JP2015096525A5 - - Google Patents
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- Publication number
- JP2015096525A5 JP2015096525A5 JP2014249100A JP2014249100A JP2015096525A5 JP 2015096525 A5 JP2015096525 A5 JP 2015096525A5 JP 2014249100 A JP2014249100 A JP 2014249100A JP 2014249100 A JP2014249100 A JP 2014249100A JP 2015096525 A5 JP2015096525 A5 JP 2015096525A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- -1 N-hydroxysulfonamidyl Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 3
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005171 cycloalkylsulfanyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78355606P | 2006-03-17 | 2006-03-17 | |
| US60/783,556 | 2006-03-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013032658A Division JP5764590B2 (ja) | 2006-03-17 | 2013-02-21 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016141628A Division JP2017057190A (ja) | 2006-03-17 | 2016-07-19 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015096525A JP2015096525A (ja) | 2015-05-21 |
| JP2015096525A5 true JP2015096525A5 (enExample) | 2015-07-02 |
| JP6060139B2 JP6060139B2 (ja) | 2017-01-11 |
Family
ID=38284031
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500519A Expired - Fee Related JP5548869B2 (ja) | 2006-03-17 | 2007-03-16 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2013032658A Active JP5764590B2 (ja) | 2006-03-17 | 2013-02-21 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2014249100A Expired - Fee Related JP6060139B2 (ja) | 2006-03-17 | 2014-12-09 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2016141628A Pending JP2017057190A (ja) | 2006-03-17 | 2016-07-19 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500519A Expired - Fee Related JP5548869B2 (ja) | 2006-03-17 | 2007-03-16 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2013032658A Active JP5764590B2 (ja) | 2006-03-17 | 2013-02-21 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016141628A Pending JP2017057190A (ja) | 2006-03-17 | 2016-07-19 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (11) | US8030356B2 (enExample) |
| EP (8) | EP2489350B1 (enExample) |
| JP (4) | JP5548869B2 (enExample) |
| KR (7) | KR20140147155A (enExample) |
| CN (4) | CN103435524B (enExample) |
| AU (4) | AU2007227457B2 (enExample) |
| BR (1) | BRPI0708804B8 (enExample) |
| CA (1) | CA2645988C (enExample) |
| CY (3) | CY1115314T1 (enExample) |
| DK (2) | DK2586435T3 (enExample) |
| ES (4) | ES2811258T3 (enExample) |
| HU (2) | HUE030920T2 (enExample) |
| IL (3) | IL193839A (enExample) |
| LT (1) | LT2586435T (enExample) |
| MX (3) | MX2008011643A (enExample) |
| NO (2) | NO342523B1 (enExample) |
| NZ (4) | NZ595770A (enExample) |
| PL (3) | PL2489350T3 (enExample) |
| PT (3) | PT2489350E (enExample) |
| RU (2) | RU2448087C2 (enExample) |
| SG (2) | SG170737A1 (enExample) |
| SI (3) | SI2489350T1 (enExample) |
| TR (1) | TR200807066T1 (enExample) |
| WO (1) | WO2007109175A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007002444A1 (en) * | 2005-06-23 | 2007-01-04 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| ES2811258T3 (es) | 2006-03-17 | 2021-03-11 | Univ Johns Hopkins | Derivados de N-hidroxilsulfonamida como nuevos donantes de nitroxilo fisiológicamente útiles |
| KR101905004B1 (ko) | 2007-09-26 | 2018-10-08 | 존스 홉킨스 유니버시티 | 신규의 생리적으로 유용한 니트록실 도너로서 ｎ-히드록실술폰아미드 유도체 |
| MX2010011924A (es) | 2008-05-07 | 2010-11-30 | Cardioxyl Pharmaceuticals Inc | Nuevos compuestos nitrosos como donadores de nitroxilo y metodos de uso de los mismos. |
| US20100234827A1 (en) * | 2009-03-13 | 2010-09-16 | Sigg Daniel C | Method of treating heart failure |
| US20110160200A1 (en) * | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| AU2010328230B2 (en) | 2009-12-07 | 2016-06-02 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
| AU2010328234B2 (en) * | 2009-12-07 | 2016-05-12 | Cardioxyl Pharmaceuticals, Inc. | N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivatives |
| BR112014009282B1 (pt) | 2011-10-17 | 2021-12-14 | The Johns Hopkins University | Composto, composição farmacêutica contendo-o e uso do mesmo |
| US9676708B2 (en) | 2012-11-01 | 2017-06-13 | The Johns Hopkins University | Controlled HNO release through intramolecular cyclization-elimination |
| US10245249B2 (en) * | 2013-01-18 | 2019-04-02 | Cardioxyl Pharmaceuticals, Inc. | Pharmaceutical compositions comprising nitroxyl donors |
| EP2764868A1 (en) | 2013-02-08 | 2014-08-13 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Combination of nitroprusside and a sulfide salt as an HNO-releasing therapeutic for the treatment or prevention of cardiovascular diseases |
| WO2015109210A1 (en) | 2014-01-17 | 2015-07-23 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| EP3148972B1 (en) | 2014-05-27 | 2019-08-21 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| WO2015183838A1 (en) | 2014-05-27 | 2015-12-03 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| HK1254957A1 (zh) * | 2015-06-26 | 2019-08-02 | 约翰斯霍普金斯大学 | 作为有效的hno供体的具有碳基离去基团的n-取代的异羟肟酸及其用途 |
| US10723704B2 (en) | 2015-10-19 | 2020-07-28 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| CN108368038A (zh) * | 2015-10-19 | 2018-08-03 | 卡尔迪奥克斯尔制药公司 | 作为硝酰基供体的n-羟基磺酰胺衍生物 |
| BR112018069001B1 (pt) | 2016-03-31 | 2022-09-06 | Sumitomo Chemical Company, Limited | Composto heterocíclico e composição e método para controlar o artrópode nocivo |
| JP7194436B2 (ja) | 2016-07-28 | 2022-12-22 | ザ ジョンズ ホプキンス ユニバーシティ | Ｏ－置換ヒドロキサム酸 |
| BR112019013702A2 (pt) | 2017-01-03 | 2020-03-03 | Cardioxyl Pharmaceuticals, Inc. | Método de administração de compostos doadores de nitroxila |
| CA3132895C (en) | 2019-03-08 | 2024-05-14 | Transthera Sciences (Nanjing), Inc. | Uses of phosphodiesterase inhibitors |
| CN114230495B (zh) * | 2021-11-24 | 2023-01-06 | 海南大学 | 一种氢化亚硝酰供体及其制备方法 |
| CN114195731A (zh) * | 2021-11-24 | 2022-03-18 | 海南大学 | 一种氢化亚硝酰供体化合物及其制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
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| US1017976A (en) | 1911-08-25 | 1912-02-20 | Rudolph Koch | Automatic mail-bag catcher and deliverer. |
| US3751255A (en) * | 1972-03-24 | 1973-08-07 | Eastman Kodak Co | Photosensitive and thermosensitive element, composition and process |
| JPS567710A (en) | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
| US4539321A (en) | 1981-10-26 | 1985-09-03 | William H. Rorer, Inc. | 5-Diaza-aryl-3-substituted pyridone compounds |
| EP0188040B1 (en) | 1985-01-11 | 1991-08-14 | Abbott Laboratories Limited | Slow release solid preparation |
| US4663351A (en) | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| JPH01221371A (ja) * | 1988-02-29 | 1989-09-04 | Hokko Chem Ind Co Ltd | 環状オキシアミン誘導体の製造方法 |
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| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| US20040121399A1 (en) * | 2002-12-20 | 2004-06-24 | International Business Machines Corporation | Substrate bound linker molecules for the construction of biomolecule microarrays |
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| JP2007511535A (ja) | 2003-11-14 | 2007-05-10 | スリーエム イノベイティブ プロパティズ カンパニー | ヒドロキシルアミン置換イミダゾ環化合物 |
| EP1694686A1 (en) * | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
| AU2005209843B2 (en) | 2004-01-30 | 2012-02-16 | The Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
| US8168771B2 (en) | 2005-01-31 | 2012-05-01 | The Johns Hopkins University | Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants |
| WO2007002444A1 (en) * | 2005-06-23 | 2007-01-04 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| ES2811258T3 (es) * | 2006-03-17 | 2021-03-11 | Univ Johns Hopkins | Derivados de N-hidroxilsulfonamida como nuevos donantes de nitroxilo fisiológicamente útiles |
| KR101905004B1 (ko) | 2007-09-26 | 2018-10-08 | 존스 홉킨스 유니버시티 | 신규의 생리적으로 유용한 니트록실 도너로서 ｎ-히드록실술폰아미드 유도체 |
| US10245249B2 (en) | 2013-01-18 | 2019-04-02 | Cardioxyl Pharmaceuticals, Inc. | Pharmaceutical compositions comprising nitroxyl donors |
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2007
- 2007-03-16 ES ES16181496T patent/ES2811258T3/es active Active
- 2007-03-16 PT PT121556088T patent/PT2489350E/pt unknown
- 2007-03-16 EP EP12155608.8A patent/EP2489350B1/en active Active
- 2007-03-16 KR KR1020147034138A patent/KR20140147155A/ko not_active Ceased
- 2007-03-16 EP EP12195118.0A patent/EP2586434B3/en active Active
- 2007-03-16 RU RU2008141151/04A patent/RU2448087C2/ru active IP Right Revival
- 2007-03-16 EP EP07753345A patent/EP1998761A1/en not_active Withdrawn
- 2007-03-16 RU RU2011152369A patent/RU2616292C2/ru active
- 2007-03-16 EP EP16181496.7A patent/EP3124471B1/en not_active Not-in-force
- 2007-03-16 LT LTEP12195124.8T patent/LT2586435T/lt unknown
- 2007-03-16 KR KR1020157020302A patent/KR20150091427A/ko not_active Ceased
- 2007-03-16 HU HUE12195124A patent/HUE030920T2/en unknown
- 2007-03-16 HU HUE12195118A patent/HUE029309T2/en unknown
- 2007-03-16 US US11/724,792 patent/US8030356B2/en not_active Ceased
- 2007-03-16 SI SI200731425T patent/SI2489350T1/sl unknown
- 2007-03-16 KR KR1020197023517A patent/KR102144926B1/ko not_active Expired - Fee Related
- 2007-03-16 CN CN201310086960.XA patent/CN103435524B/zh not_active Expired - Fee Related
- 2007-03-16 ES ES12195124.8T patent/ES2600518T3/es active Active
- 2007-03-16 NZ NZ595770A patent/NZ595770A/xx not_active IP Right Cessation
- 2007-03-16 CA CA2645988A patent/CA2645988C/en active Active
- 2007-03-16 JP JP2009500519A patent/JP5548869B2/ja not_active Expired - Fee Related
- 2007-03-16 CN CN2007800110796A patent/CN101472576B/zh not_active Expired - Fee Related
- 2007-03-16 DK DK12195124.8T patent/DK2586435T3/en active
- 2007-03-16 PT PT121951248T patent/PT2586435T/pt unknown
- 2007-03-16 MX MX2008011643A patent/MX2008011643A/es active IP Right Grant
- 2007-03-16 ES ES12155608.8T patent/ES2448807T3/es active Active
- 2007-03-16 SG SG201101936-1A patent/SG170737A1/en unknown
- 2007-03-16 KR KR1020187019661A patent/KR102011703B1/ko not_active Expired - Fee Related
- 2007-03-16 NZ NZ609381A patent/NZ609381A/en not_active IP Right Cessation
- 2007-03-16 PL PL12155608T patent/PL2489350T3/pl unknown
- 2007-03-16 EP EP12195124.8A patent/EP2586435B1/en active Active
- 2007-03-16 SI SI200731790A patent/SI2586434T1/sl unknown
- 2007-03-16 MX MX2013001662A patent/MX342895B/es unknown
- 2007-03-16 KR KR1020147006611A patent/KR101595781B1/ko not_active Expired - Fee Related
- 2007-03-16 ES ES12195118T patent/ES2576292T7/es active Active
- 2007-03-16 KR KR1020167029907A patent/KR101878816B1/ko active Active
- 2007-03-16 SI SI200731845A patent/SI2586435T1/sl unknown
- 2007-03-16 PT PT121951180T patent/PT2586434T/pt unknown
- 2007-03-16 EP EP12195128.9A patent/EP2596785A1/en not_active Withdrawn
- 2007-03-16 NZ NZ700984A patent/NZ700984A/en not_active IP Right Cessation
- 2007-03-16 PL PL12195118.0T patent/PL2586434T3/pl unknown
- 2007-03-16 TR TR2008/07066T patent/TR200807066T1/xx unknown
- 2007-03-16 CN CN201811276476.2A patent/CN109438298B/zh not_active Expired - Fee Related
- 2007-03-16 BR BRPI0708804A patent/BRPI0708804B8/pt not_active IP Right Cessation
- 2007-03-16 MX MX2016005493A patent/MX368352B/es unknown
- 2007-03-16 WO PCT/US2007/006710 patent/WO2007109175A1/en not_active Ceased
- 2007-03-16 AU AU2007227457A patent/AU2007227457B2/en not_active Ceased
- 2007-03-16 PL PL12195124T patent/PL2586435T3/pl unknown
- 2007-03-16 NZ NZ570971A patent/NZ570971A/en not_active IP Right Cessation
- 2007-03-16 CN CN201410778806.3A patent/CN104672115B/zh not_active Expired - Fee Related
- 2007-03-16 DK DK12155608.8T patent/DK2489350T3/en active
- 2007-03-16 EP EP12195114.9A patent/EP2586433A1/en not_active Withdrawn
- 2007-03-16 EP EP20166739.1A patent/EP3693363A1/en not_active Withdrawn
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2008
- 2008-09-02 IL IL193839A patent/IL193839A/en active IP Right Grant
- 2008-10-16 KR KR1020087025245A patent/KR101473718B1/ko not_active Expired - Fee Related
- 2008-10-16 NO NO20084355A patent/NO342523B1/no not_active IP Right Cessation
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2011
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2012
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2013
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2014
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