JP2013511556A5 - - Google Patents
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- Publication number
- JP2013511556A5 JP2013511556A5 JP2012540154A JP2012540154A JP2013511556A5 JP 2013511556 A5 JP2013511556 A5 JP 2013511556A5 JP 2012540154 A JP2012540154 A JP 2012540154A JP 2012540154 A JP2012540154 A JP 2012540154A JP 2013511556 A5 JP2013511556 A5 JP 2013511556A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- hydroxybenzenesulfonamide
- halo
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- -1 N-hydroxylsulfonamidyl Chemical group 0.000 claims 6
- 208000002815 pulmonary hypertension Diseases 0.000 claims 6
- 206010024119 Left ventricular failure Diseases 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- JTMRAKAVHPQVLR-UHFFFAOYSA-N 2-bromo-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1Br JTMRAKAVHPQVLR-UHFFFAOYSA-N 0.000 claims 2
- QVWABNGSRMHSSC-UHFFFAOYSA-N 2-fluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1F QVWABNGSRMHSSC-UHFFFAOYSA-N 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- UHLUYTLUWPLQIV-UHFFFAOYSA-N n-hydroxy-2-(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1C(F)(F)F UHLUYTLUWPLQIV-UHFFFAOYSA-N 0.000 claims 2
- RPCWSYAQEVLTEE-UHFFFAOYSA-N n-hydroxy-2-iodobenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1I RPCWSYAQEVLTEE-UHFFFAOYSA-N 0.000 claims 2
- RZRWBKKAFHXNEQ-UHFFFAOYSA-N n-hydroxy-2-methylsulfonylbenzenesulfonamide Chemical compound CS(=O)(=O)C1=CC=CC=C1S(=O)(=O)NO RZRWBKKAFHXNEQ-UHFFFAOYSA-N 0.000 claims 2
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- ZRWVFIVDXWDXDB-UHFFFAOYSA-N 2,3-dichloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC(Cl)=C1Cl ZRWVFIVDXWDXDB-UHFFFAOYSA-N 0.000 claims 1
- PMCCDTRQTMOMDO-UHFFFAOYSA-N 2,4-dibromo-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(Br)C=C1Br PMCCDTRQTMOMDO-UHFFFAOYSA-N 0.000 claims 1
- XZXRZAJTPROFFJ-UHFFFAOYSA-N 2,4-difluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(F)C=C1F XZXRZAJTPROFFJ-UHFFFAOYSA-N 0.000 claims 1
- NQRQXMMHKBZSFH-UHFFFAOYSA-N 2,6-dichloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=C(Cl)C=CC=C1Cl NQRQXMMHKBZSFH-UHFFFAOYSA-N 0.000 claims 1
- KYAYUXVCXCRWGE-UHFFFAOYSA-N 2-bromo-4-fluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(F)C=C1Br KYAYUXVCXCRWGE-UHFFFAOYSA-N 0.000 claims 1
- KDAUHUPSWREKDU-UHFFFAOYSA-N 2-chloro-4-fluoro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(F)C=C1Cl KDAUHUPSWREKDU-UHFFFAOYSA-N 0.000 claims 1
- CRGRKPVYYZZUHX-UHFFFAOYSA-N 2-chloro-n-hydroxy-4-(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1Cl CRGRKPVYYZZUHX-UHFFFAOYSA-N 0.000 claims 1
- BASKBTQCHRZHSH-UHFFFAOYSA-N 2-chloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1Cl BASKBTQCHRZHSH-UHFFFAOYSA-N 0.000 claims 1
- SNDSZUKNUDOLGZ-UHFFFAOYSA-N 4-bromo-2-chloro-n-hydroxybenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(Br)C=C1Cl SNDSZUKNUDOLGZ-UHFFFAOYSA-N 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000026151 Chronic thromboembolic pulmonary hypertension Diseases 0.000 claims 1
- 208000003037 Diastolic Heart Failure Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000008253 Systolic Heart Failure Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005171 cycloalkylsulfanyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- YWZWWGLSOOIVSN-UHFFFAOYSA-N n-hydroxy-2,4,6-tri(propan-2-yl)benzenesulfonamide Chemical compound CC(C)C1=CC(C(C)C)=C(S(=O)(=O)NO)C(C(C)C)=C1 YWZWWGLSOOIVSN-UHFFFAOYSA-N 0.000 claims 1
- NBJISJHKYNUFIN-UHFFFAOYSA-N n-hydroxy-2,5-bis(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC(C(F)(F)F)=CC=C1C(F)(F)F NBJISJHKYNUFIN-UHFFFAOYSA-N 0.000 claims 1
- SEBLDBIKKKKJMQ-UHFFFAOYSA-N n-hydroxy-2-nitro-4-(trifluoromethyl)benzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O SEBLDBIKKKKJMQ-UHFFFAOYSA-N 0.000 claims 1
- MGMDZPKSAJJKCS-UHFFFAOYSA-N n-hydroxy-2-phenylbenzenesulfonamide Chemical compound ONS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 MGMDZPKSAJJKCS-UHFFFAOYSA-N 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26369809P | 2009-11-23 | 2009-11-23 | |
| US61/263,698 | 2009-11-23 | ||
| US26412909P | 2009-11-24 | 2009-11-24 | |
| US61/264,129 | 2009-11-24 | ||
| PCT/US2010/057844 WO2011063400A1 (en) | 2009-11-23 | 2010-11-23 | Nitroxyl donors for the treatment of pulmonary hypertension |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015102A Division JP2016128481A (ja) | 2009-11-23 | 2016-01-29 | 肺高血圧症の処置のためのニトロキシル供与体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511556A JP2013511556A (ja) | 2013-04-04 |
| JP2013511556A5 true JP2013511556A5 (enExample) | 2014-01-16 |
Family
ID=43513876
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540154A Pending JP2013511556A (ja) | 2009-11-23 | 2010-11-23 | 肺高血圧症の処置のためのニトロキシル供与体 |
| JP2016015102A Pending JP2016128481A (ja) | 2009-11-23 | 2016-01-29 | 肺高血圧症の処置のためのニトロキシル供与体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015102A Pending JP2016128481A (ja) | 2009-11-23 | 2016-01-29 | 肺高血圧症の処置のためのニトロキシル供与体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20110160200A1 (enExample) |
| EP (1) | EP2504003B1 (enExample) |
| JP (2) | JP2013511556A (enExample) |
| CY (1) | CY1118603T1 (enExample) |
| DK (1) | DK2504003T3 (enExample) |
| ES (1) | ES2611852T3 (enExample) |
| HR (1) | HRP20170183T1 (enExample) |
| HU (1) | HUE032253T2 (enExample) |
| LT (1) | LT2504003T (enExample) |
| PL (1) | PL2504003T3 (enExample) |
| PT (1) | PT2504003T (enExample) |
| RS (1) | RS55697B1 (enExample) |
| SI (1) | SI2504003T1 (enExample) |
| SM (2) | SMT201700090T1 (enExample) |
| WO (2) | WO2011063339A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX356796B (es) * | 2009-12-07 | 2018-06-14 | Cardioxyl Pharmaceuticals Inc | Derivados de hidroxilamina bis-acilados. |
| CN105919987B (zh) * | 2009-12-07 | 2020-04-03 | 约翰斯霍普金斯大学 | N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物及其用途 |
| AU2013201929B2 (en) | 2011-10-17 | 2015-07-23 | The Johns Hopkins University | N-substituted hydroxylamine derivatives with carbon-based leaving groups |
| TWI619491B (zh) * | 2013-01-18 | 2018-04-01 | 卡爾迪奧克斯爾製藥公司 | 包含硝醯基予體的醫藥組合物 |
| CN105377837B (zh) * | 2013-05-14 | 2017-08-04 | 活跃生物技术有限公司 | 用作s100‑抑制剂的n‑(杂芳基)磺酰胺衍生物 |
| EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
| US10723704B2 (en) | 2015-10-19 | 2020-07-28 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| JP6957459B2 (ja) | 2015-10-19 | 2021-11-02 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシルドナーとしてのｎ−ヒドロキシルスルホンアミド誘導体 |
| US10913728B2 (en) | 2016-07-28 | 2021-02-09 | The Johns Hopkins University | O-substituted hydroxamic acids |
| WO2018128999A1 (en) | 2017-01-03 | 2018-07-12 | Cardioxyl Pharmaceuticals, Inc. | Method of administering nitroxyl donating compounds |
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| MX356796B (es) * | 2009-12-07 | 2018-06-14 | Cardioxyl Pharmaceuticals Inc | Derivados de hidroxilamina bis-acilados. |
| CN105919987B (zh) * | 2009-12-07 | 2020-04-03 | 约翰斯霍普金斯大学 | N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物及其用途 |
-
2010
- 2010-11-22 US US12/951,900 patent/US20110160200A1/en not_active Abandoned
- 2010-11-22 WO PCT/US2010/057640 patent/WO2011063339A1/en not_active Ceased
- 2010-11-23 HR HRP20170183TT patent/HRP20170183T1/hr unknown
- 2010-11-23 ES ES10784416.9T patent/ES2611852T3/es active Active
- 2010-11-23 PT PT107844169T patent/PT2504003T/pt unknown
- 2010-11-23 DK DK10784416.9T patent/DK2504003T3/en active
- 2010-11-23 RS RS20170138A patent/RS55697B1/sr unknown
- 2010-11-23 EP EP10784416.9A patent/EP2504003B1/en active Active
- 2010-11-23 JP JP2012540154A patent/JP2013511556A/ja active Pending
- 2010-11-23 SI SI201031332A patent/SI2504003T1/sl unknown
- 2010-11-23 HU HUE10784416A patent/HUE032253T2/en unknown
- 2010-11-23 WO PCT/US2010/057844 patent/WO2011063400A1/en not_active Ceased
- 2010-11-23 PL PL10784416T patent/PL2504003T3/pl unknown
- 2010-11-23 SM SM20170090T patent/SMT201700090T1/it unknown
- 2010-11-23 LT LTEP10784416.9T patent/LT2504003T/lt unknown
-
2015
- 2015-04-24 US US14/696,319 patent/US20160081951A1/en not_active Abandoned
-
2016
- 2016-01-29 JP JP2016015102A patent/JP2016128481A/ja active Pending
-
2017
- 2017-02-07 CY CY20171100169T patent/CY1118603T1/el unknown
- 2017-02-09 SM SM201700090T patent/SMT201700090B/it unknown
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