JP2016522196A5 - - Google Patents
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- JP2016522196A5 JP2016522196A5 JP2016513938A JP2016513938A JP2016522196A5 JP 2016522196 A5 JP2016522196 A5 JP 2016522196A5 JP 2016513938 A JP2016513938 A JP 2016513938A JP 2016513938 A JP2016513938 A JP 2016513938A JP 2016522196 A5 JP2016522196 A5 JP 2016522196A5
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- JP
- Japan
- Prior art keywords
- composition
- subject
- peptide
- improved
- mitochondrial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 26
- 230000014509 gene expression Effects 0.000 claims description 12
- 230000002438 mitochondrial effect Effects 0.000 claims description 12
- 208000010125 myocardial infarction Diseases 0.000 claims description 12
- 108020005196 Mitochondrial DNA Proteins 0.000 claims description 8
- 239000003087 receptor blocking agent Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000000556 agonist Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- 230000003647 oxidation Effects 0.000 claims description 6
- 238000007254 oxidation reaction Methods 0.000 claims description 6
- 229940123413 Angiotensin II antagonist Drugs 0.000 claims description 4
- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 4
- 206010061216 Infarction Diseases 0.000 claims description 4
- 229940122202 Thromboxane receptor antagonist Drugs 0.000 claims description 4
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 4
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 4
- 239000004004 anti-anginal agent Substances 0.000 claims description 4
- 230000001315 anti-hyperlipaemic effect Effects 0.000 claims description 4
- 239000003416 antiarrhythmic agent Substances 0.000 claims description 4
- 229940127218 antiplatelet drug Drugs 0.000 claims description 4
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims description 4
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims description 4
- 239000000480 calcium channel blocker Substances 0.000 claims description 4
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 4
- 229960000830 captopril Drugs 0.000 claims description 4
- 239000002368 cardiac glycoside Substances 0.000 claims description 4
- 229940097217 cardiac glycoside Drugs 0.000 claims description 4
- 239000003246 corticosteroid Substances 0.000 claims description 4
- 229940068811 digitalis preparation Drugs 0.000 claims description 4
- 239000002934 diuretic Substances 0.000 claims description 4
- 230000001882 diuretic effect Effects 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000000004 hemodynamic effect Effects 0.000 claims description 4
- 230000007574 infarction Effects 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 230000000297 inotrophic effect Effects 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 239000002516 radical scavenger Substances 0.000 claims description 4
- 238000007634 remodeling Methods 0.000 claims description 4
- 239000000932 sedative agent Substances 0.000 claims description 4
- 230000001624 sedative effect Effects 0.000 claims description 4
- 238000004904 shortening Methods 0.000 claims description 4
- 230000000087 stabilizing effect Effects 0.000 claims description 4
- 229930002534 steroid glycoside Natural products 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000002396 thromboxane receptor blocking agent Substances 0.000 claims description 4
- 229940124549 vasodilator Drugs 0.000 claims description 4
- 239000003071 vasodilator agent Substances 0.000 claims description 4
- 230000002861 ventricular Effects 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 208000007848 Alcoholism Diseases 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 102000049320 CD36 Human genes 0.000 claims description 2
- 108010045374 CD36 Antigens Proteins 0.000 claims description 2
- 206010013654 Drug abuse Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 102000058061 Glucose Transporter Type 4 Human genes 0.000 claims description 2
- 101000588298 Homo sapiens Endoplasmic reticulum membrane sensor NFE2L1 Proteins 0.000 claims description 2
- 101000577547 Homo sapiens Nuclear respiratory factor 1 Proteins 0.000 claims description 2
- 101000851700 Homo sapiens Steroid hormone receptor ERR1 Proteins 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims description 2
- 208000009525 Myocarditis Diseases 0.000 claims description 2
- 102100028744 Nuclear respiratory factor 1 Human genes 0.000 claims description 2
- 108010016731 PPAR gamma Proteins 0.000 claims description 2
- 101150014691 PPARA gene Proteins 0.000 claims description 2
- 102000012132 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims description 2
- 108091006300 SLC2A4 Proteins 0.000 claims description 2
- 102100036832 Steroid hormone receptor ERR1 Human genes 0.000 claims description 2
- 101150080431 Tfam gene Proteins 0.000 claims description 2
- 208000024799 Thyroid disease Diseases 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims description 2
- 206010001584 alcohol abuse Diseases 0.000 claims description 2
- 208000025746 alcohol use disease Diseases 0.000 claims description 2
- 231100000457 cardiotoxic Toxicity 0.000 claims description 2
- 230000001451 cardiotoxic effect Effects 0.000 claims description 2
- 230000003081 coactivator Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 210000004351 coronary vessel Anatomy 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 230000009395 genetic defect Effects 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 235000003642 hunger Nutrition 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- 208000031225 myocardial ischemia Diseases 0.000 claims description 2
- 208000008494 pericarditis Diseases 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 208000021510 thyroid gland disease Diseases 0.000 claims description 2
- 208000019553 vascular disease Diseases 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 30
- 239000000150 Sympathomimetic Substances 0.000 claims 2
- 239000002327 cardiovascular agent Substances 0.000 claims 2
- 229940125692 cardiovascular agent Drugs 0.000 claims 2
- 239000003527 fibrinolytic agent Substances 0.000 claims 2
- 230000001975 sympathomimetic effect Effects 0.000 claims 2
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 2
- 229960000103 thrombolytic agent Drugs 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 1
- 230000037351 starvation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 27
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 230000002889 sympathetic effect Effects 0.000 description 2
- 230000002537 thrombolytic effect Effects 0.000 description 2
- 229940124345 antianginal agent Drugs 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823305P | 2013-05-14 | 2013-05-14 | |
| US61/823,305 | 2013-05-14 | ||
| PCT/US2013/066212 WO2014185952A1 (en) | 2013-05-14 | 2013-10-22 | Methods for the prevention or treatment of left ventricle remodeling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018210291A Division JP2019052157A (ja) | 2013-05-14 | 2018-11-08 | 左室リモデリングの予防または治療のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016522196A JP2016522196A (ja) | 2016-07-28 |
| JP2016522196A5 true JP2016522196A5 (enExample) | 2017-02-23 |
Family
ID=51898747
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513938A Pending JP2016522196A (ja) | 2013-05-14 | 2013-10-22 | 左室リモデリングの予防または治療のための方法 |
| JP2018210291A Pending JP2019052157A (ja) | 2013-05-14 | 2018-11-08 | 左室リモデリングの予防または治療のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018210291A Pending JP2019052157A (ja) | 2013-05-14 | 2018-11-08 | 左室リモデリングの予防または治療のための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20160256514A1 (enExample) |
| EP (2) | EP3586864A1 (enExample) |
| JP (2) | JP2016522196A (enExample) |
| CN (2) | CN110051843A (enExample) |
| WO (1) | WO2014185952A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3586864A1 (en) * | 2013-05-14 | 2020-01-01 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricle remodeling |
| US20180318381A1 (en) * | 2015-10-23 | 2018-11-08 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Methods of Treatment of Rhabdomyolysis |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| CN108042525B (zh) * | 2017-12-20 | 2020-09-01 | 岳红 | 一种治疗心肌梗死后心室重塑的药物组合物 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| GB202000945D0 (en) * | 2020-01-22 | 2020-03-04 | Univ Oslo | Treatment of cardiac remodelling |
| EP4168425A4 (en) * | 2020-06-17 | 2024-06-19 | Stealth BioTherapeutics Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MUSCULAR DYSTROPHY |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| EP3725324A1 (en) * | 2005-09-16 | 2020-10-21 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method for reducing cd36 expression |
| EP3603658B1 (en) * | 2009-10-05 | 2025-01-08 | Cornell University | Peptide for use in the treatment of heart failure resulting from hypertrophic cardiomyopathy |
| EP2519249A4 (en) * | 2009-12-31 | 2013-06-26 | Stealth Peptides Int Inc | METHOD FOR CARRYING OUT A CORONARY ARTERY BYPASS PROCEDURE |
| US20130195837A1 (en) * | 2009-12-31 | 2013-08-01 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| EP2808029A3 (en) * | 2010-03-15 | 2015-04-01 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| CN103249423A (zh) * | 2010-07-09 | 2013-08-14 | 康肽德生物医药技术有限公司 | 预防或治疗缺血/再灌注损伤之后无复流的方法 |
| WO2012115987A2 (en) * | 2011-02-21 | 2012-08-30 | The Trustees Of Columbia University In The City Of New York | Methods for Treating and Preventing Cardiac Dysfunction in Septic Shock |
| CN107496899A (zh) * | 2011-09-29 | 2017-12-22 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| EP3586864A1 (en) * | 2013-05-14 | 2020-01-01 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricle remodeling |
-
2013
- 2013-10-22 EP EP19172063.0A patent/EP3586864A1/en active Pending
- 2013-10-22 JP JP2016513938A patent/JP2016522196A/ja active Pending
- 2013-10-22 EP EP13884895.7A patent/EP2996707B1/en active Active
- 2013-10-22 CN CN201811549998.5A patent/CN110051843A/zh active Pending
- 2013-10-22 CN CN201380078124.5A patent/CN105579054A/zh active Pending
- 2013-10-22 US US14/891,205 patent/US20160256514A1/en not_active Abandoned
- 2013-10-22 WO PCT/US2013/066212 patent/WO2014185952A1/en not_active Ceased
-
2018
- 2018-11-08 JP JP2018210291A patent/JP2019052157A/ja active Pending
- 2018-11-15 US US16/192,728 patent/US20190358286A1/en not_active Abandoned
-
2022
- 2022-02-25 US US17/680,842 patent/US20220296671A1/en not_active Abandoned
-
2024
- 2024-11-21 US US18/954,860 patent/US20250319152A1/en active Pending
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