AR050612A1 - Novedoso uso de compuestos peptidos para tratar dolor por cancer de huesos, dolor inducido por quimioterapia y nucleosidos y composicion farmaceutica - Google Patents
Novedoso uso de compuestos peptidos para tratar dolor por cancer de huesos, dolor inducido por quimioterapia y nucleosidos y composicion farmaceuticaInfo
- Publication number
- AR050612A1 AR050612A1 ARP050103528A ARP050103528A AR050612A1 AR 050612 A1 AR050612 A1 AR 050612A1 AR P050103528 A ARP050103528 A AR P050103528A AR P050103528 A ARP050103528 A AR P050103528A AR 050612 A1 AR050612 A1 AR 050612A1
- Authority
- AR
- Argentina
- Prior art keywords
- heterocyclic
- lower alkyl
- group
- unsubstituted
- substituted
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title abstract 7
- 238000002512 chemotherapy Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010005949 Bone cancer Diseases 0.000 title abstract 2
- 208000018084 Bone neoplasm Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 125000000623 heterocyclic group Chemical group 0.000 abstract 13
- 125000003342 alkenyl group Chemical group 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical group C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- -1 methylpyrrolyl Chemical group 0.000 abstract 3
- 239000002777 nucleoside Substances 0.000 abstract 3
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 3
- 206010045171 Tumour pain Diseases 0.000 abstract 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000004593 Epoxy Chemical group 0.000 abstract 1
- 101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000003838 furazanyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000002632 imidazolidinyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000001422 pyrrolinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60481004P | 2004-08-27 | 2004-08-27 | |
| EP04020402A EP1629839A1 (en) | 2004-08-27 | 2004-08-27 | Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050612A1 true AR050612A1 (es) | 2006-11-08 |
Family
ID=35456911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103528A AR050612A1 (es) | 2004-08-27 | 2005-08-23 | Novedoso uso de compuestos peptidos para tratar dolor por cancer de huesos, dolor inducido por quimioterapia y nucleosidos y composicion farmaceutica |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7687553B2 (enExample) |
| EP (1) | EP1781276B1 (enExample) |
| JP (1) | JP2008510758A (enExample) |
| KR (1) | KR20070045271A (enExample) |
| AR (1) | AR050612A1 (enExample) |
| AT (1) | ATE471717T1 (enExample) |
| AU (1) | AU2005276634B2 (enExample) |
| BR (1) | BRPI0514721A (enExample) |
| CA (1) | CA2573125A1 (enExample) |
| DE (1) | DE602005021970D1 (enExample) |
| EA (1) | EA014055B1 (enExample) |
| IL (1) | IL181383A0 (enExample) |
| MX (1) | MX2007002269A (enExample) |
| NO (1) | NO20071585L (enExample) |
| NZ (1) | NZ552651A (enExample) |
| PL (1) | PL1781276T3 (enExample) |
| WO (1) | WO2006021412A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19633169A1 (de) | 1996-08-17 | 1998-02-19 | Teves Gmbh Alfred | Elektromotor-/Pumpenaggregat |
| ATE327744T1 (de) * | 2001-03-20 | 2006-06-15 | Sanol Arznei Schwarz Gmbh | Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz |
| DE60100055T2 (de) * | 2001-03-21 | 2003-07-24 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| US7794987B2 (en) * | 2003-12-02 | 2010-09-14 | Ucb Pharma Gmbh | Method for treating central neuropathic pain |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
| EP1604655A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| PL1781276T3 (pl) | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1873527A1 (en) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| US8829033B2 (en) | 2009-09-23 | 2014-09-09 | The University Of North Carolina At Chapel Hill | N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| EP2646001A2 (en) | 2010-12-02 | 2013-10-09 | UCB Pharma GmbH | Formulation of lacosamide |
| US9134395B2 (en) | 2012-03-07 | 2015-09-15 | Freescale Semiconductor, Inc. | Method for testing comparator and device therefor |
| CN108292823A (zh) * | 2016-01-07 | 2018-07-17 | 松下知识产权经营株式会社 | 发光装置 |
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| EP1579858A1 (en) | 2004-03-26 | 2005-09-28 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in painful diabetic neuropathy |
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| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| US7427601B2 (en) | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
| PL1781276T3 (pl) | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
| EP1642889A1 (en) | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| US20060252749A1 (en) | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| EP1688137A1 (en) | 2005-01-28 | 2006-08-09 | Schwarz Pharma Ag | SPM 927 for add-on therapy of schizophrenia |
| US20070048372A1 (en) | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| US20070043120A1 (en) | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1754476A1 (en) | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| EP1873527A1 (en) | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| CN101466390B (zh) | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| US20100260716A1 (en) | 2007-10-23 | 2010-10-14 | Ucb Pharma Gmbh | Compounds for treating demyelination conditions |
-
2005
- 2005-08-22 PL PL05777341T patent/PL1781276T3/pl unknown
- 2005-08-22 MX MX2007002269A patent/MX2007002269A/es not_active Application Discontinuation
- 2005-08-22 BR BRPI0514721-2A patent/BRPI0514721A/pt not_active IP Right Cessation
- 2005-08-22 AU AU2005276634A patent/AU2005276634B2/en not_active Ceased
- 2005-08-22 NZ NZ552651A patent/NZ552651A/en not_active IP Right Cessation
- 2005-08-22 KR KR1020077004178A patent/KR20070045271A/ko not_active Ceased
- 2005-08-22 CA CA002573125A patent/CA2573125A1/en not_active Abandoned
- 2005-08-22 JP JP2007528723A patent/JP2008510758A/ja active Pending
- 2005-08-22 AT AT05777341T patent/ATE471717T1/de not_active IP Right Cessation
- 2005-08-22 WO PCT/EP2005/009067 patent/WO2006021412A2/en not_active Ceased
- 2005-08-22 EA EA200700493A patent/EA014055B1/ru not_active IP Right Cessation
- 2005-08-22 EP EP05777341A patent/EP1781276B1/en not_active Expired - Lifetime
- 2005-08-22 DE DE602005021970T patent/DE602005021970D1/de not_active Expired - Lifetime
- 2005-08-23 AR ARP050103528A patent/AR050612A1/es not_active Application Discontinuation
- 2005-08-26 US US11/211,476 patent/US7687553B2/en not_active Expired - Fee Related
-
2007
- 2007-02-15 IL IL181383A patent/IL181383A0/en unknown
- 2007-03-26 NO NO20071585A patent/NO20071585L/no not_active Application Discontinuation
-
2009
- 2009-10-12 US US12/577,304 patent/US8536137B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1781276A2 (en) | 2007-05-09 |
| JP2008510758A (ja) | 2008-04-10 |
| KR20070045271A (ko) | 2007-05-02 |
| AU2005276634A1 (en) | 2006-03-02 |
| EA200700493A1 (ru) | 2007-08-31 |
| IL181383A0 (en) | 2008-03-20 |
| BRPI0514721A (pt) | 2008-06-24 |
| US7687553B2 (en) | 2010-03-30 |
| EA014055B1 (ru) | 2010-08-30 |
| CA2573125A1 (en) | 2006-03-02 |
| US8536137B2 (en) | 2013-09-17 |
| ATE471717T1 (de) | 2010-07-15 |
| PL1781276T3 (pl) | 2010-11-30 |
| EP1781276B1 (en) | 2010-06-23 |
| NZ552651A (en) | 2010-07-30 |
| US20060046957A1 (en) | 2006-03-02 |
| DE602005021970D1 (de) | 2010-08-05 |
| US20100029543A1 (en) | 2010-02-04 |
| MX2007002269A (es) | 2007-06-15 |
| NO20071585L (no) | 2007-04-30 |
| AU2005276634B2 (en) | 2011-03-24 |
| WO2006021412A3 (en) | 2006-04-27 |
| WO2006021412A2 (en) | 2006-03-02 |
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| FA | Abandonment or withdrawal |