JP2005536519A5 - - Google Patents
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- Publication number
- JP2005536519A5 JP2005536519A5 JP2004523537A JP2004523537A JP2005536519A5 JP 2005536519 A5 JP2005536519 A5 JP 2005536519A5 JP 2004523537 A JP2004523537 A JP 2004523537A JP 2004523537 A JP2004523537 A JP 2004523537A JP 2005536519 A5 JP2005536519 A5 JP 2005536519A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- pharmaceutically acceptable
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 47
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 10
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003536 tetrazoles Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229940126409 proton pump inhibitor Drugs 0.000 claims 1
- 239000000612 proton pump inhibitor Substances 0.000 claims 1
- 125000001174 sulfone group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39745902P | 2002-07-19 | 2002-07-19 | |
| PCT/US2003/022419 WO2004009583A2 (en) | 2002-07-19 | 2003-07-15 | Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005536519A JP2005536519A (ja) | 2005-12-02 |
| JP2005536519A5 true JP2005536519A5 (enExample) | 2007-05-31 |
| JP4463103B2 JP4463103B2 (ja) | 2010-05-12 |
Family
ID=30771064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004523537A Expired - Fee Related JP4463103B2 (ja) | 2002-07-19 | 2003-07-15 | ベンズイミダゾール誘導体およびプロトンポンプ阻害剤のプロドラッグとしてのその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6897227B2 (enExample) |
| EP (1) | EP1556371B1 (enExample) |
| JP (1) | JP4463103B2 (enExample) |
| KR (2) | KR100822981B1 (enExample) |
| AT (1) | ATE323695T1 (enExample) |
| AU (1) | AU2003259154B2 (enExample) |
| BR (1) | BR0312802A (enExample) |
| CA (1) | CA2492718C (enExample) |
| CO (1) | CO5690576A2 (enExample) |
| DE (1) | DE60304726T2 (enExample) |
| DK (1) | DK1556371T3 (enExample) |
| ES (1) | ES2263028T3 (enExample) |
| IL (1) | IL166371A0 (enExample) |
| MX (1) | MXPA05000657A (enExample) |
| NO (1) | NO20050801L (enExample) |
| NZ (1) | NZ538221A (enExample) |
| PL (1) | PL375255A1 (enExample) |
| PT (1) | PT1556371E (enExample) |
| RU (1) | RU2292342C2 (enExample) |
| TW (1) | TW200502231A (enExample) |
| WO (1) | WO2004009583A2 (enExample) |
| ZA (1) | ZA200501116B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| JP4634144B2 (ja) * | 2002-08-01 | 2011-02-16 | ニコックス エスエー | ニトロソ化プロトンポンプ阻害剤、組成物および使用方法 |
| MXPA06000410A (es) * | 2003-07-15 | 2006-03-17 | Allergan Inc | Procedimiento para preparar profarmacos isomericamente puros de inhibidores de la bomba de protones. |
| US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
| US20060241037A1 (en) * | 2003-10-03 | 2006-10-26 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs |
| AU2005216862A1 (en) * | 2004-02-18 | 2005-09-09 | Allergan, Inc. | Compositions comprising prodrugs of proton pump inhibitors |
| WO2005082338A2 (en) * | 2004-02-18 | 2005-09-09 | Allergan, Inc. | Prodrugs for the intravenous administration of proton pump inhibitors |
| BRPI0507796A (pt) * | 2004-03-11 | 2007-07-17 | Allergan Inc | métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico |
| PT1740571E (pt) | 2004-04-28 | 2009-09-02 | Hetero Drugs Ltd | Processo para preparar compostos de piridinilmetil-1hbenzimidazol na forma enantiomericamente enriquecida ou como enantiómeros únicos |
| WO2007073301A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Benzoimidazole derivatives as prodrugs of proton pump inhibitors |
| WO2007081871A1 (en) * | 2006-01-10 | 2007-07-19 | Allergan, Inc. | Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation |
| BRPI0711048A2 (pt) * | 2006-05-09 | 2011-08-23 | Astrazeneca Ab | formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável |
| US20070293543A1 (en) * | 2006-06-19 | 2007-12-20 | Edward Lee | THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z |
| US20100113524A1 (en) * | 2006-09-19 | 2010-05-06 | Garst Michael E | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| US20100265240A1 (en) * | 2007-10-05 | 2010-10-21 | Lg Electronics Inc. | Plasma display device |
| KR20090035195A (ko) * | 2007-10-05 | 2009-04-09 | 엘지전자 주식회사 | 플라즈마 디스플레이 장치 |
| KR100895333B1 (ko) * | 2007-11-01 | 2009-05-07 | 엘지전자 주식회사 | 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치 |
| US8927559B2 (en) | 2010-10-11 | 2015-01-06 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as CRTH2 antagonists |
| WO2012087872A1 (en) | 2010-12-23 | 2012-06-28 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as crth2 receptor modulators |
| ES2635030T3 (es) | 2010-12-23 | 2017-10-02 | Merck Sharp & Dohme Corp. | Quinoxalinas y aza-quinoxalinas como moduladores del receptor CRTH2 |
| CA2973370A1 (en) * | 2015-01-09 | 2016-07-14 | The Regents Of The University Of California | Compositions and methods for treating gastrointestinal infections |
| CN108997177A (zh) * | 2018-09-04 | 2018-12-14 | 邵阳学院 | 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US430042A (en) * | 1890-06-10 | Valve | ||
| SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| IL76839A (en) | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| US4758597A (en) | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
| US4965269A (en) | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5045522A (en) | 1990-03-27 | 1991-09-03 | Phillips Petroleum Company | Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams |
| AU649456B2 (en) | 1990-06-20 | 1994-05-26 | Astra Aktiebolag | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| SK281465B6 (sk) * | 1994-06-10 | 2001-04-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované arylalkyltioalkyltiopyridínové zlúčeniny, spôsob ich výroby a ich použitie |
| US5708017A (en) | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| US6093734A (en) | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| BR9912937A (pt) * | 1998-08-10 | 2001-05-08 | Partnership Of Michael E Garst | Pró-drogas de inibidores de bomba de prótons |
| EP1104415B1 (en) * | 1998-08-12 | 2004-11-10 | Gilead Sciences, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
| SE0002476D0 (sv) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
| US6599167B2 (en) | 2000-09-27 | 2003-07-29 | Glenn Waltz | Game call holder and amplifying device |
| WO2002030920A1 (en) * | 2000-10-12 | 2002-04-18 | Takeda Chemical Industries, Ltd. | Benzimidazole compounds, process for producing the same and use thereof |
-
2003
- 2003-07-15 BR BR0312802-4A patent/BR0312802A/pt not_active IP Right Cessation
- 2003-07-15 AT AT03765694T patent/ATE323695T1/de not_active IP Right Cessation
- 2003-07-15 DE DE60304726T patent/DE60304726T2/de not_active Expired - Lifetime
- 2003-07-15 EP EP03765694A patent/EP1556371B1/en not_active Expired - Lifetime
- 2003-07-15 AU AU2003259154A patent/AU2003259154B2/en not_active Ceased
- 2003-07-15 PT PT03765694T patent/PT1556371E/pt unknown
- 2003-07-15 PL PL03375255A patent/PL375255A1/xx not_active Application Discontinuation
- 2003-07-15 CA CA2492718A patent/CA2492718C/en not_active Expired - Lifetime
- 2003-07-15 US US10/620,252 patent/US6897227B2/en not_active Expired - Lifetime
- 2003-07-15 NZ NZ538221A patent/NZ538221A/en unknown
- 2003-07-15 ES ES03765694T patent/ES2263028T3/es not_active Expired - Lifetime
- 2003-07-15 KR KR1020067026729A patent/KR100822981B1/ko not_active Expired - Fee Related
- 2003-07-15 JP JP2004523537A patent/JP4463103B2/ja not_active Expired - Fee Related
- 2003-07-15 WO PCT/US2003/022419 patent/WO2004009583A2/en not_active Ceased
- 2003-07-15 DK DK03765694T patent/DK1556371T3/da active
- 2003-07-15 KR KR1020057000899A patent/KR100788778B1/ko not_active Expired - Fee Related
- 2003-07-15 RU RU2005105564/04A patent/RU2292342C2/ru not_active IP Right Cessation
- 2003-07-15 MX MXPA05000657A patent/MXPA05000657A/es active IP Right Grant
- 2003-11-07 TW TW092131253A patent/TW200502231A/zh unknown
-
2005
- 2005-01-18 IL IL16637105A patent/IL166371A0/xx unknown
- 2005-01-20 US US11/039,631 patent/US20050143423A1/en not_active Abandoned
- 2005-01-20 US US11/039,630 patent/US20050182101A1/en not_active Abandoned
- 2005-02-08 ZA ZA200501116A patent/ZA200501116B/xx unknown
- 2005-02-15 NO NO20050801A patent/NO20050801L/no not_active Application Discontinuation
- 2005-02-15 CO CO05013468A patent/CO5690576A2/es not_active Application Discontinuation
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