JP2008510758A5 - - Google Patents
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- Publication number
- JP2008510758A5 JP2008510758A5 JP2007528723A JP2007528723A JP2008510758A5 JP 2008510758 A5 JP2008510758 A5 JP 2008510758A5 JP 2007528723 A JP2007528723 A JP 2007528723A JP 2007528723 A JP2007528723 A JP 2007528723A JP 2008510758 A5 JP2008510758 A5 JP 2008510758A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- use according
- unsubstituted
- pain
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 208000002193 Pain Diseases 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 239000002777 nucleoside Substances 0.000 claims 8
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- -1 methylpyrrolyl Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 208000030507 AIDS Diseases 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 201000008968 osteosarcoma Diseases 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 238000002512 chemotherapy Methods 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 206010061289 metastatic neoplasm Diseases 0.000 claims 3
- 210000005036 nerve Anatomy 0.000 claims 3
- 210000004872 soft tissue Anatomy 0.000 claims 3
- 210000001835 viscera Anatomy 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010061309 Neoplasm progression Diseases 0.000 claims 2
- 206010045171 Tumour pain Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 2
- 238000007906 compression Methods 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000005751 tumor progression Effects 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- XCVDGQBGMARFRY-GFCCVEGCSA-N (2r)-2-acetamido-n-[(3-fluorophenyl)methyl]-3-methoxypropanamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC(F)=C1 XCVDGQBGMARFRY-GFCCVEGCSA-N 0.000 claims 1
- PVNGTPGYSFGJIH-GFCCVEGCSA-N (2r)-2-acetamido-n-[(4-fluorophenyl)methyl]-3-methoxypropanamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=C(F)C=C1 PVNGTPGYSFGJIH-GFCCVEGCSA-N 0.000 claims 1
- SGBCQENKTXKIRD-MRXNPFEDSA-N (2r)-2-acetamido-n-benzyl-2-phenylacetamide Chemical compound O=C([C@H](NC(=O)C)C=1C=CC=CC=1)NCC1=CC=CC=C1 SGBCQENKTXKIRD-MRXNPFEDSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 229940122803 Vinca alkaloid Drugs 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 125000004069 aziridinyl group Chemical group 0.000 claims 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003838 furazanyl group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000002636 imidazolinyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60481004P | 2004-08-27 | 2004-08-27 | |
| EP04020402.6 | 2004-08-27 | ||
| EP04020402A EP1629839A1 (en) | 2004-08-27 | 2004-08-27 | Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain |
| US60/604,810 | 2004-08-27 | ||
| PCT/EP2005/009067 WO2006021412A2 (en) | 2004-08-27 | 2005-08-22 | Use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008510758A JP2008510758A (ja) | 2008-04-10 |
| JP2008510758A5 true JP2008510758A5 (enExample) | 2008-10-16 |
Family
ID=35456911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528723A Pending JP2008510758A (ja) | 2004-08-27 | 2005-08-22 | 骨肉腫の痛み、化学療法誘発性及びヌクレオシド誘発性の痛みを治療するためのペプチド化合物の新規使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7687553B2 (enExample) |
| EP (1) | EP1781276B1 (enExample) |
| JP (1) | JP2008510758A (enExample) |
| KR (1) | KR20070045271A (enExample) |
| AR (1) | AR050612A1 (enExample) |
| AT (1) | ATE471717T1 (enExample) |
| AU (1) | AU2005276634B2 (enExample) |
| BR (1) | BRPI0514721A (enExample) |
| CA (1) | CA2573125A1 (enExample) |
| DE (1) | DE602005021970D1 (enExample) |
| EA (1) | EA014055B1 (enExample) |
| IL (1) | IL181383A0 (enExample) |
| MX (1) | MX2007002269A (enExample) |
| NO (1) | NO20071585L (enExample) |
| NZ (1) | NZ552651A (enExample) |
| PL (1) | PL1781276T3 (enExample) |
| WO (1) | WO2006021412A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19633169A1 (de) | 1996-08-17 | 1998-02-19 | Teves Gmbh Alfred | Elektromotor-/Pumpenaggregat |
| PT1243262E (pt) * | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| EP1243263B1 (en) * | 2001-03-21 | 2002-11-27 | Schwarz Pharma Ag | Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain |
| ES2325995T3 (es) * | 2003-12-02 | 2009-09-28 | Schwarz Pharma Ag | Nueva utilizacion de compuestos peptidicos para tratamiento del dolor neuropatico central. |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| JP2007532607A (ja) | 2004-04-16 | 2007-11-15 | シュバルツ ファルマ アクチェンゲゼルシャフト | 慢性頭痛の予防及び治療のためのペプチド化合物の使用 |
| EP1604655A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| BRPI0514721A (pt) * | 2004-08-27 | 2008-06-24 | Sanol Arznei Schwarz Gmbh | uso de compostos de peptìdeos para tratar dor de cáncer ósseo, dor induzida por quimioterapia e nucleosìdeo |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| ES2531118T5 (es) | 2006-06-15 | 2022-06-14 | Ucb Pharma Gmbh | Composición farmacéutica que comprende lacosamida y levetiracetamo para uso en el tratamiento de la epilepsia |
| EP1873527A1 (en) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| EP2509939A4 (en) | 2009-09-23 | 2013-09-18 | Univ North Carolina | NOVEL N-BENZYLAMIDE SUBSTITUTED DERIVATIVES OF 2- (ACYLAMIDO) ACETIC ACID AND 2- (ACYLAMIDO) PROPIONIC ACIDS: POWERFUL NEUROLOGIC AGENTS |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| EP2645997B1 (en) | 2010-12-02 | 2022-08-10 | UCB Pharma GmbH | Once daily formulation of lacosamide |
| US9134395B2 (en) | 2012-03-07 | 2015-09-15 | Freescale Semiconductor, Inc. | Method for testing comparator and device therefor |
| JP6631855B2 (ja) * | 2016-01-07 | 2020-01-15 | パナソニックＩｐマネジメント株式会社 | 発光装置 |
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| EP1579858A1 (en) | 2004-03-26 | 2005-09-28 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in painful diabetic neuropathy |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
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| JP2007532607A (ja) * | 2004-04-16 | 2007-11-15 | シュバルツ ファルマ アクチェンゲゼルシャフト | 慢性頭痛の予防及び治療のためのペプチド化合物の使用 |
| EP1604654A1 (en) * | 2004-05-18 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating dyskinesia |
| EP1604656A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
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| US7427601B2 (en) * | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
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| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
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-
2005
- 2005-08-22 BR BRPI0514721-2A patent/BRPI0514721A/pt not_active IP Right Cessation
- 2005-08-22 CA CA002573125A patent/CA2573125A1/en not_active Abandoned
- 2005-08-22 DE DE602005021970T patent/DE602005021970D1/de not_active Expired - Lifetime
- 2005-08-22 EP EP05777341A patent/EP1781276B1/en not_active Expired - Lifetime
- 2005-08-22 KR KR1020077004178A patent/KR20070045271A/ko not_active Ceased
- 2005-08-22 MX MX2007002269A patent/MX2007002269A/es not_active Application Discontinuation
- 2005-08-22 WO PCT/EP2005/009067 patent/WO2006021412A2/en not_active Ceased
- 2005-08-22 EA EA200700493A patent/EA014055B1/ru not_active IP Right Cessation
- 2005-08-22 PL PL05777341T patent/PL1781276T3/pl unknown
- 2005-08-22 AT AT05777341T patent/ATE471717T1/de not_active IP Right Cessation
- 2005-08-22 NZ NZ552651A patent/NZ552651A/en not_active IP Right Cessation
- 2005-08-22 AU AU2005276634A patent/AU2005276634B2/en not_active Ceased
- 2005-08-22 JP JP2007528723A patent/JP2008510758A/ja active Pending
- 2005-08-23 AR ARP050103528A patent/AR050612A1/es not_active Application Discontinuation
- 2005-08-26 US US11/211,476 patent/US7687553B2/en not_active Expired - Fee Related
-
2007
- 2007-02-15 IL IL181383A patent/IL181383A0/en unknown
- 2007-03-26 NO NO20071585A patent/NO20071585L/no not_active Application Discontinuation
-
2009
- 2009-10-12 US US12/577,304 patent/US8536137B2/en not_active Expired - Fee Related
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