JP2009513713A5 - - Google Patents
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- Publication number
- JP2009513713A5 JP2009513713A5 JP2008538997A JP2008538997A JP2009513713A5 JP 2009513713 A5 JP2009513713 A5 JP 2009513713A5 JP 2008538997 A JP2008538997 A JP 2008538997A JP 2008538997 A JP2008538997 A JP 2008538997A JP 2009513713 A5 JP2009513713 A5 JP 2009513713A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor compound
- composition
- group
- composition according
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 147
- 150000001875 compounds Chemical class 0.000 claims 124
- 239000012826 P38 inhibitor Substances 0.000 claims 119
- 229910052739 hydrogen Inorganic materials 0.000 claims 75
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 45
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 30
- 125000003545 alkoxy group Chemical group 0.000 claims 22
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 20
- 125000001475 halogen functional group Chemical group 0.000 claims 20
- 229920001282 polysaccharide Polymers 0.000 claims 19
- 239000005017 polysaccharide Substances 0.000 claims 19
- 229920001542 oligosaccharide Polymers 0.000 claims 18
- 125000003342 alkenyl group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000001188 haloalkyl group Chemical group 0.000 claims 15
- -1 hydrate Substances 0.000 claims 15
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 15
- 125000004971 nitroalkyl group Chemical group 0.000 claims 15
- 125000000547 substituted alkyl group Chemical group 0.000 claims 15
- 125000004001 thioalkyl group Chemical group 0.000 claims 15
- 239000007963 capsule composition Substances 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 230000005764 inhibitory process Effects 0.000 claims 10
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 10
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 10
- 206010003119 arrhythmia Diseases 0.000 claims 9
- 230000006793 arrhythmia Effects 0.000 claims 9
- 239000002775 capsule Substances 0.000 claims 9
- 239000003826 tablet Substances 0.000 claims 9
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 210000001124 body fluid Anatomy 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 5
- 230000000004 hemodynamic effect Effects 0.000 claims 5
- 239000002207 metabolite Substances 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 5
- 229960003073 pirfenidone Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 239000007916 tablet composition Substances 0.000 claims 4
- 239000010839 body fluid Substances 0.000 claims 3
- 206010061592 cardiac fibrillation Diseases 0.000 claims 3
- 230000002600 fibrillogenic effect Effects 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 230000001746 atrial effect Effects 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000033764 rhythmic process Effects 0.000 claims 2
- 208000020446 Cardiac disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 230000001010 compromised effect Effects 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 *c(cc1)ccc1N(C=C(*)C=C1*)C1=O Chemical compound *c(cc1)ccc1N(C=C(*)C=C1*)C1=O 0.000 description 7
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73267605P | 2005-11-01 | 2005-11-01 | |
| PCT/US2006/042653 WO2007053685A2 (en) | 2005-11-01 | 2006-11-01 | Methods of treating atrial fibrillation with p38 inhibitor compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513713A JP2009513713A (ja) | 2009-04-02 |
| JP2009513713A5 true JP2009513713A5 (enExample) | 2009-10-15 |
Family
ID=38006459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538997A Pending JP2009513713A (ja) | 2005-11-01 | 2006-11-01 | ｐ３８阻害剤化合物による心房細動の治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20100029578A1 (enExample) |
| EP (1) | EP1948178A4 (enExample) |
| JP (1) | JP2009513713A (enExample) |
| CA (1) | CA2627547A1 (enExample) |
| WO (2) | WO2007053610A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0608907A2 (pt) | 2005-05-10 | 2010-02-17 | Itermune Inc | método de modulação de sistema de proteìna cinase ativada por estresse |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| US20110313004A1 (en) | 2008-12-04 | 2011-12-22 | Concert Pharmaceuticals, Inc. | Deuterated pyridinones |
| WO2010085805A1 (en) * | 2009-01-26 | 2010-07-29 | Intermune, Inc. | Methods for treating acute myocardial infarctions and associated disorders |
| EP2436670B1 (en) | 2009-05-25 | 2014-04-16 | Central South University | Preparation of 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and salts thereof and their applications |
| CN102149683B (zh) | 2009-05-25 | 2013-10-02 | 中南大学 | 1-（取代苄基）-5-三氟甲基-2-（1h）吡啶酮化合物及其盐，其制备方法及其用途 |
| JP2013513086A (ja) * | 2009-09-18 | 2013-04-18 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| TWI508726B (zh) | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| US10092552B2 (en) | 2011-01-31 | 2018-10-09 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| CN102846555B (zh) * | 2012-04-09 | 2014-06-25 | 珠海亿邦制药股份有限公司 | 一种以吡非尼酮为活性成分的固体制剂及其应用 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP4491180A1 (en) | 2014-01-10 | 2025-01-15 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| EP3176164B1 (en) | 2014-07-30 | 2019-08-21 | Aetas Pharma Co. Ltd. | Optical isomer of 1,4-benzothiazepine-1-oxide derivative, and pharmaceutical composition prepared using same |
| US10515284B2 (en) * | 2014-09-30 | 2019-12-24 | Qualcomm Incorporated | Single-processor computer vision hardware control and application execution |
| EP3237385B1 (en) | 2014-12-22 | 2021-11-24 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Mutant idh1 inhibitors useful for treating cancer |
| CN105878243B (zh) * | 2016-06-14 | 2019-05-21 | 四川大学 | 吡非尼酮衍生物在制药中的应用 |
| CN105998018B (zh) * | 2016-06-16 | 2019-01-25 | 杨若一 | 吡非尼酮衍生物在制药中的应用 |
| CN107556234A (zh) * | 2016-06-30 | 2018-01-09 | 陕西合成药业股份有限公司 | 一种新型吡啶酮类化合物及其制备方法和在医学上的应用 |
| EP3569249A4 (en) * | 2016-12-27 | 2020-11-11 | Osaka University | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF REFRACTORY HEART DISEASE |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| US4042699A (en) * | 1972-12-18 | 1977-08-16 | Affiliated Medical Research, Inc. | Method for reducing serum glucose levels |
| US4052509A (en) * | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
| US3839346A (en) * | 1972-12-18 | 1974-10-01 | Affiliated Med Res | N-substituted pyridone and general method for preparing pyridones |
| PT590455E (pt) * | 1992-09-28 | 2001-04-30 | Hoechst Ag | 1(2h)-isoquinolinas substituidas anti-arritmicas e cardioprotectoras processo para a sua preparacao medicamento contendo estes compostos e sua utilizacao para a preparacao de um medicamento para o combate de falhas cardiacas |
| JP2004523479A (ja) * | 2000-10-18 | 2004-08-05 | マサチューセッツ インスティテュート オブ テクノロジー | 多糖の肺送達に関する方法および産物 |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| US20040110710A1 (en) * | 2002-08-23 | 2004-06-10 | Xinkang Wang | Methods of reducing ischemic injury |
| WO2004019863A2 (en) * | 2002-08-28 | 2004-03-11 | Intermune, Inc. | Combination therapy for treatment of fibrotic disorders |
| WO2005040758A2 (en) * | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| US7550487B2 (en) * | 2004-03-26 | 2009-06-23 | Hoffmann-La Roche Inc. | Pyrrolidine-3,4-dicarboxamide derivatives |
-
2006
- 2006-10-31 WO PCT/US2006/042454 patent/WO2007053610A2/en not_active Ceased
- 2006-11-01 US US12/091,161 patent/US20100029578A1/en not_active Abandoned
- 2006-11-01 JP JP2008538997A patent/JP2009513713A/ja active Pending
- 2006-11-01 WO PCT/US2006/042653 patent/WO2007053685A2/en not_active Ceased
- 2006-11-01 CA CA002627547A patent/CA2627547A1/en not_active Abandoned
- 2006-11-01 EP EP06836759A patent/EP1948178A4/en not_active Withdrawn
-
2011
- 2011-09-26 US US13/244,707 patent/US20120046321A1/en not_active Abandoned
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