JP2010532340A5 - - Google Patents
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- Publication number
- JP2010532340A5 JP2010532340A5 JP2010514144A JP2010514144A JP2010532340A5 JP 2010532340 A5 JP2010532340 A5 JP 2010532340A5 JP 2010514144 A JP2010514144 A JP 2010514144A JP 2010514144 A JP2010514144 A JP 2010514144A JP 2010532340 A5 JP2010532340 A5 JP 2010532340A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- compounds
- present
- examples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 150000001875 compounds Chemical class 0.000 description 7
- 238000000034 method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000007257 deesterification reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94801207P | 2007-07-05 | 2007-07-05 | |
| US60/948,012 | 2007-07-05 | ||
| PCT/GB2008/050525 WO2009004379A1 (en) | 2007-07-05 | 2008-07-01 | Novel compounds 951: a biphenyloxypropanoic acid as crth2 modulator and intermediates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532340A JP2010532340A (ja) | 2010-10-07 |
| JP2010532340A5 true JP2010532340A5 (enExample) | 2011-07-28 |
| JP5368438B2 JP5368438B2 (ja) | 2013-12-18 |
Family
ID=39942682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514144A Expired - Fee Related JP5368438B2 (ja) | 2007-07-05 | 2008-07-01 | 新規化合物９５１：ｃｒｔｈ２モジュレーターとしてのビフェニルオキシプロパン酸および中間体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8507544B2 (enExample) |
| EP (1) | EP2173730B1 (enExample) |
| JP (1) | JP5368438B2 (enExample) |
| KR (1) | KR20100039326A (enExample) |
| CN (1) | CN101796042B (enExample) |
| AR (1) | AR067461A1 (enExample) |
| AU (1) | AU2008272690B2 (enExample) |
| BR (1) | BRPI0813992A2 (enExample) |
| CA (1) | CA2691615A1 (enExample) |
| CL (1) | CL2008001982A1 (enExample) |
| CO (1) | CO6270211A2 (enExample) |
| CY (1) | CY1114804T1 (enExample) |
| DK (1) | DK2173730T3 (enExample) |
| EC (1) | ECSP109848A (enExample) |
| ES (1) | ES2442523T3 (enExample) |
| HR (1) | HRP20140004T1 (enExample) |
| MY (1) | MY153957A (enExample) |
| NZ (1) | NZ582192A (enExample) |
| PE (2) | PE20090475A1 (enExample) |
| PL (1) | PL2173730T3 (enExample) |
| PT (1) | PT2173730E (enExample) |
| RS (1) | RS53129B (enExample) |
| SA (1) | SA08290406B1 (enExample) |
| SI (1) | SI2173730T1 (enExample) |
| TW (1) | TWI453017B (enExample) |
| UA (1) | UA100983C2 (enExample) |
| UY (1) | UY31208A1 (enExample) |
| WO (1) | WO2009004379A1 (enExample) |
| ZA (1) | ZA200909226B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| AR051966A1 (es) | 2004-11-23 | 2007-02-21 | Astrazeneca Ab | Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias |
| WO2007039736A1 (en) | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| JP2009514935A (ja) * | 2005-11-05 | 2009-04-09 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| EP2305640A3 (en) * | 2005-12-15 | 2011-07-20 | AstraZeneca AB | Substituted diphenyl-ethers, -amines, -sulfides and -methanes for the treatment of respiratory diseases |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| JP5491416B2 (ja) | 2008-02-01 | 2014-05-14 | パンミラ ファーマシューティカルズ，エルエルシー． | プロスタグランジンｄ２受容体のｎ，ｎ−２置換アミノアルキルビフェニルアンタゴニスト |
| JP2011513242A (ja) | 2008-02-25 | 2011-04-28 | アミラ ファーマシューティカルズ，インク． | プロスタグランジンｄ２受容体アンタゴニスト |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| US8378107B2 (en) | 2008-10-01 | 2013-02-19 | Panmira Pharmaceuticals, Llc | Heteroaryl antagonists of prostaglandin D2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
| WO2011014587A2 (en) | 2009-07-31 | 2011-02-03 | Amira Pharmaceuticals, Inc. | Ophthalmic pharmaceutical compositions of dp2 receptor antagonists |
| WO2011017201A2 (en) | 2009-08-05 | 2011-02-10 | Amira Pharmaceuticals, Inc. | Dp2 antagonist and uses thereof |
| KR101920090B1 (ko) | 2010-07-05 | 2018-11-19 | 이도르시아 파마슈티컬스 리미티드 | 1-페닐-치환된 헤테로시클릴 유도체 및 프로스타글란딘 ｄ２ 수용체 조절자로서 이의 용도 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| ES2624379T3 (es) | 2011-12-21 | 2017-07-14 | Idorsia Pharmaceuticals Ltd | Derivados de heterociclilo y su uso como moduladores del receptor de prostaglandina D2 |
| CN104428305A (zh) | 2012-07-05 | 2015-03-18 | 埃科特莱茵药品有限公司 | 1-苯基-取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途 |
| KR101538846B1 (ko) | 2013-07-30 | 2015-07-22 | 동아에스티 주식회사 | 신규한 바이페닐 유도체 및 그의 제조방법 |
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| US3278524A (en) | 1962-03-13 | 1966-10-11 | Beecham Group Ltd | Penicillins and their production |
| CH432119A (de) | 1963-02-22 | 1967-03-15 | Geigy Ag J R | Verwendung von Halogen-o-hydroxy-diphenyläthern als antimikrobielle Mittel |
| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| DD113545A5 (enExample) | 1973-03-30 | 1975-06-12 | ||
| JPS5239888B2 (enExample) | 1973-05-28 | 1977-10-07 | ||
| CH582476A5 (enExample) | 1973-10-29 | 1976-12-15 | Ciba Geigy Ag | |
| GB1585963A (en) | 1976-10-14 | 1981-03-11 | Lilly Industries Ltd | Aryl sulphur compounds |
| JPS5951943B2 (ja) | 1978-08-21 | 1984-12-17 | キツセイ薬品工業株式会社 | 新規なイミダゾ−ル誘導体 |
| GB2041363B (en) | 1979-01-19 | 1982-10-06 | Pfizer Ltd | N-benzyl-imidazoles |
| US4670566A (en) | 1979-07-12 | 1987-06-02 | A. H. Robins Company, Incorporated | 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones |
| US4486593A (en) | 1983-01-19 | 1984-12-04 | The Upjohn Company | 2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors |
| US5006542A (en) | 1988-10-31 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use |
| US5145790A (en) | 1990-05-04 | 1992-09-08 | Abbott Laboratories | Reagents and method for detecting polychlorinated biphenyls |
| EP0540165A1 (en) | 1991-10-03 | 1993-05-05 | Zeneca Limited | Alkanoic acid derivatives |
| WO1993012086A1 (fr) | 1991-12-11 | 1993-06-24 | Ss Pharmaceutical Co., Ltd. | Derive d'arylamide |
| CA2090283A1 (en) | 1992-02-28 | 1993-08-29 | Nobuyuki Hamanaka | Phenoxyacetic acid derivatives |
| DE69329894T2 (de) | 1992-12-08 | 2001-05-03 | Ss Pharmaceutical Co., Ltd. | Arylamidderivate |
| JPH06313995A (ja) | 1993-04-28 | 1994-11-08 | Hodogaya Chem Co Ltd | 静電荷像現像用トナー |
| JPH07140725A (ja) | 1993-06-25 | 1995-06-02 | Hodogaya Chem Co Ltd | 負帯電性トナー用摩擦帯電付与部材 |
| NZ313896A (en) | 1995-08-28 | 2000-08-25 | American Home Prod | 4-formyl-2-(naphthalenylmethyl)phenoxyacetic acids or salts and antihyperglycemic agents for the treatment of diabetes mellitus |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | ４―アニリノキナゾリン誘導体 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| EP0839808A1 (en) | 1996-10-29 | 1998-05-06 | Novartis AG | Pyrazole derivatives, processes for their preparation, and their use as herbicides |
| FR2763588B1 (fr) | 1997-05-23 | 1999-07-09 | Cird Galderma | Composes triaromatiques, compositions les contenant et utilisations |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| US5942532A (en) | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| ATE273279T1 (de) | 1997-09-12 | 2004-08-15 | Merck Frosst Canada Inc | 2,3,5-trisubstituierte pyridine als inhibitoren von cyclooxygenase-2 |
| AU735737B2 (en) | 1997-10-14 | 2001-07-12 | Asahi Kasei Kabushiki Kaisha | Biphenyl-5-alkanoic acid derivatives and use thereof |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EP1211513B1 (en) | 1999-08-23 | 2006-01-04 | BML, Inc. | Method of identifying modulators of prostaglandin d2 receptors |
| AU7073400A (en) | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| CA2400021A1 (en) | 2000-02-18 | 2001-08-23 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| EP1278734A2 (en) | 2000-04-24 | 2003-01-29 | Merck Frosst Canada & Co. | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore |
| IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| IL153688A0 (en) | 2000-06-28 | 2003-07-06 | Teva Pharma | Carvedilol |
| CA2410562A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| US20040097555A1 (en) | 2000-12-26 | 2004-05-20 | Shinegori Ohkawa | Concomitant drugs |
| US7067507B2 (en) | 2001-06-12 | 2006-06-27 | Pharmacia & Upjohn Company | Macrocycles useful in the treatment of Alzheimer's disease |
| MXPA04007414A (es) | 2002-02-01 | 2004-10-11 | Hoffmann La Roche | Indoles sustituidos como agonistas alfa-1. |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| AU2003211427A1 (en) | 2002-02-18 | 2003-09-04 | Ishihara Sangyo Kaisha, Ltd. | Pyridine derivatives or salts thereof and cytokine production inhibitors containing the same |
| AU2003237787B2 (en) | 2002-03-20 | 2008-12-18 | Metabolex, Inc. | Substituted phenylacetic acids |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| CA2511214C (en) | 2002-12-20 | 2012-12-18 | Tularik, Inc. | Asthma and allergic inflammation modulators |
| CN1768040A (zh) | 2003-03-28 | 2006-05-03 | 伊莱利利公司 | 作为akt(蛋白激酶b)抑制剂的异喹啉－5－磺酸酰胺 |
| SE0301009D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| ES2257616T3 (es) | 2003-04-25 | 2006-08-01 | Actimis Pharmaceuticals, Inc. | Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2. |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
| US8022063B2 (en) | 2004-05-29 | 2011-09-20 | 7Tm Pharma A/S | CRTH2 receptor ligands for medicinal uses |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) * | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| AR051966A1 (es) | 2004-11-23 | 2007-02-21 | Astrazeneca Ab | Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007039736A1 (en) | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
| JP2009514935A (ja) | 2005-11-05 | 2009-04-09 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| EP2305640A3 (en) | 2005-12-15 | 2011-07-20 | AstraZeneca AB | Substituted diphenyl-ethers, -amines, -sulfides and -methanes for the treatment of respiratory diseases |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
-
2008
- 2008-01-07 UA UAA200913443A patent/UA100983C2/ru unknown
- 2008-07-01 WO PCT/GB2008/050525 patent/WO2009004379A1/en not_active Ceased
- 2008-07-01 HR HRP20140004AT patent/HRP20140004T1/hr unknown
- 2008-07-01 JP JP2010514144A patent/JP5368438B2/ja not_active Expired - Fee Related
- 2008-07-01 RS RS20140008A patent/RS53129B/sr unknown
- 2008-07-01 PT PT87761649T patent/PT2173730E/pt unknown
- 2008-07-01 BR BRPI0813992A patent/BRPI0813992A2/pt not_active IP Right Cessation
- 2008-07-01 ES ES08776164.9T patent/ES2442523T3/es active Active
- 2008-07-01 CA CA002691615A patent/CA2691615A1/en not_active Abandoned
- 2008-07-01 KR KR1020107000017A patent/KR20100039326A/ko not_active Abandoned
- 2008-07-01 CN CN2008801056933A patent/CN101796042B/zh not_active Expired - Fee Related
- 2008-07-01 SI SI200831132T patent/SI2173730T1/sl unknown
- 2008-07-01 AU AU2008272690A patent/AU2008272690B2/en not_active Ceased
- 2008-07-01 MY MYPI2010000009A patent/MY153957A/en unknown
- 2008-07-01 NZ NZ582192A patent/NZ582192A/en not_active IP Right Cessation
- 2008-07-01 PL PL08776164T patent/PL2173730T3/pl unknown
- 2008-07-01 EP EP08776164.9A patent/EP2173730B1/en active Active
- 2008-07-01 DK DK08776164.9T patent/DK2173730T3/da active
- 2008-07-03 US US12/167,513 patent/US8507544B2/en not_active Expired - Fee Related
- 2008-07-04 PE PE2008001135A patent/PE20090475A1/es not_active Application Discontinuation
- 2008-07-04 UY UY31208A patent/UY31208A1/es not_active Application Discontinuation
- 2008-07-04 TW TW097125273A patent/TWI453017B/zh not_active IP Right Cessation
- 2008-07-04 CL CL2008001982A patent/CL2008001982A1/es unknown
- 2008-07-04 PE PE2012000994A patent/PE20121515A1/es not_active Application Discontinuation
- 2008-07-05 SA SA8290406A patent/SA08290406B1/ar unknown
- 2008-07-07 AR ARP080102918A patent/AR067461A1/es unknown
-
2009
- 2009-12-23 ZA ZA2009/09226A patent/ZA200909226B/en unknown
-
2010
- 2010-01-05 EC EC2010009848A patent/ECSP109848A/es unknown
- 2010-01-06 CO CO10001081A patent/CO6270211A2/es active IP Right Grant
-
2014
- 2014-01-15 CY CY20141100033T patent/CY1114804T1/el unknown
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