JP2009543794A5 - - Google Patents
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- Publication number
- JP2009543794A5 JP2009543794A5 JP2009519603A JP2009519603A JP2009543794A5 JP 2009543794 A5 JP2009543794 A5 JP 2009543794A5 JP 2009519603 A JP2009519603 A JP 2009519603A JP 2009519603 A JP2009519603 A JP 2009519603A JP 2009543794 A5 JP2009543794 A5 JP 2009543794A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- carbon atoms
- compound
- alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- -1 5- (3-propyl) thiophen-2-yl Chemical group 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 230000004410 intraocular pressure Effects 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80681306P | 2006-07-10 | 2006-07-10 | |
| US60/806,813 | 2006-07-10 | ||
| PCT/US2007/072917 WO2008008701A2 (en) | 2006-07-10 | 2007-07-06 | Substituted cyclopentane derivatives as therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543794A JP2009543794A (ja) | 2009-12-10 |
| JP2009543794A5 true JP2009543794A5 (enExample) | 2010-08-26 |
| JP5532302B2 JP5532302B2 (ja) | 2014-06-25 |
Family
ID=38740285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519603A Expired - Fee Related JP5532302B2 (ja) | 2006-07-10 | 2007-07-06 | 治療化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7605178B2 (enExample) |
| EP (1) | EP2069295B1 (enExample) |
| JP (1) | JP5532302B2 (enExample) |
| AU (1) | AU2007272683B2 (enExample) |
| BR (1) | BRPI0714709A2 (enExample) |
| CA (1) | CA2657625C (enExample) |
| ES (1) | ES2447065T3 (enExample) |
| WO (2) | WO2008008701A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5532302B2 (ja) * | 2006-07-10 | 2014-06-25 | アラーガン インコーポレイテッド | 治療化合物 |
| BRPI0714885B8 (pt) * | 2006-07-11 | 2021-05-25 | Allergan Inc | compostos terapêuticos e seu uso |
| KR20100051803A (ko) | 2007-07-03 | 2010-05-18 | 알러간, 인코포레이티드 | 안압을 감소시키기 위한 치료적인 치환된 사이클로펜탄 |
| US7947732B2 (en) * | 2007-07-13 | 2011-05-24 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
| AU2009251474B2 (en) | 2008-05-15 | 2014-06-05 | Allergan, Inc. | Prostaglandin prodrugs as hypotensive agents |
| AU2009246573B2 (en) * | 2008-05-15 | 2014-04-24 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| CA2724474A1 (en) | 2008-05-20 | 2009-11-26 | Allergan, Inc. | Therapeutic prostaglandin compounds used as ocular hypotensive agents |
| JP6569661B2 (ja) * | 2014-02-27 | 2019-09-04 | 小野薬品工業株式会社 | 選択的ｅｐ２アゴニスト活性を有する化合物 |
| AU2015269064B2 (en) * | 2014-06-06 | 2020-02-13 | Allergan, Inc. | Novel EP4 agonists as therapeutic compounds |
| ES2837399T3 (es) | 2015-07-23 | 2021-06-30 | Ono Pharmaceutical Co | Derivados de ácido 2-(octahidrociclopenta(b)piran-2-il)1,3-tiazol-4-carboxílico y compuestos relacionados como agonistas de EP2 con actividad reductora de la presión intraocular |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980700A (en) | 1971-10-07 | 1976-09-14 | G. D. Searle & Co. | Prostaglandin intermediates and optically active isomers thereof |
| DE2256537A1 (de) | 1972-11-17 | 1974-10-10 | Merck Patent Gmbh | Neue sulfide |
| US4073799A (en) * | 1975-02-27 | 1978-02-14 | (Zaidanhojin) Sagami Chemical Research Center | Process for producing 3-formylcyclopentanone derivatives |
| JPS51110557A (en) | 1975-03-26 | 1976-09-30 | Sagami Chem Res | Rakutonsurufuidono seizohoho |
| US4094886A (en) | 1976-03-01 | 1978-06-13 | (Zaidanhojin) Sagami Chemical Research Center | Process for producing allyl alcohol derivatives useful in prostaglandin synthesis |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| HU180705B (hu) * | 1978-07-13 | 1983-04-29 | Chinoin Gyogyszer Es Vegyeszet | Eljárás új 4-ariltiometil-2H-ciklopentano[b]furán-származékok előállítására |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| HU191196B (hu) * | 1982-04-09 | 1987-01-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Eljárás új ariltió-klórmetil-c1klopentán-származékok előállítására |
| JP2943306B2 (ja) | 1990-10-12 | 1999-08-30 | 住友化学工業株式会社 | シクロペンタンアルデヒド類およびその製造法 |
| US6531485B2 (en) | 1997-06-23 | 2003-03-11 | Pfizer Inc. | Prostaglandin agonists |
| JP2001527063A (ja) * | 1998-12-24 | 2001-12-25 | 小野薬品工業株式会社 | ω−シクロアルキル−プロスタグランジンＥ２誘導体 |
| EP1108426A3 (en) | 1999-12-02 | 2002-10-02 | Pfizer Products Inc. | Use of prostaglandin agonists to treat erectile dysfunction or impotence |
| US6291522B1 (en) * | 2000-09-27 | 2001-09-18 | Allergan Sales, Inc. | Cyclopentane heptan(ENE)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents |
| KR20040023707A (ko) * | 2001-07-31 | 2004-03-18 | 수캄포 아게 | 안내압항진 및 녹내장의 치료 |
| JP4149153B2 (ja) * | 2001-09-28 | 2008-09-10 | 富士フイルム株式会社 | ポジ型レジスト組成物 |
| US7235586B2 (en) * | 2003-09-09 | 2007-06-26 | Allergan, Inc. | Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents |
| NZ555945A (en) * | 2005-01-14 | 2011-01-28 | Allergan Inc | Substituted cyclopentanes or cyclopentanones for the treatment of ocular hypertensive conditions |
| PL212658B1 (pl) * | 2005-04-18 | 2012-11-30 | Inst Farmaceutyczny | Sposób otrzymywania pochodnych 13,14-dihydro-PGF<sub>2</sub><sub>α</sub> |
| US7323591B2 (en) * | 2006-01-10 | 2008-01-29 | Allergan, Inc. | Substituted cyclopentanes or cyclopentanones as therapeutic agents |
| US7439372B2 (en) | 2006-05-03 | 2008-10-21 | Allergan, Inc. | Therapeutic compounds |
| US7491844B2 (en) | 2006-05-04 | 2009-02-17 | Allergan, Inc. | Therapeutic cyclopentane derivatives |
| US7547727B2 (en) | 2006-05-22 | 2009-06-16 | Allergan, Inc. | Therapeutic cyclopentane derivatives |
| US7429669B2 (en) * | 2006-06-20 | 2008-09-30 | Allergan, Inc. | Therapeutic compounds |
| JP5532302B2 (ja) * | 2006-07-10 | 2014-06-25 | アラーガン インコーポレイテッド | 治療化合物 |
| US20080015219A1 (en) * | 2006-07-11 | 2008-01-17 | Allergan, Inc. | Therapeutic compounds |
| US7507817B2 (en) * | 2006-11-17 | 2009-03-24 | Allergan, Inc. | Prostaglandin prodrugs |
| AU2008207991B9 (en) * | 2007-01-22 | 2014-02-27 | Allergan, Inc. | Thiophene derivatives useful as ocular hypotensive agents |
-
2007
- 2007-07-06 JP JP2009519603A patent/JP5532302B2/ja not_active Expired - Fee Related
- 2007-07-06 WO PCT/US2007/072917 patent/WO2008008701A2/en not_active Ceased
- 2007-07-06 WO PCT/US2007/072915 patent/WO2008008700A2/en not_active Ceased
- 2007-07-06 EP EP07812665.3A patent/EP2069295B1/en not_active Not-in-force
- 2007-07-06 ES ES07812665.3T patent/ES2447065T3/es active Active
- 2007-07-06 CA CA2657625A patent/CA2657625C/en not_active Expired - Fee Related
- 2007-07-06 AU AU2007272683A patent/AU2007272683B2/en not_active Ceased
- 2007-07-06 US US11/774,411 patent/US7605178B2/en active Active
- 2007-07-06 BR BRPI0714709-0A patent/BRPI0714709A2/pt not_active IP Right Cessation
-
2009
- 2009-09-08 US US12/555,521 patent/US8003680B2/en active Active