JP2016529306A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016529306A5 JP2016529306A5 JP2016539571A JP2016539571A JP2016529306A5 JP 2016529306 A5 JP2016529306 A5 JP 2016529306A5 JP 2016539571 A JP2016539571 A JP 2016539571A JP 2016539571 A JP2016539571 A JP 2016539571A JP 2016529306 A5 JP2016529306 A5 JP 2016529306A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyano
- hydroxyl
- disease
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183519 | 2013-09-09 | ||
| EP13183519.1 | 2013-09-09 | ||
| EP14151979 | 2014-01-21 | ||
| EP14151979.3 | 2014-01-21 | ||
| PCT/EP2014/069088 WO2015032945A1 (en) | 2013-09-09 | 2014-09-08 | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529306A JP2016529306A (ja) | 2016-09-23 |
| JP2016529306A5 true JP2016529306A5 (enExample) | 2017-10-12 |
| JP6408008B2 JP6408008B2 (ja) | 2018-10-17 |
Family
ID=51535425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539571A Active JP6408008B2 (ja) | 2013-09-09 | 2014-09-08 | ジペプチジルペプチダーゼｉインヒビターとしてのペプチジルニトリル化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9856228B2 (enExample) |
| EP (1) | EP3044214B1 (enExample) |
| JP (1) | JP6408008B2 (enExample) |
| CN (1) | CN105612149A (enExample) |
| AU (1) | AU2014317048B2 (enExample) |
| CA (1) | CA2923484C (enExample) |
| DK (1) | DK3044214T3 (enExample) |
| EA (1) | EA029030B1 (enExample) |
| SG (1) | SG11201601150WA (enExample) |
| WO (2) | WO2015032943A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105612149A (zh) | 2013-09-09 | 2016-05-25 | 普罗技迈克斯公司 | 作为二肽基肽酶i抑制剂的肽基腈化合物 |
| NO2699580T3 (enExample) | 2014-01-24 | 2018-02-24 | ||
| DK3265452T3 (en) * | 2015-03-05 | 2020-06-08 | Neuprozyme Therapeutics ApS | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
| ES2912276T3 (es) * | 2015-04-07 | 2022-05-25 | Ela Pharma Ltd | Composiciones para tratar y/o prevenir necrosis celular o tisular que seleccionan como diana específicamente catepsina C y/o CELA1 y/o CELA3A y/o enzimas estructuralmente relacionadas con las mismas |
| PT3758708T (pt) | 2018-03-01 | 2025-02-13 | Astrazeneca Ab | Composições farmacêuticas compreendendo (2s)-{(1,s)-1-ciano-2-[4-(3-metil-2-oxo-2,3-di-hidro-1,3-benzoxazol-5-il)fenil]etil}-1,4-oxazepano-2-carboxamida |
| CA3106269A1 (en) | 2018-07-17 | 2020-01-23 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis |
| AU2021314104A1 (en) | 2020-07-20 | 2023-01-19 | Insmed, Inc. | Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions |
| CN114159446A (zh) | 2020-09-11 | 2022-03-11 | 中国科学院上海营养与健康研究所 | 组织蛋白酶c抑制剂在治疗肿瘤转移中的应用 |
| WO2023243601A1 (ja) | 2022-06-13 | 2023-12-21 | モジュラス株式会社 | アザシクロアルキルカルボニル環状アミン化合物 |
| JP2026503035A (ja) | 2023-01-06 | 2026-01-27 | インスメッド インコーポレイテッド | 新規な可逆性ｄｐｐ１阻害剤及びその用途 |
| WO2025162472A1 (en) | 2024-01-31 | 2025-08-07 | Insmed Incorporated | Linear dipeptidyl peptidase 1 inhibitors and uses thereof |
| WO2026148258A2 (en) | 2025-01-03 | 2026-07-09 | Insmed Incorporated | Dipeptidyl peptidase 1 inhibitors and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7902181B2 (en) * | 2007-12-12 | 2011-03-08 | Astrazeneca Ab | Compounds 010 |
| KR100903499B1 (ko) | 2007-12-27 | 2009-06-18 | 엔에이치엔비즈니스플랫폼 주식회사 | 검색 의도 분류에 따른 광고 제공 방법 및 상기 방법을수행하기 위한 시스템 |
| EA201190235A1 (ru) * | 2009-05-07 | 2012-05-30 | Астразенека Аб | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 |
| WO2010142985A1 (en) * | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
| WO2011154677A1 (en) | 2010-06-09 | 2011-12-15 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl] 1-aminocycloalk-1-ylcarboxamide compounds - 760 |
| WO2012119941A1 (en) * | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| WO2012130299A1 (en) | 2011-03-30 | 2012-10-04 | Prozymex A/S | Peptidase inhibitors |
| US8999975B2 (en) | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
| CN105612149A (zh) | 2013-09-09 | 2016-05-25 | 普罗技迈克斯公司 | 作为二肽基肽酶i抑制剂的肽基腈化合物 |
-
2014
- 2014-09-08 CN CN201480049595.8A patent/CN105612149A/zh active Pending
- 2014-09-08 EA EA201690561A patent/EA029030B1/ru not_active IP Right Cessation
- 2014-09-08 WO PCT/EP2014/069081 patent/WO2015032943A1/en not_active Ceased
- 2014-09-08 US US14/917,147 patent/US9856228B2/en active Active
- 2014-09-08 EP EP14761986.0A patent/EP3044214B1/en active Active
- 2014-09-08 SG SG11201601150WA patent/SG11201601150WA/en unknown
- 2014-09-08 WO PCT/EP2014/069088 patent/WO2015032945A1/en not_active Ceased
- 2014-09-08 AU AU2014317048A patent/AU2014317048B2/en active Active
- 2014-09-08 CA CA2923484A patent/CA2923484C/en active Active
- 2014-09-08 JP JP2016539571A patent/JP6408008B2/ja active Active
- 2014-09-08 DK DK14761986.0T patent/DK3044214T3/da active