HRP20170183T1 - Donori nitroksila za liječenje plućne hipertenzije - Google Patents

Donori nitroksila za liječenje plućne hipertenzije Download PDF

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Publication number
HRP20170183T1
HRP20170183T1 HRP20170183TT HRP20170183T HRP20170183T1 HR P20170183 T1 HRP20170183 T1 HR P20170183T1 HR P20170183T T HRP20170183T T HR P20170183TT HR P20170183 T HRP20170183 T HR P20170183T HR P20170183 T1 HRP20170183 T1 HR P20170183T1
Authority
HR
Croatia
Prior art keywords
nitroxyl donor
halo
benzene sulfonamide
alkyl
nitro
Prior art date
Application number
HRP20170183TT
Other languages
English (en)
Croatian (hr)
Inventor
Vincent J. Kalish
Reza Mazhari
Original Assignee
Cardioxyl Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardioxyl Pharmaceuticals Inc. filed Critical Cardioxyl Pharmaceuticals Inc.
Publication of HRP20170183T1 publication Critical patent/HRP20170183T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20170183TT 2009-11-23 2010-11-23 Donori nitroksila za liječenje plućne hipertenzije HRP20170183T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26369809P 2009-11-23 2009-11-23
US26412909P 2009-11-24 2009-11-24
EP10784416.9A EP2504003B1 (en) 2009-11-23 2010-11-23 Nitroxyl donors for the treatment of pulmonary hypertension
PCT/US2010/057844 WO2011063400A1 (en) 2009-11-23 2010-11-23 Nitroxyl donors for the treatment of pulmonary hypertension

Publications (1)

Publication Number Publication Date
HRP20170183T1 true HRP20170183T1 (hr) 2017-03-24

Family

ID=43513876

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20170183TT HRP20170183T1 (hr) 2009-11-23 2010-11-23 Donori nitroksila za liječenje plućne hipertenzije

Country Status (15)

Country Link
US (2) US20110160200A1 (enExample)
EP (1) EP2504003B1 (enExample)
JP (2) JP2013511556A (enExample)
CY (1) CY1118603T1 (enExample)
DK (1) DK2504003T3 (enExample)
ES (1) ES2611852T3 (enExample)
HR (1) HRP20170183T1 (enExample)
HU (1) HUE032253T2 (enExample)
LT (1) LT2504003T (enExample)
PL (1) PL2504003T3 (enExample)
PT (1) PT2504003T (enExample)
RS (1) RS55697B1 (enExample)
SI (1) SI2504003T1 (enExample)
SM (2) SMT201700090T1 (enExample)
WO (2) WO2011063339A1 (enExample)

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JP5832447B2 (ja) 2009-12-07 2015-12-16 ザ ジョンズ ホプキンス ユニバーシティ ビスアシル化ヒドロキシルアミン誘導体
CA2852914C (en) 2011-10-17 2019-11-26 The Johns Hopkins University Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors
BR112015017251B1 (pt) * 2013-01-18 2021-10-26 Cardioxyl Pharmaceuticals, Inc. Composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas
MX360455B (es) 2013-05-14 2018-11-01 Active Biotech Ab Derivados de n-(heteroaril)-sulfonamida utiles como inhibidores de s100.
ES2734060T3 (es) 2014-01-17 2019-12-04 Cardioxyl Pharmaceuticals Inc Donadores de nitroxilo de N-hidroximetanosulfonamida
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
ES2749682T3 (es) 2014-05-27 2020-03-23 Cardioxyl Pharmaceuticals Inc Derivados de pirazolona como donadores de nitroxilo
JP6889704B2 (ja) 2015-10-19 2021-06-18 カルディオキシル ファーマシューティカルズ，インク． ニトロキシルドナーとしてのピラゾロン誘導体
EP3365325A1 (en) 2015-10-19 2018-08-29 Cardioxyl Pharmaceuticals Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
KR20190070912A (ko) 2016-07-28 2019-06-21 더 존스 홉킨스 유니버시티 O-치환된 히드록삼산
AU2018205621B2 (en) 2017-01-03 2023-01-05 Cardioxyl Pharmaceuticals, Inc. Method of administering nitroxyl donating compounds

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Also Published As

Publication number Publication date
SI2504003T1 (sl) 2017-01-31
JP2016128481A (ja) 2016-07-14
LT2504003T (lt) 2017-01-25
DK2504003T3 (en) 2017-02-20
EP2504003B1 (en) 2016-11-09
WO2011063339A1 (en) 2011-05-26
US20110160200A1 (en) 2011-06-30
SMT201700090T1 (it) 2017-03-08
PL2504003T3 (pl) 2017-04-28
US20160081951A1 (en) 2016-03-24
EP2504003A1 (en) 2012-10-03
WO2011063400A1 (en) 2011-05-26
JP2013511556A (ja) 2013-04-04
RS55697B1 (sr) 2017-07-31
ES2611852T3 (es) 2017-05-10
SMT201700090B (it) 2017-03-08
CY1118603T1 (el) 2017-07-12
HUE032253T2 (en) 2017-09-28
PT2504003T (pt) 2017-01-31

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