JP2015096525A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015096525A5 JP2015096525A5 JP2014249100A JP2014249100A JP2015096525A5 JP 2015096525 A5 JP2015096525 A5 JP 2015096525A5 JP 2014249100 A JP2014249100 A JP 2014249100A JP 2014249100 A JP2014249100 A JP 2014249100A JP 2015096525 A5 JP2015096525 A5 JP 2015096525A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- -1 N-hydroxysulfonamidyl Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 3
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005171 cycloalkylsulfanyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78355606P | 2006-03-17 | 2006-03-17 | |
| US60/783,556 | 2006-03-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013032658A Division JP5764590B2 (ja) | 2006-03-17 | 2013-02-21 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016141628A Division JP2017057190A (ja) | 2006-03-17 | 2016-07-19 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015096525A JP2015096525A (ja) | 2015-05-21 |
| JP2015096525A5 true JP2015096525A5 (enExample) | 2015-07-02 |
| JP6060139B2 JP6060139B2 (ja) | 2017-01-11 |
Family
ID=38284031
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500519A Expired - Fee Related JP5548869B2 (ja) | 2006-03-17 | 2007-03-16 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2013032658A Expired - Fee Related JP5764590B2 (ja) | 2006-03-17 | 2013-02-21 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2014249100A Expired - Fee Related JP6060139B2 (ja) | 2006-03-17 | 2014-12-09 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2016141628A Pending JP2017057190A (ja) | 2006-03-17 | 2016-07-19 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500519A Expired - Fee Related JP5548869B2 (ja) | 2006-03-17 | 2007-03-16 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
| JP2013032658A Expired - Fee Related JP5764590B2 (ja) | 2006-03-17 | 2013-02-21 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016141628A Pending JP2017057190A (ja) | 2006-03-17 | 2016-07-19 | 新規で生理学的に有用なニトロキシル供与体としてのｎ−ヒドロキシルスルホンアミド誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (11) | US8030356B2 (enExample) |
| EP (8) | EP3693363A1 (enExample) |
| JP (4) | JP5548869B2 (enExample) |
| KR (7) | KR101878816B1 (enExample) |
| CN (4) | CN104672115B (enExample) |
| AU (4) | AU2007227457B2 (enExample) |
| BR (1) | BRPI0708804B8 (enExample) |
| CA (1) | CA2645988C (enExample) |
| CY (3) | CY1115314T1 (enExample) |
| DK (2) | DK2586435T3 (enExample) |
| ES (4) | ES2811258T3 (enExample) |
| HU (2) | HUE030920T2 (enExample) |
| IL (3) | IL193839A (enExample) |
| LT (1) | LT2586435T (enExample) |
| MX (3) | MX2008011643A (enExample) |
| NO (2) | NO342523B1 (enExample) |
| NZ (4) | NZ595770A (enExample) |
| PL (3) | PL2586435T3 (enExample) |
| PT (3) | PT2586434T (enExample) |
| RU (2) | RU2616292C2 (enExample) |
| SG (2) | SG170737A1 (enExample) |
| SI (3) | SI2586435T1 (enExample) |
| TR (1) | TR200807066T1 (enExample) |
| WO (1) | WO2007109175A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2613477C (en) * | 2005-06-23 | 2013-12-03 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| AU2007227457B2 (en) | 2006-03-17 | 2013-03-28 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| US8227639B2 (en) * | 2007-09-26 | 2012-07-24 | Cardioxyl Pharmaceuticals | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| DK2278975T3 (en) | 2008-05-07 | 2016-12-19 | Cardioxyl Pharmaceuticals Inc | NOVEL nitroso compounds WHICH NITROXYLDONORER AND METHODS OF USE THEREOF |
| WO2010105081A1 (en) * | 2009-03-13 | 2010-09-16 | Medtronic, Inc. | Method of treating heart failure |
| US20110160200A1 (en) * | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| IN2012DN05028A (enExample) | 2009-12-07 | 2015-10-23 | Univ Johns Hopkins | |
| CA2782110A1 (en) * | 2009-12-07 | 2011-06-16 | Johns Hopkins University | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
| CN108409662B (zh) * | 2011-10-17 | 2021-10-26 | 约翰斯霍普金斯大学 | 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物 |
| WO2014070919A1 (en) | 2012-11-01 | 2014-05-08 | The Johns Hopkins University | Controlled hno release through intramolecular cyclization-elimination |
| MX363843B (es) * | 2013-01-18 | 2019-04-05 | Cardioxyl Pharmaceuticals Inc | Composiciones farmaceuticas que comprenden donadores de nitroxilo. |
| EP2764868A1 (en) | 2013-02-08 | 2014-08-13 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Combination of nitroprusside and a sulfide salt as an HNO-releasing therapeutic for the treatment or prevention of cardiovascular diseases |
| EP3126329B1 (en) * | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| WO2015183838A1 (en) | 2014-05-27 | 2015-12-03 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
| EP3148972B1 (en) | 2014-05-27 | 2019-08-21 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| EP3313831B1 (en) * | 2015-06-26 | 2021-03-10 | The Johns Hopkins University | N-substituted hydroxamic acids with carbon-based leaving groups as efficient hno donors and uses thereof |
| US10730828B2 (en) | 2015-10-19 | 2020-08-04 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| US10723704B2 (en) | 2015-10-19 | 2020-07-28 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| EP3444245B1 (en) | 2016-03-31 | 2022-02-23 | Sumitomo Chemical Company, Limited | Heterocyclic compound |
| KR20190070912A (ko) | 2016-07-28 | 2019-06-21 | 더 존스 홉킨스 유니버시티 | O-치환된 히드록삼산 |
| CN110520116A (zh) | 2017-01-03 | 2019-11-29 | 卡尔迪奥克斯尔制药公司 | 供硝酰化合物的给予方法 |
| TWI816026B (zh) | 2019-03-08 | 2023-09-21 | 大陸商藥捷安康(南京)科技股份有限公司 | 磷酸二酯酶抑制劑的用途和藥盒 |
| CN114230495B (zh) * | 2021-11-24 | 2023-01-06 | 海南大学 | 一种氢化亚硝酰供体及其制备方法 |
| CN114195731A (zh) * | 2021-11-24 | 2022-03-18 | 海南大学 | 一种氢化亚硝酰供体化合物及其制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1017976A (en) | 1911-08-25 | 1912-02-20 | Rudolph Koch | Automatic mail-bag catcher and deliverer. |
| US3751255A (en) * | 1972-03-24 | 1973-08-07 | Eastman Kodak Co | Photosensitive and thermosensitive element, composition and process |
| JPS567710A (en) | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
| US4539321A (en) | 1981-10-26 | 1985-09-03 | William H. Rorer, Inc. | 5-Diaza-aryl-3-substituted pyridone compounds |
| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| US4663351A (en) | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| JPH01221371A (ja) * | 1988-02-29 | 1989-09-04 | Hokko Chem Ind Co Ltd | 環状オキシアミン誘導体の製造方法 |
| JPH01221372A (ja) | 1988-03-01 | 1989-09-04 | Hokko Chem Ind Co Ltd | 環状アシルヒドロキシルアミン誘導体 |
| JPH0221372A (ja) | 1988-07-08 | 1990-01-24 | Sharp Corp | はんだ付検査装置 |
| JPH0446169A (ja) * | 1990-06-14 | 1992-02-17 | Mitsubishi Petrochem Co Ltd | 新規なベンゾフラン誘導体及びそれを含有する除草剤 |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| JPH04321671A (ja) * | 1991-04-17 | 1992-11-11 | Mitsubishi Petrochem Co Ltd | カルバモイルトリアゾール誘導体およびそれを有効成分とする除草剤 |
| JP2728357B2 (ja) * | 1992-10-28 | 1998-03-18 | 塩野義製薬株式会社 | ベンジリデン誘導体 |
| ES2089736T3 (es) | 1992-10-28 | 1996-10-01 | Shionogi & Co | Derivados de bencilideno. |
| JPH09165365A (ja) * | 1995-09-27 | 1997-06-24 | Ono Pharmaceut Co Ltd | スルホンアミド誘導体 |
| JPH10142729A (ja) * | 1996-11-05 | 1998-05-29 | Fuji Photo Film Co Ltd | 熱現像画像記録材料 |
| WO1999021554A1 (en) * | 1997-10-24 | 1999-05-06 | Shionogi & Co., Ltd. | Antiulcerative |
| CA2306914A1 (en) * | 1997-10-24 | 1999-05-06 | Shionogi & Co., Ltd. | Antirheumatic |
| HU227841B1 (en) * | 1997-11-12 | 2012-05-02 | Bayer Pharma AG | 2-phenyl substituted imidazotriazinones, process for their preparation and pharmaceutical compositions thereof |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| EP1101490B1 (en) | 1998-07-28 | 2005-04-13 | Tanabe Seiyaku Co., Ltd. | Preparation capable of releasing drug at target site in intestine |
| LT4727B (lt) | 1998-12-29 | 2000-11-27 | Jonas Šarlauskas | 5-pakeisti sulfamoilbenzimidazol-2-ilkarbamino rūgščių metilo esteriai, turintys antihelmintinį aktyvumą |
| AU2482800A (en) * | 1999-01-13 | 2000-08-01 | Warner-Lambert Company | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
| GB9918684D0 (en) * | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| CA2383781A1 (en) * | 1999-09-01 | 2001-03-08 | Aventis Pharma Deutschland Gmbh | Sulfonyl carboxamide derivatives, method for their production and their use as medicaments |
| DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| JP2002072459A (ja) | 2000-08-28 | 2002-03-12 | Toyo Gosei Kogyo Kk | 光酸発生剤及びそれを含有する感光性樹脂組成物 |
| GB0114223D0 (en) | 2001-06-12 | 2001-08-01 | Ici Plc | Catalytic oxidation process |
| US20040038947A1 (en) | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| US20040121399A1 (en) * | 2002-12-20 | 2004-06-24 | International Business Machines Corporation | Substrate bound linker molecules for the construction of biomolecule microarrays |
| WO2005018556A2 (en) * | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo-containing compounds |
| US8598192B2 (en) | 2003-11-14 | 2013-12-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazoquinolines |
| US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2007522135A (ja) | 2004-01-30 | 2007-08-09 | ザ ジョンズ ホプキンス ユニバーシティ | ニトロキシル前駆化合物および使用方法 |
| US8168771B2 (en) | 2005-01-31 | 2012-05-01 | The Johns Hopkins University | Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants |
| CA2613477C (en) | 2005-06-23 | 2013-12-03 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| AU2007227457B2 (en) | 2006-03-17 | 2013-03-28 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| US8227639B2 (en) | 2007-09-26 | 2012-07-24 | Cardioxyl Pharmaceuticals | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| MX363843B (es) | 2013-01-18 | 2019-04-05 | Cardioxyl Pharmaceuticals Inc | Composiciones farmaceuticas que comprenden donadores de nitroxilo. |
-
2007
- 2007-03-16 AU AU2007227457A patent/AU2007227457B2/en not_active Ceased
- 2007-03-16 US US11/724,792 patent/US8030356B2/en not_active Ceased
- 2007-03-16 SG SG201101936-1A patent/SG170737A1/en unknown
- 2007-03-16 CN CN201410778806.3A patent/CN104672115B/zh not_active Expired - Fee Related
- 2007-03-16 KR KR1020167029907A patent/KR101878816B1/ko not_active Expired - Fee Related
- 2007-03-16 HU HUE12195124A patent/HUE030920T2/en unknown
- 2007-03-16 SI SI200731845A patent/SI2586435T1/sl unknown
- 2007-03-16 ES ES16181496T patent/ES2811258T3/es active Active
- 2007-03-16 KR KR1020147006611A patent/KR101595781B1/ko not_active Expired - Fee Related
- 2007-03-16 EP EP20166739.1A patent/EP3693363A1/en not_active Withdrawn
- 2007-03-16 PT PT121951180T patent/PT2586434T/pt unknown
- 2007-03-16 CN CN201811276476.2A patent/CN109438298B/zh not_active Expired - Fee Related
- 2007-03-16 ES ES12155608.8T patent/ES2448807T3/es active Active
- 2007-03-16 WO PCT/US2007/006710 patent/WO2007109175A1/en not_active Ceased
- 2007-03-16 JP JP2009500519A patent/JP5548869B2/ja not_active Expired - Fee Related
- 2007-03-16 NZ NZ595770A patent/NZ595770A/xx not_active IP Right Cessation
- 2007-03-16 NZ NZ609381A patent/NZ609381A/en not_active IP Right Cessation
- 2007-03-16 EP EP12195118.0A patent/EP2586434B3/en active Active
- 2007-03-16 EP EP07753345A patent/EP1998761A1/en not_active Withdrawn
- 2007-03-16 EP EP12195128.9A patent/EP2596785A1/en not_active Withdrawn
- 2007-03-16 KR KR1020157020302A patent/KR20150091427A/ko not_active Ceased
- 2007-03-16 RU RU2011152369A patent/RU2616292C2/ru active
- 2007-03-16 PT PT121556088T patent/PT2489350E/pt unknown
- 2007-03-16 EP EP12195114.9A patent/EP2586433A1/en not_active Withdrawn
- 2007-03-16 KR KR1020087025245A patent/KR101473718B1/ko not_active Expired - Fee Related
- 2007-03-16 LT LTEP12195124.8T patent/LT2586435T/lt unknown
- 2007-03-16 KR KR1020197023517A patent/KR102144926B1/ko not_active Expired - Fee Related
- 2007-03-16 CN CN201310086960.XA patent/CN103435524B/zh not_active Expired - Fee Related
- 2007-03-16 EP EP12155608.8A patent/EP2489350B1/en active Active
- 2007-03-16 DK DK12195124.8T patent/DK2586435T3/en active
- 2007-03-16 ES ES12195124.8T patent/ES2600518T3/es active Active
- 2007-03-16 SI SI200731790A patent/SI2586434T1/sl unknown
- 2007-03-16 PL PL12195124T patent/PL2586435T3/pl unknown
- 2007-03-16 MX MX2008011643A patent/MX2008011643A/es active IP Right Grant
- 2007-03-16 EP EP16181496.7A patent/EP3124471B1/en not_active Not-in-force
- 2007-03-16 DK DK12155608.8T patent/DK2489350T3/en active
- 2007-03-16 PL PL12155608T patent/PL2489350T3/pl unknown
- 2007-03-16 BR BRPI0708804A patent/BRPI0708804B8/pt not_active IP Right Cessation
- 2007-03-16 NZ NZ700984A patent/NZ700984A/en not_active IP Right Cessation
- 2007-03-16 CN CN2007800110796A patent/CN101472576B/zh not_active Expired - Fee Related
- 2007-03-16 RU RU2008141151/04A patent/RU2448087C2/ru active IP Right Revival
- 2007-03-16 PT PT121951248T patent/PT2586435T/pt unknown
- 2007-03-16 EP EP12195124.8A patent/EP2586435B1/en active Active
- 2007-03-16 MX MX2013001662A patent/MX342895B/es unknown
- 2007-03-16 HU HUE12195118A patent/HUE029309T2/en unknown
- 2007-03-16 ES ES12195118T patent/ES2576292T7/es active Active
- 2007-03-16 CA CA2645988A patent/CA2645988C/en active Active
- 2007-03-16 PL PL12195118.0T patent/PL2586434T3/pl unknown
- 2007-03-16 MX MX2016005493A patent/MX368352B/es unknown
- 2007-03-16 SI SI200731425T patent/SI2489350T1/sl unknown
- 2007-03-16 NZ NZ570971A patent/NZ570971A/en not_active IP Right Cessation
- 2007-03-16 KR KR1020147034138A patent/KR20140147155A/ko not_active Ceased
- 2007-03-16 KR KR1020187019661A patent/KR102011703B1/ko not_active Expired - Fee Related
- 2007-03-16 TR TR2008/07066T patent/TR200807066T1/xx unknown
-
2008
- 2008-09-02 IL IL193839A patent/IL193839A/en active IP Right Grant
- 2008-10-16 NO NO20084355A patent/NO342523B1/no not_active IP Right Cessation
-
2011
- 2011-08-19 US US13/213,480 patent/US20110306614A1/en not_active Abandoned
-
2012
- 2012-01-26 IL IL217739A patent/IL217739A/en active IP Right Grant
-
2013
- 2013-02-21 JP JP2013032658A patent/JP5764590B2/ja not_active Expired - Fee Related
- 2013-03-19 AU AU2013201667A patent/AU2013201667A1/en not_active Abandoned
- 2013-10-03 US US14/045,404 patent/USRE45314E1/en active Active
-
2014
- 2014-02-28 CY CY20141100166T patent/CY1115314T1/el unknown
- 2014-05-16 US US14/280,133 patent/US9221780B2/en not_active Expired - Fee Related
- 2014-12-09 JP JP2014249100A patent/JP6060139B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-25 SG SG10201503828QA patent/SG10201503828QA/en unknown
- 2015-04-14 IL IL238271A patent/IL238271A/en active IP Right Grant
- 2015-09-17 US US14/857,308 patent/US9487498B2/en active Active
-
2016
- 2016-02-19 AU AU2016201037A patent/AU2016201037B2/en not_active Ceased
- 2016-07-19 JP JP2016141628A patent/JP2017057190A/ja active Pending
- 2016-07-20 CY CY20161100710T patent/CY1117844T1/el unknown
- 2016-10-05 US US15/286,145 patent/US9725410B2/en active Active
- 2016-10-26 CY CY20161101084T patent/CY1118237T1/el unknown
-
2017
- 2017-06-30 US US15/640,342 patent/US9969684B2/en not_active Expired - Fee Related
- 2017-08-30 AU AU2017221796A patent/AU2017221796B2/en not_active Ceased
-
2018
- 2018-04-24 US US15/961,441 patent/US10179765B2/en active Active
- 2018-05-02 NO NO20180624A patent/NO343986B1/no not_active IP Right Cessation
-
2019
- 2019-01-09 US US16/243,251 patent/US10487049B2/en not_active Expired - Fee Related
- 2019-11-15 US US16/685,534 patent/US10829445B2/en active Active
-
2020
- 2020-11-09 US US17/093,506 patent/US11306056B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2013111317A (ru) | Производные n-гидроксилсульфонамида как новые физиологически применимые доноры нитроксила | |
| RU2008141151A (ru) | Производные n-гидроксилсульфонамида в качестве новых физиологически полезных доноров нитроксила | |
| RU2477723C2 (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| JP2019094345A5 (enExample) | ||
| JP2010510215A5 (enExample) | ||
| JP2016121196A5 (enExample) | ||
| JP2010510237A5 (enExample) | ||
| JP2017536416A5 (enExample) | ||
| JP2013543842A5 (enExample) | ||
| JP2019527203A5 (enExample) | ||
| JP2018507877A5 (enExample) | ||
| JP2018504437A5 (enExample) | ||
| JP2019077713A5 (enExample) | ||
| AR113826A1 (es) | Indol-2-carboxamidas sustituidas con amino-tiazol activas contra el virus de la hepatitis b (vhb) | |
| AR082667A1 (es) | 6-cicloalquil-pirazolopirimidinonas para el tratamiento de trastornos del snc | |
| JP2017514910A5 (enExample) | ||
| JP2012532137A5 (enExample) | ||
| JP2015510508A5 (enExample) | ||
| JP2017527561A5 (enExample) | ||
| JP2017507160A5 (enExample) | ||
| JP2015537020A5 (enExample) | ||
| CA2593428A1 (en) | Pyrrolopyrazoles, potent kinase inhibitors | |
| JP2014029973A5 (enExample) | ||
| AR069916A1 (es) | Compuesto de oxadiazol, su uso para fabricar un medicamento, su uso para el tratamiento de enfermedades o trastornos mediados por los receptores s1p1 y composicion farmaceutica que lo comprende | |
| WO2006086705B1 (en) | Substituted bis aryl and heteroaryl compounds as selective 5ht2a antagonists |