JP2013521303A5 - - Google Patents
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- Publication number
- JP2013521303A5 JP2013521303A5 JP2012556211A JP2012556211A JP2013521303A5 JP 2013521303 A5 JP2013521303 A5 JP 2013521303A5 JP 2012556211 A JP2012556211 A JP 2012556211A JP 2012556211 A JP2012556211 A JP 2012556211A JP 2013521303 A5 JP2013521303 A5 JP 2013521303A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- laquinimod
- pharmaceutical composition
- effective
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 72
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 claims description 43
- 229960004577 laquinimod Drugs 0.000 claims description 43
- 229940109239 creatinine Drugs 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 35
- 102000004169 proteins and genes Human genes 0.000 claims description 28
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims description 27
- 229960004866 mycophenolate mofetil Drugs 0.000 claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 16
- 102000009027 Albumins Human genes 0.000 claims description 12
- 108010088751 Albumins Proteins 0.000 claims description 12
- 150000003431 steroids Chemical class 0.000 claims description 10
- 210000002700 urine Anatomy 0.000 claims description 9
- 201000001474 proteinuria Diseases 0.000 claims description 8
- 230000002485 urinary effect Effects 0.000 claims description 7
- 229940125364 angiotensin receptor blocker Drugs 0.000 claims description 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 4
- 239000013049 sediment Substances 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 2
- 108010036949 Cyclosporine Proteins 0.000 claims description 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 2
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims description 2
- 229960003697 abatacept Drugs 0.000 claims description 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 2
- 239000003430 antimalarial agent Substances 0.000 claims description 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims description 2
- 229960002170 azathioprine Drugs 0.000 claims description 2
- 229960003270 belimumab Drugs 0.000 claims description 2
- 229960001265 ciclosporin Drugs 0.000 claims description 2
- 229960004397 cyclophosphamide Drugs 0.000 claims description 2
- 229930182912 cyclosporin Natural products 0.000 claims description 2
- 229960001428 mercaptopurine Drugs 0.000 claims description 2
- 229960004584 methylprednisolone Drugs 0.000 claims description 2
- 229960005205 prednisolone Drugs 0.000 claims description 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 2
- 229960004618 prednisone Drugs 0.000 claims description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 2
- 229960004641 rituximab Drugs 0.000 claims description 2
- 238000009098 adjuvant therapy Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- GEDJUAKXFJRZSG-UHFFFAOYSA-N 7-[3-[(3-acetylphenoxy)methyl]-1,5-dimethylpyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid Chemical compound CC(=O)c1cccc(OCc2nn(C)c(C)c2-c2cccc3c(CCCOc4cccc5ccccc45)c([nH]c23)C(O)=O)c1 GEDJUAKXFJRZSG-UHFFFAOYSA-N 0.000 claims 1
- 229940046731 calcineurin inhibitors Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 1
- 229940014456 mycophenolate Drugs 0.000 claims 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 43
- 230000000737 periodic effect Effects 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 4
- 229940122739 Calcineurin inhibitor Drugs 0.000 description 1
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 description 1
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33936310P | 2010-03-03 | 2010-03-03 | |
| US61/339,363 | 2010-03-03 | ||
| PCT/US2011/026879 WO2011109526A1 (en) | 2010-03-03 | 2011-03-02 | Treatment of lupus nephritis using laquinimod |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006199A Division JP2016128464A (ja) | 2010-03-03 | 2016-01-15 | ラキニモドを使用したループス腎炎の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013521303A JP2013521303A (ja) | 2013-06-10 |
| JP2013521303A5 true JP2013521303A5 (enExample) | 2014-02-06 |
Family
ID=44531856
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556211A Pending JP2013521303A (ja) | 2010-03-03 | 2011-03-02 | ラキニモドを使用したループス腎炎の治療 |
| JP2016006199A Withdrawn JP2016128464A (ja) | 2010-03-03 | 2016-01-15 | ラキニモドを使用したループス腎炎の治療 |
| JP2017079018A Pending JP2017165740A (ja) | 2010-03-03 | 2017-04-12 | ラキニモドを使用したループス腎炎の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006199A Withdrawn JP2016128464A (ja) | 2010-03-03 | 2016-01-15 | ラキニモドを使用したループス腎炎の治療 |
| JP2017079018A Pending JP2017165740A (ja) | 2010-03-03 | 2017-04-12 | ラキニモドを使用したループス腎炎の治療 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US8889661B2 (enExample) |
| EP (1) | EP2542078B1 (enExample) |
| JP (3) | JP2013521303A (enExample) |
| KR (3) | KR20130006640A (enExample) |
| CN (1) | CN102791130B (enExample) |
| AU (2) | AU2011223692A1 (enExample) |
| BR (1) | BR112012021905A2 (enExample) |
| CA (1) | CA2791691A1 (enExample) |
| CL (1) | CL2012002423A1 (enExample) |
| CO (1) | CO6630082A2 (enExample) |
| EA (1) | EA201290837A1 (enExample) |
| ES (1) | ES2558556T3 (enExample) |
| IL (1) | IL250357A0 (enExample) |
| MX (1) | MX337614B (enExample) |
| NZ (1) | NZ602510A (enExample) |
| PE (2) | PE20130613A1 (enExample) |
| PH (1) | PH12012501739A1 (enExample) |
| SG (2) | SG183512A1 (enExample) |
| WO (1) | WO2011109526A1 (enExample) |
| ZA (1) | ZA201207129B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0617477A2 (pt) * | 2005-10-19 | 2011-07-26 | Teva Pharma | mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica |
| CN101466379B (zh) | 2006-06-12 | 2012-10-31 | 泰华制药工业有限公司 | 稳定的拉喹莫德的制剂 |
| WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
| AU2009288108B2 (en) * | 2008-09-03 | 2013-10-17 | Teva Pharmaceutical Industries, Ltd. | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
| NZ597378A (en) * | 2009-06-19 | 2014-08-29 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| BR112012002124A2 (pt) * | 2009-07-30 | 2015-09-15 | Teva Pharma | tratamento da doença de crohn com laquinimode. |
| WO2011019375A1 (en) | 2009-08-10 | 2011-02-17 | Teva Pharmaceutical Industries Ltd. | Treatment of bdnf-related disorders using laquinimod |
| EA201290860A1 (ru) * | 2010-03-03 | 2013-04-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение ревматоидного артрита комбинацией лаквинимода и метотрексата |
| AU2011274496B2 (en) | 2010-07-09 | 2016-03-10 | Teva Pharmaceutical Industries Ltd. | Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| WO2013116657A1 (en) | 2012-02-03 | 2013-08-08 | Teva Pharmaceutical Industries Ltd. | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
| MX2014009889A (es) | 2012-02-16 | 2014-11-13 | Teva Pharma | N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos. |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| WO2014004733A1 (en) * | 2012-06-26 | 2014-01-03 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| JP2016514162A (ja) | 2013-03-14 | 2016-05-19 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドナトリウムの結晶およびその製造のための改善された方法 |
| WO2014152009A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Transdermal formulations of laquinimod |
| HK1231413A1 (zh) | 2014-04-29 | 2017-12-22 | Teva Pharmaceutical Industries Ltd. | 用於治疗具有高残疾状况的复发-缓解型多发性硬化症(rrms)的患者的拉喹莫德 |
| AR103636A1 (es) | 2015-02-05 | 2017-05-24 | Teva Pharmaceuticals Int Gmbh | Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol |
| EP3684938A1 (en) * | 2017-09-22 | 2020-07-29 | The Trustees of the University of Pennsylvania | Gene therapy for treating mucopolysaccharidosis type ii |
| US20240228644A1 (en) * | 2021-05-04 | 2024-07-11 | Novartis Ag | Treatment for systemic lupus erythematosus using anti-baffr antibodies |
| CA3219742A1 (en) * | 2021-05-21 | 2022-11-24 | Gabor Illei | Cd40l antagonist and uses thereof in the treatment of lupus nephritis |
| WO2023166487A1 (en) * | 2022-03-04 | 2023-09-07 | Novartis Ag | Use of iptacopan for the treatment of lupus nephritis |
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| PL2276740T3 (pl) | 2008-04-28 | 2015-01-30 | Actavis Group Ptc Ehf | Ulepszony sposób wytwarzania pochodnych chinolino-3-karboksyamidowych |
| US8354428B2 (en) | 2008-07-01 | 2013-01-15 | Actavis Group Ptc Ehf | Solid state forms of laquinimod and its sodium salt |
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| AR073295A1 (es) * | 2008-09-16 | 2010-10-28 | Genentech Inc | Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. |
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| UY32427A (es) * | 2009-02-13 | 2010-09-30 | Boheringer Ingelheim Internat Gmbh | Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma |
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| BR112012002124A2 (pt) * | 2009-07-30 | 2015-09-15 | Teva Pharma | tratamento da doença de crohn com laquinimode. |
| WO2011019375A1 (en) * | 2009-08-10 | 2011-02-17 | Teva Pharmaceutical Industries Ltd. | Treatment of bdnf-related disorders using laquinimod |
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| EA201290860A1 (ru) * | 2010-03-03 | 2013-04-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение ревматоидного артрита комбинацией лаквинимода и метотрексата |
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| HK1198278A1 (en) * | 2011-07-28 | 2015-03-27 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and interferon-beta |
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2011
- 2011-03-02 KR KR1020127025651A patent/KR20130006640A/ko not_active Ceased
- 2011-03-02 PH PH1/2012/501739A patent/PH12012501739A1/en unknown
- 2011-03-02 AU AU2011223692A patent/AU2011223692A1/en not_active Abandoned
- 2011-03-02 EA EA201290837A patent/EA201290837A1/ru unknown
- 2011-03-02 MX MX2012010070A patent/MX337614B/es active IP Right Grant
- 2011-03-02 SG SG2012063483A patent/SG183512A1/en unknown
- 2011-03-02 PE PE2012001384A patent/PE20130613A1/es not_active Application Discontinuation
- 2011-03-02 WO PCT/US2011/026879 patent/WO2011109526A1/en not_active Ceased
- 2011-03-02 JP JP2012556211A patent/JP2013521303A/ja active Pending
- 2011-03-02 SG SG10201501535UA patent/SG10201501535UA/en unknown
- 2011-03-02 KR KR1020157033160A patent/KR20150135552A/ko not_active Ceased
- 2011-03-02 BR BR112012021905A patent/BR112012021905A2/pt not_active IP Right Cessation
- 2011-03-02 NZ NZ602510A patent/NZ602510A/en not_active IP Right Cessation
- 2011-03-02 EP EP11751295.4A patent/EP2542078B1/en active Active
- 2011-03-02 ES ES11751295.4T patent/ES2558556T3/es active Active
- 2011-03-02 KR KR1020167029950A patent/KR20160129093A/ko not_active Ceased
- 2011-03-02 CA CA2791691A patent/CA2791691A1/en not_active Abandoned
- 2011-03-02 PE PE2016000557A patent/PE20181523A1/es not_active Application Discontinuation
- 2011-03-02 US US13/039,178 patent/US8889661B2/en not_active Expired - Fee Related
- 2011-03-02 CN CN201180012157.0A patent/CN102791130B/zh not_active Expired - Fee Related
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2012
- 2012-08-31 CL CL2012002423A patent/CL2012002423A1/es unknown
- 2012-09-14 CO CO12158824A patent/CO6630082A2/es unknown
- 2012-09-21 ZA ZA2012/07129A patent/ZA201207129B/en unknown
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2014
- 2014-10-21 US US14/520,134 patent/US20150038508A1/en not_active Abandoned
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2016
- 2016-01-15 JP JP2016006199A patent/JP2016128464A/ja not_active Withdrawn
- 2016-06-29 AU AU2016204466A patent/AU2016204466A1/en not_active Abandoned
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2017
- 2017-01-30 IL IL250357A patent/IL250357A0/en unknown
- 2017-04-12 JP JP2017079018A patent/JP2017165740A/ja active Pending
- 2017-05-30 US US15/608,634 patent/US20170258780A1/en not_active Abandoned
- 2017-09-07 US US15/698,365 patent/US20170368053A1/en not_active Abandoned
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2018
- 2018-01-22 US US15/877,184 patent/US20180140594A1/en not_active Abandoned
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