RU2665373C2 - Налмефен для уменьшения потребления алкоголя у конкретных целевых популяций - Google Patents
Налмефен для уменьшения потребления алкоголя у конкретных целевых популяций Download PDFInfo
- Publication number
- RU2665373C2 RU2665373C2 RU2014151156A RU2014151156A RU2665373C2 RU 2665373 C2 RU2665373 C2 RU 2665373C2 RU 2014151156 A RU2014151156 A RU 2014151156A RU 2014151156 A RU2014151156 A RU 2014151156A RU 2665373 C2 RU2665373 C2 RU 2665373C2
- Authority
- RU
- Russia
- Prior art keywords
- alcohol
- patient
- nalmefene
- day
- patients
- Prior art date
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 205
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 title claims abstract description 124
- 229960005297 nalmefene Drugs 0.000 title claims abstract description 123
- 230000009467 reduction Effects 0.000 title description 4
- 238000011282 treatment Methods 0.000 claims abstract description 38
- 208000007848 Alcoholism Diseases 0.000 claims abstract description 25
- 201000007930 alcohol dependence Diseases 0.000 claims abstract description 23
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 12
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- 239000002775 capsule Substances 0.000 claims description 10
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- 150000003839 salts Chemical class 0.000 claims description 7
- 206010019663 Hepatic failure Diseases 0.000 claims description 6
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- 238000001784 detoxification Methods 0.000 claims description 6
- NSNHWTBQMQIDCF-UHFFFAOYSA-N dihydrate;hydrochloride Chemical class O.O.Cl NSNHWTBQMQIDCF-UHFFFAOYSA-N 0.000 claims description 6
- 230000001965 increasing effect Effects 0.000 claims description 6
- 201000006370 kidney failure Diseases 0.000 claims description 6
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- 201000005040 opiate dependence Diseases 0.000 claims description 6
- 206010010904 Convulsion Diseases 0.000 claims description 5
- 206010048010 Withdrawal syndrome Diseases 0.000 claims description 5
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical class N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664804P | 2012-06-27 | 2012-06-27 | |
| US61/664,804 | 2012-06-27 | ||
| US201261721539P | 2012-11-02 | 2012-11-02 | |
| US61/721,539 | 2012-11-02 | ||
| US201261736740P | 2012-12-13 | 2012-12-13 | |
| US61/736,740 | 2012-12-13 | ||
| US201361788810P | 2013-03-15 | 2013-03-15 | |
| US61/788,810 | 2013-03-15 | ||
| PCT/EP2013/063461 WO2014001427A1 (en) | 2012-06-27 | 2013-06-27 | Nalmefene for reduction of alcohol consumption in specific target populations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014151156A RU2014151156A (ru) | 2016-08-20 |
| RU2665373C2 true RU2665373C2 (ru) | 2018-08-29 |
Family
ID=48703496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014151156A RU2665373C2 (ru) | 2012-06-27 | 2013-06-27 | Налмефен для уменьшения потребления алкоголя у конкретных целевых популяций |
Country Status (35)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| WO2014170353A1 (en) * | 2013-04-17 | 2014-10-23 | H. Lundbeck A/S | Nalmefene for treatment of patients with sleep disorder |
| AU2015250611A1 (en) | 2014-04-22 | 2016-11-24 | H. Lundbeck A/S | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| US20170071590A1 (en) * | 2015-09-10 | 2017-03-16 | Suture Armor Llc | Suture anchor |
| KR102699603B1 (ko) | 2018-04-20 | 2024-08-29 | 삼성전자주식회사 | 반도체 메모리 소자 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003015783A1 (en) * | 2001-08-14 | 2003-02-27 | Biotie Therapies Corporation | Method of treating alcoholism or alcohol abuse |
| WO2010063292A1 (en) * | 2008-12-05 | 2010-06-10 | H. Lundbeck A/S | Nalmefene hydrochloride dihydrate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3814768A (en) | 1971-11-26 | 1974-06-04 | Lewenstein E | 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts |
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US5086058A (en) * | 1990-06-04 | 1992-02-04 | Alko Ltd. | Method for treating alcoholism with nalmefene |
| CN102459276B (zh) | 2009-05-25 | 2016-09-21 | H.隆德贝克有限公司 | 从纳曲酮制备盐酸纳美芬 |
| CA2815093C (en) | 2010-11-05 | 2019-08-06 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| JP5738470B2 (ja) | 2011-03-31 | 2015-06-24 | イムネクス ファーマ イラチュ サナイ ヴェ ティジャレット ア．シェ．Ｉｍｕｎｅｋｓ Ｆａｒｍａ Ｉｌａｃ Ｓａｎａｙｉ Ｖｅ Ｔｉｃａｒｅｔ Ａ．Ｓ． | オピオイド拮抗体組成物、および強皮症の治療のためのその使用 |
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
-
2013
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- 2013-06-26 US US13/928,317 patent/US20140005216A1/en not_active Abandoned
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- 2013-06-27 AU AU2013283281A patent/AU2013283281B2/en not_active Ceased
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- 2013-06-27 LT LTEP16187426.8T patent/LT3138564T/lt unknown
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- 2013-06-27 KR KR1020147035322A patent/KR20150023396A/ko not_active Abandoned
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- 2013-06-27 SM SM20160471T patent/SMT201600471T1/it unknown
- 2013-06-27 ES ES16187426.8T patent/ES2663532T3/es active Active
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- 2013-06-27 HU HUE23163177A patent/HUE070621T2/hu unknown
- 2013-06-27 JP JP2015519085A patent/JP6258933B2/ja active Active
- 2013-06-27 RS RS20161173A patent/RS55456B1/sr unknown
- 2013-06-27 HU HUE17206034A patent/HUE063313T2/hu unknown
- 2013-06-27 HR HRP20230762TT patent/HRP20230762T8/hr unknown
- 2013-06-27 SG SG11201408704WA patent/SG11201408704WA/en unknown
- 2013-06-27 CA CA2874703A patent/CA2874703C/en active Active
- 2013-06-27 HU HUE16187426A patent/HUE036272T2/hu unknown
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- 2013-06-27 PL PL23163177.1T patent/PL4223296T3/pl unknown
- 2013-06-27 DK DK16187426.8T patent/DK3138564T3/en active
- 2013-06-27 PL PL16187426T patent/PL3138564T3/pl unknown
- 2013-06-27 EP EP24221142.3A patent/EP4541421A3/en active Pending
- 2013-06-27 SI SI201330449A patent/SI2866808T1/sl unknown
- 2013-06-27 ES ES23163177T patent/ES3014068T3/es active Active
- 2013-06-27 EP EP13732471.1A patent/EP2866808B1/en not_active Revoked
- 2013-06-27 HU HUE13732471A patent/HUE031110T2/en unknown
- 2013-06-27 MY MYPI2014003570A patent/MY166914A/en unknown
- 2013-06-27 EP EP23163177.1A patent/EP4223296B1/en active Active
- 2013-06-27 PT PT161874268T patent/PT3138564T/pt unknown
- 2013-06-27 MX MX2014015488A patent/MX371373B/es active IP Right Grant
- 2013-06-27 RS RS20180359A patent/RS57046B1/sr unknown
- 2013-06-27 HR HRP20161717TT patent/HRP20161717T1/hr unknown
- 2013-06-27 SI SI201330973T patent/SI3138564T1/en unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003015783A1 (en) * | 2001-08-14 | 2003-02-27 | Biotie Therapies Corporation | Method of treating alcoholism or alcohol abuse |
| WO2010063292A1 (en) * | 2008-12-05 | 2010-06-10 | H. Lundbeck A/S | Nalmefene hydrochloride dihydrate |
Non-Patent Citations (1)
| Title |
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| John David Sinclai. Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol Alcohol (2001) 36 (1): 2-10. Karhuvaara S et al. Targeted nalmefene with simple medical management in the treatment of heavy drinkers: a randomized double-blind placebo-controlled multicenter study. Alcohol Clin Exp Res. 2007 Jul;31(7):1179-87, PMID 17451401. * |
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