AR030609A1 - Composicion catartica - Google Patents

Composicion catartica

Info

Publication number
AR030609A1
AR030609A1 ARP010104216A ARP010104216A AR030609A1 AR 030609 A1 AR030609 A1 AR 030609A1 AR P010104216 A ARP010104216 A AR P010104216A AR P010104216 A ARP010104216 A AR P010104216A AR 030609 A1 AR030609 A1 AR 030609A1
Authority
AR
Argentina
Prior art keywords
composition
catartic
constipation
halogenated
bicyclic compound
Prior art date
Application number
ARP010104216A
Other languages
English (en)
Original Assignee
Sucampo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24630250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR030609(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sucampo Pharmaceuticals Inc filed Critical Sucampo Pharmaceuticals Inc
Publication of AR030609A1 publication Critical patent/AR030609A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

Un objeto de la presente invencion consiste en proveer una composicion contra la constipacion que contenga un compuesto bicíclico halogenado como ingrediente activo en una relacion de estructura bicíclica/monocíclica de al menos 1 : 1. El compuesto bicíclico halogenado se representa por medio de la formula (1) donde X1 y X2 son preferentemente átomos de fluor. La composicion puede utilizarse para tratar la constipacion sin importantes efectos colaterales, tales como dolor de estomago.
ARP010104216A 2000-09-05 2001-09-05 Composicion catartica AR030609A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/655,760 US6414016B1 (en) 2000-09-05 2000-09-05 Anti-constipation composition

Publications (1)

Publication Number Publication Date
AR030609A1 true AR030609A1 (es) 2003-08-27

Family

ID=24630250

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP010104216A AR030609A1 (es) 2000-09-05 2001-09-05 Composicion catartica
ARP130103006A AR100291A2 (es) 2000-09-05 2013-08-26 Composición catártica

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP130103006A AR100291A2 (es) 2000-09-05 2013-08-26 Composición catártica

Country Status (25)

Country Link
US (7) US6414016B1 (es)
EP (2) EP1857105B1 (es)
JP (3) JP2004508327A (es)
KR (2) KR100918223B1 (es)
CN (1) CN100335049C (es)
AR (2) AR030609A1 (es)
AT (1) ATE476975T1 (es)
AU (2) AU2001282615B2 (es)
BR (1) BRPI0114042B8 (es)
CA (1) CA2419741C (es)
CZ (1) CZ304740B6 (es)
DE (2) DE60131547T2 (es)
DK (2) DK1315485T3 (es)
ES (2) ES2347697T3 (es)
HU (1) HU229319B1 (es)
IL (2) IL154534A0 (es)
MX (1) MXPA03001959A (es)
NL (1) NL300757I2 (es)
NO (1) NO332701B1 (es)
NZ (1) NZ524401A (es)
PT (2) PT1857105E (es)
RU (1) RU2694361C3 (es)
TW (1) TWI305147B (es)
WO (1) WO2002020007A1 (es)
ZA (1) ZA200301673B (es)

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US6414016B1 (en) * 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
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AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
US7732487B2 (en) * 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
PT1562604E (pt) * 2002-10-23 2012-04-09 Sucampo Ag Compostos de prostaglandina para o tratamento de obesidade
CA2510051C (en) * 2002-12-27 2016-07-05 Sucampo Ag Derivatives of prostaglandins for treating abdominal discomfort
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
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US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
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EP1871380B1 (en) * 2005-04-12 2011-10-19 Sucampo AG Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
BRPI0707333B8 (pt) * 2006-01-24 2021-05-25 R Tech Ueno Ltd composição farmacêutica que compreende um composto bicíclico, método de estabilização do composto bicíclico e formulação de cápsula de gelatina mole
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US20090030072A1 (en) * 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20090082442A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched lubiprostone
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CN102245176B (zh) * 2008-10-31 2015-05-27 脂质医药有限公司 用作药物的脂肪酸
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
MX345283B (es) 2008-12-31 2017-01-24 Ardelyx Inc Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.
US9382272B2 (en) 2009-01-22 2016-07-05 Apotex Pharmachem Inc. Methods of making lubiprostone and intermediates thereof
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
TW201118084A (en) * 2009-09-18 2011-06-01 Adolor Corp The use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders
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Also Published As

Publication number Publication date
US8071613B2 (en) 2011-12-06
AU8261501A (en) 2002-03-22
CZ304740B6 (cs) 2014-09-17
EP1315485B1 (en) 2007-11-21
CA2419741A1 (en) 2002-03-14
IL154534A0 (en) 2003-09-17
US20030040528A1 (en) 2003-02-27
KR20080091278A (ko) 2008-10-09
NO20030996D0 (no) 2003-03-04
KR20030029919A (ko) 2003-04-16
US20050222195A1 (en) 2005-10-06
US6610732B2 (en) 2003-08-26
NL300757I1 (es) 2015-12-29
NZ524401A (en) 2004-08-27
NL300757I2 (es) 2015-12-29
ES2347697T3 (es) 2010-11-03
IL154534A (en) 2010-04-29
RU2694361C2 (ru) 2019-07-12
ATE476975T1 (de) 2010-08-15
US20120237598A1 (en) 2012-09-20
CN100335049C (zh) 2007-09-05
DE60131547T2 (de) 2008-10-23
US20030216465A1 (en) 2003-11-20
EP1857105A2 (en) 2007-11-21
KR100918223B1 (ko) 2009-09-21
CA2419741C (en) 2010-11-30
MXPA03001959A (es) 2003-06-24
RU2694361C3 (ru) 2020-07-20
RU2694361C9 (ru) 2019-12-25
DK1857105T3 (da) 2010-09-20
AR100291A2 (es) 2016-09-28
US8748454B2 (en) 2014-06-10
JP4684334B2 (ja) 2011-05-18
EP1857105B1 (en) 2010-08-11
BR0114042A (pt) 2003-07-22
HU229319B1 (en) 2013-10-28
JP2004508327A (ja) 2004-03-18
US8114890B1 (en) 2012-02-14
CN1655776A (zh) 2005-08-17
PT1315485E (pt) 2008-01-23
BRPI0114042B1 (pt) 2016-11-08
EP1857105A3 (en) 2008-03-05
KR100901102B1 (ko) 2009-06-08
DK1315485T3 (da) 2008-03-03
ES2296786T3 (es) 2008-05-01
PT1857105E (pt) 2010-10-08
JP2009286806A (ja) 2009-12-10
DE60131547D1 (de) 2008-01-03
NO20030996L (no) 2003-05-02
JP2009114217A (ja) 2009-05-28
US20140235665A1 (en) 2014-08-21
NO332701B1 (no) 2012-12-10
US20120022152A1 (en) 2012-01-26
TWI305147B (en) 2009-01-11
BRPI0114042B8 (pt) 2021-05-25
US6414016B1 (en) 2002-07-02
WO2002020007A1 (en) 2002-03-14
ZA200301673B (en) 2003-11-26
AU2001282615B2 (en) 2006-06-22
EP1315485A1 (en) 2003-06-04
DE60142810D1 (de) 2010-09-23
HUP0302422A2 (hu) 2003-10-28
HUP0302422A3 (en) 2005-02-28

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