JP2008528704A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008528704A5 JP2008528704A5 JP2007554271A JP2007554271A JP2008528704A5 JP 2008528704 A5 JP2008528704 A5 JP 2008528704A5 JP 2007554271 A JP2007554271 A JP 2007554271A JP 2007554271 A JP2007554271 A JP 2007554271A JP 2008528704 A5 JP2008528704 A5 JP 2008528704A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cardiovascular disease
- composition according
- nitroxide antioxidant
- spirocyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 208000024172 Cardiovascular disease Diseases 0.000 claims 9
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 9
- 239000003963 antioxidant agent Substances 0.000 claims 9
- 230000003078 antioxidant effect Effects 0.000 claims 9
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 6
- 208000033774 Ventricular Remodeling Diseases 0.000 claims 4
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 3
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical group CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims 2
- 102000011690 Adiponectin Human genes 0.000 claims 2
- 108010076365 Adiponectin Proteins 0.000 claims 2
- 102000003952 Caspase 3 Human genes 0.000 claims 2
- 108090000397 Caspase 3 Proteins 0.000 claims 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 210000005003 heart tissue Anatomy 0.000 claims 2
- 230000037041 intracellular level Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64925405P | 2005-02-02 | 2005-02-02 | |
| PCT/US2006/003975 WO2006084200A2 (en) | 2005-02-02 | 2006-02-02 | Nitroxides for use in treating or preventing cardiovascular disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528704A JP2008528704A (ja) | 2008-07-31 |
| JP2008528704A5 true JP2008528704A5 (enExample) | 2008-11-06 |
Family
ID=36777999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007554271A Pending JP2008528704A (ja) | 2005-02-02 | 2006-02-02 | 心臓血管系疾患の治療または予防において使用するためのニトロキシド類 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20090062338A1 (enExample) |
| JP (1) | JP2008528704A (enExample) |
| WO (1) | WO2006084200A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180078539A1 (en) * | 2016-03-23 | 2018-03-22 | Louis Habash | T-cell regulation in t-cell mediated diseases by reducing pathogenic function of th17 in a human subject through treatment with a nitroxide |
| US10231959B2 (en) | 2016-03-23 | 2019-03-19 | Louis Habash | Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide |
| US10828291B2 (en) * | 2018-01-22 | 2020-11-10 | Louis Habash | Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide |
| EP4100010A4 (en) * | 2020-02-07 | 2024-02-14 | Case Western Reserve University | COMPOSITIONS AND METHODS FOR ATTENUATING OPIOID-INDUCED CARDIAC AND/OR RESPIRATORY DEPRESSION |
| US20220378771A1 (en) * | 2021-05-25 | 2022-12-01 | Louis Habash | Modifying the expression level of a gene encoding an cyclooxygenase enzyme by treating a human subject with a nitroxide |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096759A (en) * | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| GB9801398D0 (en) * | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| AU765110B2 (en) * | 1998-06-26 | 2003-09-11 | Georgetown University Medical Center | Compositions and methods for inducing cell death |
| WO2002026231A1 (en) * | 2000-09-26 | 2002-04-04 | Georgetown University | Use of nitroxides for the treatment of vascular disorders in a diabetic mammal |
| EP1389181A4 (en) * | 2001-04-02 | 2005-10-19 | Panorama Res Inc | ANTIOXIDANT NITROXIDES AND NITRONES AS THERAPEUTIC AGENTS |
| AU2004216541A1 (en) * | 2003-02-28 | 2004-09-10 | Howard Florey Institute Of Experimental Physiology And Medicine | Therapeutic compositions |
| EP1620097A4 (en) * | 2003-04-25 | 2008-03-05 | Mitos Inc | PROPHYLACTIC PRE-TREATMENT WITH ANTIOXIDANTS |
-
2006
- 2006-02-02 JP JP2007554271A patent/JP2008528704A/ja active Pending
- 2006-02-02 US US11/815,446 patent/US20090062338A1/en not_active Abandoned
- 2006-02-02 WO PCT/US2006/003975 patent/WO2006084200A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2469042C2 (ru) | Терапевтически активные триазолы и их использование | |
| JP2010504908A5 (enExample) | ||
| JP2017524704A5 (enExample) | ||
| JP2009530398A5 (enExample) | ||
| JP2012529486A5 (enExample) | ||
| JP2010077141A5 (enExample) | ||
| RU2003121236A (ru) | Арилированные амиды фуран- и тиофенкарбоновых кислот с блокирующим калиевый канал действием | |
| JP2005528393A5 (enExample) | ||
| JP2015508103A5 (enExample) | ||
| JP2013508279A5 (enExample) | ||
| JP2007522135A5 (enExample) | ||
| JP2010536761A5 (enExample) | ||
| JP2018135343A5 (enExample) | ||
| JP2012533546A5 (enExample) | ||
| JP2010526840A5 (enExample) | ||
| JP2012502048A5 (enExample) | ||
| JP2010248215A (ja) | 筋弛緩促進剤及び筋弛緩不全等の筋組織に係る疾病の治療薬 | |
| JP2006501201A5 (enExample) | ||
| JP5643213B2 (ja) | 肥大性心筋症治療用のホスホジエステラーゼタイプＩＩＩ（ＰＤＥＩＩＩ）インヒビターまたはＣａ２＋感作剤 | |
| JP2006501306A5 (enExample) | ||
| JP2008503533A5 (enExample) | ||
| JP2009513713A (ja) | ｐ３８阻害剤化合物による心房細動の治療方法 | |
| JP2009541387A5 (enExample) | ||
| JP2011046708A5 (enExample) | ||
| JP2016522196A5 (enExample) |