BRPI0418078A - composto ou um seu sal, solvato, tautÈmero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteìna quinase b e medida pela proteìna quinase a, para tratar uma doença ou condição, para inibir uma proteìna quinase b e uma proteìna quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamìfero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto - Google Patents
composto ou um seu sal, solvato, tautÈmero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteìna quinase b e medida pela proteìna quinase a, para tratar uma doença ou condição, para inibir uma proteìna quinase b e uma proteìna quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamìfero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um compostoInfo
- Publication number
- BRPI0418078A BRPI0418078A BRPI0418078-0A BRPI0418078A BRPI0418078A BR PI0418078 A BRPI0418078 A BR PI0418078A BR PI0418078 A BRPI0418078 A BR PI0418078A BR PI0418078 A BRPI0418078 A BR PI0418078A
- Authority
- BR
- Brazil
- Prior art keywords
- protein kinase
- compound
- condition
- treat
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 title abstract 5
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 108091008611 Protein Kinase B Proteins 0.000 title abstract 3
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 title abstract 3
- 230000006907 apoptotic process Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 208000026278 immune system disease Diseases 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000033077 cellular process Effects 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 239000012453 solvate Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000005647 linker group Chemical group 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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Abstract
"COMPOSTO OU UM SEU SAL, SOLVATO, TAUTÈMERO OU NóXIDO, USO DE UM COMPOSTO, MéTODOS PARA A PROFILAXIA OU TRATAMENTO DE UM ESTADO OU CONDIçãO DOENTIA MEDIADA PELA PROTEìNA QUINASE B E MEDIADA PELA PROTEìNA QUINASE A, PARA TRATAR UMA DOENçA OU CONDIçãO, PARA INIBIR UMA PROTEìNA QUINASE B E UMA PROTEìNA QUINASE A, PARA MODULAR UM PROCESSO CELULAR, PARA TRATAR UM DISTúRBIO IMUNE EM UM MAMìFERO E PARA INDUZIR APOPTOSE EM UMA CéLULA CANCEROSA, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTOS". A invenção provê compostos de Fórmula: tendo atividade inibidora da proteina quinase B: em que A é um grupo ligador de hidrocarboneto saturado, contendo de 1 a 7 átomos de carbono, o grupo ligador tendo um comprimento de cadeia máximo de 5 átomos, estendendo-se entre R¬ 1¬ e NR¬ 2¬R¬ 3¬ e um comprimento máximo de cadela de 4 átomos, estendendo-se entre E e NR¬ 2¬R¬ 3¬, em que um dos átomos de carbono do grupo ligador pode opcionalmente ser substituído com um átomo de oxigênio ou nitrogênio; e em que os átomos de carbono do grupo ligador A podem opcionalmente conter um ou mais substituintes selecionados de oxo, flúor e hidróxi, desde que o grupo hidróxi, quando presente, não seja localizado em um átomo de carbono com respeito ao grupo NR¬ 2¬R¬ 3¬ e desde que o grupo oxo, quando presente, seja localizado em um átomo de carbono com respeito ao grupo NR¬ 2¬R¬ 3¬; E é um grupo monocíclico ou bicíclico carbocíclico ou heterocíclico; R¬ 1¬ é um grupo arila ou heteroarila; e R¬ 2¬, R¬ 3¬, R¬ 4¬ e R¬ 5¬ são como definidos nas reivindicações. São também providas composições farmacêuticas contendo os compostos, métodos para preparar os compostos e seu uso como agentes anti-câncer.
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US53219903P | 2003-12-23 | 2003-12-23 | |
GB0329617A GB0329617D0 (en) | 2003-12-23 | 2003-12-23 | Pharmaceutical compounds |
US57784304P | 2004-06-08 | 2004-06-08 | |
PCT/GB2004/005464 WO2005061463A1 (en) | 2003-12-23 | 2004-12-23 | Pyrazole derivatives as protein kinase modulators |
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BRPI0418078A true BRPI0418078A (pt) | 2007-04-17 |
BRPI0418078A8 BRPI0418078A8 (pt) | 2018-01-02 |
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Application Number | Title | Priority Date | Filing Date |
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BRPI0418078A BRPI0418078A8 (pt) | 2003-12-23 | 2004-12-23 | composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto |
Country Status (17)
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US (4) | US8247576B2 (pt) |
EP (2) | EP2228369A1 (pt) |
JP (1) | JP4928949B2 (pt) |
KR (1) | KR101164258B1 (pt) |
AU (1) | AU2004303602C1 (pt) |
BR (1) | BRPI0418078A8 (pt) |
CA (1) | CA2548374C (pt) |
CY (1) | CY1111493T1 (pt) |
HK (1) | HK1097543A1 (pt) |
HR (1) | HRP20100675T1 (pt) |
IL (1) | IL176400A (pt) |
MX (1) | MXPA06007326A (pt) |
NO (1) | NO20062633L (pt) |
NZ (1) | NZ547696A (pt) |
PL (1) | PL1706385T3 (pt) |
UY (1) | UY28946A1 (pt) |
WO (1) | WO2005061463A1 (pt) |
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US7994172B2 (en) | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
WO2006091450A1 (en) | 2005-02-18 | 2006-08-31 | Lexicon Genetics Incorporated | 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds |
UY29610A1 (es) | 2005-06-21 | 2007-01-31 | Cancer Rec Tech Ltd | Aril-alquilaminas y heteroaril-alquilaminas como inhibidores de la quinasa proteínica |
GB2427406A (en) | 2005-06-21 | 2006-12-27 | Astex Technology Ltd | Silicon-containing PKB/PKA kinase inhibitors |
WO2006136823A1 (en) | 2005-06-21 | 2006-12-28 | Astex Therapeutics Limited | Heterocyclic containing amines as kinase b inhibitors |
WO2006136829A2 (en) | 2005-06-21 | 2006-12-28 | Astex Therapeutics Limited | Pyrazole derivatives and their use as pka and pkb modulators |
WO2006136821A1 (en) | 2005-06-22 | 2006-12-28 | Astex Therapeutics Limited | Pharmaceutical compounds |
WO2006136837A2 (en) | 2005-06-23 | 2006-12-28 | Astex Therapeutics Limited | Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators |
GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
-
2004
- 2004-12-23 NZ NZ547696A patent/NZ547696A/en not_active IP Right Cessation
- 2004-12-23 PL PL04806258T patent/PL1706385T3/pl unknown
- 2004-12-23 BR BRPI0418078A patent/BRPI0418078A8/pt active Search and Examination
- 2004-12-23 JP JP2006546339A patent/JP4928949B2/ja not_active Expired - Fee Related
- 2004-12-23 EP EP10168024A patent/EP2228369A1/en not_active Withdrawn
- 2004-12-23 CA CA2548374A patent/CA2548374C/en not_active Expired - Fee Related
- 2004-12-23 AU AU2004303602A patent/AU2004303602C1/en not_active Ceased
- 2004-12-23 EP EP04806258A patent/EP1706385B1/en active Active
- 2004-12-23 MX MXPA06007326A patent/MXPA06007326A/es active IP Right Grant
- 2004-12-23 WO PCT/GB2004/005464 patent/WO2005061463A1/en active Application Filing
- 2004-12-23 KR KR1020067014742A patent/KR101164258B1/ko not_active IP Right Cessation
- 2004-12-23 US US10/596,788 patent/US8247576B2/en not_active Expired - Fee Related
-
2005
- 2005-06-08 UY UY28946A patent/UY28946A1/es not_active Application Discontinuation
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2006
- 2006-06-08 NO NO20062633A patent/NO20062633L/no not_active Application Discontinuation
- 2006-06-19 IL IL176400A patent/IL176400A/en not_active IP Right Cessation
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2007
- 2007-04-03 HK HK07103603.6A patent/HK1097543A1/xx not_active IP Right Cessation
-
2010
- 2010-12-07 HR HR20100675T patent/HRP20100675T1/hr unknown
-
2011
- 2011-01-03 CY CY20111100002T patent/CY1111493T1/el unknown
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2012
- 2012-06-28 US US13/536,174 patent/US8691806B2/en not_active Expired - Fee Related
-
2014
- 2014-02-14 US US14/180,440 patent/US9283226B2/en not_active Expired - Fee Related
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2016
- 2016-01-29 US US15/010,831 patent/US20160250187A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL176400A (en) | 2011-10-31 |
WO2005061463A1 (en) | 2005-07-07 |
KR20060130621A (ko) | 2006-12-19 |
HK1097543A1 (en) | 2007-06-29 |
US9283226B2 (en) | 2016-03-15 |
AU2004303602C1 (en) | 2009-05-28 |
HRP20100675T1 (hr) | 2011-01-31 |
EP1706385B1 (en) | 2010-10-06 |
US20160250187A1 (en) | 2016-09-01 |
JP2007516272A (ja) | 2007-06-21 |
US8247576B2 (en) | 2012-08-21 |
NO20062633L (no) | 2006-07-20 |
UY28946A1 (es) | 2006-01-31 |
CY1111493T1 (el) | 2015-08-05 |
US20110144080A1 (en) | 2011-06-16 |
EP1706385A1 (en) | 2006-10-04 |
BRPI0418078A8 (pt) | 2018-01-02 |
EP2228369A1 (en) | 2010-09-15 |
MXPA06007326A (es) | 2007-01-26 |
CA2548374A1 (en) | 2005-07-07 |
US20140271662A1 (en) | 2014-09-18 |
US20130005702A1 (en) | 2013-01-03 |
NZ547696A (en) | 2009-12-24 |
KR101164258B1 (ko) | 2012-07-11 |
PL1706385T3 (pl) | 2011-03-31 |
US8691806B2 (en) | 2014-04-08 |
JP4928949B2 (ja) | 2012-05-09 |
IL176400A0 (en) | 2006-10-05 |
AU2004303602B2 (en) | 2008-12-18 |
AU2004303602A1 (en) | 2005-07-07 |
CA2548374C (en) | 2014-05-27 |
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