JP2006503850A5 - - Google Patents
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- Publication number
- JP2006503850A5 JP2006503850A5 JP2004540164A JP2004540164A JP2006503850A5 JP 2006503850 A5 JP2006503850 A5 JP 2006503850A5 JP 2004540164 A JP2004540164 A JP 2004540164A JP 2004540164 A JP2004540164 A JP 2004540164A JP 2006503850 A5 JP2006503850 A5 JP 2006503850A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- mammal
- pharmaceutically acceptable
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000051367 mu Opioid Receptors Human genes 0.000 claims 2
- 108020001612 μ-opioid receptors Proteins 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000005284 excitation Effects 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41325402P | 2002-09-25 | 2002-09-25 | |
| US60/413,254 | 2002-09-25 | ||
| PCT/US2003/029876 WO2004029059A1 (en) | 2002-09-25 | 2003-09-24 | N-substituted hydromorphones and the use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010242645A Division JP2011042681A (ja) | 2002-09-25 | 2010-10-28 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503850A JP2006503850A (ja) | 2006-02-02 |
| JP2006503850A5 true JP2006503850A5 (enExample) | 2006-06-29 |
| JP4806190B2 JP4806190B2 (ja) | 2011-11-02 |
Family
ID=32043224
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004540164A Expired - Fee Related JP4806190B2 (ja) | 2002-09-25 | 2003-09-24 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
| JP2010242645A Withdrawn JP2011042681A (ja) | 2002-09-25 | 2010-10-28 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010242645A Withdrawn JP2011042681A (ja) | 2002-09-25 | 2010-10-28 | Ｎ−置換ヒドロモルホン及びそれらの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6825205B2 (enExample) |
| EP (2) | EP1803724A1 (enExample) |
| JP (2) | JP4806190B2 (enExample) |
| KR (1) | KR20050074462A (enExample) |
| CN (1) | CN100387600C (enExample) |
| AT (1) | ATE360633T1 (enExample) |
| AU (1) | AU2003272642B2 (enExample) |
| BR (1) | BR0314488A (enExample) |
| CA (1) | CA2500118C (enExample) |
| CY (1) | CY1106697T1 (enExample) |
| DE (1) | DE60313478T2 (enExample) |
| DK (1) | DK1543010T3 (enExample) |
| ES (1) | ES2286461T3 (enExample) |
| MX (1) | MXPA05003104A (enExample) |
| NZ (1) | NZ538726A (enExample) |
| PT (1) | PT1543010E (enExample) |
| WO (1) | WO2004029059A1 (enExample) |
| ZA (1) | ZA200502174B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
| EP2099764B1 (en) | 2006-09-20 | 2011-07-27 | Mallinckrodt Inc. | Preparation of substituted morphinan-6-ones and salts and intermediates thereof |
| US20080234306A1 (en) * | 2006-11-22 | 2008-09-25 | Progenics Pharmaceuticals, Inc. | N-Oxides of 4,5-Epoxy-Morphinanium Analogs |
| JP2010510329A (ja) * | 2006-11-22 | 2010-04-02 | プロジェニックス ファーマスーティカルス インコーポレーテッド | ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体 |
| JP5875748B2 (ja) * | 2007-03-06 | 2016-03-02 | マリンクロッド エルエルシー | 第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法 |
| US9040726B2 (en) | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| WO2009023567A1 (en) * | 2007-08-09 | 2009-02-19 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
| CA2702680A1 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| WO2009070733A1 (en) * | 2007-11-26 | 2009-06-04 | Pharmacofore, Inc. | Peripheral phenolic opioid antagonist |
| EP2896614B1 (en) | 2008-05-27 | 2017-07-12 | Mallinckrodt LLC | Processes and compounds for the preparation of normorphinans |
| WO2010028004A2 (en) | 2008-09-03 | 2010-03-11 | Mallinckrodt Inc. | Substituted berbines and processes for their synthesis |
| ME02367B (me) | 2010-09-21 | 2016-06-20 | Purdue Pharma Lp | Analozi buprenorfina kao agonisti i/ili antagonisti opioidnog receptora |
| US10138207B2 (en) | 2012-11-09 | 2018-11-27 | Purdue Pharma, L.P. | Benzomorphan analogs and the use thereof |
| EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| EP3087057A4 (en) | 2013-12-26 | 2017-06-28 | Purdue Pharma LP | Ring-contracted morphinans and the use thereof |
| EP3087078B1 (en) | 2013-12-26 | 2019-05-15 | Purdue Pharma LP | 7-beta-alkyl analogs of orvinols |
| US9862726B2 (en) | 2013-12-26 | 2018-01-09 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| EP3086790A4 (en) | 2013-12-27 | 2017-07-19 | Purdue Pharma LP | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| CA2950567A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| CA2951697A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| CN117567477B (zh) * | 2023-11-15 | 2026-05-26 | 宜昌人福药业有限责任公司 | 一种氢吗啡酮和二氢吗啡类药物低分子聚乙二醇化物及其制备方法和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| DE3780819T2 (de) * | 1987-09-10 | 1993-01-14 | Univ Chicago | Quaternaere derivate von noroxymorphon zur behandlung von uebelkeit und erbrechen. |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| CN1535687A (zh) * | 1996-11-25 | 2004-10-13 | ������������ʽ���� | 止痒药物 |
| WO2001014382A1 (en) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan |
-
2003
- 2003-09-24 MX MXPA05003104A patent/MXPA05003104A/es active IP Right Grant
- 2003-09-24 NZ NZ538726A patent/NZ538726A/en not_active IP Right Cessation
- 2003-09-24 US US10/668,326 patent/US6825205B2/en not_active Expired - Lifetime
- 2003-09-24 EP EP07007240A patent/EP1803724A1/en not_active Withdrawn
- 2003-09-24 CN CNB038229587A patent/CN100387600C/zh not_active Expired - Fee Related
- 2003-09-24 EP EP03754837A patent/EP1543010B1/en not_active Expired - Lifetime
- 2003-09-24 JP JP2004540164A patent/JP4806190B2/ja not_active Expired - Fee Related
- 2003-09-24 DE DE60313478T patent/DE60313478T2/de not_active Expired - Lifetime
- 2003-09-24 AU AU2003272642A patent/AU2003272642B2/en not_active Ceased
- 2003-09-24 AT AT03754837T patent/ATE360633T1/de active
- 2003-09-24 BR BR0314488-7A patent/BR0314488A/pt not_active IP Right Cessation
- 2003-09-24 KR KR1020057005255A patent/KR20050074462A/ko not_active Ceased
- 2003-09-24 DK DK03754837T patent/DK1543010T3/da active
- 2003-09-24 CA CA2500118A patent/CA2500118C/en not_active Expired - Fee Related
- 2003-09-24 WO PCT/US2003/029876 patent/WO2004029059A1/en not_active Ceased
- 2003-09-24 PT PT03754837T patent/PT1543010E/pt unknown
- 2003-09-24 ES ES03754837T patent/ES2286461T3/es not_active Expired - Lifetime
-
2005
- 2005-03-15 ZA ZA200502174A patent/ZA200502174B/en unknown
-
2007
- 2007-07-03 CY CY20071100881T patent/CY1106697T1/el unknown
-
2010
- 2010-10-28 JP JP2010242645A patent/JP2011042681A/ja not_active Withdrawn
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