DK2504003T3 - NITROXYL DONORS FOR TREATMENT OF PULMONAL HYPERTENSION - Google Patents

NITROXYL DONORS FOR TREATMENT OF PULMONAL HYPERTENSION Download PDF

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Publication number
DK2504003T3
DK2504003T3 DK10784416.9T DK10784416T DK2504003T3 DK 2504003 T3 DK2504003 T3 DK 2504003T3 DK 10784416 T DK10784416 T DK 10784416T DK 2504003 T3 DK2504003 T3 DK 2504003T3
Authority
DK
Denmark
Prior art keywords
alkyl
halo
nitro
hydroxy
nitroxyl donor
Prior art date
Application number
DK10784416.9T
Other languages
Danish (da)
English (en)
Inventor
Vincent J Kalish
Reza Mazhari
Original Assignee
Cardioxyl Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardioxyl Pharmaceuticals Inc filed Critical Cardioxyl Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2504003T3 publication Critical patent/DK2504003T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK10784416.9T 2009-11-23 2010-11-23 NITROXYL DONORS FOR TREATMENT OF PULMONAL HYPERTENSION DK2504003T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26369809P 2009-11-23 2009-11-23
US26412909P 2009-11-24 2009-11-24
PCT/US2010/057844 WO2011063400A1 (en) 2009-11-23 2010-11-23 Nitroxyl donors for the treatment of pulmonary hypertension

Publications (1)

Publication Number Publication Date
DK2504003T3 true DK2504003T3 (en) 2017-02-20

Family

ID=43513876

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10784416.9T DK2504003T3 (en) 2009-11-23 2010-11-23 NITROXYL DONORS FOR TREATMENT OF PULMONAL HYPERTENSION

Country Status (15)

Country Link
US (2) US20110160200A1 (enExample)
EP (1) EP2504003B1 (enExample)
JP (2) JP2013511556A (enExample)
CY (1) CY1118603T1 (enExample)
DK (1) DK2504003T3 (enExample)
ES (1) ES2611852T3 (enExample)
HR (1) HRP20170183T1 (enExample)
HU (1) HUE032253T2 (enExample)
LT (1) LT2504003T (enExample)
PL (1) PL2504003T3 (enExample)
PT (1) PT2504003T (enExample)
RS (1) RS55697B1 (enExample)
SI (1) SI2504003T1 (enExample)
SM (2) SMT201700090T1 (enExample)
WO (2) WO2011063339A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753519B (zh) * 2009-12-07 2015-08-05 约翰斯霍普金斯大学 二酰基化的羟基胺衍生物
CA2782110A1 (en) * 2009-12-07 2011-06-16 Johns Hopkins University N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives
CN104053647B (zh) 2011-10-17 2018-06-01 约翰斯霍普金斯大学 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物
PL2945620T3 (pl) * 2013-01-18 2018-03-30 Cardioxyl Pharmaceuticals, Inc. Donory nitroksylu o korzystniejszym indeksie terapeutycznym
AU2014267360B2 (en) * 2013-05-14 2018-07-05 Active Biotech Ab N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
EP3365325A1 (en) 2015-10-19 2018-08-29 Cardioxyl Pharmaceuticals Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
EP3365328A1 (en) 2015-10-19 2018-08-29 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
KR20190070912A (ko) 2016-07-28 2019-06-21 더 존스 홉킨스 유니버시티 O-치환된 히드록삼산
CA3049003A1 (en) 2017-01-03 2018-07-12 Cardioxyl Pharmaceuticals, Inc. Method of administering nitroxyl donating compounds

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Also Published As

Publication number Publication date
CY1118603T1 (el) 2017-07-12
JP2016128481A (ja) 2016-07-14
WO2011063339A1 (en) 2011-05-26
US20110160200A1 (en) 2011-06-30
EP2504003A1 (en) 2012-10-03
ES2611852T3 (es) 2017-05-10
US20160081951A1 (en) 2016-03-24
SMT201700090T1 (it) 2017-03-08
HUE032253T2 (en) 2017-09-28
LT2504003T (lt) 2017-01-25
SMT201700090B (it) 2017-03-08
EP2504003B1 (en) 2016-11-09
RS55697B1 (sr) 2017-07-31
JP2013511556A (ja) 2013-04-04
WO2011063400A1 (en) 2011-05-26
SI2504003T1 (sl) 2017-01-31
PL2504003T3 (pl) 2017-04-28
HRP20170183T1 (hr) 2017-03-24
PT2504003T (pt) 2017-01-31

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