JP2015521647A5 - - Google Patents
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- Publication number
- JP2015521647A5 JP2015521647A5 JP2015519085A JP2015519085A JP2015521647A5 JP 2015521647 A5 JP2015521647 A5 JP 2015521647A5 JP 2015519085 A JP2015519085 A JP 2015519085A JP 2015519085 A JP2015519085 A JP 2015519085A JP 2015521647 A5 JP2015521647 A5 JP 2015521647A5
- Authority
- JP
- Japan
- Prior art keywords
- nalmefene
- pharmaceutical composition
- composition according
- day
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims description 36
- 229960005297 nalmefene Drugs 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 230000035622 drinking Effects 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 4
- 238000009223 counseling Methods 0.000 claims description 4
- 241000995051 Brenda Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- NSNHWTBQMQIDCF-UHFFFAOYSA-N dihydrate;hydrochloride Chemical compound O.O.Cl NSNHWTBQMQIDCF-UHFFFAOYSA-N 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 101100278529 Caenorhabditis elegans drl-1 gene Proteins 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664804P | 2012-06-27 | 2012-06-27 | |
| US61/664,804 | 2012-06-27 | ||
| US201261721539P | 2012-11-02 | 2012-11-02 | |
| US61/721,539 | 2012-11-02 | ||
| US201261736740P | 2012-12-13 | 2012-12-13 | |
| US61/736,740 | 2012-12-13 | ||
| US201361788810P | 2013-03-15 | 2013-03-15 | |
| US61/788,810 | 2013-03-15 | ||
| PCT/EP2013/063461 WO2014001427A1 (en) | 2012-06-27 | 2013-06-27 | Nalmefene for reduction of alcohol consumption in specific target populations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017182608A Division JP2018039810A (ja) | 2012-06-27 | 2017-09-22 | 特定の標的集団におけるアルコール消費を低減するためのナルメフェン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521647A JP2015521647A (ja) | 2015-07-30 |
| JP2015521647A5 true JP2015521647A5 (enExample) | 2017-02-09 |
| JP6258933B2 JP6258933B2 (ja) | 2018-01-10 |
Family
ID=48703496
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015519085A Active JP6258933B2 (ja) | 2012-06-27 | 2013-06-27 | 特定の標的集団におけるアルコール消費を低減するためのナルメフェン |
| JP2017182608A Withdrawn JP2018039810A (ja) | 2012-06-27 | 2017-09-22 | 特定の標的集団におけるアルコール消費を低減するためのナルメフェン |
| JP2019083718A Active JP6857684B2 (ja) | 2012-06-27 | 2019-04-25 | 特定の標的集団におけるアルコール消費を低減するためのナルメフェン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017182608A Withdrawn JP2018039810A (ja) | 2012-06-27 | 2017-09-22 | 特定の標的集団におけるアルコール消費を低減するためのナルメフェン |
| JP2019083718A Active JP6857684B2 (ja) | 2012-06-27 | 2019-04-25 | 特定の標的集団におけるアルコール消費を低減するためのナルメフェン |
Country Status (35)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| WO2014170353A1 (en) * | 2013-04-17 | 2014-10-23 | H. Lundbeck A/S | Nalmefene for treatment of patients with sleep disorder |
| AU2015250611A1 (en) | 2014-04-22 | 2016-11-24 | H. Lundbeck A/S | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| US20170071590A1 (en) * | 2015-09-10 | 2017-03-16 | Suture Armor Llc | Suture anchor |
| KR102699603B1 (ko) | 2018-04-20 | 2024-08-29 | 삼성전자주식회사 | 반도체 메모리 소자 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3814768A (en) | 1971-11-26 | 1974-06-04 | Lewenstein E | 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts |
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US5086058A (en) * | 1990-06-04 | 1992-02-04 | Alko Ltd. | Method for treating alcoholism with nalmefene |
| WO2003015783A1 (en) * | 2001-08-14 | 2003-02-27 | Biotie Therapies Corporation | Method of treating alcoholism or alcohol abuse |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| CN102459276B (zh) | 2009-05-25 | 2016-09-21 | H.隆德贝克有限公司 | 从纳曲酮制备盐酸纳美芬 |
| CA2815093C (en) | 2010-11-05 | 2019-08-06 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| JP5738470B2 (ja) | 2011-03-31 | 2015-06-24 | イムネクス ファーマ イラチュ サナイ ヴェ ティジャレット ア．シェ．Ｉｍｕｎｅｋｓ Ｆａｒｍａ Ｉｌａｃ Ｓａｎａｙｉ Ｖｅ Ｔｉｃａｒｅｔ Ａ．Ｓ． | オピオイド拮抗体組成物、および強皮症の治療のためのその使用 |
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
-
2013
- 2013-06-26 US US13/928,332 patent/US20140005217A1/en not_active Abandoned
- 2013-06-26 US US13/928,317 patent/US20140005216A1/en not_active Abandoned
- 2013-06-27 EA EA201492152A patent/EA029908B1/ru not_active IP Right Cessation
- 2013-06-27 EP EP16187426.8A patent/EP3138564B1/en not_active Revoked
- 2013-06-27 AU AU2013283281A patent/AU2013283281B2/en not_active Ceased
- 2013-06-27 PT PT137324711T patent/PT2866808T/pt unknown
- 2013-06-27 BR BR112014032555A patent/BR112014032555A2/pt not_active Application Discontinuation
- 2013-06-27 LT LTEP16187426.8T patent/LT3138564T/lt unknown
- 2013-06-27 NZ NZ702191A patent/NZ702191A/en not_active IP Right Cessation
- 2013-06-27 KR KR1020147035322A patent/KR20150023396A/ko not_active Abandoned
- 2013-06-27 ES ES13732471.1T patent/ES2609122T3/es active Active
- 2013-06-27 PL PL17206034.5T patent/PL3345604T3/pl unknown
- 2013-06-27 PL PL13732471T patent/PL2866808T3/pl unknown
- 2013-06-27 LT LTEP13732471.1T patent/LT2866808T/lt unknown
- 2013-06-27 SM SM20180164T patent/SMT201800164T1/it unknown
- 2013-06-27 SM SM20160471T patent/SMT201600471T1/it unknown
- 2013-06-27 ES ES16187426.8T patent/ES2663532T3/es active Active
- 2013-06-27 EP EP17206034.5A patent/EP3345604B1/en active Active
- 2013-06-27 HR HRP20250329TT patent/HRP20250329T1/hr unknown
- 2013-06-27 HU HUE23163177A patent/HUE070621T2/hu unknown
- 2013-06-27 JP JP2015519085A patent/JP6258933B2/ja active Active
- 2013-06-27 RS RS20161173A patent/RS55456B1/sr unknown
- 2013-06-27 HU HUE17206034A patent/HUE063313T2/hu unknown
- 2013-06-27 HR HRP20230762TT patent/HRP20230762T8/hr unknown
- 2013-06-27 SG SG11201408704WA patent/SG11201408704WA/en unknown
- 2013-06-27 CA CA2874703A patent/CA2874703C/en active Active
- 2013-06-27 HU HUE16187426A patent/HUE036272T2/hu unknown
- 2013-06-27 DK DK17206034.5T patent/DK3345604T3/da active
- 2013-06-27 PL PL23163177.1T patent/PL4223296T3/pl unknown
- 2013-06-27 DK DK16187426.8T patent/DK3138564T3/en active
- 2013-06-27 PL PL16187426T patent/PL3138564T3/pl unknown
- 2013-06-27 EP EP24221142.3A patent/EP4541421A3/en active Pending
- 2013-06-27 SI SI201330449A patent/SI2866808T1/sl unknown
- 2013-06-27 ES ES23163177T patent/ES3014068T3/es active Active
- 2013-06-27 EP EP13732471.1A patent/EP2866808B1/en not_active Revoked
- 2013-06-27 HU HUE13732471A patent/HUE031110T2/en unknown
- 2013-06-27 MY MYPI2014003570A patent/MY166914A/en unknown
- 2013-06-27 EP EP23163177.1A patent/EP4223296B1/en active Active
- 2013-06-27 PT PT161874268T patent/PT3138564T/pt unknown
- 2013-06-27 MX MX2014015488A patent/MX371373B/es active IP Right Grant
- 2013-06-27 RS RS20180359A patent/RS57046B1/sr unknown
- 2013-06-27 HR HRP20161717TT patent/HRP20161717T1/hr unknown
- 2013-06-27 SI SI201330973T patent/SI3138564T1/en unknown
- 2013-06-27 ES ES17206034T patent/ES2950492T3/es active Active
- 2013-06-27 ME MEP-2016-286A patent/ME02587B/me unknown
- 2013-06-27 PT PT172060345T patent/PT3345604T/pt unknown
- 2013-06-27 CN CN201380034056.2A patent/CN104411313A/zh active Pending
- 2013-06-27 FI FIEP17206034.5T patent/FI3345604T3/fi active
- 2013-06-27 ME MEP-2018-68A patent/ME03030B/me unknown
- 2013-06-27 DK DK13732471.1T patent/DK2866808T3/en active
- 2013-06-27 UA UAA201500199A patent/UA114199C2/uk unknown
- 2013-06-27 RU RU2014151156A patent/RU2665373C2/ru active
- 2013-06-27 LT LTEP17206034.5T patent/LT3345604T/lt unknown
- 2013-06-27 WO PCT/EP2013/063461 patent/WO2014001427A1/en not_active Ceased
- 2013-06-27 SI SI201332054T patent/SI3345604T1/sl unknown
-
2014
- 2014-12-02 IL IL236035A patent/IL236035B/en active IP Right Grant
- 2014-12-15 PH PH12014502798A patent/PH12014502798A1/en unknown
- 2014-12-22 CL CL2014003484A patent/CL2014003484A1/es unknown
- 2014-12-22 CO CO14280546A patent/CO7160087A2/es not_active Application Discontinuation
- 2014-12-23 ZA ZA2014/09525A patent/ZA201409525B/en unknown
-
2016
- 2016-04-07 US US15/093,097 patent/US9642849B2/en active Active
- 2016-12-27 SM SM201600471T patent/SMT201600471B/it unknown
-
2017
- 2017-01-03 CY CY20171100004T patent/CY1118579T1/el unknown
- 2017-03-22 US US15/466,024 patent/US10034874B2/en active Active
- 2017-09-22 JP JP2017182608A patent/JP2018039810A/ja not_active Withdrawn
-
2018
- 2018-02-28 HR HRP20180363TT patent/HRP20180363T1/hr unknown
- 2018-03-27 CY CY20181100346T patent/CY1120097T1/el unknown
- 2018-11-20 HK HK18114830.5A patent/HK1255683A1/en unknown
-
2019
- 2019-04-25 JP JP2019083718A patent/JP6857684B2/ja active Active
-
2023
- 2023-07-25 CY CY20231100359T patent/CY1126140T1/el unknown
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