DE60300986D1 - Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) - Google Patents
Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron)Info
- Publication number
- DE60300986D1 DE60300986D1 DE60300986T DE60300986T DE60300986D1 DE 60300986 D1 DE60300986 D1 DE 60300986D1 DE 60300986 T DE60300986 T DE 60300986T DE 60300986 T DE60300986 T DE 60300986T DE 60300986 D1 DE60300986 D1 DE 60300986D1
- Authority
- DE
- Germany
- Prior art keywords
- granisetron
- preparing
- compound
- formula
- active compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 title abstract 3
- 229960003727 granisetron Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 230000011987 methylation Effects 0.000 abstract 2
- 238000007069 methylation reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200200713A ES2197001B1 (es) | 2002-03-26 | 2002-03-26 | Procedimiento de obtencion de un compuesto farmaceuticamente activo. |
| PCT/IB2003/001058 WO2003080606A1 (en) | 2002-03-26 | 2003-03-21 | Process for preparing a pharmaceutically active compound (granisetron) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60300986D1 true DE60300986D1 (de) | 2005-08-11 |
Family
ID=28051970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60300986T Expired - Lifetime DE60300986D1 (de) | 2002-03-26 | 2003-03-21 | Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7071209B2 (de) |
| EP (1) | EP1487833B1 (de) |
| JP (1) | JP4560293B2 (de) |
| KR (1) | KR100835553B1 (de) |
| AT (1) | ATE299144T1 (de) |
| AU (1) | AU2003208552A1 (de) |
| CA (1) | CA2481703A1 (de) |
| DE (1) | DE60300986D1 (de) |
| ES (1) | ES2197001B1 (de) |
| IL (1) | IL164742A0 (de) |
| PL (1) | PL211464B1 (de) |
| PT (1) | PT1487833E (de) |
| TW (1) | TWI291959B (de) |
| WO (1) | WO2003080606A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL210065B1 (pl) | 2002-09-25 | 2011-11-30 | Memory Pharm Corp | Związki indazole, benzotiazole i benzoizotiazole, kompozycje farmaceutyczne je zawierające oraz zastosowanie związków |
| JP4824578B2 (ja) | 2003-12-22 | 2011-11-30 | メモリー・ファーマシューティカルズ・コーポレイション | インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用 |
| KR101176670B1 (ko) | 2004-03-25 | 2012-08-23 | 메모리 파마슈티칼스 코포레이션 | 인다졸, 벤조티아졸, 벤조이소티아졸, 벤즈이속사졸, 및그의 제조법 및 용도 |
| EP1742944B1 (de) | 2004-04-22 | 2010-11-10 | Memory Pharmaceuticals Corporation | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen |
| WO2005111038A2 (en) | 2004-05-07 | 2005-11-24 | Memory Pharmaceuticals Corporation | 1h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
| AU2005319248A1 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| CA2613303C (en) * | 2005-07-11 | 2012-06-19 | Mitsubishi Tanabe Pharma Corporation | An oxime derivative for use as a glucokinase activator |
| US8911751B2 (en) | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
| US20080242696A1 (en) * | 2007-03-27 | 2008-10-02 | Chemagis Ltd. | Crystalline granisetron base and production process therefor |
| EP2164848B1 (de) | 2007-06-13 | 2016-02-24 | Inke, S.A. | Polymorphe form von granisetronbase, verfahren zu deren gewinnung und formulierung, die diese enthält |
| CN102131506B (zh) * | 2008-08-19 | 2013-07-24 | 台湾神隆股份有限公司 | 盐酸格拉司琼的多晶型和其制备方法 |
| US20120101089A1 (en) * | 2010-10-26 | 2012-04-26 | Ashwani Agarwal | Anti-Emetic Substance |
| CN112778203B (zh) * | 2021-01-29 | 2022-02-15 | 兰州交通大学 | 1h-吲唑-3-羧酸衍生物及格拉斯琼和氯尼达明的制备方法 |
| CN115372487B (zh) * | 2021-05-18 | 2023-10-10 | 成都倍特得诺药业有限公司 | 盐酸格拉司琼中杂质e的hplc测定方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3687080T2 (de) * | 1985-04-27 | 1993-03-25 | Beecham Group Plc | Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung. |
| GB9404055D0 (en) * | 1994-03-03 | 1994-04-20 | Smithkline Beecham Plc | Novel process |
| GB9602862D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
| GB9602866D0 (en) * | 1996-02-13 | 1996-04-10 | Smithkline Beecham Plc | Novel process |
-
2002
- 2002-03-26 ES ES200200713A patent/ES2197001B1/es not_active Expired - Fee Related
-
2003
- 2003-03-21 PL PL374447A patent/PL211464B1/pl not_active IP Right Cessation
- 2003-03-21 US US10/508,493 patent/US7071209B2/en not_active Expired - Fee Related
- 2003-03-21 AU AU2003208552A patent/AU2003208552A1/en not_active Abandoned
- 2003-03-21 CA CA002481703A patent/CA2481703A1/en not_active Abandoned
- 2003-03-21 AT AT03706845T patent/ATE299144T1/de not_active IP Right Cessation
- 2003-03-21 DE DE60300986T patent/DE60300986D1/de not_active Expired - Lifetime
- 2003-03-21 JP JP2003578360A patent/JP4560293B2/ja not_active Expired - Fee Related
- 2003-03-21 EP EP03706845A patent/EP1487833B1/de not_active Expired - Lifetime
- 2003-03-21 WO PCT/IB2003/001058 patent/WO2003080606A1/en active IP Right Grant
- 2003-03-21 PT PT03706845T patent/PT1487833E/pt unknown
- 2003-03-21 KR KR1020047015135A patent/KR100835553B1/ko not_active IP Right Cessation
- 2003-03-26 TW TW092106806A patent/TWI291959B/zh active
-
2004
- 2004-10-20 IL IL16474204A patent/IL164742A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL211464B1 (pl) | 2012-05-31 |
| PL374447A1 (en) | 2005-10-17 |
| US20050124650A1 (en) | 2005-06-09 |
| KR20040099361A (ko) | 2004-11-26 |
| ES2197001A1 (es) | 2003-12-16 |
| JP2006511439A (ja) | 2006-04-06 |
| WO2003080606A8 (en) | 2005-03-17 |
| TWI291959B (en) | 2008-01-01 |
| EP1487833A1 (de) | 2004-12-22 |
| KR100835553B1 (ko) | 2008-06-09 |
| JP4560293B2 (ja) | 2010-10-13 |
| CA2481703A1 (en) | 2003-10-02 |
| TW200305572A (en) | 2003-11-01 |
| ATE299144T1 (de) | 2005-07-15 |
| IL164742A0 (en) | 2005-12-18 |
| ES2197001B1 (es) | 2004-11-16 |
| US7071209B2 (en) | 2006-07-04 |
| WO2003080606A1 (en) | 2003-10-02 |
| AU2003208552A1 (en) | 2003-10-08 |
| EP1487833B1 (de) | 2005-07-06 |
| PT1487833E (pt) | 2005-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |