AR042511A1 - Intermedio de formulacion no higroscopico que comprende un farmaco higroscopico - Google Patents
Intermedio de formulacion no higroscopico que comprende un farmaco higroscopicoInfo
- Publication number
- AR042511A1 AR042511A1 ARP030104684A ARP030104684A AR042511A1 AR 042511 A1 AR042511 A1 AR 042511A1 AR P030104684 A ARP030104684 A AR P030104684A AR P030104684 A ARP030104684 A AR P030104684A AR 042511 A1 AR042511 A1 AR 042511A1
- Authority
- AR
- Argentina
- Prior art keywords
- hygroscopic
- drug
- polymer
- composition
- composition according
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Addiction (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Composición particulada sólida que comprende un fármaco higroscópico y/o delicuescente y al menos un polímero no higroscópico. El fármaco y el por lo menos un polímero están en asociación íntima y la composición es no higroscópica. Reivindicación 1: Una composición sólida particulada caracterizada porque comprende un fármaco y al menos un polímero no higroscópico, en la que el fármaco y dicho al menos un polímero no higroscópico están en asociación íntima, dicha composición es aceptablemente no higroscópica y el fármaco es higroscópico y/o delicuescente. Reivindicación 2: La composición según la reivindicación 1 ó 2 caracterizado porque el fármaco es un inhibidor iNOS. Reivindicación 3: La composición según la reivindicación 2, caracterizada porque el fármaco es S-[2-[(1-iminoetil)amino]etil]-2-meril-L-cisteína, o una sal farmacéuticamente aceptable del mismo. Reivindicación 5: La composición según una cualquiera de las reivindicaciones 1-4, caracterizada porque al menos un polímero no higroscópico es un polímero celulósico. Reivindicación 15: Un procedimiento para preparar una composición según una cualquiera de las reivindicaciones 1-14, caracterizada porque el procedimiento comprende una primera etapa de dispersión de un fármaco higroscópico y/o delicuescente y al menos un polímero no higroscópico en un líquido acuoso para formar una dispersión y una segunda etapa de eliminación del líquido acuoso de la dispersión.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43542202P | 2002-12-19 | 2002-12-19 | |
US43514702P | 2002-12-19 | 2002-12-19 | |
US43502202P | 2002-12-19 | 2002-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR042511A1 true AR042511A1 (es) | 2005-06-22 |
Family
ID=32719157
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104684A AR042511A1 (es) | 2002-12-19 | 2003-12-17 | Intermedio de formulacion no higroscopico que comprende un farmaco higroscopico |
ARP030104716A AR042536A1 (es) | 2002-12-19 | 2003-12-18 | Dispersiones solidas que comprenden un farmaco higroscopico y/o delicuescente |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104716A AR042536A1 (es) | 2002-12-19 | 2003-12-18 | Dispersiones solidas que comprenden un farmaco higroscopico y/o delicuescente |
Country Status (17)
Country | Link |
---|---|
US (2) | US20040197411A1 (es) |
EP (2) | EP1575563B1 (es) |
JP (2) | JP2006513238A (es) |
AR (2) | AR042511A1 (es) |
AT (1) | ATE353633T1 (es) |
AU (2) | AU2003298010A1 (es) |
BR (2) | BR0317392A (es) |
CA (2) | CA2511385A1 (es) |
DE (1) | DE60311875T2 (es) |
ES (1) | ES2280835T3 (es) |
HN (1) | HN2003000417A (es) |
MX (2) | MXPA05006802A (es) |
NL (1) | NL1025069C2 (es) |
PE (1) | PE20040972A1 (es) |
TW (2) | TW200423971A (es) |
UY (1) | UY28138A1 (es) |
WO (2) | WO2004060352A1 (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1243262T3 (da) | 2001-03-20 | 2006-10-02 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter |
EP1243263B1 (en) * | 2001-03-21 | 2002-11-27 | Schwarz Pharma Ag | Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain |
SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
ES2280835T3 (es) * | 2002-12-19 | 2007-09-16 | Pharmacia Corporation | Formulacion no higroscopica que comprende un farmaco higroscopico. |
KR20050096922A (ko) | 2002-12-20 | 2005-10-06 | 니코노범 에이비 | 물리적 및 화학적으로 안정된 니코틴 함유 입자물질 |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
FR2865133B1 (fr) * | 2004-01-19 | 2008-01-18 | Rytek | Compositions pour le traitement de pathologies digestives |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
EP1765309B1 (en) * | 2004-07-02 | 2009-08-05 | Radi Medical Biodegradable AB | Smokeless toabacco product |
EA014055B1 (ru) | 2004-08-27 | 2010-08-30 | Шварц Фарма Аг | Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами |
US20060147518A1 (en) * | 2004-12-30 | 2006-07-06 | Pierre Fabre Medicament | Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it |
US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
US20090304786A1 (en) * | 2005-11-25 | 2009-12-10 | Viswaprasad Varanasi | Stable Dosage Forms of an Antidepressant |
AU2007224584A1 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
RU2406502C2 (ru) * | 2006-06-06 | 2010-12-20 | Тиботек Фармасьютикалз Лтд. | Способ получения препаратов тмс125, полученных сушкой распылением |
TWI397417B (zh) | 2006-06-15 | 2013-06-01 | Ucb Pharma Gmbh | 具有協同抗驚厥功效之醫藥組成物 |
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-
2003
- 2003-12-05 ES ES03796731T patent/ES2280835T3/es not_active Expired - Lifetime
- 2003-12-05 EP EP03796731A patent/EP1575563B1/en not_active Expired - Lifetime
- 2003-12-05 CA CA002511385A patent/CA2511385A1/en not_active Abandoned
- 2003-12-05 WO PCT/US2003/038792 patent/WO2004060352A1/en active IP Right Grant
- 2003-12-05 MX MXPA05006802A patent/MXPA05006802A/es unknown
- 2003-12-05 AT AT03796731T patent/ATE353633T1/de not_active IP Right Cessation
- 2003-12-05 DE DE60311875T patent/DE60311875T2/de not_active Expired - Fee Related
- 2003-12-05 JP JP2004565235A patent/JP2006513238A/ja active Pending
- 2003-12-05 BR BR0317392-5A patent/BR0317392A/pt not_active IP Right Cessation
- 2003-12-05 AU AU2003298010A patent/AU2003298010A1/en not_active Abandoned
- 2003-12-11 AU AU2003296948A patent/AU2003296948A1/en not_active Abandoned
- 2003-12-11 CA CA002509261A patent/CA2509261A1/en not_active Abandoned
- 2003-12-11 JP JP2004565403A patent/JP2006514052A/ja not_active Withdrawn
- 2003-12-11 EP EP03814729A patent/EP1575564A1/en not_active Withdrawn
- 2003-12-11 MX MXPA05005667A patent/MXPA05005667A/es unknown
- 2003-12-11 WO PCT/US2003/039510 patent/WO2004060353A1/en not_active Application Discontinuation
- 2003-12-11 BR BR0317103-5A patent/BR0317103A/pt not_active IP Right Cessation
- 2003-12-17 TW TW092135756A patent/TW200423971A/zh unknown
- 2003-12-17 AR ARP030104684A patent/AR042511A1/es unknown
- 2003-12-18 NL NL1025069A patent/NL1025069C2/nl not_active IP Right Cessation
- 2003-12-18 US US10/741,530 patent/US20040197411A1/en not_active Abandoned
- 2003-12-18 AR ARP030104716A patent/AR042536A1/es unknown
- 2003-12-18 US US10/741,526 patent/US20050013856A1/en not_active Abandoned
- 2003-12-18 TW TW092135960A patent/TW200413006A/zh unknown
- 2003-12-19 UY UY28138A patent/UY28138A1/es not_active Application Discontinuation
- 2003-12-19 HN HN2003000417A patent/HN2003000417A/es unknown
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2004
- 2004-01-05 PE PE2004000027A patent/PE20040972A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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CA2509261A1 (en) | 2004-07-22 |
EP1575563B1 (en) | 2007-02-14 |
BR0317392A (pt) | 2005-12-20 |
WO2004060352A1 (en) | 2004-07-22 |
JP2006514052A (ja) | 2006-04-27 |
ES2280835T3 (es) | 2007-09-16 |
DE60311875T2 (de) | 2007-08-30 |
US20050013856A1 (en) | 2005-01-20 |
MXPA05005667A (es) | 2005-07-26 |
NL1025069C2 (nl) | 2005-02-16 |
HN2003000417A (es) | 2005-11-01 |
EP1575564A1 (en) | 2005-09-21 |
NL1025069A1 (nl) | 2004-07-01 |
UY28138A1 (es) | 2004-08-31 |
CA2511385A1 (en) | 2004-07-22 |
ATE353633T1 (de) | 2007-03-15 |
PE20040972A1 (es) | 2004-12-14 |
TW200423971A (en) | 2004-11-16 |
AU2003298010A1 (en) | 2004-07-29 |
JP2006513238A (ja) | 2006-04-20 |
AR042536A1 (es) | 2005-06-22 |
WO2004060353A1 (en) | 2004-07-22 |
US20040197411A1 (en) | 2004-10-07 |
TW200413006A (en) | 2004-08-01 |
WO2004060353A9 (en) | 2004-10-07 |
EP1575563A1 (en) | 2005-09-21 |
DE60311875D1 (de) | 2007-03-29 |
MXPA05006802A (es) | 2005-09-08 |
WO2004060352A8 (en) | 2005-09-15 |
BR0317103A (pt) | 2005-10-25 |
AU2003296948A1 (en) | 2004-07-29 |
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