JP2008540628A5 - - Google Patents

Info

Publication number

JP2008540628A5

JP2008540628A5 JP2008511798A JP2008511798A JP2008540628A5 JP 2008540628 A5 JP2008540628 A5 JP 2008540628A5 JP 2008511798 A JP2008511798 A JP 2008511798A JP 2008511798 A JP2008511798 A JP 2008511798A JP 2008540628 A5 JP2008540628 A5 JP 2008540628A5

Authority

JP

Japan

Prior art keywords

formula

compound

alkyl

hydroxyl

amino

Prior art date

2006-05-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 9
• 125000000217 alkyl group Chemical group 0.000 claims 7
• 125000005843 halogen group Chemical group 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 150000001412 amines Chemical class 0.000 claims 2
• -1 amino, hydroxyl Chemical group 0.000 claims 2
• 150000002009 diols Chemical class 0.000 claims 2
• 239000002798 polar solvent Substances 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 150000003212 purines Chemical class 0.000 claims 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical class C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
• 239000003054 catalyst Substances 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• 125000006575 electron-withdrawing group Chemical group 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 229960004396 famciclovir Drugs 0.000 claims 1
• GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims 1
• 125000001475 halogen functional group Chemical group 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 238000005984 hydrogenation reaction Methods 0.000 claims 1
• 239000003960 organic solvent Substances 0.000 claims 1
• 229940083251 peripheral vasodilators purine derivative Drugs 0.000 claims 1
• 150000003512 tertiary amines Chemical class 0.000 claims 1
• 0 *CC(C*)*[n]1c2nc(*)ncc2nc1 Chemical compound *CC(C*)*[n]1c2nc(*)ncc2nc1 0.000 description 6