JP2008528704A - 心臓血管系疾患の治療または予防において使用するためのニトロキシド類 - Google Patents

心臓血管系疾患の治療または予防において使用するためのニトロキシド類 Download PDF

Info

Publication number
JP2008528704A
JP2008528704A JP2007554271A JP2007554271A JP2008528704A JP 2008528704 A JP2008528704 A JP 2008528704A JP 2007554271 A JP2007554271 A JP 2007554271A JP 2007554271 A JP2007554271 A JP 2007554271A JP 2008528704 A JP2008528704 A JP 2008528704A
Authority
JP
Japan
Prior art keywords
nitroxide antioxidant
effective amount
range
cardiovascular disease
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007554271A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008528704A5 (enExample
Inventor
ルイス・ハバッシュ
クラレンス・ジョーンズ
Original Assignee
ミトス・ファーマシューティカルズ・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ミトス・ファーマシューティカルズ・インコーポレーテッド filed Critical ミトス・ファーマシューティカルズ・インコーポレーテッド
Publication of JP2008528704A publication Critical patent/JP2008528704A/ja
Publication of JP2008528704A5 publication Critical patent/JP2008528704A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007554271A 2005-02-02 2006-02-02 心臓血管系疾患の治療または予防において使用するためのニトロキシド類 Pending JP2008528704A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64925405P 2005-02-02 2005-02-02
PCT/US2006/003975 WO2006084200A2 (en) 2005-02-02 2006-02-02 Nitroxides for use in treating or preventing cardiovascular disease

Publications (2)

Publication Number Publication Date
JP2008528704A true JP2008528704A (ja) 2008-07-31
JP2008528704A5 JP2008528704A5 (enExample) 2008-11-06

Family

ID=36777999

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007554271A Pending JP2008528704A (ja) 2005-02-02 2006-02-02 心臓血管系疾患の治療または予防において使用するためのニトロキシド類

Country Status (3)

Country Link
US (1) US20090062338A1 (enExample)
JP (1) JP2008528704A (enExample)
WO (1) WO2006084200A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180078539A1 (en) * 2016-03-23 2018-03-22 Louis Habash T-cell regulation in t-cell mediated diseases by reducing pathogenic function of th17 in a human subject through treatment with a nitroxide
US10231959B2 (en) 2016-03-23 2019-03-19 Louis Habash Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide
US10828291B2 (en) * 2018-01-22 2020-11-10 Louis Habash Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide
CA3167312A1 (en) * 2020-02-07 2021-08-12 Stephen J. Lewis Compositions and methods for attenuating opioid induced cardio and/or respiratory depression
US20220378771A1 (en) * 2021-05-25 2022-12-01 Louis Habash Modifying the expression level of a gene encoding an cyclooxygenase enzyme by treating a human subject with a nitroxide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519311A (ja) * 1998-06-26 2002-07-02 ジョージタウン・ユニバーシティ・メディカル・センター 細胞死を誘発するための組成物と方法
WO2004096219A1 (en) * 2003-04-25 2004-11-11 Mitos Incorporated Prophylactic pretreatment with antioxidants
JP2006520326A (ja) * 2003-02-28 2006-09-07 ハワード フローリー インスティチュート オブ エクスペリメンタル フィジオロジー アンド メディシン 治療薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096759A (en) * 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
GB9801398D0 (en) * 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
WO2002026231A1 (en) * 2000-09-26 2002-04-04 Georgetown University Use of nitroxides for the treatment of vascular disorders in a diabetic mammal
JP2004527520A (ja) * 2001-04-02 2004-09-09 パノラマ リサーチ,インコーポレイティド 治療剤としての抗酸化ニトロキシドおよびニトロン

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519311A (ja) * 1998-06-26 2002-07-02 ジョージタウン・ユニバーシティ・メディカル・センター 細胞死を誘発するための組成物と方法
JP2006520326A (ja) * 2003-02-28 2006-09-07 ハワード フローリー インスティチュート オブ エクスペリメンタル フィジオロジー アンド メディシン 治療薬
WO2004096219A1 (en) * 2003-04-25 2004-11-11 Mitos Incorporated Prophylactic pretreatment with antioxidants

Also Published As

Publication number Publication date
WO2006084200A3 (en) 2006-12-14
WO2006084200A2 (en) 2006-08-10
US20090062338A1 (en) 2009-03-05

Similar Documents

Publication Publication Date Title
US5453436A (en) Treatment of athereosclerosis using, carbazolyl-(4)-oxypropanolamine compounds
TW449473B (en) Compositions for inhibition of the pathophysiologic actions in mammals of tumor necrosis factor-alpha
TWI251491B (en) Pharmaceutical combinations
IL297211B1 (en) Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
JP2002542298A (ja) 低分子量トロンビン阻害物質およびそのプロドラッグを含む医薬製剤
JP2004503508A (ja) メラガトラン及びXa因子阻害剤を含んでなる組合せ製品
JP2008528704A (ja) 心臓血管系疾患の治療または予防において使用するためのニトロキシド類
US20090042937A1 (en) Nitroxides for use in treating or preventing amyloid-related diseases
JPH06234636A (ja) インターロイキン8を阻害するためのレフルノミドの使用
JPH1192382A (ja) 細胞接着阻害剤
JP2008528694A (ja) 糖尿病の治療または予防において使用するためのニトロキシド類
JP2008007512A (ja) 動脈狭窄の減弱方法
CN108836965A (zh) 尼克酰胺组合物在制备治疗索拉非尼手足皮肤反应药物中的应用
US20100099731A1 (en) Use of Endothelial Interrupters in the Treatment of Neurodegenerative Diseases
JP2004503509A (ja) メラガトラン及びVIIa因子阻害剤を含んでなる組合せ製品
AU679462B2 (en) Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
KR100895031B1 (ko) 지질 농후 플라크의 감소, 안정화 및 파열 방지 방법
WO2019166874A1 (en) Treatment of hereditary angioedema
JP4686704B2 (ja) 動脈瘤予防および/または治療剤
JPH09151137A (ja) 平滑筋細胞増殖抑制剤
JPWO2001076587A1 (ja) 狭窄性血管病変に基づく疾患治療剤
JP2006111563A (ja) 動脈硬化抑制剤
WO2023220396A1 (en) Methods of treatment using a dual specificity tyrosine-phosphorylation-regulated kinase 1a (dyrk1a) inhibitor
HK40041266A (en) Treatment of hereditary angioedema
WO2002072131A1 (fr) Médicaments contre des affections hépatiques

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080917

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080917

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120117

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120612