BRPI0418078A8 - composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto - Google Patents

composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto

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Publication number
BRPI0418078A8
BRPI0418078A8 BRPI0418078A BRPI0418078A BRPI0418078A8 BR PI0418078 A8 BRPI0418078 A8 BR PI0418078A8 BR PI0418078 A BRPI0418078 A BR PI0418078A BR PI0418078 A BRPI0418078 A BR PI0418078A BR PI0418078 A8 BRPI0418078 A8 BR PI0418078A8
Authority
BR
Brazil
Prior art keywords
protein kinase
compound
condition
treat
group
Prior art date
Application number
BRPI0418078A
Other languages
English (en)
Inventor
Winter Walker David
Saxty Gordon
Fiona Sore Hannah
Collins Ian
Leendert Verdonk Marinus
Graham Wyatt Paul
Downham Robert
Georg Boyle Robert
Arthur Ellis Carr Robin
John Woodhead Steven
Berdini Valerio
Original Assignee
Astex Therapeutics Ltd
Cancer Research Tech Ltd
The Institute Of Cancer Res Royal Cancer Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329617A external-priority patent/GB0329617D0/en
Application filed by Astex Therapeutics Ltd, Cancer Research Tech Ltd, The Institute Of Cancer Res Royal Cancer Hospital filed Critical Astex Therapeutics Ltd
Publication of BRPI0418078A publication Critical patent/BRPI0418078A/pt
Publication of BRPI0418078A8 publication Critical patent/BRPI0418078A8/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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Abstract

"composto ou um seu sal, solvato, tautômero ou nóxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um compostos". a invenção provê compostos de fórmula: tendo atividade inibidora da proteina quinase b: em que a é um grupo ligador de hidrocarboneto saturado, contendo de 1 a 7 átomos de carbono, o grupo ligador tendo um comprimento de cadeia máximo de 5 átomos, estendendo-se entre r^ 1^ e nr^ 2^r^ 3^ e um comprimento máximo de cadela de 4 átomos, estendendo-se entre e e nr^ 2^r^ 3^, em que um dos átomos de carbono do grupo ligador pode opcionalmente ser substituído com um átomo de oxigênio ou nitrogênio; e em que os átomos de carbono do grupo ligador a podem opcionalmente conter um ou mais substituintes selecionados de oxo, flúor e hidróxi, desde que o grupo hidróxi, quando presente, não seja localizado em um átomo de carbono com respeito ao grupo nr^ 2^r^ 3^ e desde que o grupo oxo, quando presente, seja localizado em um átomo de carbono com respeito ao grupo nr^ 2^r^ 3^; e é um grupo monocíclico ou bicíclico carbocíclico ou heterocíclico; r^ 1^ é um grupo arila ou heteroarila; e r^ 2^, r^ 3^, r^ 4^ e r^ 5^ são como definidos nas reivindicações. são também providas composições farmacêuticas contendo os compostos, métodos para preparar os compostos e seu uso como agentes anti-câncer.
BRPI0418078A 2003-12-23 2004-12-23 composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto BRPI0418078A8 (pt)

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PCT/GB2004/005464 WO2005061463A1 (en) 2003-12-23 2004-12-23 Pyrazole derivatives as protein kinase modulators

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