BR0317392A - Formulação não-higroscópica incluindo uma droga higroscópica - Google Patents

Formulação não-higroscópica incluindo uma droga higroscópica

Info

Publication number
BR0317392A
BR0317392A BR0317392-5A BR0317392A BR0317392A BR 0317392 A BR0317392 A BR 0317392A BR 0317392 A BR0317392 A BR 0317392A BR 0317392 A BR0317392 A BR 0317392A
Authority
BR
Brazil
Prior art keywords
hygroscopic
drug
formulation including
polymer
composition
Prior art date
Application number
BR0317392-5A
Other languages
English (en)
Inventor
Danchen Gao
Ann M Czyzewski
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0317392A publication Critical patent/BR0317392A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"FORMULAçãO NãO-HIGROSCóPICA INCLUINDO UMA DROGA HIGROSCóPICA". A presente invenção refere-se a uma composição sólida em partículas, que inclui uma droga higroscópica ou deliq³escente e pelo menos um polímero não-higroscópico. A droga e pelo menos um polímero estão intimamente associados, e a composição é aceitavelmente não-higroscópica.
BR0317392-5A 2002-12-19 2003-12-05 Formulação não-higroscópica incluindo uma droga higroscópica BR0317392A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43514702P 2002-12-19 2002-12-19
US43542202P 2002-12-19 2002-12-19
US43502202P 2002-12-19 2002-12-19
PCT/US2003/038792 WO2004060352A1 (en) 2002-12-19 2003-12-05 Non-hygroscopic formulation comprising a hydroscopic drug

Publications (1)

Publication Number Publication Date
BR0317392A true BR0317392A (pt) 2005-12-20

Family

ID=32719157

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0317392-5A BR0317392A (pt) 2002-12-19 2003-12-05 Formulação não-higroscópica incluindo uma droga higroscópica
BR0317103-5A BR0317103A (pt) 2002-12-19 2003-12-11 Dispersões sólidas comprendendo um fármaco higroscópico e/ou deliquescente

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0317103-5A BR0317103A (pt) 2002-12-19 2003-12-11 Dispersões sólidas comprendendo um fármaco higroscópico e/ou deliquescente

Country Status (17)

Country Link
US (2) US20040197411A1 (pt)
EP (2) EP1575563B1 (pt)
JP (2) JP2006513238A (pt)
AR (2) AR042511A1 (pt)
AT (1) ATE353633T1 (pt)
AU (2) AU2003298010A1 (pt)
BR (2) BR0317392A (pt)
CA (2) CA2511385A1 (pt)
DE (1) DE60311875T2 (pt)
ES (1) ES2280835T3 (pt)
HN (1) HN2003000417A (pt)
MX (2) MXPA05006802A (pt)
NL (1) NL1025069C2 (pt)
PE (1) PE20040972A1 (pt)
TW (2) TW200423971A (pt)
UY (1) UY28138A1 (pt)
WO (2) WO2004060352A1 (pt)

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TW200423971A (en) 2004-11-16
DE60311875D1 (de) 2007-03-29
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WO2004060352A8 (en) 2005-09-15
NL1025069C2 (nl) 2005-02-16
ES2280835T3 (es) 2007-09-16
EP1575563A1 (en) 2005-09-21
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CA2511385A1 (en) 2004-07-22
AU2003296948A1 (en) 2004-07-29
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WO2004060353A1 (en) 2004-07-22
AU2003298010A1 (en) 2004-07-29
PE20040972A1 (es) 2004-12-14
ATE353633T1 (de) 2007-03-15
JP2006513238A (ja) 2006-04-20
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CA2509261A1 (en) 2004-07-22
US20040197411A1 (en) 2004-10-07
BR0317103A (pt) 2005-10-25
TW200413006A (en) 2004-08-01
WO2004060353A9 (en) 2004-10-07
AR042511A1 (es) 2005-06-22
DE60311875T2 (de) 2007-08-30
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