DE69813571D1 - 11,15-o-dialkylprostaglandin-e-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese als aktiven inhaltsstoff enthalten - Google Patents
11,15-o-dialkylprostaglandin-e-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese als aktiven inhaltsstoff enthaltenInfo
- Publication number
- DE69813571D1 DE69813571D1 DE69813571T DE69813571T DE69813571D1 DE 69813571 D1 DE69813571 D1 DE 69813571D1 DE 69813571 T DE69813571 T DE 69813571T DE 69813571 T DE69813571 T DE 69813571T DE 69813571 D1 DE69813571 D1 DE 69813571D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- active ingredient
- dialkylprostaglandin
- production
- products containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 101150053131 PTGER3 gene Proteins 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 108010088540 Prostaglandin E receptors Proteins 0.000 abstract 1
- 102000008866 Prostaglandin E receptors Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical class CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4157197 | 1997-02-10 | ||
JP4157197 | 1997-02-10 | ||
PCT/JP1998/000544 WO1998034916A1 (fr) | 1997-02-10 | 1998-02-10 | Derives de 11,15-o-dialkylprostaglandine e, leur procede de production, et medicaments renfermant ceux-ci comme principe actif |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69813571D1 true DE69813571D1 (de) | 2003-05-22 |
DE69813571T2 DE69813571T2 (de) | 2004-02-12 |
Family
ID=12612138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69813571T Expired - Fee Related DE69813571T2 (de) | 1997-02-10 | 1998-02-10 | 11,15-o-dialkylprostaglandin-e-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese als aktiven inhaltsstoff enthalten |
Country Status (10)
Country | Link |
---|---|
US (1) | US6288119B1 (de) |
EP (1) | EP1008588B1 (de) |
JP (1) | JP4044967B2 (de) |
KR (1) | KR20000070903A (de) |
AT (1) | ATE237587T1 (de) |
DE (1) | DE69813571T2 (de) |
DK (1) | DK1008588T3 (de) |
ES (1) | ES2196527T3 (de) |
PT (1) | PT1008588E (de) |
WO (1) | WO1998034916A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4834224B2 (ja) | 1999-03-05 | 2011-12-14 | デューク ユニバーシティ | C16不飽和fp−選択的プロスタグランジン類縁体 |
US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
WO2004032964A1 (ja) * | 2002-10-10 | 2004-04-22 | Ono Pharmaceutical Co., Ltd. | アレルギー性疾患治療剤 |
TW200413000A (en) | 2002-10-10 | 2004-08-01 | Ono Pharmaceutical Co | Intrinsic repair factor producing accelerator |
WO2004074842A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep3 (prostaglandin e2 ep3) |
US20070167403A1 (en) * | 2003-04-03 | 2007-07-19 | Yoshifumi Takenobu | Remedy for spinal canal stenosis |
EP2422814A1 (de) * | 2003-07-25 | 2012-02-29 | Ono Pharmaceutical Co., Ltd. | Heilmittel für Knorpelerkrankungen |
EP1707208A4 (de) * | 2003-12-05 | 2010-03-17 | Ono Pharmaceutical Co | Blutflusspromotoren für cauda-equina-gewebe |
EP1723132A1 (de) | 2004-02-12 | 2006-11-22 | Asterand Uk Limited | Agonisten des ep2-rezeptors |
AR056968A1 (es) * | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
EP2494990A1 (de) | 2005-06-03 | 2012-09-05 | Ono Pharmaceutical Co., Ltd. | Wirkstoff zur Regenerierung und/oder zum Schutz von Nerven |
EP1951701A2 (de) | 2005-08-09 | 2008-08-06 | Asterand Uk Limited | Agonisten des ep2-rezeptors |
HUE031972T2 (en) | 2005-12-29 | 2017-08-28 | Celtaxsys Inc | Diamin derivatives as leukotriene A4 hydrolase inhibitors |
TW200833695A (en) | 2006-10-12 | 2008-08-16 | Xenon Pharmaceuticals Inc | Use of spiro-oxindole compounds as therapeutic agents |
CL2007002953A1 (es) * | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia. |
US20090124695A1 (en) | 2007-11-14 | 2009-05-14 | Cayman Chemical Company | Prostaglandin e1 and e2 analogs for the treatment of various medical conditions |
RU2011119626A (ru) * | 2008-10-17 | 2012-11-27 | Ксенон Фармасьютикалз Инк. | Спирооксиндольные соединения и их применение в качестве терапевтичеких средств |
US8101647B2 (en) * | 2008-10-17 | 2012-01-24 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
PL2441760T3 (pl) | 2009-06-10 | 2014-05-30 | Ono Pharmaceutical Co | Związek o działaniu kurczącym mięsień-wypieracz i zwiotczającym mięsień-zwieracz cewki moczowej |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
WO2011047173A2 (en) | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
EP2488531B1 (de) * | 2009-10-14 | 2014-03-26 | Xenon Pharmaceuticals Inc. | Verfahren zur herstellung von spiro-oxindol derivaten |
WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
WO2013154712A1 (en) | 2012-04-12 | 2013-10-17 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
TWI597274B (zh) | 2012-08-31 | 2017-09-01 | 小野藥品工業股份有限公司 | 胺鹽及其結晶 |
WO2014152229A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
EP2818484A1 (de) | 2013-06-28 | 2014-12-31 | Universitat Autònoma de Barcelona | Synergistische Kombination eines Anti-IgE-Antikörpers und eines EP2-Rezeptoragonisten |
WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
WO2017218920A1 (en) | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Asymmetric synthesis of funapide |
JP7174700B2 (ja) | 2016-12-09 | 2022-11-17 | セルタクシー、エルエルシー | ロイコトリエンa4ヒドロラーゼの阻害剤としてのモノアミン及びモノアミン誘導体 |
JP7145154B2 (ja) | 2016-12-09 | 2022-09-30 | セルタクシー、エルエルシー | ロイコトリエンa4ヒドロラーゼの阻害剤 |
EP3551608A1 (de) | 2016-12-09 | 2019-10-16 | Celtaxsys Inc. | Anhängende amine und derivate als inhibitoren der leukotrien-a4-hydrolase |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3835180A (en) * | 1971-05-04 | 1974-09-10 | Upjohn Co | 15 alkoxy pge compounds |
US3876690A (en) * | 1973-05-11 | 1975-04-08 | American Cyanamid Co | 1-alkoxy-9-keto-prostenoic acid derivatives |
GB1451798A (en) * | 1973-08-02 | 1976-10-06 | Ici Ltd | Prostanoic acid derivatives |
US4236027A (en) * | 1977-10-17 | 1980-11-25 | American Cyanamid Company | Novel 11-alkoxy-9-keto (or hydroxy)-prostenoic acid derivatives and method for preparing same |
JPS55115836A (en) * | 1979-03-02 | 1980-09-06 | Toray Ind Inc | Preparation of methyl ether derivative |
DE3510978A1 (de) * | 1985-03-22 | 1986-09-25 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPH03101622A (ja) * | 1989-09-11 | 1991-04-26 | Green Cross Corp:The | 肝炎予防治療剤 |
-
1998
- 1998-02-10 KR KR1019997007168A patent/KR20000070903A/ko not_active Application Discontinuation
- 1998-02-10 ES ES98901576T patent/ES2196527T3/es not_active Expired - Lifetime
- 1998-02-10 JP JP53414898A patent/JP4044967B2/ja not_active Expired - Lifetime
- 1998-02-10 WO PCT/JP1998/000544 patent/WO1998034916A1/ja not_active Application Discontinuation
- 1998-02-10 PT PT98901576T patent/PT1008588E/pt unknown
- 1998-02-10 AT AT98901576T patent/ATE237587T1/de not_active IP Right Cessation
- 1998-02-10 US US09/355,626 patent/US6288119B1/en not_active Expired - Lifetime
- 1998-02-10 DE DE69813571T patent/DE69813571T2/de not_active Expired - Fee Related
- 1998-02-10 EP EP98901576A patent/EP1008588B1/de not_active Expired - Lifetime
- 1998-02-10 DK DK98901576T patent/DK1008588T3/da active
Also Published As
Publication number | Publication date |
---|---|
US6288119B1 (en) | 2001-09-11 |
EP1008588A1 (de) | 2000-06-14 |
DK1008588T3 (da) | 2003-07-28 |
WO1998034916A1 (fr) | 1998-08-13 |
ES2196527T3 (es) | 2003-12-16 |
JP4044967B2 (ja) | 2008-02-06 |
KR20000070903A (ko) | 2000-11-25 |
ATE237587T1 (de) | 2003-05-15 |
PT1008588E (pt) | 2003-09-30 |
EP1008588B1 (de) | 2003-04-16 |
EP1008588A4 (de) | 2000-06-14 |
DE69813571T2 (de) | 2004-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69813571D1 (de) | 11,15-o-dialkylprostaglandin-e-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese als aktiven inhaltsstoff enthalten | |
NL300175I1 (nl) | Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2. | |
ATE260255T1 (de) | 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate | |
MA27867A1 (fr) | Nouveaux derives de 2h-pyridazine-3-one, compositions pharmaceutiques contenant ces derives et procede de preparation de l'ingredient actif. | |
EP1090908A3 (de) | Cyclobutan-Derivate als Inhibitoren der Protein-Farnesyltransferase | |
NO974163L (no) | Ester av 5-aminolevulinsyre som fotosensibiliserings-middel i fotokjemoterapi | |
MA27568A1 (fr) | Derives de pyrrolopyrimidine | |
ATE264337T1 (de) | Glucopyranosyloxypyrazol-derivate, diese enthaltende arzneimittel und zwischenprodukte zu deren herstellung | |
ATE321543T1 (de) | Pharmazeutische zusammensetzungen mit hydroximsäurederivaten | |
EP1314719A4 (de) | Benzoesäurederivate und medikamente die diese als aktiven wirkstoff enthalten | |
AU8811401A (en) | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | |
MA26725A1 (fr) | Derives de resorcinol, compositions pharmaceutiques les contenant et procede pour leur preparation | |
DE69600272D1 (de) | Chinolin-4-carbonylguanidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen | |
AU5879798A (en) | Agents inhibiting progress of pterygium and postoperative recurrence of the same | |
HUP0004900A2 (hu) | Mozgászavarok kezelésére szolgáló, hatóanyagként NMDA-receptor antagonista hatású piperidinszármazékokat tartalmazó gyógyszerkészítmények | |
WO2003080631A8 (en) | Plasma carboxypeptidase b inhibitors | |
ATE303991T1 (de) | Aralkyltetrahydropyridine, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten | |
DE69217613D1 (de) | Stickstoff enthaltende bizyklische Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
DE60234024D1 (de) | Neue retinoidderivate und eine pharmazeutische anti-krebs-zusammensetzung, die diese verbindungen enthält | |
DK1179342T3 (da) | Medicinske sammensætninger til öjeblikkelig frigivelse ved oral anvendelse | |
ATE267832T1 (de) | Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung | |
MXPA04003200A (es) | Nuevos compuestos de isoquinolina, un proceso para su preparacion y composiciones farmaceuticas que los contienen. | |
BR0109252A (pt) | Composto, processo para produzir um composto, composição farmacêutica, e, uso de um composto ou de uma composição | |
ATE265459T1 (de) | Triazolpurin-derivate, medikamentzusammensetzungen, die diese enthalten und mittel, die affinität zum adenosin a3 rezeptor zeigen | |
DE69528984T2 (de) | Hemmung der leukotrienbiosynthese mittels harnstoffderivaten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |