HUP0004900A2 - Mozgászavarok kezelésére szolgáló, hatóanyagként NMDA-receptor antagonista hatású piperidinszármazékokat tartalmazó gyógyszerkészítmények - Google Patents

Mozgászavarok kezelésére szolgáló, hatóanyagként NMDA-receptor antagonista hatású piperidinszármazékokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0004900A2
HUP0004900A2 HU0004900A HUP0004900A HUP0004900A2 HU P0004900 A2 HUP0004900 A2 HU P0004900A2 HU 0004900 A HU0004900 A HU 0004900A HU P0004900 A HUP0004900 A HU P0004900A HU P0004900 A2 HUP0004900 A2 HU P0004900A2
Authority
HU
Hungary
Prior art keywords
drug
active ingredient
receptor antagonist
nmda receptor
pharmaceutical compositions
Prior art date
Application number
HU0004900A
Other languages
English (en)
Inventor
Leonard Theodore Meltzer
Original Assignee
Warner-Lambert Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Co. filed Critical Warner-Lambert Co.
Publication of HUP0004900A2 publication Critical patent/HUP0004900A2/hu
Publication of HUP0004900A3 publication Critical patent/HUP0004900A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A találmány tárgya betegséggel kapcsolatos vagy gyógyszer általelőidézett mozgászavarok kezelésére alkalmas gyógyszerkészítmények. Agyógyszerkészítmények hatóanyagként egy NR1A/2B hely-szelektív NMDA-receptor antagonista vegyületet tartalmaznak, amely az (I) képletteljellemezhető. Ó
HU0004900A 1997-10-24 1998-09-16 Pharmaceutical compositions for treating disease-related or drug-induced dyskinesias containing piperidine derivatives as nmda receptor antagonist as active ingredient HUP0004900A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6315697P 1997-10-24 1997-10-24
PCT/US1998/019357 WO1999021539A1 (en) 1997-10-24 1998-09-16 Method for treating disease-related or drug-induced dyskinesias

Publications (2)

Publication Number Publication Date
HUP0004900A2 true HUP0004900A2 (hu) 2001-06-28
HUP0004900A3 HUP0004900A3 (en) 2002-03-28

Family

ID=22047302

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004900A HUP0004900A3 (en) 1997-10-24 1998-09-16 Pharmaceutical compositions for treating disease-related or drug-induced dyskinesias containing piperidine derivatives as nmda receptor antagonist as active ingredient

Country Status (15)

Country Link
US (1) US6284776B1 (hu)
EP (1) EP1024799A1 (hu)
JP (1) JP2001520988A (hu)
KR (1) KR20010024548A (hu)
AU (1) AU760800B2 (hu)
BR (1) BR9814867A (hu)
CA (1) CA2299400C (hu)
HU (1) HUP0004900A3 (hu)
IL (1) IL134363A0 (hu)
IS (1) IS5384A (hu)
NO (1) NO20001893D0 (hu)
NZ (1) NZ502785A (hu)
PL (1) PL340080A1 (hu)
WO (1) WO1999021539A1 (hu)
ZA (1) ZA989693B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2440284A1 (en) * 2001-03-08 2002-09-19 Emory University Ph-dependent nmda receptor antagonists
CA2381630A1 (en) * 2001-04-23 2002-10-23 Leonard Theodore Meltzer Method for preventing dyskinesias
ES2312603T3 (es) 2001-07-24 2009-03-01 Richter Gedeon Nyrt Derivados de piperidina como antagonistas del receptor nmda.
US7160913B2 (en) * 2002-09-13 2007-01-09 Thomas Jefferson University Methods and kit for treating Parkinson's disease
EP1673366A1 (en) * 2003-10-08 2006-06-28 Pfizer, Inc. 1-"2-(4-hydroxyphenyl)-2-hydroxyethyl]-piperidin-4-ol compounds as nmda receptor antagonists
US8420680B2 (en) 2007-06-29 2013-04-16 Emory University NMDA receptor antagonists for neuroprotection
US8951968B2 (en) 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
US20140322315A1 (en) 2011-11-22 2014-10-30 The Regents Of The University Of California Cysteamine and/or cystamine for treating ischemic injury
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5733M (hu) 1966-09-27 1968-01-22
US5272160A (en) 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
WO1991006297A1 (en) * 1989-10-27 1991-05-16 The Du Pont Merck Pharmaceutical Company (n-phthalimidoalkyl) piperidines
US5356906A (en) * 1989-10-27 1994-10-18 The Du Pont Merck Pharmaceutical Company (N-phthalimidoalkyl) piperidines useful as treatments for psychosis
US5116846A (en) * 1990-03-28 1992-05-26 Du Pont Merck Pharmaceutical Company N-aralkyl piperidine derivatives as psychotropic drugs
EP0591426A4 (en) * 1991-06-27 1996-08-21 Univ Virginia Commonwealth Sigma receptor ligands and the use thereof
US5364867A (en) * 1992-11-30 1994-11-15 Sterling Winthrop Inc. 4-phenylpiperdine agents for treating cns disorders
TW281670B (hu) 1993-09-02 1996-07-21 Hoffmann La Roche
FR2717080B1 (fr) 1994-03-09 1996-12-13 Synthelabo Utilisation de l'éliprodil et de ses énantiomères pour la préparation de médicaments utiles dans le traitement des neuropathies périphériques et des maladies neurodégénératives centrales.
FR2717810B1 (fr) * 1994-03-22 1996-04-26 Adir Nouvelles aminoalkyl benzoxazolinones et benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ATE258067T1 (de) * 1995-05-26 2004-02-15 Pfizer Kombinationspräparat zur behandlung der parkinsonschen krankheit, das selektive nmda- antagonisten enthält
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists

Also Published As

Publication number Publication date
ZA989693B (en) 1999-04-29
US6284776B1 (en) 2001-09-04
IL134363A0 (en) 2001-04-30
WO1999021539A1 (en) 1999-05-06
CA2299400C (en) 2004-04-27
NO20001893L (no) 2000-04-12
EP1024799A1 (en) 2000-08-09
IS5384A (is) 2000-02-25
AU9318198A (en) 1999-05-17
HUP0004900A3 (en) 2002-03-28
NZ502785A (en) 2003-03-28
AU760800B2 (en) 2003-05-22
JP2001520988A (ja) 2001-11-06
CA2299400A1 (en) 1999-05-06
PL340080A1 (en) 2001-01-15
NO20001893D0 (no) 2000-04-12
KR20010024548A (ko) 2001-03-26
BR9814867A (pt) 2000-10-03

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