KR100822981B1 - 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용 - Google Patents

벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용 Download PDF

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Publication number
KR100822981B1
KR100822981B1 KR1020067026729A KR20067026729A KR100822981B1 KR 100822981 B1 KR100822981 B1 KR 100822981B1 KR 1020067026729 A KR1020067026729 A KR 1020067026729A KR 20067026729 A KR20067026729 A KR 20067026729A KR 100822981 B1 KR100822981 B1 KR 100822981B1
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South Korea
Prior art keywords
sulfonyl
methoxy
mixture
compound
acid
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Expired - Fee Related
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KR1020067026729A
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English (en)
Korean (ko)
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KR20070005029A (ko
Inventor
마이클 이 가스트
죠지 사크
재무 신
Original Assignee
윈스턴 파마슈티컬즈, 엘엘씨
더 리전트 오브 더 유니버시티 오브 캘리포니아
유.에스. 거번먼트(레프리젠티드 바이 더 디파트먼트 오브 베테랑스 어페어즈)
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Application filed by 윈스턴 파마슈티컬즈, 엘엘씨, 더 리전트 오브 더 유니버시티 오브 캘리포니아, 유.에스. 거번먼트(레프리젠티드 바이 더 디파트먼트 오브 베테랑스 어페어즈) filed Critical 윈스턴 파마슈티컬즈, 엘엘씨
Publication of KR20070005029A publication Critical patent/KR20070005029A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
KR1020067026729A 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용 Expired - Fee Related KR100822981B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
US60/397,459 2002-07-19

Related Parent Applications (1)

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KR1020057000899A Division KR100788778B1 (ko) 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용

Publications (2)

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KR20070005029A KR20070005029A (ko) 2007-01-09
KR100822981B1 true KR100822981B1 (ko) 2008-04-16

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067026729A Expired - Fee Related KR100822981B1 (ko) 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용
KR1020057000899A Expired - Fee Related KR100788778B1 (ko) 2002-07-19 2003-07-15 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용

Family Applications After (1)

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Country Status (22)

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US (3) US6897227B2 (enExample)
EP (1) EP1556371B1 (enExample)
JP (1) JP4463103B2 (enExample)
KR (2) KR100822981B1 (enExample)
AT (1) ATE323695T1 (enExample)
AU (1) AU2003259154B2 (enExample)
BR (1) BR0312802A (enExample)
CA (1) CA2492718C (enExample)
CO (1) CO5690576A2 (enExample)
DE (1) DE60304726T2 (enExample)
DK (1) DK1556371T3 (enExample)
ES (1) ES2263028T3 (enExample)
IL (1) IL166371A0 (enExample)
MX (1) MXPA05000657A (enExample)
NO (1) NO20050801L (enExample)
NZ (1) NZ538221A (enExample)
PL (1) PL375255A1 (enExample)
PT (1) PT1556371E (enExample)
RU (1) RU2292342C2 (enExample)
TW (1) TW200502231A (enExample)
WO (1) WO2004009583A2 (enExample)
ZA (1) ZA200501116B (enExample)

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US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AU2003254282A1 (en) * 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
EP1644352A1 (en) * 2003-07-15 2006-04-12 Allergan, Inc. Process for preparing isomerically pure prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
CA2557471A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors
EP1715861A2 (en) * 2004-02-18 2006-11-02 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
BRPI0507796A (pt) * 2004-03-11 2007-07-17 Allergan Inc métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico
ATE437869T1 (de) 2004-04-28 2009-08-15 Hetero Drugs Ltd Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
BRPI0711048A2 (pt) * 2006-05-09 2011-08-23 Astrazeneca Ab formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
EP2193518A4 (en) * 2007-10-05 2010-10-27 Lg Electronics Inc PLASMA DISPLAY DEVICE
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
WO2012087872A1 (en) 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
KR20130133219A (ko) 2010-12-23 2013-12-06 머크 샤프 앤드 돔 코포레이션 Crth₂ 수용체 조절제로서의 퀴녹살린 및 아자-퀴녹살린
EP3242664A4 (en) * 2015-01-09 2018-06-20 The Regents of the University of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

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WO2000009498A1 (en) 1998-08-10 2000-02-24 Partnership Of Michael E. Garst, George Sachs And Jai Moo Shin Prodrugs of proton pump inhibitors
WO2002030920A1 (en) 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Benzimidazole compounds, process for producing the same and use thereof

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JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
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WO2002030920A1 (en) 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
JP2005536519A (ja) 2005-12-02
AU2003259154B2 (en) 2006-12-07
US20040102484A1 (en) 2004-05-27
WO2004009583A3 (en) 2004-03-18
ATE323695T1 (de) 2006-05-15
NO20050801L (no) 2005-02-15
WO2004009583A2 (en) 2004-01-29
DE60304726T2 (de) 2007-08-09
RU2005105564A (ru) 2005-10-10
KR100788778B1 (ko) 2007-12-27
US20050182101A1 (en) 2005-08-18
DE60304726D1 (de) 2006-05-24
DK1556371T3 (da) 2006-08-21
NZ538221A (en) 2006-11-30
JP4463103B2 (ja) 2010-05-12
US6897227B2 (en) 2005-05-24
ES2263028T3 (es) 2006-12-01
AU2003259154A1 (en) 2004-02-09
US20050143423A1 (en) 2005-06-30
KR20050047078A (ko) 2005-05-19
RU2292342C2 (ru) 2007-01-27
ZA200501116B (en) 2006-11-29
KR20070005029A (ko) 2007-01-09
HK1079207A1 (en) 2006-03-31
MXPA05000657A (es) 2005-08-19
TW200502231A (en) 2005-01-16
EP1556371B1 (en) 2006-04-19
PL375255A1 (en) 2005-11-28
IL166371A0 (en) 2006-01-16
CA2492718A1 (en) 2004-01-29
AU2003259154C1 (en) 2004-02-09
CA2492718C (en) 2010-12-21
EP1556371A2 (en) 2005-07-27
CO5690576A2 (es) 2006-10-31
BR0312802A (pt) 2005-04-19
PT1556371E (pt) 2006-09-29

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