EA029908B1 - Налмефен для уменьшения потребления алкоголя у конкретных целевых популяций - Google Patents
Налмефен для уменьшения потребления алкоголя у конкретных целевых популяций Download PDFInfo
- Publication number
- EA029908B1 EA029908B1 EA201492152A EA201492152A EA029908B1 EA 029908 B1 EA029908 B1 EA 029908B1 EA 201492152 A EA201492152 A EA 201492152A EA 201492152 A EA201492152 A EA 201492152A EA 029908 B1 EA029908 B1 EA 029908B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nalmefene
- alcohol
- patient
- day
- months
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 210
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 title claims abstract description 175
- 229960005297 nalmefene Drugs 0.000 title claims abstract description 175
- 230000009467 reduction Effects 0.000 title abstract description 8
- 208000007848 Alcoholism Diseases 0.000 claims abstract description 39
- 201000007930 alcohol dependence Diseases 0.000 claims abstract description 37
- 235000019441 ethanol Nutrition 0.000 claims description 223
- 238000000034 method Methods 0.000 claims description 74
- 230000002354 daily effect Effects 0.000 claims description 47
- 238000011282 treatment Methods 0.000 claims description 33
- 238000011156 evaluation Methods 0.000 claims description 15
- 239000002775 capsule Substances 0.000 claims description 10
- 230000003203 everyday effect Effects 0.000 claims description 10
- 238000009223 counseling Methods 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- 239000006186 oral dosage form Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- NSNHWTBQMQIDCF-UHFFFAOYSA-N dihydrate;hydrochloride Chemical compound O.O.Cl NSNHWTBQMQIDCF-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 4
- 230000035622 drinking Effects 0.000 abstract 1
- 230000008859 change Effects 0.000 description 34
- 239000000902 placebo Substances 0.000 description 27
- 229940068196 placebo Drugs 0.000 description 27
- 239000003814 drug Substances 0.000 description 23
- 238000012216 screening Methods 0.000 description 18
- 230000002085 persistent effect Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 239000003826 tablet Substances 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 9
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 8
- 206010048010 Withdrawal syndrome Diseases 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 229940005483 opioid analgesics Drugs 0.000 description 7
- 230000001154 acute effect Effects 0.000 description 6
- 206010019663 Hepatic failure Diseases 0.000 description 5
- 208000026251 Opioid-Related disease Diseases 0.000 description 5
- 208000001647 Renal Insufficiency Diseases 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 238000001784 detoxification Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 201000006370 kidney failure Diseases 0.000 description 5
- 206010010904 Convulsion Diseases 0.000 description 4
- 206010012225 Delirium tremens Diseases 0.000 description 4
- 208000000857 Hepatic Insufficiency Diseases 0.000 description 4
- 208000029650 alcohol withdrawal Diseases 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 239000012458 free base Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 3
- 208000004547 Hallucinations Diseases 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 201000005040 opiate dependence Diseases 0.000 description 3
- 239000000014 opioid analgesic Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 206010053164 Alcohol withdrawal syndrome Diseases 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 2
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 102000003840 Opioid Receptors Human genes 0.000 description 2
- 108090000137 Opioid Receptors Proteins 0.000 description 2
- RVWDHKGCQPULBK-BTKPBHANSA-N [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] heptanoate [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] pentanoate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2.C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 RVWDHKGCQPULBK-BTKPBHANSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 2
- 229960003086 naltrexone Drugs 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 229940044601 receptor agonist Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000004229 Alkannin Substances 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 239000004230 Fast Yellow AB Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004233 Indanthrene blue RS Substances 0.000 description 1
- HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 description 1
- 239000004235 Orange GGN Substances 0.000 description 1
- 239000004237 Ponceau 6R Substances 0.000 description 1
- 239000004236 Ponceau SX Substances 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 239000004231 Riboflavin-5-Sodium Phosphate Substances 0.000 description 1
- 238000007239 Wittig reaction Methods 0.000 description 1
- 101100299498 Xenopus laevis pteg gene Proteins 0.000 description 1
- 239000004234 Yellow 2G Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 235000019232 alkannin Nutrition 0.000 description 1
- 239000004191 allura red AC Substances 0.000 description 1
- 235000012741 allura red AC Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000004176 azorubin Substances 0.000 description 1
- 235000012733 azorubine Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000004161 brilliant blue FCF Substances 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 239000004106 carminic acid Substances 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- 239000001679 citrus red 2 Substances 0.000 description 1
- 235000013986 citrus red 2 Nutrition 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 235000019788 craving Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003001 depressive effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000004174 erythrosine Substances 0.000 description 1
- 235000012732 erythrosine Nutrition 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 235000019233 fast yellow AB Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 235000019239 indanthrene blue RS Nutrition 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 239000008184 oral solid dosage form Substances 0.000 description 1
- 235000019236 orange GGN Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000004177 patent blue V Substances 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000004175 ponceau 4R Substances 0.000 description 1
- 235000012731 ponceau 4R Nutrition 0.000 description 1
- 235000019238 ponceau 6R Nutrition 0.000 description 1
- 235000019237 ponceau SX Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 239000004172 quinoline yellow Substances 0.000 description 1
- 235000012752 quinoline yellow Nutrition 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000004180 red 2G Substances 0.000 description 1
- 235000012739 red 2G Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 235000019234 riboflavin-5-sodium phosphate Nutrition 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 235000012751 sunset yellow FCF Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 101150072448 thrB gene Proteins 0.000 description 1
- 235000019235 yellow 2G Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664804P | 2012-06-27 | 2012-06-27 | |
| US201261721539P | 2012-11-02 | 2012-11-02 | |
| US201261736740P | 2012-12-13 | 2012-12-13 | |
| US201361788810P | 2013-03-15 | 2013-03-15 | |
| PCT/EP2013/063461 WO2014001427A1 (en) | 2012-06-27 | 2013-06-27 | Nalmefene for reduction of alcohol consumption in specific target populations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201492152A1 EA201492152A1 (ru) | 2015-11-30 |
| EA029908B1 true EA029908B1 (ru) | 2018-05-31 |
Family
ID=48703496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201492152A EA029908B1 (ru) | 2012-06-27 | 2013-06-27 | Налмефен для уменьшения потребления алкоголя у конкретных целевых популяций |
Country Status (35)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| WO2014170353A1 (en) * | 2013-04-17 | 2014-10-23 | H. Lundbeck A/S | Nalmefene for treatment of patients with sleep disorder |
| AU2015250611A1 (en) | 2014-04-22 | 2016-11-24 | H. Lundbeck A/S | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| US20170071590A1 (en) * | 2015-09-10 | 2017-03-16 | Suture Armor Llc | Suture anchor |
| KR102699603B1 (ko) | 2018-04-20 | 2024-08-29 | 삼성전자주식회사 | 반도체 메모리 소자 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003015783A1 (en) * | 2001-08-14 | 2003-02-27 | Biotie Therapies Corporation | Method of treating alcoholism or alcohol abuse |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3814768A (en) | 1971-11-26 | 1974-06-04 | Lewenstein E | 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts |
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US5086058A (en) * | 1990-06-04 | 1992-02-04 | Alko Ltd. | Method for treating alcoholism with nalmefene |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| CN102459276B (zh) | 2009-05-25 | 2016-09-21 | H.隆德贝克有限公司 | 从纳曲酮制备盐酸纳美芬 |
| CA2815093C (en) | 2010-11-05 | 2019-08-06 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| JP5738470B2 (ja) | 2011-03-31 | 2015-06-24 | イムネクス ファーマ イラチュ サナイ ヴェ ティジャレット ア．シェ．Ｉｍｕｎｅｋｓ Ｆａｒｍａ Ｉｌａｃ Ｓａｎａｙｉ Ｖｅ Ｔｉｃａｒｅｔ Ａ．Ｓ． | オピオイド拮抗体組成物、および強皮症の治療のためのその使用 |
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
-
2013
- 2013-06-26 US US13/928,332 patent/US20140005217A1/en not_active Abandoned
- 2013-06-26 US US13/928,317 patent/US20140005216A1/en not_active Abandoned
- 2013-06-27 EA EA201492152A patent/EA029908B1/ru not_active IP Right Cessation
- 2013-06-27 EP EP16187426.8A patent/EP3138564B1/en not_active Revoked
- 2013-06-27 AU AU2013283281A patent/AU2013283281B2/en not_active Ceased
- 2013-06-27 PT PT137324711T patent/PT2866808T/pt unknown
- 2013-06-27 BR BR112014032555A patent/BR112014032555A2/pt not_active Application Discontinuation
- 2013-06-27 LT LTEP16187426.8T patent/LT3138564T/lt unknown
- 2013-06-27 NZ NZ702191A patent/NZ702191A/en not_active IP Right Cessation
- 2013-06-27 KR KR1020147035322A patent/KR20150023396A/ko not_active Abandoned
- 2013-06-27 ES ES13732471.1T patent/ES2609122T3/es active Active
- 2013-06-27 PL PL17206034.5T patent/PL3345604T3/pl unknown
- 2013-06-27 PL PL13732471T patent/PL2866808T3/pl unknown
- 2013-06-27 LT LTEP13732471.1T patent/LT2866808T/lt unknown
- 2013-06-27 SM SM20180164T patent/SMT201800164T1/it unknown
- 2013-06-27 SM SM20160471T patent/SMT201600471T1/it unknown
- 2013-06-27 ES ES16187426.8T patent/ES2663532T3/es active Active
- 2013-06-27 EP EP17206034.5A patent/EP3345604B1/en active Active
- 2013-06-27 HR HRP20250329TT patent/HRP20250329T1/hr unknown
- 2013-06-27 HU HUE23163177A patent/HUE070621T2/hu unknown
- 2013-06-27 JP JP2015519085A patent/JP6258933B2/ja active Active
- 2013-06-27 RS RS20161173A patent/RS55456B1/sr unknown
- 2013-06-27 HU HUE17206034A patent/HUE063313T2/hu unknown
- 2013-06-27 HR HRP20230762TT patent/HRP20230762T8/hr unknown
- 2013-06-27 SG SG11201408704WA patent/SG11201408704WA/en unknown
- 2013-06-27 CA CA2874703A patent/CA2874703C/en active Active
- 2013-06-27 HU HUE16187426A patent/HUE036272T2/hu unknown
- 2013-06-27 DK DK17206034.5T patent/DK3345604T3/da active
- 2013-06-27 PL PL23163177.1T patent/PL4223296T3/pl unknown
- 2013-06-27 DK DK16187426.8T patent/DK3138564T3/en active
- 2013-06-27 PL PL16187426T patent/PL3138564T3/pl unknown
- 2013-06-27 EP EP24221142.3A patent/EP4541421A3/en active Pending
- 2013-06-27 SI SI201330449A patent/SI2866808T1/sl unknown
- 2013-06-27 ES ES23163177T patent/ES3014068T3/es active Active
- 2013-06-27 EP EP13732471.1A patent/EP2866808B1/en not_active Revoked
- 2013-06-27 HU HUE13732471A patent/HUE031110T2/en unknown
- 2013-06-27 MY MYPI2014003570A patent/MY166914A/en unknown
- 2013-06-27 EP EP23163177.1A patent/EP4223296B1/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003015783A1 (en) * | 2001-08-14 | 2003-02-27 | Biotie Therapies Corporation | Method of treating alcoholism or alcohol abuse |
Non-Patent Citations (2)
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| SAKARI KARHUVAARA, KAARLO SIMOJOKI, ANTTI VIRTA, MARKUS ROSBERG, ELIISA L�YTTYNIEMI, TOMMI NURMINEN, ANTERO KALLIO, RAUNO M�KEL�: "Targeted Nalmefene With Simple Medical Management in the Treatment of Heavy Drinkers: A Randomized Double-Blind Placebo-Controlled Multicenter Study", ALCOHOLISM: CLINICAL AND EXPERIMENTAL RESEARCH., WILEY-BLACKWELL PUBLISHING, INC., US, vol. 31, no. 7, 1 July 2007 (2007-07-01), US, pages 1179 - 1187, XP055072462, ISSN: 0145-6008, DOI: 10.1111/j.1530-0277.2007.00401.x * |
| SINCLAIR JOHN DAVID: "Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism", ALCOHOL AND ALCOHOLISM, PERGAMON, OXFORD, GB, vol. 36, no. 1, 1 January 2001 (2001-01-01), GB, pages 2 - 10, XP002958401, ISSN: 0735-0414, DOI: 10.1093/alcalc/36.1.2 * |
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