BR0313734A - Derivados do tiofeno, o seu processo de preparação e as composições farmacêuticas que os contêm - Google Patents
Derivados do tiofeno, o seu processo de preparação e as composições farmacêuticas que os contêmInfo
- Publication number
- BR0313734A BR0313734A BR0313734-1A BR0313734A BR0313734A BR 0313734 A BR0313734 A BR 0313734A BR 0313734 A BR0313734 A BR 0313734A BR 0313734 A BR0313734 A BR 0313734A
- Authority
- BR
- Brazil
- Prior art keywords
- sym
- alkyl
- halogen
- pharmaceutical compositions
- preparation process
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DO TIOFENO, O SEU PROCESSO DE PREPARAçãO E AS COMPOSIçõES FARMACêUTICAS QUE OS CONTêM". A presente invenção refere-se a compostos com a fórmula (I) nos quais <sym> X represente oxigênio ou enxofre, <sym> Y represente oxigênio, -NH ou -N-alqUila(C~ 1~-C~ 6~), <sym> R~ 2~, represente hidrogênio, halogêneo, alquila (C~ 1~-C~ 3~), hidróxi, ou alcóxi(C~ 1~-C~ 3~), <sym> R~ b~ represente hidrogênio, halogêneo ou alquila(C~ 1~C~ 3~), <sym> A represente fenila, piridila, cicloalquila(C~ 5~-C~ 6~) ou cicloalquileno(C~ 5~-C~ 6~), <sym> R~ 1~ e R~ 2~ representem cada um deles um grupo selecionado dentre hidrogênio, halogêneo, ciano, halogenoalquila, halogenoalcóxi, alquila, alcenila, alcinila, -OR~ 4~, -NR~ 4~R~ 5~, -S(O)~ n~R~ 4~, -C(O)R~ 4~, -CO~ 2~R~ 4~, -C(O)NR~ 4~R~ 5~ -NR~ 5~-C(O)R~ 4~, -NR~ 5~-SO~ 2~NR~ 4~, -T-CN, -T-OR~ 4~, -T-OCF~ 3~, -T-NR~ 4~R~ 5~, -T-S(O)~ n~R~ 4~, -T-C(O)R~ 4~, -T-CO~ 2~R~ 4~, -T-O-C(O)R~ 4~, -T-C(O)NR~ 4~R~ 5~, -T-NR~ 4~C(O)R~ 5~, -T-NR~ 4~-SO~ 2~R~ 5~, -R~ 6~, e -T-R~ 6~, em que n, T, R~ 4~, R~ 5~ e R~ 6~ sejam tais como foram definidos na descrição, <sym> R~ 3~ represente um grupo -R~ 7~ ou -U-R~ 11~, nos quais R~ 7~ represente hidrogênio, alquila, arila, cicioalquila ou heterociclo., U represente uma cadeia alquileno linear ou ramificada, e R~ 11~, seja tal como foi definido na descrição, os seus isómeros ópticos ou os seus sais de adição de ácido ou de base aceitáveis do ponto de vista farmacêutico, e a sua utilização na qualidade de inibidores de metaloproteinase, e mais em particular da metaloproteinase-12.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02292037A EP1394159A1 (fr) | 2002-08-13 | 2002-08-13 | Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
PCT/EP2003/008750 WO2004018448A1 (fr) | 2002-08-13 | 2003-08-07 | Nouveaux derives de thiophene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313734A true BR0313734A (pt) | 2005-07-12 |
Family
ID=31197970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313734-1A BR0313734A (pt) | 2002-08-13 | 2003-08-07 | Derivados do tiofeno, o seu processo de preparação e as composições farmacêuticas que os contêm |
Country Status (8)
Country | Link |
---|---|
US (1) | US20040072871A1 (pt) |
EP (2) | EP1394159A1 (pt) |
JP (1) | JP2006504674A (pt) |
AU (1) | AU2003251695A1 (pt) |
BR (1) | BR0313734A (pt) |
CA (1) | CA2497632A1 (pt) |
MX (1) | MXPA05001782A (pt) |
WO (1) | WO2004018448A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1493740A1 (fr) * | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés de 5-fluoro-thiophene, leur procédé de preparation, les compositions pharmaceutiques les contenant et leur utilisation comme inhibiteurs de métalloprotéinases |
RU2391339C2 (ru) * | 2004-08-19 | 2010-06-10 | Квест Фармасьютикал Сёвисес (КьюПиЭс) | 5-[3-(4-бензилоксифенилтио)-фур-2-ил]-имидазолидин-2,4-дион и аналоги в качестве ингибиторов эластазы макрофагов |
JP2009522295A (ja) * | 2005-12-30 | 2009-06-11 | アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド | 置換ビス−アミドメタロプロテアーゼ阻害剤 |
GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
JP5869222B2 (ja) | 2008-01-04 | 2016-02-24 | インテリカイン, エルエルシー | 特定の化学的実体、組成物および方法 |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
US9090584B2 (en) * | 2010-01-26 | 2015-07-28 | Allergan, Inc. | Therapeutic agents for treatment of ocular hypertension |
CA2824197C (en) | 2011-01-10 | 2020-02-25 | Michael Martin | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
MA41253A (fr) * | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
MX2018016227A (es) | 2016-06-24 | 2019-07-08 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
ES2978192T3 (es) | 2018-05-15 | 2024-09-06 | Foresee Pharmaceuticals Usa Inc | Inhibidores de metaloproteinasas de matriz (MMP) y métodos de uso de estos |
TW202345793A (zh) * | 2022-02-15 | 2023-12-01 | 南韓商治納輔醫藥科技有限公司 | 包含抑制前列腺素e2受體之新穎化合物與抗癌藥物的用於治療癌症之藥學組成物 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5425289A (en) * | 1993-10-21 | 1995-06-20 | Snap-On Incorporated | Bung tool |
DE3931432A1 (de) * | 1989-09-21 | 1991-04-04 | Hoechst Ag | Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
US5260323A (en) * | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
GB9424379D0 (en) * | 1994-12-02 | 1995-01-18 | Agrevo Uk Ltd | Fungicides |
US6080767A (en) * | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
CN1088711C (zh) * | 1996-04-04 | 2002-08-07 | 盐野义制药株式会社 | 头孢烯化合物及含该化合物的医药 |
DE19629828A1 (de) * | 1996-07-24 | 1998-01-29 | Bayer Ag | Carbanilide |
US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
US6013664A (en) * | 1996-11-27 | 2000-01-11 | Bayer Aktiengesellschaft | Microbicidal agents based on thiophene-2-carboxylic acid derivatives |
PT853083E (pt) * | 1997-01-06 | 2001-12-28 | Pfizer | Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica |
US6046229A (en) * | 1998-01-06 | 2000-04-04 | Industrial Technology Research Institute | Polyaryl antitumor agents |
CA2321025A1 (en) * | 1998-02-09 | 1999-08-12 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors |
EP1140768A1 (en) * | 1998-12-30 | 2001-10-10 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases |
JP2002534435A (ja) * | 1998-12-31 | 2002-10-15 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | Mmp−12の選択的阻害剤 |
US6410013B1 (en) * | 1999-01-25 | 2002-06-25 | Musc Foundation For Research Development | Viral vectors for use in monitoring HIV drug resistance |
WO2000075129A1 (en) * | 1999-06-07 | 2000-12-14 | Shire Biochem Inc. | Thiophene integrin inhibitors |
MXPA03004926A (es) * | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas. |
DOP2002000333A (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
US6734207B2 (en) * | 2001-04-20 | 2004-05-11 | Parker Hughes Institute | Cytotoxic compounds |
US6924276B2 (en) * | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
EP1434585A1 (en) * | 2001-10-12 | 2004-07-07 | Warner-Lambert Company LLC | Alkyne matrix metalloproteinase inhibitors |
US6933298B2 (en) * | 2001-12-08 | 2005-08-23 | Aventis Pharma Deutschland Gmbh | Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases |
AU2002352443A1 (en) * | 2001-12-21 | 2003-07-15 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
PA8578101A1 (es) * | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
JP2006501215A (ja) * | 2002-08-13 | 2006-01-12 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリックスメタロプロテイナーゼ阻害剤としての単環式誘導体 |
-
2002
- 2002-08-13 EP EP02292037A patent/EP1394159A1/fr not_active Withdrawn
-
2003
- 2003-08-07 EP EP03792270A patent/EP1534700A1/fr not_active Withdrawn
- 2003-08-07 WO PCT/EP2003/008750 patent/WO2004018448A1/fr not_active Application Discontinuation
- 2003-08-07 JP JP2004530099A patent/JP2006504674A/ja active Pending
- 2003-08-07 BR BR0313734-1A patent/BR0313734A/pt not_active Application Discontinuation
- 2003-08-07 MX MXPA05001782A patent/MXPA05001782A/es unknown
- 2003-08-07 AU AU2003251695A patent/AU2003251695A1/en not_active Abandoned
- 2003-08-07 CA CA002497632A patent/CA2497632A1/fr not_active Abandoned
- 2003-08-08 US US10/638,016 patent/US20040072871A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2497632A1 (fr) | 2004-03-04 |
EP1394159A1 (fr) | 2004-03-03 |
AU2003251695A1 (en) | 2004-03-11 |
EP1534700A1 (fr) | 2005-06-01 |
WO2004018448A1 (fr) | 2004-03-04 |
US20040072871A1 (en) | 2004-04-15 |
MXPA05001782A (es) | 2005-04-25 |
JP2006504674A (ja) | 2006-02-09 |
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