CN101796042B - 新型化合物951: 作为crth2调节剂的联苯氧基丙酸和中间体 - Google Patents
新型化合物951: 作为crth2调节剂的联苯氧基丙酸和中间体 Download PDFInfo
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- CN101796042B CN101796042B CN2008801056933A CN200880105693A CN101796042B CN 101796042 B CN101796042 B CN 101796042B CN 2008801056933 A CN2008801056933 A CN 2008801056933A CN 200880105693 A CN200880105693 A CN 200880105693A CN 101796042 B CN101796042 B CN 101796042B
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- chloro
- carbonyl
- dimethylpyrrolidin
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- AFIDJUXVZLKEJK-UHFFFAOYSA-N CC(C(O)=O)Oc(c(-c(cc1)cc(Cl)c1C(N1C(C)(C)CCC1)=O)c1)ccc1F Chemical compound CC(C(O)=O)Oc(c(-c(cc1)cc(Cl)c1C(N1C(C)(C)CCC1)=O)c1)ccc1F AFIDJUXVZLKEJK-UHFFFAOYSA-N 0.000 description 1
- VAUBQKAOBVDEAS-UHFFFAOYSA-N CC(C1)C1c(cc(cc1)-c2cc(F)ccc2O)c1C(N1C(C)(C)CCC1)=O Chemical compound CC(C1)C1c(cc(cc1)-c2cc(F)ccc2O)c1C(N1C(C)(C)CCC1)=O VAUBQKAOBVDEAS-UHFFFAOYSA-N 0.000 description 1
- HKFYFTYEUVRWCI-UHFFFAOYSA-N CCCCCN(CC)C(c(ccc(-c1cc(F)ccc1O)c1)c1Cl)=C Chemical compound CCCCCN(CC)C(c(ccc(-c1cc(F)ccc1O)c1)c1Cl)=C HKFYFTYEUVRWCI-UHFFFAOYSA-N 0.000 description 1
- DTHZKUZAGBIMKR-KRWDZBQOSA-N CCCCCN(CC)C(c(ccc(-c1cc(F)ccc1O[C@@H](C)C(O)=O)c1)c1Cl)=C Chemical compound CCCCCN(CC)C(c(ccc(-c1cc(F)ccc1O[C@@H](C)C(O)=O)c1)c1Cl)=C DTHZKUZAGBIMKR-KRWDZBQOSA-N 0.000 description 1
- CRQCHEZMUOTMFZ-UHFFFAOYSA-N COc(c(-c(cc1)cc(Cl)c1C(O)=O)c1)ccc1F Chemical compound COc(c(-c(cc1)cc(Cl)c1C(O)=O)c1)ccc1F CRQCHEZMUOTMFZ-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94801207P | 2007-07-05 | 2007-07-05 | |
| US60/948,012 | 2007-07-05 | ||
| PCT/GB2008/050525 WO2009004379A1 (en) | 2007-07-05 | 2008-07-01 | Novel compounds 951: a biphenyloxypropanoic acid as crth2 modulator and intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101796042A CN101796042A (zh) | 2010-08-04 |
| CN101796042B true CN101796042B (zh) | 2013-05-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801056933A Expired - Fee Related CN101796042B (zh) | 2007-07-05 | 2008-07-01 | 新型化合物951: 作为crth2调节剂的联苯氧基丙酸和中间体 |
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| HR (1) | HRP20140004T1 (enExample) |
| MY (1) | MY153957A (enExample) |
| NZ (1) | NZ582192A (enExample) |
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| UA (1) | UA100983C2 (enExample) |
| UY (1) | UY31208A1 (enExample) |
| WO (1) | WO2009004379A1 (enExample) |
| ZA (1) | ZA200909226B (enExample) |
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| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) * | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| JP5208510B2 (ja) | 2004-11-23 | 2013-06-12 | アストラゼネカ・アクチエボラーグ | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| US20080255150A1 (en) * | 2005-11-05 | 2008-10-16 | Astrazeneca Ab | Novel Compounds |
| EP1963259B1 (en) * | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| BRPI0907364A2 (pt) | 2008-02-01 | 2015-07-14 | Amira Pharmaceuticals Inc | Antagonistas aminoalquilbifenil n,n-disubstituídos de receptores d2 de prostaglandina |
| WO2009108720A2 (en) | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| US8378107B2 (en) | 2008-10-01 | 2013-02-19 | Panmira Pharmaceuticals, Llc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
| GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
| EP2461809A4 (en) | 2009-07-31 | 2013-06-19 | Panmira Pharmaceuticals Llc | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONSITES |
| EP2462110A4 (en) | 2009-08-05 | 2013-04-03 | Panmira Pharmaceuticals Llc | DP2 ANTAGONIST AND USES THEREOF |
| JP5800898B2 (ja) | 2010-07-05 | 2015-10-28 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | 1−フェニル−置換ヘテロシクリル誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| RU2014129613A (ru) | 2011-12-21 | 2016-02-10 | Актелион Фармасьютиклз Лтд | Гетероциклильные производные и их применение в качестве модуляторов рецептора простагландина d2 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1791572A (zh) * | 2003-04-07 | 2006-06-21 | 阿斯利康(瑞典)有限公司 | 新化合物 |
| CN101048369A (zh) * | 2004-08-24 | 2007-10-03 | 阿斯利康(瑞典)有限公司 | 用于治疗呼吸系统疾病的联苯基氧基乙酸衍生物 |
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