JP2009513713A - ｐ３８阻害剤化合物による心房細動の治療方法 - Google Patents

ｐ３８阻害剤化合物による心房細動の治療方法 Download PDF

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Publication number
JP2009513713A
JP2009513713A JP2008538997A JP2008538997A JP2009513713A JP 2009513713 A JP2009513713 A JP 2009513713A JP 2008538997 A JP2008538997 A JP 2008538997A JP 2008538997 A JP2008538997 A JP 2008538997A JP 2009513713 A JP2009513713 A JP 2009513713A
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inhibitor compound
group
phenyl
subject
alkyl
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JP2009513713A5 (enExample
Inventor
ジェフ オルジン，
スーザン アイゼンバーグ，
ローレンス エム． ブラット，
スコット ザイベルト，
カール コッセン，
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University of California
University of California Berkeley
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008538997A 2005-11-01 2006-11-01 ｐ３８阻害剤化合物による心房細動の治療方法 Pending JP2009513713A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73267605P 2005-11-01 2005-11-01
PCT/US2006/042653 WO2007053685A2 (en) 2005-11-01 2006-11-01 Methods of treating atrial fibrillation with p38 inhibitor compounds

Publications (2)

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JP2009513713A true JP2009513713A (ja) 2009-04-02
JP2009513713A5 JP2009513713A5 (enExample) 2009-10-15

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JP2008538997A Pending JP2009513713A (ja) 2005-11-01 2006-11-01 ｐ３８阻害剤化合物による心房細動の治療方法

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US (2) US20100029578A1 (enExample)
EP (1) EP1948178A4 (enExample)
JP (1) JP2009513713A (enExample)
CA (1) CA2627547A1 (enExample)
WO (2) WO2007053610A2 (enExample)

Cited By (3)

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JP2016176953A (ja) * 2009-09-18 2016-10-06 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
KR20170031712A (ko) 2014-07-30 2017-03-21 가부시키가이샤 아에타스 파루마 1,4-벤조티아제핀-1-옥사이드 유도체의 광학 이성질체, 및 그것을 사용한 의약 조성물
WO2018124236A1 (ja) * 2016-12-27 2018-07-05 国立大学法人大阪大学 難治性心疾患治療用医薬組成物

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PT1928454E (pt) 2005-05-10 2014-12-04 Intermune Inc Derivativos da piridona para modulação do sistema de proteína quinase ativada pelo stress
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
WO2010065755A1 (en) 2008-12-04 2010-06-10 Concert Pharmaceuticals, Inc. Deuterated pyridinones
AP2011005824A0 (en) * 2009-01-26 2011-08-31 Intermune Inc Methods for treating acute myocardial infarctions and associated disorders.
ES2536200T3 (es) 2009-05-25 2015-05-21 Central South University Preparación de compuestos de tipo 1-(bencilo sustituido)-5-trifluorometil-2-(1H)piridona, sales de estos y sus aplicaciones
US8426407B2 (en) 2009-05-25 2013-04-23 Central South University Preparation of 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and salts thereof and their applications
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
JP6021117B2 (ja) 2011-01-31 2016-11-02 ジェノア ファーマシューティカルズ，インク． エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
CN102846555B (zh) * 2012-04-09 2014-06-25 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP4491180A1 (en) 2014-01-10 2025-01-15 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
US10515284B2 (en) * 2014-09-30 2019-12-24 Qualcomm Incorporated Single-processor computer vision hardware control and application execution
WO2016106331A1 (en) 2014-12-22 2016-06-30 The United States Of America Mutant idh1 inhibitors useful for treating cancer
CN105878243B (zh) * 2016-06-14 2019-05-21 四川大学 吡非尼酮衍生物在制药中的应用
CN105998018B (zh) * 2016-06-16 2019-01-25 杨若一 吡非尼酮衍生物在制药中的应用
CN107556234A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型吡啶酮类化合物及其制备方法和在医学上的应用

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US4042699A (en) * 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
US3839346A (en) * 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones
US4052509A (en) * 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
DK0590455T3 (da) * 1992-09-28 2001-01-22 Hoechst Ag Antiarrytmiske og cardioprotektive substiuerede 1(2H)-isoquinoliner, fremgangsmåde til deres fremstilling, lægemiddel indeh
EP1328260A2 (en) * 2000-10-18 2003-07-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
EP1546181A2 (en) * 2002-08-23 2005-06-29 Bristol-Myers Squibb Company Methods of reducing ischemic injury
JP2006502152A (ja) * 2002-08-28 2006-01-19 インターミューン インコーポレイテッド 線維性疾患治療用の併用療法
US7407973B2 (en) * 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US7550487B2 (en) * 2004-03-26 2009-06-23 Hoffmann-La Roche Inc. Pyrrolidine-3,4-dicarboxamide derivatives

Non-Patent Citations (4)

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JPN6011069619; Ｂｒｉｔｉｓｈ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．１３３，　Ｎｏ．５, 2001, ｐ．６８７-６９４ *
JPN6011069620; Ｂｒｉｔｉｓｈ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．１３５，　Ｎｏ．４, 2002, ｐ．９６１-９６８ *
JPN6011069622; 順天堂医学 第５０巻，第３号, 2004, ｐ．２２３-２３５ *
JPN6011069623; 日本内科学会雑誌 第８９巻，第１２号, 2000, ｐ．２５４１-２５４６ *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016176953A (ja) * 2009-09-18 2016-10-06 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
KR20170031712A (ko) 2014-07-30 2017-03-21 가부시키가이샤 아에타스 파루마 1,4-벤조티아제핀-1-옥사이드 유도체의 광학 이성질체, 및 그것을 사용한 의약 조성물
US10071996B2 (en) 2014-07-30 2018-09-11 Aetas Pharma Co., Ltd. Optical isomer of 1,4-benzothiazepine-1-oxide derivative, and pharmaceutical composition prepared using same
WO2018124236A1 (ja) * 2016-12-27 2018-07-05 国立大学法人大阪大学 難治性心疾患治療用医薬組成物
JPWO2018124236A1 (ja) * 2016-12-27 2019-11-14 国立大学法人大阪大学 難治性心疾患治療用医薬組成物

Also Published As

Publication number Publication date
WO2007053685A3 (en) 2007-07-19
WO2007053685A2 (en) 2007-05-10
EP1948178A4 (en) 2011-03-02
US20100029578A1 (en) 2010-02-04
WO2007053610A2 (en) 2007-05-10
US20120046321A1 (en) 2012-02-23
WO2007053610A3 (en) 2007-11-29
EP1948178A2 (en) 2008-07-30
CA2627547A1 (en) 2007-05-10

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