SE0201778D0 - Process for the manufacture of quinoline derivatives - Google Patents

Process for the manufacture of quinoline derivatives

Info

Publication number
SE0201778D0
SE0201778D0 SE0201778A SE0201778A SE0201778D0 SE 0201778 D0 SE0201778 D0 SE 0201778D0 SE 0201778 A SE0201778 A SE 0201778A SE 0201778 A SE0201778 A SE 0201778A SE 0201778 D0 SE0201778 D0 SE 0201778D0
Authority
SE
Sweden
Prior art keywords
manufacture
quinoline derivatives
formula
quinoline
chaineded
Prior art date
Application number
SE0201778A
Other languages
English (en)
Inventor
Karl Jansson
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Priority to SE0201778A priority Critical patent/SE0201778D0/sv
Publication of SE0201778D0 publication Critical patent/SE0201778D0/sv
Priority to EP03725956A priority patent/EP1511732B9/en
Priority to AU2003228195A priority patent/AU2003228195B2/en
Priority to ES03725956T priority patent/ES2278160T3/es
Priority to SI200330688T priority patent/SI1511732T1/sl
Priority to JP2004513257A priority patent/JP4584709B2/ja
Priority to YUP-1076/04A priority patent/RS51021B/sr
Priority to NZ536768A priority patent/NZ536768A/en
Priority to MEP-2008-656A priority patent/ME00435B/me
Priority to MXPA04012276A priority patent/MXPA04012276A/es
Priority to PT03725956T priority patent/PT1511732E/pt
Priority to CA2487329A priority patent/CA2487329C/en
Priority to KR1020047020088A priority patent/KR100979216B1/ko
Priority to RU2005100054/04A priority patent/RU2291861C2/ru
Priority to CNB038135310A priority patent/CN100418950C/zh
Priority to PL373817A priority patent/PL210259B1/pl
Priority to BRPI0311674-3A priority patent/BR0311674A/pt
Priority to DE60310554T priority patent/DE60310554T2/de
Priority to DK03725956T priority patent/DK1511732T5/da
Priority to PCT/SE2003/000780 priority patent/WO2003106424A1/en
Priority to UA20041109639A priority patent/UA78310C2/xx
Priority to AT03725956T priority patent/ATE348814T1/de
Priority to IL165155A priority patent/IL165155A/en
Priority to ZA200409430A priority patent/ZA200409430B/xx
Priority to IS7550A priority patent/IS2975B/is
Priority to NO20045703A priority patent/NO329162B1/no
Priority to HRP20050028AA priority patent/HRP20050028B1/hr
Priority to CY20071100295T priority patent/CY1107555T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
SE0201778A 2002-06-12 2002-06-12 Process for the manufacture of quinoline derivatives SE0201778D0 (sv)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE0201778A SE0201778D0 (sv) 2002-06-12 2002-06-12 Process for the manufacture of quinoline derivatives
AT03725956T ATE348814T1 (de) 2002-06-12 2003-05-14 Verfahren zur herstellung von chinolinderivaten
KR1020047020088A KR100979216B1 (ko) 2002-06-12 2003-05-14 퀴놀린 유도체의 제조 방법
CNB038135310A CN100418950C (zh) 2002-06-12 2003-05-14 制备喹啉衍生物的方法
ES03725956T ES2278160T3 (es) 2002-06-12 2003-05-14 Procedimiento para la fabricacion de derivados de quinolina.
SI200330688T SI1511732T1 (sl) 2002-06-12 2003-05-14 Postopek za pripravo kinolinskih derivatov
JP2004513257A JP4584709B2 (ja) 2002-06-12 2003-05-14 キノリン誘導体の製造工程
YUP-1076/04A RS51021B (sr) 2002-06-12 2003-05-14 Postupak za dobijanje derivata hinolina
NZ536768A NZ536768A (en) 2002-06-12 2003-05-14 Process for the manufacture of quinoline carboxamide derivatives using an alkane or cycloalkane solvent
MEP-2008-656A ME00435B (me) 2002-06-12 2003-05-14 Postupak za dobijanje derivata hinolina
MXPA04012276A MXPA04012276A (es) 2002-06-12 2003-05-14 Proceso para la elaboracion de derivados de quinolina.
PT03725956T PT1511732E (pt) 2002-06-12 2003-05-14 Processo para o fabrico de derivados quinolina
CA2487329A CA2487329C (en) 2002-06-12 2003-05-14 Process for the manufacture of quinoline derivatives
EP03725956A EP1511732B9 (en) 2002-06-12 2003-05-14 Process for the manufacture of quinoline derivatives
RU2005100054/04A RU2291861C2 (ru) 2002-06-12 2003-05-14 Способ получения производных хинолина
AU2003228195A AU2003228195B2 (en) 2002-06-12 2003-05-14 Process for the manufacture of quinoline derivatives
PL373817A PL210259B1 (pl) 2002-06-12 2003-05-14 Sposób wytwarzania pochodnych chinoliny
BRPI0311674-3A BR0311674A (pt) 2002-06-12 2003-05-14 processo para a preparação de compostos
DE60310554T DE60310554T2 (de) 2002-06-12 2003-05-14 Verfahren zur herstellung von chinolinderivaten
DK03725956T DK1511732T5 (da) 2002-06-12 2003-05-14 Fremgangsmåde til fremstilling af quinolinderivater
PCT/SE2003/000780 WO2003106424A1 (en) 2002-06-12 2003-05-14 Process for the manufacture of quinoline derivatives
UA20041109639A UA78310C2 (en) 2002-06-12 2003-05-14 Method for preparing quinolin derivatives
IL165155A IL165155A (en) 2002-06-12 2004-11-11 A process to create a history of quinoline
ZA200409430A ZA200409430B (en) 2002-06-12 2004-11-23 Process for the manufacture of quinoline derivatives.
IS7550A IS2975B (is) 2002-06-12 2004-11-24 Aðferð til framleiðslu á kvínólín-afleiðum
NO20045703A NO329162B1 (no) 2002-06-12 2004-12-29 Fremgangsmate ved fremstilling av quinolin-derivater
HRP20050028AA HRP20050028B1 (hr) 2002-06-12 2005-01-11 Postupak za proizvodnju derivata kinolina
CY20071100295T CY1107555T1 (el) 2002-06-12 2007-03-01 Μεθοδος για την βιομηχανικη παρασκευη παραγωγων κινολινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0201778A SE0201778D0 (sv) 2002-06-12 2002-06-12 Process for the manufacture of quinoline derivatives

Publications (1)

Publication Number Publication Date
SE0201778D0 true SE0201778D0 (sv) 2002-06-12

Family

ID=20288148

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0201778A SE0201778D0 (sv) 2002-06-12 2002-06-12 Process for the manufacture of quinoline derivatives

Country Status (28)

Country Link
EP (1) EP1511732B9 (sv)
JP (1) JP4584709B2 (sv)
KR (1) KR100979216B1 (sv)
CN (1) CN100418950C (sv)
AT (1) ATE348814T1 (sv)
AU (1) AU2003228195B2 (sv)
BR (1) BR0311674A (sv)
CA (1) CA2487329C (sv)
CY (1) CY1107555T1 (sv)
DE (1) DE60310554T2 (sv)
DK (1) DK1511732T5 (sv)
ES (1) ES2278160T3 (sv)
HR (1) HRP20050028B1 (sv)
IL (1) IL165155A (sv)
IS (1) IS2975B (sv)
ME (1) ME00435B (sv)
MX (1) MXPA04012276A (sv)
NO (1) NO329162B1 (sv)
NZ (1) NZ536768A (sv)
PL (1) PL210259B1 (sv)
PT (1) PT1511732E (sv)
RS (1) RS51021B (sv)
RU (1) RU2291861C2 (sv)
SE (1) SE0201778D0 (sv)
SI (1) SI1511732T1 (sv)
UA (1) UA78310C2 (sv)
WO (1) WO2003106424A1 (sv)
ZA (1) ZA200409430B (sv)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0400235D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
BRPI0617477A2 (pt) 2005-10-19 2011-07-26 Teva Pharma mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica
PT2035001E (pt) * 2006-06-12 2012-02-06 Teva Pharma Preparações de laquinimod estáveis
MX2009005652A (es) 2006-11-28 2009-08-07 Valeant Pharmaceuticals Int Analogos 1,4 diamino biciclicos de retigabina como moduladores de canales de potasio.
PT2234485E (pt) 2007-12-20 2014-02-17 Teva Pharma Preparações de laquinimod estáveis
CN104311486A (zh) 2008-09-03 2015-01-28 泰华制药工业有限公司 2-羰基-1,2-二氢喹啉免疫功能调节剂
EP2376456A2 (en) * 2008-12-17 2011-10-19 Actavis Group Ptc Ehf Highly pure laquinimod or a pharmaceutically acceptable salt thereof
DE102010048788A1 (de) 2009-02-13 2011-05-19 Amw Gmbh Transdermales System mit Immunmodulator
DE102009008851A1 (de) 2009-02-13 2010-08-19 Amw Gmbh Transdermales System mit Immunmodulator
ES2564931T3 (es) 2009-07-30 2016-03-30 Teva Pharmaceutical Industries Ltd. Tratamiento de enfermedad de Crohn con laquinimod
EP3064206B1 (en) 2009-08-10 2019-03-20 Active Biotech AB Treatment of huntington's disease using laquinimod
DE102010026879A1 (de) 2010-02-11 2011-08-11 AMW GmbH, 83627 Transdermales System mit Immunmodulator
JP5819328B2 (ja) 2010-03-03 2015-11-24 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療
KR20160129093A (ko) 2010-03-03 2016-11-08 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 루푸스 신장염의 치료
WO2012006544A1 (en) * 2010-07-09 2012-01-12 Teva Pharmaceutical Industries Ltd. 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof
SG10201505236YA (en) 2010-07-09 2015-08-28 Teva Pharma Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
BR112012033465A2 (pt) * 2010-07-09 2017-06-20 Active Biotech Ab método para preparar um composto
EP2537517A1 (en) * 2011-06-22 2012-12-26 Active Biotech AB Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide
MX2014004420A (es) 2011-10-12 2014-07-09 Teva Pharma Tratamiento de esclerosis multiple con combinacion de laquinimod y fingolimod.
AU2013214909A1 (en) 2012-02-03 2014-09-18 Teva Pharmaceutical Industries Ltd. Use of laquinimod for treating Crohn's disease patients who failed first-line anti-TNFa therapy
SG11201404419WA (en) 2012-02-16 2014-10-30 Teva Pharma N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoline carboxamide, preparation and uses thereof
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
CN103626701A (zh) * 2012-08-28 2014-03-12 天津药物研究院 一种制备喹啉衍生物的方法
CN103626702A (zh) * 2012-08-30 2014-03-12 天津药物研究院 一种制备喹啉酮衍生物的方法
EA201590788A1 (ru) 2012-11-07 2015-12-30 Тева Фармасьютикал Индастриз Лтд. Аминные соли лахинимода
NZ630427A (en) 2013-03-14 2017-06-30 Teva Pharma Crystals of laquinimod sodium and improved process for the manufacture thereof
EA201692180A1 (ru) 2014-04-29 2017-08-31 Тева Фармасьютикал Индастриз Лтд. Лахинимод для лечения пациентов с рецидивирующе-ремиттирующим рассеянным склерозом (рррс) с высоким статусом инвалидизации
AU2015316824B2 (en) 2014-09-23 2020-10-29 Active Biotech Ab Quinoline carboxamides for use in the treatment of multiple myeloma
US10300053B2 (en) 2014-11-19 2019-05-28 Active Biotech Ab Quinoline carboxamides for use in the treatment of leukemia
KR20220149579A (ko) 2020-03-03 2022-11-08 액티브 바이오테크 에이비 조합 요법에 사용하기 위한 타스퀴니모드 또는 이의 약학적으로 허용가능한 염
CN111732540B (zh) * 2020-07-20 2020-11-13 湖南速博生物技术有限公司 一种罗喹美克的制备方法
JP2023535021A (ja) 2020-07-23 2023-08-15 イラスマス・ユニバーシティ・メディカル・センター・ロッテルダム 骨髄増殖性腫瘍における新規治療用標的としてのｓ１００タンパク質
AU2022208424A1 (en) 2021-01-18 2023-08-24 Active Biotech Ab Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome
EP4346773A1 (en) 2021-05-25 2024-04-10 Active Biotech AB A plurality of tasquinimod particles and use thereof
AU2022303084A1 (en) 2021-07-02 2024-01-25 Active Biotech Ab A pharmaceutical product containing tasquinimod and a method for assessing the purity of said product

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
SE9801474D0 (sv) * 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
SE9802550D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
US6121287A (en) * 1998-07-15 2000-09-19 Active Biotech Ab Quinoline derivatives

Also Published As

Publication number Publication date
RU2291861C2 (ru) 2007-01-20
ZA200409430B (en) 2006-02-22
PL373817A1 (en) 2005-09-19
ES2278160T3 (es) 2007-08-01
PL210259B1 (pl) 2011-12-30
JP2005535612A (ja) 2005-11-24
JP4584709B2 (ja) 2010-11-24
CN100418950C (zh) 2008-09-17
KR100979216B1 (ko) 2010-08-31
NZ536768A (en) 2006-10-27
EP1511732A1 (en) 2005-03-09
PT1511732E (pt) 2007-03-30
DK1511732T5 (da) 2007-10-01
EP1511732B1 (en) 2006-12-20
RS51021B (sr) 2010-10-31
AU2003228195A1 (en) 2003-12-31
RS107604A (en) 2007-02-05
KR20050016537A (ko) 2005-02-21
CN1659146A (zh) 2005-08-24
CA2487329C (en) 2010-11-16
CY1107555T1 (el) 2013-03-13
IL165155A (en) 2009-11-18
UA78310C2 (en) 2007-03-15
ATE348814T1 (de) 2007-01-15
MXPA04012276A (es) 2005-04-08
HRP20050028B1 (hr) 2013-07-31
IL165155A0 (en) 2005-12-18
EP1511732B9 (en) 2008-11-12
IS2975B (is) 2017-07-15
RU2005100054A (ru) 2005-07-10
WO2003106424A1 (en) 2003-12-24
BR0311674A (pt) 2008-01-08
CA2487329A1 (en) 2003-12-24
HRP20050028A2 (en) 2006-02-28
DE60310554D1 (de) 2007-02-01
IS7550A (is) 2004-11-24
NO329162B1 (no) 2010-08-30
ME00435B (me) 2011-10-10
DK1511732T3 (da) 2007-04-30
NO20045703L (no) 2004-12-29
AU2003228195B2 (en) 2009-05-28
DE60310554T2 (de) 2007-11-29
SI1511732T1 (sl) 2007-06-30

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