LT2504003T - Nitroksilo donorai, skirti plaučių hipertenzijos gydymui - Google Patents
Nitroksilo donorai, skirti plaučių hipertenzijos gydymuiInfo
- Publication number
- LT2504003T LT2504003T LTEP10784416.9T LT10784416T LT2504003T LT 2504003 T LT2504003 T LT 2504003T LT 10784416 T LT10784416 T LT 10784416T LT 2504003 T LT2504003 T LT 2504003T
- Authority
- LT
- Lithuania
- Prior art keywords
- treatment
- pulmonary hypertension
- nitroxyl donors
- nitroxyl
- donors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26369809P | 2009-11-23 | 2009-11-23 | |
US26412909P | 2009-11-24 | 2009-11-24 | |
PCT/US2010/057844 WO2011063400A1 (en) | 2009-11-23 | 2010-11-23 | Nitroxyl donors for the treatment of pulmonary hypertension |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2504003T true LT2504003T (lt) | 2017-01-25 |
Family
ID=43513876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP10784416.9T LT2504003T (lt) | 2009-11-23 | 2010-11-23 | Nitroksilo donorai, skirti plaučių hipertenzijos gydymui |
Country Status (15)
Country | Link |
---|---|
US (2) | US20110160200A1 (lt) |
EP (1) | EP2504003B1 (lt) |
JP (2) | JP2013511556A (lt) |
CY (1) | CY1118603T1 (lt) |
DK (1) | DK2504003T3 (lt) |
ES (1) | ES2611852T3 (lt) |
HR (1) | HRP20170183T1 (lt) |
HU (1) | HUE032253T2 (lt) |
LT (1) | LT2504003T (lt) |
PL (1) | PL2504003T3 (lt) |
PT (1) | PT2504003T (lt) |
RS (1) | RS55697B1 (lt) |
SI (1) | SI2504003T1 (lt) |
SM (1) | SMT201700090B (lt) |
WO (2) | WO2011063339A1 (lt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011071951A2 (en) * | 2009-12-07 | 2011-06-16 | Johns Hopkins University | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
MX356796B (es) * | 2009-12-07 | 2018-06-14 | Cardioxyl Pharmaceuticals Inc | Derivados de hidroxilamina bis-acilados. |
BR112014009282B1 (pt) | 2011-10-17 | 2021-12-14 | The Johns Hopkins University | Composto, composição farmacêutica contendo-o e uso do mesmo |
KR102277165B1 (ko) * | 2013-01-18 | 2021-07-14 | 카르디옥실 파마슈티칼스 인코포레이티드 | 향상된 치료 지수를 갖는 니트록실 공여체 |
EP2925743B1 (en) | 2013-05-14 | 2016-02-03 | Active Biotech AB | N-(heteroaryl)-sulfonamide derivatives useful as s100-inhibitors |
EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
US10730828B2 (en) | 2015-10-19 | 2020-08-04 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
WO2017070081A1 (en) | 2015-10-19 | 2017-04-27 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
ES2878060T3 (es) | 2016-07-28 | 2021-11-18 | Univ Johns Hopkins | Acidos hidroxámicos O-sustituidos |
US11083704B2 (en) | 2017-01-03 | 2021-08-10 | Bristol-Myers Squibb Company | Method of administering nitroxyl donating compounds |
Family Cites Families (59)
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US3219428A (en) * | 1961-04-17 | 1965-11-23 | Hooker Chemical Corp | O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides |
US3382243A (en) * | 1965-05-17 | 1968-05-07 | American Home Prod | Acetamides and their preparation |
US3948967A (en) * | 1968-01-03 | 1976-04-06 | Velsicol Chemical Corporation | Aryl urea carbonates |
US3661944A (en) * | 1970-07-01 | 1972-05-09 | Smith Kline French Lab | 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds |
US3746727A (en) * | 1971-06-07 | 1973-07-17 | Shell Oil Co | Benzenesulfhydroxamic acids and their derivatives |
US3751255A (en) * | 1972-03-24 | 1973-08-07 | Eastman Kodak Co | Photosensitive and thermosensitive element, composition and process |
JPS567710A (en) * | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
US4405357A (en) * | 1980-06-02 | 1983-09-20 | Fmc Corporation | Herbicidal 3-isoxazolidinones and hydroxamic acids |
US4539321A (en) * | 1981-10-26 | 1985-09-03 | William H. Rorer, Inc. | 5-Diaza-aryl-3-substituted pyridone compounds |
ATE66143T1 (de) * | 1985-01-11 | 1991-08-15 | Abbott Lab | Feste zubereitung mit langsamer freisetzung. |
US4663351A (en) * | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
US5721365A (en) * | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
US5212204A (en) * | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
JPH07507200A (ja) * | 1991-09-20 | 1995-08-10 | ゼネカ リミテッド | ピラノン |
DE69223157T2 (de) * | 1991-09-24 | 1998-06-10 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Bethesda, Md. | Sauerstoff-substituierte derivate von nucleophil-stickstoffoxid-addukten und ihre verwendung als stickstoffoxid-donor-prodrugs |
US5814666A (en) * | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
US6200558B1 (en) * | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
ATE254594T1 (de) * | 1993-06-24 | 2003-12-15 | Albany Molecular Res Inc | Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate |
DE69424560T2 (de) * | 1993-11-02 | 2001-01-18 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, Baton Rouge | Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden |
US5700830A (en) * | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
DE19545878A1 (de) * | 1995-12-08 | 1997-06-12 | Basf Ag | Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung |
US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US5958427A (en) * | 1996-11-08 | 1999-09-28 | Salzman; Andrew L. | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
WO1999021844A1 (fr) * | 1997-10-24 | 1999-05-06 | Shionogi & Co., Ltd. | Agent anti-rhumatismal |
US6596705B1 (en) * | 1998-02-09 | 2003-07-22 | The Regents Of The University Of California | Inhibition of L-selectin and P-selection mediated binding using heparin |
UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
AU4800999A (en) * | 1998-07-28 | 2000-02-21 | Tanabe Seiyaku Co., Ltd. | Preparation capable of releasing drug at target site in intestine |
EP1126838A4 (en) * | 1998-10-30 | 2005-02-16 | Nitromed Inc | NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
RU2276997C2 (ru) * | 1999-08-30 | 2006-05-27 | Санофи-Авентис Дойчланд Гмбх | Применение ингибиторов ренин-ангиотензиновой системы для профилактики сердечно-сосудистых явлений |
US7045152B2 (en) * | 1999-09-08 | 2006-05-16 | Duke University | Treating pulmonary disorders with gaseous agent causing repletion of GSNO |
US20010053795A1 (en) * | 2000-06-20 | 2001-12-20 | Bond Richard A. | Paradoxical pharmacology |
AU7007001A (en) * | 2000-06-22 | 2002-01-02 | Nitromed Inc | Nitrosated and nitrosylated taxanes, compositions and methods of use |
CA2432642A1 (en) * | 2000-12-21 | 2002-08-08 | Subhash P. Khanapure | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
US7122529B2 (en) * | 2001-07-12 | 2006-10-17 | The Johns Hopkins University | Compounds that release nitric oxide at controlled rates upon photolysis |
FR2832634A1 (fr) * | 2001-11-29 | 2003-05-30 | Univ Pasteur | Utilisation des isomeres l de derives aminoacides de l'hydroxyguanidine pour la production de no, compositions pharmaceutiques les contenant et utilisations pharmaceutiques |
US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
US20040077691A1 (en) * | 2002-06-21 | 2004-04-22 | Medinox, Inc. | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs |
US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
US20050009789A1 (en) * | 2003-05-13 | 2005-01-13 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service | Cyclooxygenase inhibition with nitroxyl |
EP1694686A1 (en) * | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
EP1718621A4 (en) | 2004-01-30 | 2009-08-19 | Univ Johns Hopkins | NITROXYL PREPARATION COMPOUNDS APPLICATION METHOD |
WO2006086188A2 (en) * | 2005-01-31 | 2006-08-17 | The Johns Hopkins University | Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants |
CA2613477C (en) * | 2005-06-23 | 2013-12-03 | Johns Hopkins University | Thiol-sensitive positive inotropes |
US20070088043A1 (en) * | 2005-10-18 | 2007-04-19 | Orchid Research Laboratories Limited. | Novel HDAC inhibitors |
RU2616292C2 (ru) * | 2006-03-17 | 2017-04-14 | Дзе Джонс Хопкинс Юниверсити | Производные n-гидроксилсульфонамида в качестве новых физиологически полезных доноров нитроксила |
US8227639B2 (en) * | 2007-09-26 | 2012-07-24 | Cardioxyl Pharmaceuticals | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
CA2723590C (en) * | 2008-05-07 | 2017-06-27 | Cardioxyl Pharmaceuticals Inc. | Novel nitroso compounds as nitroxyl donors and methods of use thereof |
WO2011071951A2 (en) * | 2009-12-07 | 2011-06-16 | Johns Hopkins University | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
MX356796B (es) * | 2009-12-07 | 2018-06-14 | Cardioxyl Pharmaceuticals Inc | Derivados de hidroxilamina bis-acilados. |
-
2010
- 2010-11-22 US US12/951,900 patent/US20110160200A1/en not_active Abandoned
- 2010-11-22 WO PCT/US2010/057640 patent/WO2011063339A1/en active Application Filing
- 2010-11-23 JP JP2012540154A patent/JP2013511556A/ja active Pending
- 2010-11-23 WO PCT/US2010/057844 patent/WO2011063400A1/en active Application Filing
- 2010-11-23 HU HUE10784416A patent/HUE032253T2/en unknown
- 2010-11-23 ES ES10784416.9T patent/ES2611852T3/es active Active
- 2010-11-23 RS RS20170138A patent/RS55697B1/sr unknown
- 2010-11-23 SI SI201031332A patent/SI2504003T1/sl unknown
- 2010-11-23 LT LTEP10784416.9T patent/LT2504003T/lt unknown
- 2010-11-23 PL PL10784416T patent/PL2504003T3/pl unknown
- 2010-11-23 EP EP10784416.9A patent/EP2504003B1/en active Active
- 2010-11-23 PT PT107844169T patent/PT2504003T/pt unknown
- 2010-11-23 DK DK10784416.9T patent/DK2504003T3/en active
-
2015
- 2015-04-24 US US14/696,319 patent/US20160081951A1/en not_active Abandoned
-
2016
- 2016-01-29 JP JP2016015102A patent/JP2016128481A/ja active Pending
-
2017
- 2017-02-03 HR HRP20170183TT patent/HRP20170183T1/hr unknown
- 2017-02-07 CY CY20171100169T patent/CY1118603T1/el unknown
- 2017-02-09 SM SM201700090T patent/SMT201700090B/it unknown
Also Published As
Publication number | Publication date |
---|---|
WO2011063339A1 (en) | 2011-05-26 |
SMT201700090B (it) | 2017-03-08 |
SI2504003T1 (sl) | 2017-01-31 |
CY1118603T1 (el) | 2017-07-12 |
WO2011063400A1 (en) | 2011-05-26 |
ES2611852T3 (es) | 2017-05-10 |
EP2504003A1 (en) | 2012-10-03 |
HRP20170183T1 (hr) | 2017-03-24 |
JP2016128481A (ja) | 2016-07-14 |
DK2504003T3 (en) | 2017-02-20 |
US20160081951A1 (en) | 2016-03-24 |
RS55697B1 (sr) | 2017-07-31 |
JP2013511556A (ja) | 2013-04-04 |
EP2504003B1 (en) | 2016-11-09 |
HUE032253T2 (en) | 2017-09-28 |
PL2504003T3 (pl) | 2017-04-28 |
PT2504003T (pt) | 2017-01-31 |
US20110160200A1 (en) | 2011-06-30 |
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