BR0312802A - Pró-drogas de inibidores de bombas de próton - Google Patents

Pró-drogas de inibidores de bombas de próton

Info

Publication number
BR0312802A
BR0312802A BR0312802-4A BR0312802A BR0312802A BR 0312802 A BR0312802 A BR 0312802A BR 0312802 A BR0312802 A BR 0312802A BR 0312802 A BR0312802 A BR 0312802A
Authority
BR
Brazil
Prior art keywords
proton pump
pump inhibitor
inhibitor prodrugs
prodrugs
group
Prior art date
Application number
BR0312802-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Original Assignee
Michael E Garst
George Sachs
Jai Moo Shin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael E Garst, George Sachs, Jai Moo Shin filed Critical Michael E Garst
Publication of BR0312802A publication Critical patent/BR0312802A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
BR0312802-4A 2002-07-19 2003-07-15 Pró-drogas de inibidores de bombas de próton BR0312802A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
PCT/US2003/022419 WO2004009583A2 (en) 2002-07-19 2003-07-15 Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor

Publications (1)

Publication Number Publication Date
BR0312802A true BR0312802A (pt) 2005-04-19

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312802-4A BR0312802A (pt) 2002-07-19 2003-07-15 Pró-drogas de inibidores de bombas de próton

Country Status (22)

Country Link
US (3) US6897227B2 (enExample)
EP (1) EP1556371B1 (enExample)
JP (1) JP4463103B2 (enExample)
KR (2) KR100822981B1 (enExample)
AT (1) ATE323695T1 (enExample)
AU (1) AU2003259154B2 (enExample)
BR (1) BR0312802A (enExample)
CA (1) CA2492718C (enExample)
CO (1) CO5690576A2 (enExample)
DE (1) DE60304726T2 (enExample)
DK (1) DK1556371T3 (enExample)
ES (1) ES2263028T3 (enExample)
IL (1) IL166371A0 (enExample)
MX (1) MXPA05000657A (enExample)
NO (1) NO20050801L (enExample)
NZ (1) NZ538221A (enExample)
PL (1) PL375255A1 (enExample)
PT (1) PT1556371E (enExample)
RU (1) RU2292342C2 (enExample)
TW (1) TW200502231A (enExample)
WO (1) WO2004009583A2 (enExample)
ZA (1) ZA200501116B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AU2003254282A1 (en) * 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
EP1644352A1 (en) * 2003-07-15 2006-04-12 Allergan, Inc. Process for preparing isomerically pure prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
CA2557471A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors
EP1715861A2 (en) * 2004-02-18 2006-11-02 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
BRPI0507796A (pt) * 2004-03-11 2007-07-17 Allergan Inc métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico
ATE437869T1 (de) 2004-04-28 2009-08-15 Hetero Drugs Ltd Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
BRPI0711048A2 (pt) * 2006-05-09 2011-08-23 Astrazeneca Ab formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
EP2193518A4 (en) * 2007-10-05 2010-10-27 Lg Electronics Inc PLASMA DISPLAY DEVICE
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
WO2012087872A1 (en) 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
KR20130133219A (ko) 2010-12-23 2013-12-06 머크 샤프 앤드 돔 코포레이션 Crth₂ 수용체 조절제로서의 퀴녹살린 및 아자-퀴녹살린
EP3242664A4 (en) * 2015-01-09 2018-06-20 The Regents of the University of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
US4758597A (en) * 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) * 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
PL166209B1 (pl) * 1990-06-20 1995-04-28 Astra Ab Sposób wytwarzania nowych pochodnych benzimidazolu PL
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
NZ288609A (en) * 1994-06-10 1998-12-23 Byk Gulden Lomberg Chem Fab Substituted (4-thiopyridinyl) methylthio-benzimidazole (or 1h-imidazo-[2,3-b]-pyridine) and medicaments
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
CN100396675C (zh) * 1998-08-10 2008-06-25 加利福尼亚州大学董事会 质子泵抑制剂的前药
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
EP1535921A1 (en) * 1998-08-12 2005-06-01 Gilead Sciences, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) * 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
US20040039027A1 (en) 2000-10-12 2004-02-26 Keiji Kamiyama Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
JP2005536519A (ja) 2005-12-02
AU2003259154B2 (en) 2006-12-07
US20040102484A1 (en) 2004-05-27
WO2004009583A3 (en) 2004-03-18
ATE323695T1 (de) 2006-05-15
NO20050801L (no) 2005-02-15
WO2004009583A2 (en) 2004-01-29
DE60304726T2 (de) 2007-08-09
RU2005105564A (ru) 2005-10-10
KR100788778B1 (ko) 2007-12-27
US20050182101A1 (en) 2005-08-18
DE60304726D1 (de) 2006-05-24
DK1556371T3 (da) 2006-08-21
NZ538221A (en) 2006-11-30
JP4463103B2 (ja) 2010-05-12
US6897227B2 (en) 2005-05-24
ES2263028T3 (es) 2006-12-01
AU2003259154A1 (en) 2004-02-09
US20050143423A1 (en) 2005-06-30
KR20050047078A (ko) 2005-05-19
RU2292342C2 (ru) 2007-01-27
ZA200501116B (en) 2006-11-29
KR20070005029A (ko) 2007-01-09
HK1079207A1 (en) 2006-03-31
MXPA05000657A (es) 2005-08-19
TW200502231A (en) 2005-01-16
EP1556371B1 (en) 2006-04-19
PL375255A1 (en) 2005-11-28
IL166371A0 (en) 2006-01-16
CA2492718A1 (en) 2004-01-29
AU2003259154C1 (en) 2004-02-09
CA2492718C (en) 2010-12-21
EP1556371A2 (en) 2005-07-27
CO5690576A2 (es) 2006-10-31
KR100822981B1 (ko) 2008-04-16
PT1556371E (pt) 2006-09-29

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: WINSTON PHARMACEUTICALS LLC (US) , THE REGENTS OF

Free format text: TRANSFERIDO DE: MICHAEL E. GARST, GEORGE SACHS E JAI MOO SHIN

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 401/00, C07D 401/12, C07D 401/14, C07D 409/14, A61K 31/4427, A61K 31/4439, A61P 1/04, A61P 11/04, A61P 11/06, A61P 31/04, A61P 43/00

Ipc: C07D 401/00 (2011.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012.