SI3353177T1 - Triciklični heterocikli za zdravljenje raka - Google Patents

Triciklični heterocikli za zdravljenje raka

Info

Publication number
SI3353177T1
SI3353177T1 SI201630856T SI201630856T SI3353177T1 SI 3353177 T1 SI3353177 T1 SI 3353177T1 SI 201630856 T SI201630856 T SI 201630856T SI 201630856 T SI201630856 T SI 201630856T SI 3353177 T1 SI3353177 T1 SI 3353177T1
Authority
SI
Slovenia
Prior art keywords
cancer
treatment
tricyclic heterocycles
tricyclic
heterocycles
Prior art date
Application number
SI201630856T
Other languages
English (en)
Inventor
Patrick Rene Angibaud
Diego Fernando Domenico Broggini
Helene France Solange Colombel
Filip Albert C Cuyckens
Steven Anna Hostyn
Russell Mark Jones
Olivier Alexis Georges Querolle
Wim Vermeulen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SI3353177T1 publication Critical patent/SI3353177T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201630856T 2015-09-23 2016-09-22 Triciklični heterocikli za zdravljenje raka SI3353177T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186491 2015-09-23
EP16770011.1A EP3353177B1 (en) 2015-09-23 2016-09-22 Tricyclic heterocycles for the treatment of cancer
PCT/EP2016/072499 WO2017050864A1 (en) 2015-09-23 2016-09-22 New compounds

Publications (1)

Publication Number Publication Date
SI3353177T1 true SI3353177T1 (sl) 2020-08-31

Family

ID=54196892

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201630856T SI3353177T1 (sl) 2015-09-23 2016-09-22 Triciklični heterocikli za zdravljenje raka

Country Status (17)

Country Link
US (1) US11155555B2 (sl)
EP (1) EP3353177B1 (sl)
JP (1) JP6898919B2 (sl)
CN (1) CN108026095B (sl)
AU (1) AU2016328692B2 (sl)
BR (1) BR112018005637B1 (sl)
CA (1) CA2996857C (sl)
DK (1) DK3353177T3 (sl)
ES (1) ES2811845T3 (sl)
HK (1) HK1254965A1 (sl)
HR (1) HRP20201157T1 (sl)
HU (1) HUE050567T2 (sl)
LT (1) LT3353177T (sl)
MX (1) MX2018003563A (sl)
RU (1) RU2747645C2 (sl)
SI (1) SI3353177T1 (sl)
WO (1) WO2017050864A1 (sl)

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CN108445033B (zh) * 2018-01-16 2020-01-31 温州大学 一种4-(3h)喹唑啉酮类化合物的生物碱光学纯度的测定方法
JP7378488B2 (ja) * 2019-03-08 2023-11-13 ショウヤオ ホールディングス（ベイジン） カンパニー， リミテッド Ｆｇｆｒ４キナーゼ阻害剤、その製造方法及び用途
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US20230002384A1 (en) * 2021-06-09 2023-01-05 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CA3220274A1 (en) * 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

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