07-08 | 重水素化されたｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４−ヒドロキシ−５−クロロ−１−メチル−２−オキソキノリン−３−カルボキサミド、その塩および使用 |
| JP2016148514A Pending JP2017014238A (ja) | 2010-07-09 | 2016-07-28 | 重水素化されたｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４−ヒドロキシ−５−クロロ−１−メチル−２−オキソキノリン−３−カルボキサミド、その塩および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148514A Pending JP2017014238A (ja) | 2010-07-09 | 2016-07-28 | 重水素化されたｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４−ヒドロキシ−５−クロロ−１−メチル−２−オキソキノリン−３−カルボキサミド、その塩および使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8580819B2 (enExample) |
| EP (2) | EP3213636A1 (enExample) |
| JP (2) | JP2013535437A (enExample) |
| KR (1) | KR20130092558A (enExample) |
| CN (2) | CN104610144A (enExample) |
| AR (1) | AR082150A1 (enExample) |
| AU (1) | AU2011274496B2 (enExample) |
| BR (1) | BR112013000599A2 (enExample) |
| CA (1) | CA2804986A1 (enExample) |
| CL (1) | CL2013000063A1 (enExample) |
| EA (1) | EA025377B1 (enExample) |
| IL (1) | IL251600A0 (enExample) |
| MX (1) | MX2013000333A (enExample) |
| NZ (1) | NZ606587A (enExample) |
| PE (1) | PE20130396A1 (enExample) |
| PH (1) | PH12013500065A1 (enExample) |
| SG (2) | SG186948A1 (enExample) |
| UY (1) | UY33504A (enExample) |
| WO (1) | WO2012006538A1 (enExample) |
| ZA (1) | ZA201300956B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0617477A2 (pt) * | 2005-10-19 | 2011-07-26 | Teva Pharma | mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica |
| CN101466379B (zh) | 2006-06-12 | 2012-10-31 | 泰华制药工业有限公司 | 稳定的拉喹莫德的制剂 |
| WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
| NZ597378A (en) * | 2009-06-19 | 2014-08-29 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| BR112012002124A2 (pt) * | 2009-07-30 | 2015-09-15 | Teva Pharma | tratamento da doença de crohn com laquinimode. |
| WO2011019375A1 (en) | 2009-08-10 | 2011-02-17 | Teva Pharmaceutical Industries Ltd. | Treatment of bdnf-related disorders using laquinimod |
| KR20130006640A (ko) * | 2010-03-03 | 2013-01-17 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| EA201290860A1 (ru) * | 2010-03-03 | 2013-04-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение ревматоидного артрита комбинацией лаквинимода и метотрексата |
| US20110217295A1 (en) * | 2010-03-03 | 2011-09-08 | Asi Haviv | Treatment of lupus arthritis using laquinimod |
| AU2011274496B2 (en) | 2010-07-09 | 2016-03-10 | Teva Pharmaceutical Industries Ltd. | Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| WO2013116657A1 (en) * | 2012-02-03 | 2013-08-08 | Teva Pharmaceutical Industries Ltd. | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
| MX2014009889A (es) | 2012-02-16 | 2014-11-13 | Teva Pharma | N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos. |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| EA201590788A1 (ru) | 2012-11-07 | 2015-12-30 | Тева Фармасьютикал Индастриз Лтд. | Аминные соли лахинимода |
| WO2014086284A1 (zh) * | 2012-12-04 | 2014-06-12 | 上海医药集团股份有限公司 | 一类氘代3-氰基喹啉类化合物、其药用组合物、制备方法及其用途 |
| JP2016514162A (ja) | 2013-03-14 | 2016-05-19 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドナトリウムの結晶およびその製造のための改善された方法 |
| WO2014152009A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Transdermal formulations of laquinimod |
| CN103145562B (zh) * | 2013-03-18 | 2015-06-17 | 黄河三角洲京博化工研究院有限公司 | 一种n-乙基苯胺的制备方法 |
| HK1231413A1 (zh) | 2014-04-29 | 2017-12-22 | Teva Pharmaceutical Industries Ltd. | 用於治疗具有高残疾状况的复发-缓解型多发性硬化症(rrms)的患者的拉喹莫德 |
| EP3347006B1 (en) | 2015-03-20 | 2022-07-27 | GABA Therapeutics Inc. | Deuterated analogs of etifoxine, their derivatives and uses therof |
| US11861914B2 (en) * | 2019-08-28 | 2024-01-02 | Nissan Motor Co., Ltd. | Object recognition method and object recognition device |
| WO2021097427A1 (en) | 2019-11-15 | 2021-05-20 | Karuna Therapeutics, Inc. | Xanomeline derivatives and methods for treating neurological disorders |
| CA3157394A1 (en) * | 2019-12-19 | 2021-06-24 | Helena ERIKSSON | Compounds for treatment of eye diseases associated with excessive vascularisation |
| GB202006390D0 (en) * | 2020-04-30 | 2020-06-17 | Aqilion Ab | Novel treatments |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52670B1 (en) | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| SE9801474D0 (sv) | 1998-04-27 | 1998-04-27 | Active Biotech Ab | Quinoline Derivatives |
| US6077851A (en) | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
| US6133285A (en) | 1998-07-15 | 2000-10-17 | Active Biotech Ab | Quinoline derivatives |
| US6121287A (en) | 1998-07-15 | 2000-09-19 | Active Biotech Ab | Quinoline derivatives |
| SE9802550D0 (sv) | 1998-07-15 | 1998-07-15 | Active Biotech Ab | Quinoline derivatives |
| SE9802549D0 (sv) | 1998-07-15 | 1998-07-15 | Active Biotech Ab | Quinoline derivatives |
| EE200100660A (et) | 1999-06-07 | 2003-04-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Ravimvorm happe suhtes labiilsete toimeainete jaoks, toimeaine üksus, selle valmistamismeetod ja mikrokerake |
| US6875869B2 (en) | 2002-06-12 | 2005-04-05 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
| US7560557B2 (en) | 2002-06-12 | 2009-07-14 | Active Biotech Ag | Process for the manufacture of quinoline derivatives |
| SE0201778D0 (sv) | 2002-06-12 | 2002-06-12 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
| SE0400235D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
| US8314124B2 (en) | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
| US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
| BRPI0617477A2 (pt) * | 2005-10-19 | 2011-07-26 | Teva Pharma | mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica |
| CN101466379B (zh) | 2006-06-12 | 2012-10-31 | 泰华制药工业有限公司 | 稳定的拉喹莫德的制剂 |
| US7528131B2 (en) | 2007-04-19 | 2009-05-05 | Concert Pharmaceuticals Inc. | Substituted morpholinyl compounds |
| WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
| AU2009288108B2 (en) | 2008-09-03 | 2013-10-17 | Teva Pharmaceutical Industries, Ltd. | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
| NZ597378A (en) | 2009-06-19 | 2014-08-29 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| JP2011001308A (ja) * | 2009-06-19 | 2011-01-06 | Research Foundation Itsuu Laboratory | 重水素化カルボスチリル化合物 |
| BR112012002124A2 (pt) | 2009-07-30 | 2015-09-15 | Teva Pharma | tratamento da doença de crohn com laquinimode. |
| WO2011019375A1 (en) | 2009-08-10 | 2011-02-17 | Teva Pharmaceutical Industries Ltd. | Treatment of bdnf-related disorders using laquinimod |
| EA201290860A1 (ru) | 2010-03-03 | 2013-04-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение ревматоидного артрита комбинацией лаквинимода и метотрексата |
| KR20130006640A (ko) | 2010-03-03 | 2013-01-17 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| US20110217295A1 (en) | 2010-03-03 | 2011-09-08 | Asi Haviv | Treatment of lupus arthritis using laquinimod |
| JP5934202B2 (ja) | 2010-07-09 | 2016-06-15 | テバ ファーマシューティカル インダストリーズ リミティド | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
| AU2011274496B2 (en) | 2010-07-09 | 2016-03-10 | Teva Pharmaceutical Industries Ltd. | Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| PE20140872A1 (es) | 2010-12-07 | 2014-08-09 | Teva Pharma | Uso de laquinimod para reducir la fatiga, mejorar el estado funcional y mejorar la calidad de vida en pacientes con esclerosis multiple |
-
2011
- 2011-07-08 AU AU2011274496A patent/AU2011274496B2/en not_active Ceased
- 2011-07-08 EP EP16196628.8A patent/EP3213636A1/en not_active Withdrawn
- 2011-07-08 EA EA201390081A patent/EA025377B1/ru not_active IP Right Cessation
- 2011-07-08 CN CN201410831557.XA patent/CN104610144A/zh active Pending
- 2011-07-08 CA CA2804986A patent/CA2804986A1/en not_active Abandoned
- 2011-07-08 JP JP2013519724A patent/JP2013535437A/ja not_active Withdrawn
- 2011-07-08 SG SG2013000948A patent/SG186948A1/en unknown
- 2011-07-08 MX MX2013000333A patent/MX2013000333A/es unknown
- 2011-07-08 AR ARP110102478A patent/AR082150A1/es unknown
- 2011-07-08 NZ NZ60658711A patent/NZ606587A/en not_active IP Right Cessation
- 2011-07-08 CN CN2011800340883A patent/CN102984939A/zh active Pending
- 2011-07-08 KR KR1020137003480A patent/KR20130092558A/ko not_active Ceased
- 2011-07-08 SG SG10201505236YA patent/SG10201505236YA/en unknown
- 2011-07-08 PE PE2013000039A patent/PE20130396A1/es not_active Application Discontinuation
- 2011-07-08 EP EP20110804411 patent/EP2597954A4/en not_active Withdrawn
- 2011-07-08 WO PCT/US2011/043383 patent/WO2012006538A1/en not_active Ceased
- 2011-07-08 US US13/178,842 patent/US8580819B2/en not_active Expired - Fee Related
- 2011-07-08 PH PH1/2013/500065A patent/PH12013500065A1/en unknown
- 2011-07-08 BR BR112013000599A patent/BR112013000599A2/pt not_active IP Right Cessation
- 2011-07-11 UY UY0001033504A patent/UY33504A/es not_active Application Discontinuation
-
2013
- 2013-01-08 CL CL2013000063A patent/CL2013000063A1/es unknown
- 2013-02-05 ZA ZA2013/00956A patent/ZA201300956B/en unknown
- 2013-10-24 US US14/062,685 patent/US20140051723A1/en not_active Abandoned
-
2014
- 2014-03-14 US US14/213,279 patent/US9102620B2/en not_active Expired - Fee Related
-
2016
- 2016-07-28 JP JP2016148514A patent/JP2017014238A/ja active Pending
-
2017
- 2017-04-05 IL IL251600A patent/IL251600A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013507415A5 (enExample) | ||
| JP2014506321A5 (enExample) | ||
| CA2923685A1 (en) | Application of r-ketamine and salt thereof as pharmaceuticals | |
| JP2014517050A5 (enExample) | ||
| JP2015505564A5 (enExample) | ||
| JPWO2019160057A5 (enExample) | ||
| NZ611628A (en) | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients | |
| JP2014521658A5 (enExample) | ||
| JP2022547604A (ja) | 過度の眠気の治療のためのオレキシン２受容体アゴニストの使用 | |
| TW201936567A (zh) | 發炎性疾病或骨病之預防或治療劑及醫藥組成物 | |
| JP2022173373A (ja) | 神経発達障害療法 | |
| JP2012502103A5 (enExample) | ||
| HK1202776A1 (en) | Use of laquinimod for treating crohn's disease patients who failed first-line anti-tnf therapy | |
| KR20170031786A (ko) | 다발성 골수종을 치료하기 위한 약물 병용물 | |
| ES3032941T3 (en) | Treatment of hyperinflammatory syndrome | |
| JP2011518168A5 (enExample) | ||
| RU2013127420A (ru) | Способы уменьшения психогенного или компульсивного переедания | |
| JP2015522077A5 (enExample) | ||
| JP2016505050A5 (enExample) | ||
| JP5973455B2 (ja) | 脱髄疾患の治療薬及び予防薬 | |
| CN111601591A (zh) | 睡眠障碍的治疗和预防 | |
| JP2013536206A5 (enExample) | ||
| JP2013526579A5 (enExample) | ||
| JP2009501226A (ja) | 軽度ないし中等度のレベルの鎮静を誘発するためのプロポフォールプロドラッグの投与の方法 | |
| WO2012041031A1 (zh) | 一种用于哮喘的吸入性复方组合物 |